Hypothalamic expression of human growth hormone induces post-pubertal hypergonadotrophism in male transgenic growth retarded rats

Journal of Neuroendocrinology

Volumn 18, Issue 10, 2006, Pages 719-731

  Davies, J S ^a   Thompson, N M ^a   Christian, H C ^b   Pinilla, L ^c   Ebling, F J P ^d   Tena Sempere, M ^c   Wells, Tim ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF CÓRDOBA   (Spain)

^d UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Gonadotrophins; Growth hormone; Growth hormone deficiency; Hypothalamo pituitary gonadal axis; Testis

Indexed keywords

ANDROGEN; FOLLITROPIN; GONADOTROPIN; HUMAN GROWTH HORMONE; LEPTIN; LUTEINIZING HORMONE; SOMATOMEDIN C; TESTOSTERONE;

ADULTHOOD; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EPIPHYSIS PLATE; FOLLITROPIN BLOOD LEVEL; GAMETOGENESIS; GONADOTROPIN BLOOD LEVEL; GONADOTROPIN RELEASE; GROWTH HORMONE DEFICIENCY; GROWTH RETARDATION; HORMONAL REGULATION; HORMONE BLOOD LEVEL; HYPERGONADOTROPIC HYPOGONADISM; HYPOTHALAMUS; HYPOTHALAMUS HYPOPHYSIS GONAD SYSTEM; LUTEINIZING HORMONE BLOOD LEVEL; MALE; NONHUMAN; ORGAN WEIGHT; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; SEMINAL VESICLE; SEMINIFEROUS TUBULE; SPERMATOZOON COUNT; STEROIDOGENESIS; TESTIS; TESTOSTERONE BLOOD LEVEL; TIBIA; TRANSGENIC ANIMAL;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; GONADOTROPINS; HORMONES; HUMAN GROWTH HORMONE; HUMANS; HYPOTHALAMUS; MALE; MICROSCOPY, ELECTRON; PITUITARY GLAND; RATS; SPERM COUNT; TESTIS;

EID: 33748434596     PISSN: 09538194     EISSN: 13652826     Source Type: Journal    
DOI: 10.1111/j.1365-2826.2006.01467.x     Document Type: Article

References (52)

