메뉴 건너뛰기




Volumn 25, Issue 2, 2008, Pages 139-143

Review of the histological effects of the anti-androgen, flutamide, on mouse testis

Author keywords

Cortactin; Ectoplasmic specialization; Flutamide; Spermatogenesis

Indexed keywords

ACTIN BINDING PROTEIN; ANDROGEN RECEPTOR; ANTIANDROGEN; CORTACTIN; ENDOCRINE DISRUPTOR; FLUTAMIDE; TESTOSTERONE;

EID: 39749127058     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.reprotox.2007.12.003     Document Type: Review
Times cited : (33)

References (38)
  • 1
    • 0032430502 scopus 로고    scopus 로고
    • An ongoing validation of a Tier I screening battery for detecting endocrine-active compounds (EACs)
    • O'Connor J.C., Cook J.C., Slone T.W., Makovec G.T., Frame S.R., and Davis L.G. An ongoing validation of a Tier I screening battery for detecting endocrine-active compounds (EACs). Toxicol Sci 46 (1998) 45-60
    • (1998) Toxicol Sci , vol.46 , pp. 45-60
    • O'Connor, J.C.1    Cook, J.C.2    Slone, T.W.3    Makovec, G.T.4    Frame, S.R.5    Davis, L.G.6
  • 2
    • 0018405978 scopus 로고
    • Anti-androgenicity of flutamide and its metabolite Sch 16423
    • Neri R., Peets E., and Watnik A. Anti-androgenicity of flutamide and its metabolite Sch 16423. Biochem Soc Trans 7 (1979) 565-569
    • (1979) Biochem Soc Trans , vol.7 , pp. 565-569
    • Neri, R.1    Peets, E.2    Watnik, A.3
  • 4
    • 2342584715 scopus 로고    scopus 로고
    • Flutamide induces ultrastructural changes in spermatids and the ectoplasmic specialization between the Sertoli cell and spermatids in mouse testes
    • Anahara R., Toyama Y., and Mori C. Flutamide induces ultrastructural changes in spermatids and the ectoplasmic specialization between the Sertoli cell and spermatids in mouse testes. Reprod Toxicol 18 (2004) 589-596
    • (2004) Reprod Toxicol , vol.18 , pp. 589-596
    • Anahara, R.1    Toyama, Y.2    Mori, C.3
  • 5
    • 30644457576 scopus 로고    scopus 로고
    • Deletion of macrophage migration inhibitory factor gene induces down regulation of sex hormones and ultrastructural abnormalities in mouse testes
    • Anahara R., Toyama Y., Koda M., Honma S., Nishihira J., Toshimori K., et al. Deletion of macrophage migration inhibitory factor gene induces down regulation of sex hormones and ultrastructural abnormalities in mouse testes. Reprod Toxicol 21 (2006) 167-170
    • (2006) Reprod Toxicol , vol.21 , pp. 167-170
    • Anahara, R.1    Toyama, Y.2    Koda, M.3    Honma, S.4    Nishihira, J.5    Toshimori, K.6
  • 6
    • 33744924449 scopus 로고    scopus 로고
    • Flutamide depresses expression of cortactin in the ectoplasmic specialization between the Sertoli cell and spermatids in the mouse testis
    • Anahara R., Toyama Y., Maekawa M., Kai M., Ishino F., Toshimori K., et al. Flutamide depresses expression of cortactin in the ectoplasmic specialization between the Sertoli cell and spermatids in the mouse testis. Food Chem Toxicol 44 (2006) 1050-1056
    • (2006) Food Chem Toxicol , vol.44 , pp. 1050-1056
    • Anahara, R.1    Toyama, Y.2    Maekawa, M.3    Kai, M.4    Ishino, F.5    Toshimori, K.6
  • 7
    • 33745714120 scopus 로고    scopus 로고
    • Estrogen agonists, 17β-estradiol, bisphenol A and diethylstilbestrol, decrease cortactin expression in mouse testis
