Direct Association between C-reactive Protein Serum Levels and Endothelial Dysfunction in Patients with Claudication

European Journal of Vascular and Endovascular Surgery

Volumn 35, Issue 4, 2008, Pages 480-486

  De Haro, J ^a   Acin, F ^a   Lopez Quintana, A ^a   Medina, F J ^a   Martinez Aguilar, E ^a   Florez, A ^a   March, J R ^a  

^a HOSPITAL UNIVERSITARIO DE GETAFE   (Spain)

Author keywords

C reactive protein; Inflammation markers; Inflammatory etiology of atherosclerosis; Peripheral arterial occlusive disease

Indexed keywords

BIOLOGICAL MARKER; C REACTIVE PROTEIN; FIBRINOGEN;

ADULT; AGE; ANKLE BRACHIAL INDEX; ARTICLE; BLOOD LEVEL; CELL FUNCTION; CIGARETTE SMOKING; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATION ANALYSIS; DIABETES MELLITUS; DISEASE ASSOCIATION; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; FIBRINOGEN BLOOD LEVEL; FLOW MEDIATED ARTERIAL DILATION; GENDER; HUMAN; HYPERLIPIDEMIA; HYPERTENSION; INFLAMMATION; INTERMITTENT CLAUDICATION; MAJOR CLINICAL STUDY; MALE; POPULATION RESEARCH; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; STATISTICAL SIGNIFICANCE; STRATIFICATION;

AGED; BIOLOGICAL MARKERS; BRACHIAL ARTERY; C-REACTIVE PROTEIN; CROSS-SECTIONAL STUDIES; ENDOTHELIUM, VASCULAR; FEMALE; FIBRINOGEN; HUMANS; INTERMITTENT CLAUDICATION; MALE; MIDDLE AGED; RISK FACTORS; VASODILATION;

EID: 39749138933     PISSN: 10785884     EISSN: 15322165     Source Type: Journal    
DOI: 10.1016/j.ejvs.2007.10.016     Document Type: Article

References (36)

