Effects of tacrolimus (FK506) on the development of osteonecrosis in a rabbit model

Immunopharmacology and Immunotoxicology

Volumn 30, Issue 1, 2008, Pages 79-90

  Miyanishi, Keita ^a,b   Yamamoto, Takuaki ^a   Irisa, Takahiko ^a   Yamashita, Akihisa ^a   Motomura, Goro ^a   Jingushi, Seiya ^a   Iwamoto, Yukihide ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b KYUSHU ROSAI HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

METHYLPREDNISOLONE ACETATE; STEROID; TACROLIMUS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE NECROSIS; CONTROLLED STUDY; DISEASE COURSE; DRUG DOSE REDUCTION; DRUG EFFECT; INCIDENCE; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT; SINGLE DRUG DOSE; STATISTICAL SIGNIFICANCE;

ANIMALS; DISEASE MODELS, ANIMAL; IMMUNOSUPPRESSIVE AGENTS; LIPOPROTEINS, LDL; LIPOPROTEINS, VLDL; MALE; OSTEONECROSIS; RABBITS; STEROIDS; TACROLIMUS;

ORYCTOLAGUS CUNICULUS;

EID: 39749109663     PISSN: 08923973     EISSN: 15322513     Source Type: Journal    
DOI: 10.1080/08923970701812647     Document Type: Article

References (27)

