The pregnancy-induced increase in baseline circulating growth hormone in rats is not induced by ghrelin

Journal of Neuroendocrinology

Volumn 20, Issue 3, 2008, Pages 309-322

  El Kasti, M M ^a   Christian, H C ^b   Huerta Ocampo, I ^b   Stolbrink, M ^b   Gill, S ^c   Houston, P A ^c   Davies, J S ^a   Chilcott, J ^a   Hill, N ^d   Matthews, D R ^d   Carter, D A ^a   Wells, Timothy ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Ghrelin; Growth hormone; Placenta; Pregnancy; Somatotrophs

Indexed keywords

GHRELIN; GROWTH HORMONE; GROWTH HORMONE RELEASING FACTOR; GROWTH HORMONE SECRETAGOGUE RECEPTOR; MESSENGER RNA; SOMATOSTATIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARCUATE NUCLEUS; ARTICLE; CELL GRANULE; CONTROLLED STUDY; ELECTRON MICROSCOPY; FEEDBACK SYSTEM; FEMALE; GENE EXPRESSION; GROWTH HORMONE RELEASE; GROWTH HORMONE SECRETING CELL; IMMUNOCYTOCHEMISTRY; IMMUNOREACTIVITY; IN SITU HYBRIDIZATION; NONHUMAN; PLACENTA; PREGNANCY; PRIORITY JOURNAL; RADIOIMMUNOASSAY; RAT; STEADY STATE; THALAMUS MIDLINE NUCLEUS;

ADIPOSITY; ANIMALS; ANTIBODIES, MONOCLONAL; BODY WEIGHT; FEMALE; GHRELIN; GROWTH AND DEVELOPMENT; GROWTH HORMONE; HYPOTHALAMIC HORMONES; MALE; PLACENTA; PREGNANCY; PREGNANCY, ANIMAL; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GHRELIN; SOMATOTROPHS; TIME FACTORS; UP-REGULATION;

EID: 39649099125     PISSN: 09538194     EISSN: 13652826     Source Type: Journal    
DOI: 10.1111/j.1365-2826.2008.01650.x     Document Type: Article

References (58)

