Association of missense variants of the PRKC, apoptosis, WT1, regulator (PAWR) gene with schizophrenia

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 32, Issue 3, 2008, Pages 870-875

  Wang, Ling Hsuan ^a   Chen, Jen Yeu ^b   Liou, Ying Jay ^b   Wang, Ying Chieh ^b   Lai, I Ching ^b   Liao, Ding Lieh ^c   Chen, Chia Hsiang ^a,c  

^a TZU CHI UNIVERSITY   (Taiwan)

^b YULI VETERANS HOSPITAL   (Taiwan)

^c NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

Author keywords

Association; Dopamine receptor; PAWR gene; Schizophrenia

Indexed keywords

PROSTATE APOPTOSIS RESPONSE 4 PROTEIN; PROSTATE PROTEIN; PROTEIN KINASE C; PROTEIN KINASE C APOPTOSIS WT1 REGULATOR PROTEIN; UNCLASSIFIED DRUG; WT1 PROTEIN;

5' UNTRANSLATED REGION; ADULT; APOPTOSIS; ARTICLE; CONTROLLED STUDY; EXON; FEMALE; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HOMOZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MALE; MISSENSE MUTATION; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 39749190721     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2008.01.003     Document Type: Article

References (38)

1. Albert K.A. Hemmings H.C. Jr. Adamo A.I. Potkin S.G. Akbarian S. Sandman C.A. Evidence for decreased DARPP-32 in the prefrontal cortex of patients with schizophrenia Arch Gen Psychiatry 59 2002 705 712
2. Amar S. Shaltiel G. Mann L. Shamir A. Dean B. Scarr E. Possible involvement of post-dopamine D2 receptor signalling components in the pathophysiology of schizophrenia Int J Neuropsychopharmacol 2007 1 9 Aug 6, [Electronic publication ahead of print]
3. Bai J. He F. Novikova S.I. Undie A.S. Dracheva S. Haroutunian V. Abnormalities in the dopamine system in schizophrenia may lie in altered levels of dopamine receptor-interacting proteins Biol Psychiatry 56 2004 427 440
4. Baracskay K.L. Haroutunian V. Meador-Woodruff J.H. Dopamine receptor signaling molecules are altered in elderly schizophrenic cortex Synapse 60 2006 271 279
5. Barrett J.C. Fry B. Maller J. Daly M.J. Haploview: analysis and visualization of LD and haplotype maps Bioinformatics 21 2005 263 265
6. Bergson C. Levenson R. Goldman-Rakic P.S. Lidow M.S. Dopamine receptor-interacting proteins: the Ca(2+) connection in dopamine signaling Trends Pharmacol Sci 24 2003 486 492
7. Bibb J.A. Decoding dopamine signaling Cell 122 2005 153 155
8. Bonci A. Hopf F.W. The dopamine D2 receptor: new surprises from an old friend Neuron 47 2005 335 338
9. Catts V.S. Catts S.V. McGrath J.J. Féron F. McLean D. Coulson E.J. Apoptosis and schizophrenia: a pilot study based on dermal fibroblast cell lines Schizophr Res 84 2006 20 28
10. Chen S.F. Chen C.H. Chen J.Y. Wang Y.C. Lai I.C. Liou Y.J. Support for association of the A277C single nucleotide polymorphism in human vesicular monoamine transporter 1 gene with schizophrenia Schizophr Res 90 2007 363 365
11. Clinton S.M. Ibrahim H.M. Frey K.A. Davis K.L. Haroutunian V. Meador-Woodruff J.H. Dopaminergic abnormalities in select thalamic nuclei in schizophrenia: involvement of the intracellular signal integrating proteins calcyon and spinophilin Am J Psychiatry 162 2005 1859 1871
12. Culmsee C. Landshamer S. Molecular insights into mechanisms of the cell death program: role in the progression of neurodegenerative disorders Curr Alzheimer Res 3 2006 269 283
13. Culmsee C. Zhu Y. Krieglstein J. Mattson M.P. Evidence for the involvement of Par-4 in ischemic neuron cell death J Cereb Blood Flow Metab 21 2001 334 343
14. Cyr M. Calon F. Morissette M. Di Paolo T. Estrogenic modulation of brain activity: implications for schizophrenia and Parkinson's disease J Psychiatry Neurosci 27 2002 12 27
