Augmenter of liver regeneration: An important intracellular survival factor for hepatocytes

Journal of Hepatology

Volumn 48, Issue 4, 2008, Pages 578-588

  Thirunavukkarasu, Chinnasamy ^a   Wang, Lian Fu ^a   Harvey, Stephen A K ^b   Watkins, Simon C ^c   Chaillet, J Richard ^b   Prelich, John ^c   Starzl, Thomas E ^a   Gandhi, Chandrashekhar R ^a,c,d  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Antisense; Apoptosis; Augmenter of liver regeneration; Hepatocytes; Necrosis

Indexed keywords

7 AMINODACTINOMYCIN; ADENOSINE TRIPHOSPHATE; ANTISENSE OLIGODEOXYNUCLEOTIDE; CASPASE 3; MESSENGER RNA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; FLOW CYTOMETRY; LIVER CELL; LIVER REGENERATION; MITOCHONDRION; NECROSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RAT;

ADENOSINE TRIPHOSPHATE; ANIMALS; APOPTOSIS; CELL COUNT; CELL SURVIVAL; CELLS, CULTURED; FLOW CYTOMETRY; HEPATOCYTES; INTRACELLULAR FLUID; MITOCHONDRIA, LIVER; OLIGONUCLEOTIDES, ANTISENSE; PROTEINS; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SPECTROPHOTOMETRY; TRANSFECTION;

EID: 39849084756     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2007.12.010     Document Type: Article

References (46)