1. Maiter D, Underwood LE, Maes M, Davenport ML, Ketelslegers JM. Different effects of intermittent and continuous growth hormone (GH) administration on serum somatomedin-C/insulin-like growth factor I and liver GH receptors in hypophysectomized rats. Endocrinology 1988; 123: 1053-1059.
2. Isgaard J, Carlsson L, Isaksson OG, Jansson JO. Pulsatile intravenous growth hormone (GH) infusion to hypophysectomized rats increases insulin-like growth factor I messenger ribonucleic acid in skeletal tissues more effectively than continuous GH infusion. Endocrinology 1988; 123: 2605-2610.
3. Jansson JO, Albertsson-Wikland K, Edén S, Thorngren KG, Isaksson O. Effect of frequency of growth hormone (GH) administration on longitudinal bone growth and body weight in hypophysectomized rats. Acta Physiol Scand 1982; 114: 261-265.
4. Clark RG, Jansson JO, Isaksson O, Robinson IC. Intravenous growth hormone: Growth responses to patterned infusions in hypophysectomized rats. J Endocrinol 1985; 104: 53-61.
5. Laursen T, Gravholt CH, Heickendorff L, Drustrup J, Kappelgaard A-M, Jørgensen JOL, Christiansen JS. Long-term effects of continuous subcutaneous infusion versus daily subcutaneous injections of growth hormone (GH) on the insulin-like growth factor system, insulin sensitivity, body composition, and bone and lipoprotein metabolism in GH-deficient adults. J Clin Endocrinol Metab 2001; 86: 1222-1228.
6. Cersosimo E, Danou F, Persson M, Miles JM. Effects of pulsatile delivery of basal growth hormone on lipolysis in humans. Am J Physiol Endocrinol Metab 1996; 271: E123-E126.
7. Pincus SM, Gevers EF, Robinson IC, van den Berg G, Roelfsema F, Hartman ML, Veldhuis JD. Females secrete growth hormone with more process irregularity than males in both humans and rats. Am J Physiol 1996; 270: E107-E115.
8. Gevers E, Pincus SM, Robinson IC, Veldhuis JD. Differential orderliness of the GH release process in castrate male and female rats. Am J Physiol 1998; 274: R437-R444.
9. Tannenbaum GS, Martin JB. Evidence for an endogenous ultradian rhythm governing growth hormone secretion in the rat. Endocrinology 1976; 98: 562-570.
10. Edén S. Age- and sex-related differences in episodic growth hormone secretion in the rat. Endocrinology 1979; 105: 555-560.
11. Clark RG, Carlsson LM, Robinson IC. Growth hormone secretory profiles in conscious female rats. J Endocrinol 1987; 114: 399-407.
12. Eriksson L. Growth hormone in human pregnancy. Maternal 24-hour serum profiles and experimental effects of continuous GH secretion. Acta Obstet Gynecol Scand Suppl 1989; 147: 1-38.
13. Eriksson L, Frankenne F, Eden S, Hennen G, von Schoultz B. Growth hormone secretion during termination of pregnancy. Further evidence of a placental variant. Acta Obstet Gynecol Scand 1988; 67: 549-552.
14. Eriksson L, Frankenne F, Eden S, Hennen G, von Schoultz B. Growth-hormone 24-h serum profiles during pregnancy-lack of pulsatility for the secretion of the placental variant. Br J Obstet Gynaecol 1989; 96: 949-953.
15. Frankenne F, Closset J, Gomez F, Scippo ML, Hennen G. The physiology of growth hormones (GHs) in pregnant women and partial characterization of the placental GH variant. J Clin Endocrinol Metab 1989; 66: 1171-1180.
16. Carlsson L, Eden S, Jansson JO. The plasma pattern of growth hormone in conscious rats during late pregnancy. J Endocrinol 1990; 124: 191-198.
17. Chien YH, Thompson EB. Genomic organization of rat prolactin and growth hormone genes. Proc Natl Acad Sci USA 1980; 77: 4583-4587.
18. Barta A, Richards RI, Baxter JD, Shine J. Primary structure and evolution of the rat growth hormone gene. Proc Natl Acad Sci USA 1981; 78: 4867-4871.
19. Sheppard MS, Bala RM. Growth hormone secretion during pregnancy: Altered effects of growth hormone releasing factor and insulin-like growth factor-I in vitro. Horm Res 1987; 27: 205-210.