1. Wehrenberg WB, Giustina A. Basic counterpoint: Mechanisms and pathways of gonadal steroid modulation of growth hormone secretion. Endocr Rev 1992; 13: 299-308.
2. Chowen JA, Garcia-Segura LM, Gonzalez-Parra S, Argente J. Sex steroid effects on the development and functioning of the growth hormone axis. Cell Mol Neurobiol 1996; 16: 297-310.
3. Hull KL, Harvey S. GH as a co-gonadotropin: The evidence of correlative changes in GH secretion and reproductive state. J Endocrinol 2002; 172: 1-9.
4. Chandrashekar V, Zaczek D, Bartke A. The consequences of altered somatotropic system on reproduction. Biol Reprod 2004; 71: 17-27.
5. Lackey BR, Gray SL, Henricks DM. The insulin-like growth factor (IGF) system and gonadotropin regulation: Actions and interactions. Cytokine Growth Factor Rev 1999; 10: 201-217.
6. Bartlett JMS, Charlton HM, Robinson ICAF, Nieschlag E. Pubertal development and testicular function in the male growth hormone-deficient rat. J Endocrinol 1990; 126: 193-201.
7. Keene DE, Suescun MO, Bostwick MG, Chandrashekar V, Bartke A, Kopchick JJ. Puberty is delayed in male growth hormone receptor gene-disrupted mice. J Androl 2002; 23: 661-668.
8. Gravance CG, Breier BH, Vickers MH, Casey PJ. Impaired sperm characteristics in postpubertal growth-hormone-deficient dwarf (dw/dw) rats. Anim Reprod Sci 1997; 49: 71-76.
9. Chandrashekar V, Bartke A, Coschigano KT, Kopchick JJ. Pituitary and testicular function in growth hormone receptor gene knockout mice. Endocrinology 1999; 140: 1082-1088.
10. Fraser RA, Harvey S. Ubiquitous distribution of growth hormone receptors and/or binding proteins in adenohypophyseal tissue. Endocrinology 1992; 130: 1125-1130.
11. Lobie PE, Breipohl W, Aragon JG, Waters MJ. Cellular localization of the growth hormone receptor/binding protein in the male and female reproductive systems. Endocrinology 1990; 126: 2214-2221.
12. Gardner MJ, Flint DJ. Long-term reductions in GH, insulin-like growth factor-I and body weight gain in rats treated neonatally with antibodies to rat GH. J Endocrinol 1990; 124: 381-186.
13. Steger RW, Bartke A, Parkening TA, Collins T, Buonomo FC, Tang K, Wagner TE, Yun JS. Effects of heterologous growth hormones on hypothalamic and pituitary function in transgenic mice. Neuroendocrinology 1991; 53: 365-372.
14. Chandrashekar V, Bartke A. The role of growth hormone in the control of gonadotropin secretion in adult male rats. Endocrinology 1998; 139: 1067-1074.
15. Arsenijevic Y, Wehrenberg WB, Conz A, Eshkol A, Sizonenko PC, Aubert ML. Growth hormone (GH) deprivation induced by passive immunization against rat GH-releasing factor delays sexual maturation in the male rat. Endocrinology 1989; 124: 3050-3059.
16. Kanzaki M, Morris PL. Growth hormone regulates steroidogenic acute regulatory protein expression and steroidogenesis in Leydig cell progenitors. Endocrinology 1999; 140: 1681-1686.
17. Mani Maran RR, Sivakumar R, Ravisankar B, Valli G, Ravichandran K, Arunakaran J, Aruldhas MM. Growth hormone directly stimulates testosterone and oestradiol secretion by rat Leydig cells in vitro and modulates the effects of LH and T3. Endocr J 2000; 47: 111-118.
18. Hiney JK, Ojeda SR, Dees WL. Insulin-like growth factor I. a possible metabolic signal involved in the regulation of female puberty. Neuroendocrinology 1991; 54: 420-423.
19. Hiney JK, Srivastava V, Nyberg CL, Ojeda SR, Dees WL. Insulin-like growth factor I of peripheral origin acts centrally to accelerate the initiation of puberty. Endocrinology 1996; 137: 3717-3728.
20. Colon E, Svechnikov KV, Carlsson-Skwirut C, Bang P, Soder O. Stimulation of steroidogenesis in immature rat Leydig cells evoked by interleukin-1alpha is potentiated by growth hormone and insulin-like growth factors. Endocrinology 2005; 146: 221-230.
21. Pazos F, Sanchez-Franco F, Balsa J, Lopez-Fernandez J, Escalada J, Cacicedo L. Regulation of gonadal and somatotropic axis by chronic intraventricular infusion of insulin-like growth factor 1 antobody at the initiation of puberty in male rats. Neuroendocrinology 1999; 69: 408-416.
22. Wilson ME. The impact of the GH-IGF-I axis on gonadotropin secretion: inferences from animal models. J Pediatr Endocrinol Metab 2001; 14: 115-120.
23. Flavell DM, Wells T, Wells SE, Carmignac DF, Thomas GB, Robinson ICAF. Dominant dwarfism in transgenic rats by targeting human growth hormone (GH) expression to hypothalamic GH-releasing factor neurons. EMBO J 1996; 15: 3871-3879.
24. Wells T, Flavell DM, Wells SE, Carmignac DF, Robinson ICAF. Effects of GH secretagogues in the transgenic growth retarded (Tgr) rat. Endocrinology 1997; 138: 580-587.
25. Davies JS, Thompson NM, Ebling FJP, Wells T. Reproductive development in male transgenic growth retarded rats. J Endocrinol 2000; 164 (Suppl.): Ab P130.
26. Wells T, Houston PA. Skeletal growth acceleration with growth hormone secretagogues in transgenic growth retarded rats. pattern-dependent effects and mechanisms of desensitisation. J Neuroendocrinol 2001; 13: 496-504.
