The T-786→C mutation in endothelial nitric oxide synthase is associated with hypertension

Hypertension

Volumn 39, Issue 4, 2002, Pages 919-922

  Hyndman, Matthew E ^a   Parsons, Howard G ^a   Verma, Subodh ^a   Bridge, Peter J ^a   Edworthy, Steven ^a   Jones, Charlotte ^a   Lonn, Eva ^a   Charbonneau, Francois ^a   Anderson, Todd J ^a  

^a FOOTHILLS HOSPITAL   (Canada)

Author keywords

Blood pressure; Essential; Hypertension; Mutation; Nitric oxide; Nitric oxide synthase; Polymorphism

Indexed keywords

ASPARTIC ACID; CYTOSINE; GLUTAMIC ACID; NITRIC OXIDE SYNTHASE; THYMIDINE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; NOS3 PROTEIN, HUMAN;

ADULT; ALLELE; ARTICLE; BLOOD PRESSURE; CLINICAL ARTICLE; CONFIDENCE INTERVAL; CONTROLLED STUDY; ESSENTIAL HYPERTENSION; GENE FREQUENCY; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; MEAN ARTERIAL PRESSURE; POINT MUTATION; PRIORITY JOURNAL; RISK FACTOR; SYSTOLIC BLOOD PRESSURE; VASCULAR ENDOTHELIUM; ENZYMOLOGY; GENETIC PREDISPOSITION; GENETICS; HYPERTENSION; MIDDLE AGED; PATHOPHYSIOLOGY;

ADULT; BLOOD PRESSURE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; HYPERTENSION; MALE; MIDDLE AGED; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE III; POINT MUTATION;

EID: 0036010970     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.HYP.0000013703.07316.7F     Document Type: Article

References (19)

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4. Endothelial nitric oxide synthase gene is positively associated with essential hypertension
5. Positive association of endothelial nitric oxide synthase gene polymorphism with hypertension in northern Japan
6. A missense Glu298Asp variant in the endothelial nitric oxide synthase gene is associated with coronary spasm in the Japanese
7. T-786→C mutation in the 5′-flanking region of the endothelial nitric oxide synthase gene is associated with coronary spasm
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14. Are there interactions and relations between genetic and environmental factors predisposing to high blood pressure?
15. Preserved endothelium-dependent vasodilatation in patients with essential hypertension
16. Defective L-arginine-nitric oxide pathway in offspring of essential hypertensive patients
17. Replication protein A1 reduces transcription of the endothelial nitric oxide synthase gene containing a -786T→C mutation associated with coronary spastic angina
18. Lack of association between T-786→C mutation in the 5′-flanking region of the endothelial nitric oxide synthase gene and essential hypertension
19. Genetic risk factors for coronary artery spasm: Significance of endothelial nitric oxide synthase gene T-786→C and missense Glu298Asp variants