15. Epstein M.P. Satten G.A. Inference on haplotype effects in case-control studies using unphased genotype data Am J Hum Genet 73 2003 1316 1329
16. Faul F. Erdfeldner E. G-power: a priori, post hoc, and compromise power analyses for the MS-DOS 1992 University of Bonn Bonn
17. Glantz L.A. Gilmore J.H. Lieberman J.A. Jarskog L.F. Apoptotic mechanisms and the synaptic pathology of schizophrenia Schizophr Res 81 2006 47 63
18. Goldstein J.M. Santangelo S.L. Simpson J.C. Tsuang M.T. The role of gender in identifying subtypes of schizophrenia: a latent class analytic approach Schizophr Bull 16 1990 263 275
19. Gottfried Y. Rotem A. Klein E. Larisch S. The pro-apoptotic ARTS/Sept4 protein is significantly reduced in post-mortem brains from schizophrenic patients Schizophr Res 96 2007 257 266
20. Jarskog L.F. Apoptosis in schizophrenia: pathophysiologic and therapeutic considerations Curr Opin Psychiatry 19 2006 307 312
21. Johnstone R.W. Tommerup N. Hansen C. Vissing H. Shi Y. Mapping of the human PAWR (par-4) gene to chromosome 12q21 Genomics 53 1998 241 243
22. Jurewicz I. Owen R.J. O'Donovan M.C. Owen M.J. Searching for susceptibility genes in schizophrenia Eur Neuropsychopharmacol 11 2001 395 398
23. Koh P.O. Bergson C. Undie A.S. Goldman-Rakic P.S. Lidow M.S. Up-regulation of the D1 dopamine receptor-interacting protein, calcyon, in patients with schizophrenia Arch Gen Psychiatry 60 2003 311 319
24. Koh P.O. Undie A.S. Kabbani N. Levenson R. Goldman-Rakic P.S. Lidow M.S. Up-regulation of neuronal calcium sensor-1 (NCS-1) in the prefrontal cortex of schizophrenic and bipolar patients Proc Natl Acad Sci USA 1001 2003 313 317
25. Leung A. Chue P. Sex differences in schizophrenia, a review of the literature Acta Psychiatr Scand Suppl 401 2000 3 38
26. Mattson M.P. Gleichmann M. The neuronal death protein par-4 mediates dopaminergic synaptic plasticity Mol Interv 5 2005 278 281
27. McGuffin P. Owen M.J. Farmer A.E. Genetic basis of schizophrenia Lancet 346 1995 678 682
28. Missale C. Nash S.R. Robinson S.W. Jaber M. Caron M.G. Dopamine receptors: from structure to function Physiol Rev 78 1998 189 225
29. Mundle S.D. Par-4: a common facilitator/enhancer of extrinsic and intrinsic pathways of apoptosis Leuk Res 30 2006 515 517
30. Neve K.A. Seamans J.K. Trantham-Davidson H. Dopamine receptor signaling J Recept Signal Transduct Res 24 2004 165 205
31. Park S.K. Nguyen M.D. Fischer A. Luke M.P. Affar el B. Dieffenbach P.B. Par-4 links dopamine signaling and depression Cell 122 2005 275 287
32. Ranganathan P. Rangnekar V.M. Regulation of cancer cell survival by Par-4 Ann N Y Acad Sci 1059 2005 76 85
33. Salem J.E. Kring A.M. The role of gender differences in the reduction of etiologic heterogeneity in schizophrenia Clin Psychol Rev 18 1998 795 819
34. Seeman P. Targeting the dopamine D2 receptor in schizophrenia Expert Opin Ther Targets 10 2006 515 531
35. Seeman P. Schwarz J. Chen J.F. Szechtman H. Perreault M. McKnight G.S. Psychosis pathways converge via D2high dopamine receptors Synapse 60 2006 319 346
36. Sells S.F. Wood D.P. Jr Joshi-Barve S.S. Muthukumar S. Jacob R.J. Crist S.A. Commonality of the gene programs induced by effectors of apoptosis in androgen-dependent and -independent prostate cells Cell Growth Differ 5 1994 457 466
37. Souza B.R. Souza R.P. Rosa D.V. Guimaraes M.M. Correa H. Romano-Silva M.A. Dopaminergic intracellular signal integrating proteins: relevance to schizophrenia Dialogues Clin Neurosci 8 2006 95 100
38. Xiao W. Oefner P.J. Denaturing high-performance liquid chromatography: a review Hum Mutat 17 2001 439 474