20. Escalada J, Sánchez-Franco F, Velasco B, Cacicedo L. Regulation of growth hormone (GH) gene expression and secretion during pregnancy and lactation in the rat: Role of insulin-like growth factor-I, somatostatin, and GH-releasing hormone. Endocrinology 1997; 138: 3435-3443.
21. Mathews LS, Engberg B, Norstedt G. Regulation of rat growth hormone receptor gene expression. J Biol Chem 1989; 264: 9905-9910.
22. Tiong TS, Herington AC. Tissue distribution, characterization, and regulation of messenger ribonucleic acid for growth hormone receptor and serum binding protein in the rat. Endocrinology 1991; 129: 1628-1634.
23. El-Kasti MM, Christian HC, Huerta I, Hill N, Matthews DR, Wells T. Pregnancy-induced plasticity in rat pituitary: A morphological and endocrine study of somatotroph and lactotroph function. Endocr Abstr 2004; 7: P143.
24. Davies JS, Carter DA, Wells T. Photic stimulation inhibits growth hormone secretion in rats: A hypothalamic mechanism for transient entrainment. Endocrinology 2004; 145: 2950-2958.
25. Davies JS, Thompson NM, Christian HC, Pinilla L, Ebling FJP, Tena-Sempere M, Wells T. Hypothalamic expression of human growth hormone induces post-pubertal hypergonadotrophism in male transgenic growth retarded rats. J Neuroendocrinol 2006; 18: 719-731.
26. McDowell IF, Morris JF, Charlton HM. Characterization of the pituitary gonadotroph cells of hypogonadal male mice: Comparison with normal mice. J Endocrinol 1982; 95: 321-330.
27. Christian HC, Taylor AD, Flower RJ, Morris JF, Buckingham JC. Characterization and localization of lipocortin 1-binding sites on rat anterior pituitary cells by fluorescence-activated cell analysis/sorting and electron microscopy. Endocrinology 1997; 138: 5341-5351.
28. Cruz-Orive LM, Weibel ER. Recent sterological methods for cell biology: a brief survey. Am J Physiol Lung Cell Mol Physiol 1990; 258: L148-L156.
29. Martin NM, Houston PA, Patterson M, Sajedi A, Carmignac DF, Ghatei MA, Bloom SR, Small CJ. Abnormalities of the somatotrophic axis in the obese agouti mouse. Int J Obes (Lond) 2006; 30: 430-481.
30. Humphries A, Klein DC, Baler R, Carter DA. cDNA array analysis of pineal gene expression reveals circadian rhythmicity of the dominant negative helix-loop-helix protein-encoding gene, Id-1. J Neuroendocrinol 2002; 14: 101-108.
31. Masson P. Some histological methods. Trichrome stainings and their preliminary technique. Bull Int Assoc Med 1929; 12: 75.
32. Merriam GR, Wachter KW. Algorithms for the study of episodic hormone secretion. Am J Physiol 1982; 243: E310-E318.
33. Matthews DR, Hindmarsh PC, Pringle PJ, Brook CG. A distribution method for analysing the baseline of pulsatile endocrine signals as exemplified by 24-hour growth hormone profiles. Clin Endocrinol 1991; 35: 245-252.
34. Matthews DR. Time series analysis in endocrinology. Acta Paediatr Scand Suppl 1988; 347: 55-62.
35. Hindmarsh PC, Matthews DR, Broox CG. Growth hormone secretion in children determined by time series analysis. Clin Endocrinol (Oxf) 1988; 29: 35-44.
36. Sotiropoulos A, Goujon L, Simonin G, Kelly PA, Postel-Vinay M-C, Finidori J. Evidence for generation of the growth hormone-binding protein through proteolysis of the growth hormone membrane receptor. Endocrinology 1993; 132: 1863-1865.
37. Baumbach WR, Horner DL, Logan JS. The growth hormone-binding protein in rat serum is an alternatively spliced form of the rat growth hormone receptor. Genes Dev 1989; 3: 1199-1205.
38. Sadeghi H, Wang BS, Lumanglas AL, Logan JS, Baumbach WR. Identification of the growth hormone binding protein in rat serum. Mol Endocrinol 1990; 4: 1799-1805.
39. Terry LC, Saunders A, Audet J, Willoughby JO, Brazeau P, Martin JB. Physiologic secretion of growth hormone and prolactin in male and female rats. Clin Endocrinol (Oxf) 1977; 6 (Suppl): 19S-28S.
40. Jahn GA, Rastrilla AM, Deis RP. Correlation of growth hormone secretion during pregnancy with circulating prolactin in rats. J Reprod Fertil 1993; 98: 327-333.