1. Lausten, G.S.; Lemser, T.; Jensen, P.K.; Egfjord, M. Necrosis of the femoral head after kidney transplantation. Clin. Transplant. 1998, 12(6), 572-574.
2. Landmann, J.; Renner, N.; Gachter, A.; Thiel, G.; Harder, F. Cyclosporin A and osteonecrosis of the femoral head. J. Bone Joint Surg. Am. 1987, 69(8), 1226-1228.
3. Kubo, T.; Yamazoe, S.; Sugano, N.; Fujioka, M.; Naruse, S.; Yoshimura, N.; Oka, T.; Hirasawa, Y. Initial MRI findings of non-traumatic osteonecrosis of the femoral head in renal allograft recipients. Magn. Reson. Imag. 1997, 15(9), 1017-1023.
4. Torii, Y.; Hasegawa, Y.; Kubo, T.; Kodera, Y.; Minami, S.; Morishita, Y.; Yamada, Y.; Iwata, H. Osteonecrosis of the femoral head after allogeneic bone marrow transplantation. Clin. Orthop. 2001, 382, 124-132.
5. Mont, M.A.; Hungerford, D.S. Non-traumatic avascular necrosis of the femoral head. J. Bone Joint Surg. Am 1995, 77(3), 459-474.
6. Jones, JP. Jr. Fat embolism, intravascular coagulation and osteonecrosis. Clin. Orthop. 1993, 292, 294-308.
7. Yamamoto, T.; Irisa, T.; Sugioka, Y.; Sueishi, K. Effects of pulse methylprednisolone on bone and marrow tissues. Arthr. Rheum. 1997, 40(11), 2055-2064.
8. Miyanishi, K.; Yamamoto, T.; Irisa, T.; Yamashita, A.; Jingushi, S.; Noguchi, Y.; Iwamoto, Y. Bone marrow fat cell enlargement and a rise in intraosseous pressure in steroid-treated rabbits with osteonecrosis. Bone 2002, 30(1), 185-190.
9. Drescher, W.; Schneider, T.; Becker, C.; Hobolth, J.; Ruther, W.; Hansen, E.S.; Bunger, C. Selective reduction of bone blood flow by short-term treatment with high-dose methylprednisolone. An experimental study in pigs. J. Bone Joint Surg. Br. 2001, 83(2), 274-277.
10. Asano, T.; Takahashi, K.A.; Fujioka, M.; Inoue, S.; Okamoto, M.; Sugioka, N.; Nishino, H.; Tanaka, T.; Hirota, Y.; Kubo, T. ABCB1 C3435T and G2677T/A polymorphism decreased the risk for steroid-induced osteonecrosis of the femoral head after kidney transplantation. Pharmacogenetics 2003, 13(11), 675-682.
11. Starzl, T.E.; Todo, S.; Fung, J.; Demetris, A.J.; Venkataramman, R.; Jain, A. FK506 for liver, kidney, and pancreas transplantation. Lancet 1989, 2(8670), 1000-1004.
12. Ho, S., Clipstone, N., Timmermann, L., Northrop, J., Graef, I., Fiorentino, D., Nourse, J., Crabtree, G.R. The mechanism of action of cyclosporin A and FK506. Clin. Immunol. Immunopathol. 1996, 80(3 Pt 2), S40-45.
13. Clipstone, N.A., Crabtree, G.R. Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation. Nature 1992, 357(6380), 695-697.
14. Miyazaki, M., Fujikawa, Y., Takita, C., Tsumura, H. Tacrolimus and cyclosporine A inhibit human osteoclast formation via targeting the calcineurin-dependent NFAT pathway and an activation pathway for c-Jun or MITF in rheumatoid arthritis. Clin. Rheumatol. 2007, 26(2), 231-239.
15. Saeki, T.; Ueda, K.; Tanigawara, Y.; Hori, R.; Komano, T. Human P-glycoprotein transports cyclosporin A and FK506. J. Biol. Chem. 1993, 268(9), 6077-6080.
16. Kralli, A.; Yamamoto, K.R. An FK506-sensitive transporter selectively decreases intracellular levels and potency of steroid hormones. J. Biol. Chem. 1996, 271(29), 17152-17156.
17. Tsujimura, S., Saito, K., Nawata, M., Nakayamada, S., Tanaka, Y. Overcoming drug resistance induced by P-glycoprotein on lymphocytes in patients with refractory rheumatoid arthritis. Ann. Rheum. Dis. 2007, in press.
18. Sakai, T.; Sugano, N.; Kokado, Y.; Takahara, S.; Ohzono, K.; Yoshikawa, H. Tacrolimus may be associated with lower osteonecrosis rates after renal transplantation. Clin. Orthop. 2003, 415, 163-170.
19. Matsumoto, T.; Saito, E.; Watanabe, H.; Fujioka, T.; Yamada, T.; Takahashi, Y.; Ueno, T.; Tochihara, T.; Kanmatsuse, K. Influence of FK506 on experimental atherosclerosis in cholesterol-fed rabbits. Atherosclerosis 1998, 139(1), 95-106.
20. Jain, A.; Mazariegos, G.; Kashyap, R.; Green, M.; Gronsky, C.; Starzl, T.E.; Fung, J.; Reyes, J. Comparative long-term evaluation of tacrolimus and cyclosporine in pediatric liver transplantation. Transplantation 2000, 70(4), 617-625.
21. Kawai, T.; Sakurabayashi, I.; Koide, A. Fractional Quantitation of Serum Betalipoprotein by a Simple Turbidimetric Method. Protides of the biological fluids; Pergamon Press: Oxford and New York, 1978; 415.
22. Matsui, M.; Ohzono, K.; Nakamura, N.; Sugano, N.; Masuhara, K.; Nakata, K.; Takaoka, K.; Ono, K.; Ochi, T. The immune reaction to heterologous serum causes osteonecrosis in rabbits. Virchows Arch. 1995, 427(2), 205-211.
23. Nakata, K.; Masuhara, K.; Nakamura, N.; Shibuya, T.; Sugano, N.; Matsui, M.; Ochi, T.; Ohzono, K. Inducible osteonecrosis in a rabbit serum sickness model: deposition of immune complexes in bone marrow. Bone 1996, 18(6), 609-615.
24. Colak, T.; Karakayali, H.; Yagmurdur, M.C.; Moray, G. Effect of conversion from cyclosporine to tacrolimus on lipid profiles in renal transplant recipients. Transplant. Proc. 2002, 34(6), 2081-2082.
25. Friemann, S.; Feuring, E.; Padberg, W.; Ernst, W. Improvement of nephrotoxicity, hypertension, and lipid metabolism after conversion of kidney transplant recipients from cyclosporine to tacrolimus. Transplant. Proc. 1998, 30(4), 1240-1242.
26. Allison, G.T.; Bostrom, M.P.; Glesby, M.J. Osteonecrosis in HIV disease: epidemiology, etiologies, and clinical management. AIDS 2003, 17(1), 1-9.
27. Miyanishi, K., Yamamoto, T., Irisa, T., Motomura, G., Jingushi, S., Sueishi, K., Iwamoto, Y. Effects of different corticosteroids on the development of osteonecrosis in rabbits. Rheumatology 2005, 44(3), 332-336.