1. LaBrecque D.R., and Pesch L.A. Preparation and partial characterization of hepatic regenerative stimulator substance (HSS) from rat liver. J Physiol 248 (1975) 273-284
2. Starzl T.E., Jones A.F., Terblanche J., Usui S., Porter K.A., and Mazzoni G. Growth-stimulating factor in regenerating canine liver. Lancet 1 (1979) 127-130
3. Francavilla A., Hagiya M., Porter K.A., Polimeno L., Ihara I., and Starzl T.E. Augmenter of liver regeneration: its place in the universe of hepatic growth factors. Hepatology 20 (1994) 747-757
4. Francavilla A., Barone M., Van Thiel D.H., Mazzaferro V., Prelich J., and Starzl T.E. Further steps of HSS (hepatic stimulatory substance) purification. Dig Dis Sci 36 (1991) 674-680
5. Francavilla A., Ove P., Polimeno L., Coetzee M., Makowka L., Rose J., et al. Extraction and partial purification of a hepatic stimulatory substance in rats, mice, and dogs. Cancer Res 47 (1987) 5600-5605
6. Hagiya M., Francavilla A., Polimeno L., Ihara I., Sakai H., Seki T., et al. Cloning and sequence analysis of the rat augmenter of liver regeneration (ALR) gene: expression of biologically active recombinant ALR and demonstration of tissue distribution. Proc Natl Acad Sci USA 91 (1994) 8142-8146 (Proc Natl Acad Sci USA 1995;92:3076 (Correction))
7. Giorda R., Hagiya M., Seki T., Shimonishi M., Sakai H., Michaelson J., et al. Analysis of the structure and expression of the augmenter of liver regeneration (ALR) gene. Mol Med 2 (1996) 97-108
8. Francavilla A., Vujanovic N.L., Polimeno L., Azzarone A., Iacobellis A., Deleo A., et al. The in vivo effect of hepatotrophic factors augmenter of liver regeneration, hepatocyte growth factor, and insulin-like growth factor-II on liver natural killer cell functions. Hepatology 25 (1997) 411-415
9. Tanigawa K., Sakaida I., Masuhara M., Hagiya M., and Okita K. Augmenter of liver regeneration (ALR) may promote liver regeneration by reducing natural killer (NK) cell activity in human liver diseases. J Gastroenterol 35 (2000) 112-119
10. Vujanovic N.L., Polimeno L., Azzarone A., Francavilla A., Chambers W.H., Starzl T.E., et al. Changes of liver-resident NK cells during liver regeneration in rats. J Immunol 154 (1995) 6324-6338
11. Francavilla A., Starzl T.E., Porter K., Scotti-Foglieni C., Michalopoulos G.K., Carrieri G., et al. Screening for candidate hepatic growth factors by selective portal infusion after Eck's fistula. Hepatology 14 (1991) 665-670
12. Gandhi C.R., Kuddus R.H., Subbotin V.M., Prelich J., Rao A.S., DeLeo A., et al. A fresh look at augmenter of liver regeneration (ALR) in rats. Hepatology 29 (1999) 1435-1445
13. Wang G., Yang X., Zhang Y., Wang Q., Chen H., Wei H., et al. Identification and characterization of receptor for mammalian hepatopoietin that is homologous to yeast ERV1. J Biol Chem 274 (1999) 11469-11472
14. Wang Y., Lu C., Wei H., Wang N., Chen X., Zhang L., et al. Hepatopoietin interacts directly with COP9 signalosome and regulates AP-1 activity. FEBS Lett 572 (2004) 85-91
15. Dayoub R., Thasler W.E., Bosserhoff A.K., Singer T., Jauch K.W., Schlitt H.J., et al. Regulation of polyamine synthesis in human hepatocytes by hepatotrophic factor augmenter of liver regeneration. Biochem Biophys Res Commun 345 (2006) 181-187
16. Hofhaus G., Stein G., Polimeno L., Francavilla A., and Lisowsky T. Highly divergent amino termini of the homologous human ALR and yeast scERV1 gene products define species specific differences in cellular localization. Eur J Cell Biol 78 (1999) 349-356
17. Lisowsky T. Dual function of a new nuclear gene for oxidative phosphorylation and vegetative growth in yeast. Mol Gen Genet 232 (1992) 58-64
18. Lisowsky T., Weinstat-Saslow D.L., Barton N., Reeders S.T., and Schneider M. A new human gene located in the PKD1 region of chromosome 16 is a functional homologue to ERV-1 of yeast. Genomics 29 (1995) 690-697
19. Lee J., Hofhaus G., and Lisowsky T. Erv1p from Saccharomyces cerevisiae is a FAD-linked sulfhydryl oxidase. FEBS Lett 477 (2000) 62-66
20. Lisowsky T., Lee J.E., Polimeno L., Francavilla A., and Hofhaus G. Mammalian augmenter of liver regeneration protein is a sulfhydryl oxidase. Dig Liver Dis 33 (2001) 173-180
21. Lange H., Lisowsky T., Gerber J., Muhlenhoff U., Kispal G., and Lill R. An essential function of the mitochondrial sulfhydryl oxidase Erv1p/ALR in the maturation of cytosolic Fe/S proteins. EMBO Rep 2 (2001) 715-720
22. Lisowsky T. ERV1 is involved in the cell-division cycle and the maintenance of mitochondrial genomes in Saccharomyces cerevisiae. Curr Genet 26 (1994) 15-20