41. Frohman LA, Kineman RD, Kamegai J, Park S, Teixeira LT, Coschigano KT, Kopchick JJ. Secretagogues and the somatotrope: Signaling and proliferation. Recent Prog Horm Res 2000; 55: 269-291.
42. Mizobuchi M, Frohman MA, Downs TR, Frohman LA. Tissue-specific transcription initiation and effects of growth hormone (GH) deficiency on the regulation of mouse and rat GH-releasing hormone gene in hypothalamus and placenta. Mol Endocrinol 1991; 5: 476-484.
43. Nogues N, Del Rio JA, Perez-Riba M, Soriano E, Flavell RA, Boronat A. Placenta-specific expression of the rat growth hormone-releasing hormone gene promoter in transgenic mice. Endocrinology 1997; 138: 3222-3227.
44. Gaylinn BD. Molecular and cell biology of the growth hormone-releasing hormone receptor. Growth Horm IGF Res 1999; 9 (Suppl A): 37-44.
45. Gualillo O, Caminos JE, Blanco M, Garcìa-Caballero T, Kojima M, Kangawa K, Dieguez C, Casaneuva FF. Ghrelin: A novel placental-derived hormone. Endocrinology 2001; 142: 788-794.
46. Shibata K, Hododa H, Kojima M, Kangawa K, Makino Y, Makino I, Kawarabayashi T, Futagami K, Gomita Y. Regulation of ghrelin secretion during pregnancy and lactation in the rat: Possible involvement of the hypothalamus. Peptides 2004; 25: 279-287.
47. Sakata I, Tanaka T, Yamazaki M, Tanizaki T, Zheng Z, Sakai T. Gastric estrogen directly induces ghrelin expression and production in the rat stomach. J Endocrinol 2006; 190: 749-757.
48. Thompson NM, Davies JS, Mode A, Houston PA, Wells T. Pattern-dependent suppression of growth hormone (GH) pulsatility by ghrelin and GH-releasing peptide-6 in moderately GH-deficient rats. Endocrinology 2003; 144: 4859-4867.
49. Singh K, Ambler GR, Breier BH, Klempt M, Gluckman PD. Ovine placental lactogen is a potent somatogen in the growth hormone (GH)-deficient rat: comparison of somatogenic activity with bovine GH. Endocrinology 1992; 130: 2758-2766.
50. Davenport ML, Clemmons DR, Miles MV, Camacho-Hubner C, D'Ercole AJ, Underwood LE. Regulation of serum insulin-like growth factor-I (IGF-I) and IGF binding proteins during rat pregnancy. Endocrinology 1990; 127: 1278-1286.
51. Donovan SM, Giudice LC, Murphy LJ, Hintz RL, Rosenfeld RG. Maternal insulin-like growth factor-binding protein messenger ribonucleic acid during rat pregnancy. Endocrinology 1991; 129: 3359-3366.
52. Gargosky SE, Walton PE, Owens PC, Wallace JC, Ballard FJ. Insulin-like growth factor-I (IGF-I) and IGF-binding proteins both decline in the rat during late pregnancy. J Endocrinol 1990; 127: 383-390.
53. Travers MT, Madon RJ, Flint DJ. Regulation of serum insulin-like growth factor-I (IGF-I), hepatic growth hormone binding and IGF-I gene expression in the rat during pregnancy and lactation. J Endocrinol 1993; 139: 89-95.
54. Aleppo G, Moskal SF II, De Grandis PA, Kineman RD, Frohman LA. Homologous down-regulation of growth hormone-releasing hormone receptor messenger ribonucleic acid levels. Endocrinology 1997; 138: 1058-1065.
55. Sato M, Frohman LA. Differential effects of central and peripheral administration of growth hormone (GH) and insulin-like growth factor on hypothalamic GH-releasing hormone and somatostatin gene expression in GH-deficient dwarf rats. Endocrinology 1993; 133: 793-799.
56. Izadyar F, Zhao J, Van Tol HT, Colenbrander B, Bevers MM. Messenger RNA expression and protein localization of growth hormone in bovine ovarian tissue and in cumulus oocyte complexes (COCs) during in vitro maturation. Mol Reprod Dev 1999; 53: 398-406.
57. Zhao J, Taverne MA, van der Weijden GC, Bevers MM, van den Hurk R. Immunohistochemical localisation of growth hormone (GH), GH receptor (GHR), insulin-like growth factor I (IGF-I) and type I IGF-I receptor, and gene expression of GH and GHR in rat pre-antral follicles. Zygote 2002; 10: 85-94.
58. Fairhall KM, Carmignac DF, Robinson ICAF. Growth hormone (GH)-binding protein and GH interactions in vivo in the guinea pig. Endocrinology 1992; 131: 1963-1969.