    • Anahara R., Yoshida M., Toyama Y., Maekawa M., Kai M., Ishino F., et al. Estrogen agonists, 17β-estradiol, bisphenol A and diethylstilbestrol, decrease cortactin expression in mouse testis. Arch Histol Cytol 69 (2006) 101-107
    • (2006) Arch Histol Cytol , vol.69 , pp. 101-107
    • Anahara, R.1    Yoshida, M.2    Toyama, Y.3    Maekawa, M.4    Kai, M.5    Ishino, F.6
  • 8
    • 33744967062 scopus 로고    scopus 로고
    • Anti-estrogen ICI 182.780 and anti-androgen flutamide induce tyrosine phosphorylation of cortactin in the ectoplasmic specialization between the Sertoli cell and spermatids in the mouse testis
    • Anahara R., Toyama Y., Maekawa M., Yoshida M., Kai M., Ishino F., et al. Anti-estrogen ICI 182.780 and anti-androgen flutamide induce tyrosine phosphorylation of cortactin in the ectoplasmic specialization between the Sertoli cell and spermatids in the mouse testis. Biochem Biophys Res Commun 346 (2006) 276-280
    • (2006) Biochem Biophys Res Commun , vol.346 , pp. 276-280
    • Anahara, R.1    Toyama, Y.2    Maekawa, M.3    Yoshida, M.4    Kai, M.5    Ishino, F.6
  • 9
    • 0036081831 scopus 로고    scopus 로고
    • Concept evaluation: androgen-stimulated immature intact male rats as an assay for antiandrogens
    • Ashby J., Owens E., and Lefevre P.A. Concept evaluation: androgen-stimulated immature intact male rats as an assay for antiandrogens. Reprod Toxicol Pharmacol 35 (2002) 280-285
    • (2002) Reprod Toxicol Pharmacol , vol.35 , pp. 280-285
    • Ashby, J.1    Owens, E.2    Lefevre, P.A.3
  • 10
    • 0033010382 scopus 로고    scopus 로고
    • Disruption of androgen-regulated male reproductive development by di(n-butyl)phthalate during late gestation in rats is different from flutamide
    • Mylchreest E., Sar M., Cattley R.C., and Foster P.M.D. Disruption of androgen-regulated male reproductive development by di(n-butyl)phthalate during late gestation in rats is different from flutamide. Toxicol Appl Pharmacol 156 (1999) 81-95
    • (1999) Toxicol Appl Pharmacol , vol.156 , pp. 81-95
    • Mylchreest, E.1    Sar, M.2    Cattley, R.C.3    Foster, P.M.D.4
  • 12
    • 0036213832 scopus 로고    scopus 로고
    • Effects of perinatal exposure to flutamide on sex hormones and androgen-dependent organs in F1 rats
    • Miyata K., Yabushita S., Sukata T., Sano M., Yoshino H., Nakanishi M., et al. Effects of perinatal exposure to flutamide on sex hormones and androgen-dependent organs in F1 rats. J Toxicol Sci 27 (2002) 19-33
    • (2002) J Toxicol Sci , vol.27 , pp. 19-33
    • Miyata, K.1    Yabushita, S.2    Sukata, T.3    Sano, M.4    Yoshino, H.5    Nakanishi, M.6
  • 13
    • 0003415734 scopus 로고
    • Fine structure of germ cells and Sertoli cells during the cycle of the seminiferous epithelium in the rat
    • Brokelmann J. Fine structure of germ cells and Sertoli cells during the cycle of the seminiferous epithelium in the rat. Z Zellforsch 59 (1963) 820-850
    • (1963) Z Zellforsch , vol.59 , pp. 820-850
    • Brokelmann, J.1
  • 14
    • 0014093435 scopus 로고
    • The junctional specializations of Sertoli cells in the seminiferous epithelium
