Biphenylsulfonyl-thiophene-carboxamidine inhibitors of the complement component C1s

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 5, 2008, Pages 1603-1606

  Travins, Jeremy M ^a   Ali, Farah ^a   Huang, Hui ^a   Ballentine, Shelley K ^a   Khalil, Ehab ^a   Hufnagel, Heather R ^a   Pan, Wenxi ^a   Gushue, Joan ^a   Leonard, Kristi ^a   Bone, Roger F ^a   Soll, Richard M ^a   DesJarlais, Renee L ^a   Crysler, Carl S ^a   Ninan, Nisha ^a   Kirkpatrick, Jennifer ^a   Cummings, Maxwell D ^a   Huebert, Norman ^a   Molloy, Christopher J ^a   Gaul, Michael ^a   Tomczuk, Bruce E ^a   Subasinghe, Nalin L ^a   more..

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Amidine; C1s; Complement; Inhibitor; Pharmacokinetic; Protease; Suzuki

Indexed keywords

COMPLEMENT COMPONENT C1; COMPLEMENT COMPONENT C1S INHIBITOR; THIOPHENE DERIVATIVE;

ARTICLE; COMPLEMENT ACTIVATION; COMPLEMENT SYSTEM; DRUG BINDING; DRUG CLEARANCE; DRUG HALF LIFE; DRUG POTENCY; DRUG SAFETY; DRUG SOLUBILITY; MOLECULAR MODEL; NONHUMAN; PHYSICAL CHEMISTRY;

ANIMALS; BINDING SITES; COMPLEMENT C1S; HALF-LIFE; HETEROCYCLIC COMPOUNDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 39849088737     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.01.064     Document Type: Article

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