Synthesis of 2-deoxy-2-fluoro and 1,2-ene derivatives of the naturally occurring glycosidase inhibitor, salacinol, and their inhibitory activities against recombinant human maltase glucoamylase

Carbohydrate Research

Volumn 343, Issue 5, 2008, Pages 951-956

  Choubdar, Niloufar ^a   Sim, Lyann ^b   Rose, David R ^b   Pinto, B Mario ^a  

^a SIMON FRASER UNIVERSITY   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

2 Deoxy 1 ene salacinol; 2 Deoxy 2 fluorosalacinol; Cyclic sulfates; Glycosidase inhibitors; Human maltase glucoamylase (MGA) inhibition; Salacinol derivatives

Indexed keywords

ACETONITRILE; BIOSYNTHESIS; DERIVATIVES; REACTION KINETICS;

HUMAN MALTASE GLUCOAMYLASE; SALACINOL;

ENZYME INHIBITION;

2 DEOXY 2 FLUORO 3,5 DI O 4 METHOXYBENZYL 1,4 ANHYDRO 4 THIO DEXTRO ARABINITOL; 2 DEOXY 2 FLUOROSALACINOL; ACETONITRILE; ALCOHOL DERIVATIVE; ALKENE DERIVATIVE; ALPHA GLUCOSIDASE; ARABINITOL; ENZYME INHIBITOR; GLUCOSE; GLYCOSIDASE INHIBITOR; HEXAFLUORO 2 PROPANOL; INTESTINE ENZYME; POTASSIUM CARBONATE; SALACINOL; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; CROSS COUPLING REACTION; DEPROTECTION REACTION; ELIMINATION REACTION; IC 50; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

EID: 39849103111     PISSN: 00086215     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.carres.2008.01.025     Document Type: Article

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