    • Flickimger C.J., and Fawcett D.W. The junctional specializations of Sertoli cells in the seminiferous epithelium. Anat Rec 158 (1967) 207-222
    • (1967) Anat Rec , vol.158 , pp. 207-222
    • Flickimger, C.J.1    Fawcett, D.W.2
  • 15
    • 0014884660 scopus 로고
    • Electron microscopic observations on the structural components of the blood-testis barrier
    • Fawcett D.W., Leak L.V., and Heidger P.M. Electron microscopic observations on the structural components of the blood-testis barrier. J Reprod Fertil Suppl 10 (1970) 105-122
    • (1970) J Reprod Fertil Suppl , vol.10 , pp. 105-122
    • Fawcett, D.W.1    Leak, L.V.2    Heidger, P.M.3
  • 16
    • 0015135086 scopus 로고
    • Morphogenetic factors influencing the shape of the sperm head
    • Fawcett D.W., Anderson W.A., and Phillips D.M. Morphogenetic factors influencing the shape of the sperm head. Dev Biol 26 (1971) 220-251
    • (1971) Dev Biol , vol.26 , pp. 220-251
    • Fawcett, D.W.1    Anderson, W.A.2    Phillips, D.M.3
  • 17
    • 0017098322 scopus 로고
    • Actin-like filaments in the Sertoli cell junctional specialization in the swine and mouse testis
    • Toyama Y. Actin-like filaments in the Sertoli cell junctional specialization in the swine and mouse testis. Anat Rec 186 (1976) 477-492
    • (1976) Anat Rec , vol.186 , pp. 477-492
    • Toyama, Y.1
  • 18
    • 0017709496 scopus 로고
    • Observations on the rat Sertoli ectoplasmic ("junctional") specializations in their association with germ cells of the rat testis
    • Russell L.D. Observations on the rat Sertoli ectoplasmic ("junctional") specializations in their association with germ cells of the rat testis. Tissue Cell 9 (1977) 475-498
    • (1977) Tissue Cell , vol.9 , pp. 475-498
    • Russell, L.D.1
  • 19
    • 0024066432 scopus 로고
    • The consequences of actin disruption at Sertoli ectoplasmic specialization sites facing spermatids after in vivo exposure of rat testis to cytochalasin D
    • Russell L.D., Goh J.C., Rashed R.M., and Vogl A.W. The consequences of actin disruption at Sertoli ectoplasmic specialization sites facing spermatids after in vivo exposure of rat testis to cytochalasin D. Biol Reprod 39 (1988) 105-108
    • (1988) Biol Reprod , vol.39 , pp. 105-108
    • Russell, L.D.1    Goh, J.C.2    Rashed, R.M.3    Vogl, A.W.4
  • 20
    • 0014806707 scopus 로고
    • The mechanism of spermiation in the hamster. I. Ultrastructure of spontaneous spermiation
    • Vitale-Calpe R., and Burgos M.H. The mechanism of spermiation in the hamster. I. Ultrastructure of spontaneous spermiation. J Ultrastruct Res 31 (1970) 381-393
    • (1970) J Ultrastruct Res , vol.31 , pp. 381-393
    • Vitale-Calpe, R.1    Burgos, M.H.2
  • 22
    • 0038519815 scopus 로고    scopus 로고
    • Ectoplasmic specialization in the Sertoli cell: new vistas based on genetic defects and testicular toxicology
    • Toyama Y., Maekawa M., and Yuasa S. Ectoplasmic specialization in the Sertoli cell: new vistas based on genetic defects and testicular toxicology. Anat Sci Int 78 (2003) 1-16
    • (2003) Anat Sci Int , vol.78 , pp. 1-16
    • Toyama, Y.1    Maekawa, M.2    Yuasa, S.3
  • 23
    • 13444269673 scopus 로고    scopus 로고
