Increased mitochondrial DNA copy-number in CEM cells resistant to delayed toxicity of 2′,3′-dideoxycytidine

Biochemical Pharmacology

Volumn 75, Issue 6, 2008, Pages 1313-1321

  Bjerke, Mia ^a   Franco, Maribel ^a   Johansson, Magnus ^a   Balzarini, Jan ^b   Karlsson, Anna ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Drug resistance; Human immunodeficiency virus; Mitochondrial DNA; Nucleoside analogs; Retroviral therapy

Indexed keywords

2',2' DIFLUORODEOXYGUANOSINE; 5 (2 BROMOVINYL) 2' DEOXYURIDINE; CLADRIBINE; CYTARABINE; DEOXYCYTIDINE KINASE; FIALURIDINE; GEMCITABINE; GUANINE ARABINOSIDE; GUANOSINE DERIVATIVE; IDOXURIDINE; MESSENGER RNA; MITOCHONDRIAL DNA; NUCLEOSIDE ANALOG; THYMIDINE KINASE; THYMIDINE KINASE 2; THYMINE ARABINOSIDE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; ZALCITABINE;

ARTICLE; CONTROLLED STUDY; DNA DETERMINATION; DNA SYNTHESIS INHIBITION; DRUG CYTOTOXICITY; DRUG INDICATION; ENZYME ANALYSIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOBLAST;

EID: 39749089925     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2007.12.002     Document Type: Article

References (31)

