Thiosemicarbazones active against Clostridium difficile

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 5, 2008, Pages 1708-1711

  Costello, Cait ^a   Karpanen, Tarja ^a   Lambert, Peter A ^a   Mistry, Preena ^a   Parker, Katy J ^a   Rathbone, Daniel L ^a   Ren, Jiangmeng ^a   Wheeldon, Laura ^a   Worthington, Tony ^a  

^a ASTON UNIVERSITY   (United Kingdom)

Author keywords

Antimicrobial; Clostridium difficile; Nitrofuran; Thiosemicarbazone

Indexed keywords

THIOSEMICARBAZONE DERIVATIVE;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; CLOSTRIDIUM DIFFICILE; DRUG ACTIVITY; DRUG SYNTHESIS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; NONHUMAN; STAPHYLOCOCCUS EPIDERMIDIS; STRUCTURE ACTIVITY RELATION;

ANTI-BACTERIAL AGENTS; CLOSTRIDIUM DIFFICILE; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; THIOSEMICARBAZONES;

CLOSTRIDIUM DIFFICILE; POSIBACTERIA;

EID: 39849095429     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.01.041     Document Type: Article

References (15)

1. Health Protection Agency, Quarterly Reporting Results for Clostridium difficile Infections and MRSA Bacteraemia; November 2007, http://www.hpa.org.uk/infections/topics_az/hai/Mandatory_Results.htm.
2. Drudy D., Harnedy N., Fanning S., Hannan M., and Kyne L. Infect. Control Hosp. Epidemiol. 28 (2007) 932
3. Noren T., Wullt M., Akerlund T., Back E., Odenholt I., and Burman L.G. Antimicrob. Agents Chemother. 50 (2006) 3028
4. Du X., Guo C., Hansell E., Doyle P.S., Caffrey C.R., Holler T.P., McKerrow J.H., and Cohen F.E. J. Med. Chem. 45 (2002) 2695
5. Greenbaum D.C., Mackey Z., Hansell E., Doyle P., Gut J., Caffrey C.R., Lehrman J., Rosenthal P.J., McKerrow J.H., and Chibale K. J. Med. Chem. 47 (2004) 3212
6. Aguirre G., Boiani L., Cerecetto H., Fernandez M., Gonzalez M., Denicola A., Otero L., Gambino D., Rigol C., Olea-Azar C., and Faundez M. Bioorg. Med. Chem. 12 (2004) 4885
7. Otero L., Vieites M., Boiani L., Denicola A., Rigol C., Opazo L., Olea-Azar C., Maya J.D., Morello A., Krauth-Siegel R.L., Piro O.E., Castellano E., Gonzalez M., Gambino D., and Cerecetto H. J. Med. Chem. 49 (2006) 3322
8. Sharma S., Athar F., Maurya M.R., Naqvi F., and Azam A. Eur. J. Med. Chem. 40 (2005) 557
9. Nardi D., Massarani E., Tajana A., Degen L., and Magistretti M.J. J. Med. Chem. 10 (1967) 530
10. Bilgin A.A., Erol D.D., Yulug N., and Istanbullu I. Fabad Farm. Bilimler Derg 14 (1989) 79
11. Pires J.R., Saito C., Gomes S.L., Giesbrecht A.M., and Amaral A.T. J. Med. Chem. 44 (2001) 3673
12. Squella J.A., Bollo S., and Nunez-Vergara L.J. Curr. Org. Chem. 9 (2005) 565
13. Rigol C., Olea-Azar C., Mendizabal F., Otero L., Gambino D., Gonzalez M., and Cerecetto H. Spectrochim. Acta, Part A 61 (2005) 2933
14. + calcd 283.0865, found 283.0845.
15. + calcd 297.1021, found 297.1013.