    • Effects of neonatal administration of 17 β-estradiol, β-estradiol 3-benzoate or bisphenol A on mouse and rat spermatogenesis
    • Toyama Y., and Yuasa S. Effects of neonatal administration of 17 β-estradiol, β-estradiol 3-benzoate or bisphenol A on mouse and rat spermatogenesis. Reprod Toxicol 19 (2004) 181-188
    • (2004) Reprod Toxicol , vol.19 , pp. 181-188
    • Toyama, Y.1    Yuasa, S.2
  • 25
    • 0029551304 scopus 로고
    • Macrophage migration inhibitory factor: a counter-regulator of glucocorticoid action and critical mediator of septic shock
    • Calandra T., and Bucala R. Macrophage migration inhibitory factor: a counter-regulator of glucocorticoid action and critical mediator of septic shock. J Inflamm 47 (1995) 39-51
    • (1995) J Inflamm , vol.47 , pp. 39-51
    • Calandra, T.1    Bucala, R.2
  • 26
    • 4344674527 scopus 로고    scopus 로고
    • Cortactin signaling and dynamic actin networks
    • Daly R.J. Cortactin signaling and dynamic actin networks. Biochem J 382 (2004) 13-25
    • (2004) Biochem J , vol.382 , pp. 13-25
    • Daly, R.J.1
  • 27
    • 0026521388 scopus 로고
    • Identification and cloning of two overexpressed genes, U21B31/PRAD1 and EMS1, within the amplified chromosome 11q13 region in human carcinomas
    • Schuuring E., Verhoeven E., Mooi W.J., and Michalides R.J. Identification and cloning of two overexpressed genes, U21B31/PRAD1 and EMS1, within the amplified chromosome 11q13 region in human carcinomas. Oncogene 7 (1992) 355-361
    • (1992) Oncogene , vol.7 , pp. 355-361
    • Schuuring, E.1    Verhoeven, E.2    Mooi, W.J.3    Michalides, R.J.4
  • 28
    • 33748086453 scopus 로고    scopus 로고
    • Cortactin overexpression regulates actin-related protein 2/3 complex activity, motility, and invasion in carcinomas with chromosome 11q13 amplification
    • Rothschild B.L., Shim A.H., Ammer A.G., Kelley L.C., Irby K.B., Head J.A., et al. Cortactin overexpression regulates actin-related protein 2/3 complex activity, motility, and invasion in carcinomas with chromosome 11q13 amplification. Cancer Res 66 (2006) 8017-8025
    • (2006) Cancer Res , vol.66 , pp. 8017-8025
    • Rothschild, B.L.1    Shim, A.H.2    Ammer, A.G.3    Kelley, L.C.4    Irby, K.B.5    Head, J.A.6
  • 30
    • 2942709560 scopus 로고    scopus 로고
    • Actin depolymerization-induced tyrosine phosphorylation of cortactin: the role of Fer kinase
    • Fan L., Ciano-Oliveira C.D., Weed S.A., Craig A.W.B., and Greer P.A. Actin depolymerization-induced tyrosine phosphorylation of cortactin: the role of Fer kinase. Biochem J 380 (2004) 581-591
    • (2004) Biochem J , vol.380 , pp. 581-591
    • Fan, L.1    Ciano-Oliveira, C.D.2    Weed, S.A.3    Craig, A.W.B.4    Greer, P.A.5
  • 31
    • 16244370694 scopus 로고    scopus 로고
    • Cortactin: an Achilles' heel of the actin cytoskeleton targeted by pathogens
    • Selbach M., and Backert S. Cortactin: an Achilles' heel of the actin cytoskeleton targeted by pathogens. Trends Microbiol 13 (2005) 181-189
    • (2005) Trends Microbiol , vol.13 , pp. 181-189
    • Selbach, M.1    Backert, S.2
  • 32
    • 0027419589 scopus 로고
    • Cortactin, an 80/85-kilodalton pp60src subtrate, is a filamentous actin-binding protein enriched in the cell cortex