23. Kuddus R.H., Nalesnik M.A., Subbotin V.M., Rao A.S., and Gandhi C.R. Enhanced synthesis and reduced metabolism of endothelin-1 (ET-1) by hepatocytes: a mechanism of increased ET-1 levels in cirrhosis. J Hepatology 33 (2000) 725-732
24. Neckers L.M. Oligodeoxynucleotide inhibitors of function: mRNA and protein interactions. Cancer J Sci Am 4 (1998) S35-S42
25. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxic assays. J Immunol Methods 65 (1983) 55-63
26. Diez-Fernandez C., Sanz N., Alvarez A.M., Wolf A., and Cascales M. The effect of non-genotoxic carcinogens, Phenobarbital and clofibrate, on the relationship between reactive oxygen species, antioxidant enzyme expression and apoptosis. Carcinogenesis 19 (1998) 1715-1722
27. Vermes I., Haanen C., and Rutelingsperger C.P.M. A novel assay for apoptosis: flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescence labeled annexin V. J Immunol Methods 180 (1995) 39-52
28. Martin S.J., Reutelingsperger C.P., McGahon A.J., Rader J.A., van Schie R.C., LaFace D.M., et al. Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl. J Exp Med 182 (1995) 1545-1556
29. Philpott N.J., Turner A.J., Scopes J., Westby M., Marsh J.C., Gordon-Smith E.C., et al. The use of 7-amino actinomycin D in identifying apoptosis: simplicity of use and broad spectrum of application compared with other techniques. Blood 87 (1996) 2244-2251
30. Wu C.K., Dailey T.A., Dailey H.A., Wang B.C., and Rose J.P. The crystal structure of augmenter of liver regeneration: a mammalian FAD-dependent sulfhydryl oxidase. Protein Sci 12 (2003) 1109-1118
31. Farrell S.R., and Thorpe C. Augmenter of liver regeneration: a flavin-dependent sulfhydryl oxidase with cytochrome c reductase activity. Biochemistry 44 (2005) 1532-1541
32. Lisowsky T. Removal of an intron with unique 3′ branch site creates an amino-terminal protein sequence directing the scERV1 gene product to mitochondria. Yeast 12 (1996) 1501-1510
33. Tury A., Mairet-Coello G., Lisowsky T., Griffond B., and Fellmann D. Expression of the sulfhydryl oxidase ALR (augmenter of liver regeneration) in adult rat brain. Brain Res 1048 (2005) 87-97
34. Morita M., Watanabe Y., and Akaike T. Protective effect of hepatocyte growth factor on interferon-gamma-induced cytotoxicity in mouse hepatocytes. Hepatology 21 (1995) 1585-1593
35. Crenesse D., Laurens M., Gugenheim J., Heurteaux C., Cursio R., Rossi B., et al. Intermittent ischemia reduces warm hypoxia-reoxygenation-induced JNK(1)/SAPK(1) activation and apoptosis in rat hepatocytes. Hepatology 34 (2001) 972-978
36. Ahlemeyer B., Klumpp S., and Krieglstein J. Release of cytochrome c into the extracellular space contributes to neuronal apoptosis induced by staurosporine. Brain Res 934 (2002) 107-116
37. Chipuk J.E., and Green D.R. Do inducers of apoptosis trigger caspase-independent cell death?. Nat Rev Mol Cell Biol 6 (2005) 268-275
38. Strasser A., O'Connor L., and Dixit V.M. Apoptosis signaling. Annu Rev Biochem 69 (2000) 217-245
39. Thornberry N.A., and Lazebnik Y. Caspases: enemies within. Science 281 (1998) 1312-1316
40. Kim J.S., He L., Qian T., and Lemasters J.J. Role of the mitochondrial permeability transition in apoptotic and necrotic death after ischemia/reperfusion injury to hepatocytes. Curr Mol Med 3 (2003) 527-535
41. Liu X., Kim C.N., Yang J., Jemmerson R., and Wang X. Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell 86 (1996) 147-157
42. Schulze-Osthoff K., Ferrari D., Los M., Wesselborg S., and Peter M.E. Apoptosis signaling by death receptors. Eur J Biochem 254 (1998) 439-459
43. Lemasters J.J. The mitochondrial permeability transition: from biochemical curiosity to pathophysiological mechanism. Gastroenterology 115 (1998) 783-786
44. Leist M., Single M., Castoldi A.F., Kuhnle S., and Nicotera P. Intracellular adenosine triphosphate (ATP) concentration: a switch in the decision between apoptosis and necrosis. J Exp Med 185 (1997) 1481-1486
45. Becher D., Kricke J., Stein G., and Lisowsky T. A mutant for the yeast scERV1 gene displays a new defect in mitochondrial morphology and distribution. Yeast 15 (1999) 1171-1181
46. Polimeno L., Capuano F., Marangi L.C., Margiotta M., Lisowsky T., Ierardi E., et al. The augmenter of liver regeneration induces mitochondrial gene expression in rat liver and enhances oxidative phosphorylation capacity of liver mitochondria. Dig Liver Dis 32 (2000) 510-517