1. De Haro J., Acin F., Medina F.J., March J.R., Utrilla F., and Lopez-Quintana A. Plasma concentration of C-Reactive Protein and severity of Peripheral Arterial Disease. Angiologia 59 2 (2007) 111-120
2. Ross R. Atherosclerosis: an inflammatory disease. N Engl J Med 340 (1999) 115-126
3. EUROASPIRE. A European Society of Cardiology survey of secondary prevention of coronary heart disease: principal results. Eur Heart J 17 (1997) 1569-1582
4. Greenland P., Knoll M.D., Stamler J., Neaton J.D., Dyer A.R.., Garside D.B., et al. Major risk factors as antecedents of fatal and non-fatal coronary heart disease events. JAMA 290 (2003) 891-897
5. Ridker P.M., Hennekens C.H., and Rifai N. Novel risk factors for systemic atherosclerosis: a comparison of C-reactive protein, fibrinogen, homocysteine, lipoprotein(a) and standard cholesterol screening as predictors of peripheral vascular disease. JAMA 285 (2001) 2481-2485
6. Liuzzo G., Biasucci L.M., Gallimore J.R., Grillo R.L., Rebuzzi A.G., Pepys M.B., et al. The prognostic value of C-reactive protein and serum amyloid A protein in severe unstable angina. N Engl J Med 331 (1994) 417-424
7. Ridker P.M., Cushman M., Stampfer M.J., Tracy R.P., and Hennekens C.R. Plasma concentration of C-reactive protein and risk of developing peripheral vascular disease. Circulation 97 (1998) 425-428
8. Wang T.J., Nam B.H., Wilson P.W., Wolf P.A., Levy D., Polak J.F., et al. Association of C-reactive protein and carotid atherosclerosis in men and women: the Frammingham Heart Study. Atheroscler Thromb Vasc Biol 22 (2002) 1412-1415
9. Zimmerman M.A., Selzman C.H., Cothren C., Sorensen A.C., Raeburn C.D., Harken A.H., et al. Diagnostic implications of C-reactive protein. Arch Surg 138 (2003) 220-224
10. Puras E., Cancer S., Lujan S., Gutierrez M., Perera M., Alfayate J.M., and in the name of CRATER study researchers. Valoración de la proteína C reactiva en pacientes con arteriopatía periférica. Modificaciones con tratamiento antiagregante. Angiologia 57 (2005) 5-18
11. Medina FJ, De Haro J, Martinez-Aguilar E, De Benito L, March JR, Acin F. Relationship between endotelial function meassured by a non-invasive method and Peripheral Arterial Disease. Heart, submitted.
12. Furchgott R.F., Zawadzki J.Y., and Jothiananda D. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetyl-choline. Nature 288 (1980) 373-376
13. Dexler H., Zeiher A., Wollschlager H., Meinertz T., Just H., and Bonzel T. Flow-dependent artery dilation in humans. Circulation 80 (1989) 466-474
14. Celemajer D.S., Sorensen K.E., Bull C., Robinson J., and Deanfield J.E. Endothelium-dependent dilation in the systemic arteries of asymptomatic subjects relates to coronary risk factors and their interaction. J Am Coll Cardiol 24 (1994) 1468-1474
15. Anderson T.J., Vehata A., Gerhard M.D., Meredith I.T., Knol J., Delagrance D., et al. Close relation of endothelial function in the human coronary and peripheral circulations. J Am Coll Cardiol 26 (1995) 1235-1241
16. Perticone F., Ceravolo R., Pujia A., Ventura G., Iacopino S., Scozzafara A., et al. Prognostic significance of endothelial dysfunction in hypertensive patients. Circulation 104 (2001) 191-196
17. Neunteufl T., Heher S., Katzenschlager R., Wolf G., Kostner K., Maurer G., et al. Late prognostic value of flow-mediated dilation in the brachial artery of patients with chest pain. Am J Cardiol 86 (2000) 207-210
18. Sinisalo J., Paronen J., Mattila K.J., Syrjala M., Alfthan G., Palosuo T., et al. Relation of inflammation to vascular function in patients with coronary heart disease. Atherosclerosis 149 (2000) 403-411
19. Fichtscherer S., Rosenberger G., Walter D.H., Breuer S., Dimmeler S., and Zeiher A.M. Elevated C-reactive protein levels and impaired endothelial vasoreactivity in patients with coronary artery disease. Circulation 102 (2000) 1000-1006
20. Yatako A.R., Corretti M.C., Gardner A.W., Womack C.J., and Katzel L.I. Endothelial reactivity and cardiac risk factors in older patients with peripheral arterial disease. Am J Cardiol 83 (1999) 754-758
21. Brevetti G., Martone V.D., de Cristoforo T., Corrado S., Silvestre A., Di Donato A.M., et al. High levels of adhesion molecules are associated with impaired endothelium-dependent vasodilation in patients with peripheral arterial disease. Thromb Haemost 85 (2001) 63-66
22. Silvestro A., Scopacasa F., Oliva G., de Cristoforo T., Iulano L., and Brevetti G. Vitamin C prevents endothelial dysfunction induced by acute exercise in patients with intermittent claudication. Atherosclerosis 165 (2002) 277-283
23. Brevetti G., Silvestro A., Di Giacomo S., Bucur R., Di Donato A.M., Schiano V., et al. Endothelial dysfunction in peripheral arterial disease is related to increase in plasma markers of inflammation and severity of peripheral circulatory impairment but not to classic risk factors and atherosclerotic burden. J Vasc Surg 38 (2003) 374-379
24. Ridker P.M., Cushman M., Stampfer M.J., Tracy R.P., and Hennekens C.H. Inflammation, aspirin and risk of cardiovascular disease in apparently healthy men. N Engl J Med 336 (1997) 973-979
25. Rutherford R.B., Baker J.D., Ernst C., Johnston K.W., Porter J.M., Ahn S., et al. Recommended standards for reports dealing with lower extremity ischemia: revised version. J Vasc Surg 26 (1997) 517-538
26. Liang Y.L., Kotsopoulos D., Shiel L., Cameron J.D., Dart A.M., and McGrath B.P. Non-invasive measurements of arterial structure and function: repeatibility, interrelationships and trial sample size. Clin Scien 95 (1998) 669-679
27. Machin D., Campbell M.J., Fayers P.M., and Pinol A.P.Y. Sample size tables for clinical studies (1997), Blackwell Science Ltd., Oxford pp. 72-74
28. Corretti M.C., Anderson T.J., Benjamin E.J., Celermajer D., Charbonneau F., Creaguer M.A., et al. Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Arterial Reactivity Task Force. J Am Coll Cardiol 39 (2002) 257-265
29. Eda S., Kaufmann J., Roos W., and Pohl S. Development of a new microparticle-enhanced turbidimetric assay for C-reactive protein with superior features in analytical sensitivity and dynamic range. J Clin Lab Anal 12 (1998) 137-144
30. Mullenix P.S., Andersen C.A., and Starnes B.W. Atherosclerosis as inflammation. Annals Vasc Surg 132 (2005) 1123-1129
31. Higashi Y., Sasaki S., Nakagawa K., Matsura H., Oshima T., and Chayama K. Endothelial function and oxidative stress in renal-vascular hypertensión. N Engl J Med 346 (2002) 1954-1962
32. Landmesser V., Horning B., and Drexler H. Endothelial function: a critical determinant in atherosclerosis?. Circulation 109 (2004) II27-II33
33. Gonzales M.A., and Selwyn A.P. Endothelial function, inflammation and prognosis in cardiovascular disease. Am J Med 115 (2003) 99S-106S
34. Verma S., Wang C.H., Lonn E., Charbonneau F., Buithieu J., Title L.M., et al., for the FATE Investigators. Cross-sectional evaluation of brachial artery flow-mediated vasodilation and C-reactive protein in healthy individuals. Eur Heart J 25 (2004) 1754-1760
35. Clapp B.R., Hirschfield G.M., Storry C., Gallimores J.R., Stidwill R.P., Singer M., et al. Inflammation and endothelial function. Direct vascular effects of human C-reactive protein on Nitric Oxide bioavailability. Circulation 111 (2005) 1530-1536
36. Vita J.A., Keaney J.F., Larson M.G., Keyes M.J., Massaro J.M., Lipinske I., et al. Brachial artery vasodilator function and systemic inflammation in the Frammingham Offspring Study. Circulation 110 (2004) 3604-3609