    • Wu H., and Parsons J.T. Cortactin, an 80/85-kilodalton pp60src subtrate, is a filamentous actin-binding protein enriched in the cell cortex. J Cell Biol 120 (1993) 1417-1426
    • (1993) J Cell Biol , vol.120 , pp. 1417-1426
    • Wu, H.1    Parsons, J.T.2
  • 33
    • 0034749410 scopus 로고    scopus 로고
    • Structure and control of a cell-cell adhesion complex associated with spermiation in rat seminiferous epithelium
    • Chapin R.E., Wine R.N., Harris M.W., Borchers C.H., and Haseman J.K. Structure and control of a cell-cell adhesion complex associated with spermiation in rat seminiferous epithelium. J Androl 22 (2001) 1030-1052
    • (2001) J Androl , vol.22 , pp. 1030-1052
    • Chapin, R.E.1    Wine, R.N.2    Harris, M.W.3    Borchers, C.H.4    Haseman, J.K.5
  • 34
    • 0035160160 scopus 로고    scopus 로고
    • Rat seminiferous epithelium contains a unique junction (ectoplasmic specialization) with signaling properties both of cell/cell and cell/matrix junctions
    • Mulholland D.J., Dedhar S., and Vogl A.W. Rat seminiferous epithelium contains a unique junction (ectoplasmic specialization) with signaling properties both of cell/cell and cell/matrix junctions. Biol Reprod 64 (2001) 396-407
    • (2001) Biol Reprod , vol.64 , pp. 396-407
    • Mulholland, D.J.1    Dedhar, S.2    Vogl, A.W.3
  • 35
    • 0036150326 scopus 로고    scopus 로고
    • An anti-actin monoclonal antibody inhibits the zona pellucida-induced acrosome reaction and hyperactivated motility of human sperm
    • Liu D.Y., Martic M., Clarke G.N., Grkovic I., Garrett C., Dunlop M.E., et al. An anti-actin monoclonal antibody inhibits the zona pellucida-induced acrosome reaction and hyperactivated motility of human sperm. Mol Hum Reprod 8 (2002) 37-47
    • (2002) Mol Hum Reprod , vol.8 , pp. 37-47
    • Liu, D.Y.1    Martic, M.2    Clarke, G.N.3    Grkovic, I.4    Garrett, C.5    Dunlop, M.E.6
  • 36
    • 3242755123 scopus 로고    scopus 로고
    • Adaptors, junction dynamics, and spermatogenesis
    • Lee N.P.Y., and Cheng C.Y. Adaptors, junction dynamics, and spermatogenesis. Biol Reprod 71 (2004) 392-404
    • (2004) Biol Reprod , vol.71 , pp. 392-404
    • Lee, N.P.Y.1    Cheng, C.Y.2
  • 37
    • 0033851771 scopus 로고    scopus 로고
    • Molecular physiology and pathophysiology of tight junctions. I. Tight junction structure and function: lessons from mutant animals and proteins
    • Mitic L.L., Van I.C.M., and Anderson J.M. Molecular physiology and pathophysiology of tight junctions. I. Tight junction structure and function: lessons from mutant animals and proteins. Am J Physiol 279 (2000) G250-G254
    • (2000) Am J Physiol , vol.279
    • Mitic, L.L.1    Van, I.C.M.2    Anderson, J.M.3
  • 38
    • 0036788073 scopus 로고    scopus 로고
    • Cell junction dynamics in the testis: Sertoli-germ cell interactions and male contraceptive development
    • Cheng C.Y., and Mruk D.D. Cell junction dynamics in the testis: Sertoli-germ cell interactions and male contraceptive development. Am Physiol Soc 82 (2002) 825-874
    • (2002) Am Physiol Soc , vol.82 , pp. 825-874
    • Cheng, C.Y.1    Mruk, D.D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.