1. A.A. Johnson A.S. Ray J. Hanes Z. Suo J.M. Colacino K.S. Anderson Toxicity of antiviral nucleoside analogs and the human mitochondrial DNA polymerase J Biol Chem 276 2001 40847 40857
2. S.Y. Yao A.M. Ng M. Sundaram C.E. Cass S.A. Baldwin J.D. Young Transport of antiviral 3′-deoxy-nucleoside drugs by recombinant human and rat equilibrative, nitrobenzylthioinosine (NBMPR)-insensitive (ENT2) nucleoside transporter proteins produced in Xenopus oocytes Mol Membr Biol 18 2001 161 167
3. J.J. Song S. Walker E. Chen E.E. Johnson II J. Spychala T. Gribbin Genomic structure and chromosomal localization of the human deoxycytidine kinase gene Proc Natl Acad Sci USA 90 1993 431 434
4. C.H. Hsu J.Y. Liou G.E. Dutschman Y.C. Cheng Phosphorylation of cytidine, deoxycytidine, and their analog monophosphates by human UMP/CMP kinase is differentially regulated by ATP and magnesium Mol Pharmacol 67 2005 806 814
5. B. Schneider Y.W. Xu O. Sellam R. Sarfati J. Janin M. Veron Pre-steady state of reaction of nucleoside diphosphate kinase with anti-HIV nucleotides J Biol Chem 273 1998 11491 11497
6. C.H. Chen Y.C. Cheng The role of cytoplasmic deoxycytidine kinase in the mitochondrial effects of the anti-human immunodeficiency virus compound, 2′,3′-dideoxycytidine J Biol Chem 267 1992 2856 2859
7. D. Zhang A.M. Caliendo J.J. Eron K.M. DeVore J.C. Kaplan M.S. Hirsch Resistance to 2′,3′-dideoxycytidine conferred by a mutation in codon 65 of the human immunodeficiency virus type 1 reverse transcriptase Antimicrob Agents Chemother 38 1994 282 287
8. R.P. Agarwal W. Wang P. Yo T. Han M. Fernandez Cross-resistance of dideoxycytidine-resistant cell lines to azidothymidine Biochem Pharmacol 58 1999 1603 1608
9. D.J. Medina C.H. Tsai G.D. Hsiung Y.C. Cheng Comparison of mitochondrial morphology, mitochondrial DNA content, and cell viability in cultured cells treated with three anti-human immunodeficiency virus dideoxynucleosides Antimicrob Agents Chemother 38 1994 1824 1828
10. L. Rossi S. Serafini G.F. Schiavano A. Casabianca G. Vallanti L. Chiarantini Metabolism, mitochondrial uptake and toxicity of 2′,3′-dideoxycytidine Biochem J 344 Pt 3 1999 915 920
11. P.A. Sherman J.A. Fyfe Enzymatic assay for deoxyribonucleoside triphosphates using synthetic oligonucleotides as template primers Anal Biochem 180 1989 222 226
12. A. Bertoli M. Franco J. Balzarini M. Johansson A. Karlsson Altered deoxyribonucleotide pools in T-lymphoblastoid cells expressing the multisubstrate nucleoside kinase of Drosophila melanogaster FEBS J 272 2005 3918 3928
13. N.G. Larsson J. Wang H. Wilhelmsson A. Oldfors P. Rustin M. Lewandoski Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice Nat Genet 18 1998 231 236
14. V. Dolce G. Fiermonte M.J. Runswick F. Palmieri J.E. Walker The human mitochondrial deoxynucleotide carrier and its role in the toxicity of nucleoside antivirals Proc Natl Acad Sci USA 98 2001 2284 2288
15. H.R. Lee K.A. Johnson Fidelity of the human mitochondrial DNA polymerase J Biol Chem 281 2006 36236 36240
16. A. Trifunovic A. Wredenberg M. Falkenberg J.N. Spelbrink A.T. Rovio C.E. Bruder Premature ageing in mice expressing defective mitochondrial DNA polymerase Nature 429 2004 417 423
17. T.A. Brown D.A. Clayton Release of replication termination controls mitochondrial DNA copy number after depletion with 2′,3′-dideoxycytidine Nucl Acids Res 30 2002 2004 2010
18. A. Rantanen M. Jansson A. Oldfors N.G. Larsson Downregulation of Tfam and mtDNA copy number during mammalian spermatogenesis Mamm Genome 12 2001 787 792
19. H.C. Cote Z.L. Brumme K.J. Craib C.S. Alexander B. Wynhoven L. Ting Changes in mitochondrial DNA as a marker of nucleoside toxicity in HIV-infected patients N Engl J Med 346 2002 811 820
20. M. Casula G.J. Weverling F.W. Wit E.C. Timmermans M. Stek Jr. J.M. Lange Mitochondrial DNA and RNA increase in peripheral blood mononuclear cells from HIV-1-infected patients randomized to receive stavudine-containing or stavudine-sparing combination therapy J Infect Dis 192 2005 1794 1800
21. A. Cossarizza A. Riva M. Pinti S. Ammannato P. Fedeli C. Mussini Increased mitochondrial DNA content in peripheral blood lymphocytes from HIV-infected patients with lipodystrophy Antivir Ther 8 2003 315 321
22. C. Petit D. Mathez C. Barthelemy T. Leste-Lasserre R.K. Naviaux P. Sonigo Quantitation of blood lymphocyte mitochondrial DNA for the monitoring of antiretroviral drug-induced mitochondrial DNA depletion J Acquir Immune Defic Syndr 33 2003 461 469
23. M. Magnani G. Brandi A. Casabianca A. Fraternale G.F. Schiavano L. Rossi 2′,3′-Dideoxycytidine metabolism in a new drug-resistant cell line Biochem J 312 Pt 1 1995 115 123
24. V.W. Ruiz van Haperen G. Veerman S. Eriksson E. Boven A.P. Stegmann M. Hermsen Development and molecular characterization of a 2′,2′-difluorodeoxycytidine-resistant variant of the human ovarian carcinoma cell line A2780 Cancer Res 54 1994 4138 4143
25. J.K. Owens D.S. Shewach B. Ullman B.S. Mitchell Resistance to 1-beta- d -arabinofuranosylcytosine in human T-lymphoblasts mediated by mutations within the deoxycytidine kinase gene Cancer Res 52 1992 2389 2393
26. T. Han M. Fernandez M. Sarkar R.P. Agarwal 2′,3′-Dideoxycytidine represses thymidine kinases 1 and 2 expression in T-lymphoid cells Life Sci 74 2004 835 842
27. V. Bianchi S. Borella C. Rampazzo P. Ferraro F. Calderazzo L.C. Bianchi Cell cycle-dependent metabolism of pyrimidine deoxynucleoside triphosphates in CEM cells J Biol Chem 272 1997 16118 16124
28. M.I. Ekstrand M. Falkenberg A. Rantanen C.B. Park M. Gaspari K. Hultenby Mitochondrial transcription factor A regulates mtDNA copy number in mammals Hum Mol Genet 13 2004 935 944
29. J. Zhang F. Visser K.M. King S.A. Baldwin J.D. Young C.E. Cass The role of nucleoside transporters in cancer chemotherapy with nucleoside drugs Cancer Metastasis Rev 26 2007 85 110
30. M.J. Lindhurst G. Fiermonte S. Song E. Struys F. De Leonardis P.L. Schwartzberg Knockout of Slc25a19 causes mitochondrial thiamine pyrophosphate depletion, embryonic lethality, CNS malformations, and anemia Proc Natl Acad Sci USA 2006
31. W. Lam C. Chen S. Ruan C.H. Leung Y.C. Cheng Expression of deoxynucleotide carrier is not associated with the mitochondrial DNA depletion caused by anti-HIV dideoxynucleoside analogs and mitochondrial dNTP uptake Mol Pharmacol 67 2005 408 416