27. McDowell IF, Morris JF, Charlton HM. Characterization of the pituitary gonadotroph cells of hypogonadal male mice: Comparison with normal mice. J Endocrinol 1982; 95: 321-330.
28. Christian HC, Taylor AD, Flower RJ, Morris JF, Buckingham JC. Characterization and localization of lipocortin 1-binding sites on rat anterior pituitary cells by fluorescence-activated cell analysis/sorting and electron microscopy. Endocrinology 1997; 138: 5341-5351.
29. Farquhar MG, Reinhart JF. Electron microscopic studies of the anterior pituitary gland of castrate rats. Endocrinology 1954; 54: 516-541.
30. Nogami H, Yoshimura F. Fine structural characteristics of prolactin cells identified by immunohistochemistry in the male rat. Anat Record 1982; 202: 261-274.
31. Cruz-Orive LM, Weibel ER. Recent stereological methods for cell biology: a brief survey. Am J Physiol 1990; 258: L148-L156.
32. Ebling FJ, Cronin AS. Manipulations of glutamatergic (N-methyl-D-aspartate receptor) neurotransmission alter the rate of photoperiodically regulated sexual maturation in the male Siberian hamster. Biol Reprod 1998; 58: 1-7.
33. Evans BAJ, Warner JT, Elford C, Evans SL, Laib A, Bains RK, Gregory JW, Wells T. Morphological determinants of femoral strength in growth hormone-deficient transgenic growth-retarded (Tgr) rats. J Bone Miner Res 2003; 18: 1308-1316.
34. Charlton HM, Clark RG, Robinson ICAF, Porter-Goff AE, Cox BS, Bugnon C, Bloch BA. Growth hormone-deficient dwarfism in the rat: A new mutation. J Endocrinol 1988; 119: 51-58.
35. Park SK, Selmanoff M. Dose-dependent suppression of postcastration luteinizing hormone secretion exerted by exogenous prolactin administration in male rats: A model for studying hyperprolactinemic hypogonadism. Neuroendocrinology 1991; 53: 404-410.
36. Milenkovi'c L, D'Angelo G, Kelly PA, Weiner RI. Inhibition of gonadotropin hormone-releasing hormone release by prolactin from GT1 neuronal cell lines through prolactin receptors. Proc Natl Acad Sci USA 1994; 91: 1244-1247.
37. Nyberg F. Growth hormone in the brain. characteristics of specific brain targets for the hormone and their functional significance. Front Neuroendocrinol 2000; 21: 330-348.
38. Harvey S, Baumbach WR, Sadeghi H, Sanders EJ. Ultrastructural colocalization of growth hormone binding protein and pituitary hormones in adenohypophyseal cells of the rat. Endocrinology 1993; 133: 1125-1130.
39. Tang K, Bartke A, Gardiner CS, Wagner TE, Yun JS. Gonadotropin secretion, synthesis and gene expression in human growth hormone transgenic mice and in Ames dwarf mice. Endocrinology 1993; 132: 2518-2524.
40. Cheng TC, Beamer WG, Phillips JA III, Bartke A, Mallonee RL, Dowling C. Etiology of growth hormone deficiency in Little, Ames and Snell dwarf mice. Endocrinology 1983; 113: 1669-1678.
41. Van Vugt HH, Swarts HJ, Van de Heijning BJ, Van der Beek EM. Centrally applied somatostatin inhibits the estrogen-induced luteinizing hormone surge via hypothalamic gonadotropin-releasing hormone cell activation in female rats. Biol Reprod 2004; 71: 813-8199.
42. Yu WH, Kimura M, McCann SM. Effect of somatostatin on the release of gonadotropins in male rats. Proc Soc Exp Biol Med 1997; 214: 83-86.
43. Thomas GB, Phelps CJ, Robinson ICAF. Differential regulation of hypothalamic tuberoinfundibular dopamine neurones in two dwarf rat models with contrasting changes in pituitary prolactin. J Neuroendocrinol 1999; 11: 229-236.
44. Li S, Pelletier G. Role of dopamine in the regulation of gonadotropin-releasing hormone in the male rat brain as studied by in situ hybridisation. Endocrinology 1992; 131: 395-399.
45. Jarjour LT, Handelsman DJ, Raum WJ, Swerdloff RS. Mechanism of action of dopamine on the in vitro release of gonadotropin-releasing hormone. Endocrinology 1986; 119: 1726-1732.
46. Lacau-Mangido IM, Becú-Villalobos D, Thyssen SM, Rey EB, Lux-Lantos VAR, Libertun C. Antidopaminergic-induced hypothalamic LHRH release and pituitary gonadotropin secretion in 12 day-old female and male rats. J Neuroendocrinol 1993; 5: 705-709.
47. Martini AC, Fernández-Fernández R, Tovar S, Navarro VM, Vigo E, Vazquez MJ, Davies JS, Thompson NM, Aguilar E, Pinilla L, Wells T, Dieguez C, Tena-Sempere M. Comparative analysis of the effects of ghrelin and unacylated ghrelin upon luteinizing hormone secretion in male rats. Endocrinology 2006; 147: 2374-2382.
48. Yu WH, Kimura M, Walczewska A, Karanth S, McCann SM. Role of leptin in hypothalamic-pituitary function. Proc Natl Acad Sci USA 1997; 94: 1023-1028.
49. Watanobe H. Leptin directly acts within the hypothalamus to stimulate gonadotropin-releasing hormone secretion in vivo in rats. J Physiol 2002; 545: 255-268.
50. Carbone S, Szwarcfarb B, Reynoso R, Bollero G, Ponzo O, Rodina D, Scacchi P, Moguilevsky J. Leptin stimulates LH secretion in peripubertal male rats through NMDA receptors. Endocr Res 2005; 31: 387-396.
51. Perheentupa A, de Jong F, Huhtaniemi I. Biphasic effect of exogenous testosterone on follicle-stimulating hormone gene expression and synthesis in the male rat. Mol Cell Endocrinol 1993; 93: 135-141.
52. Bartke A, Cecim M, Tang K, Steger RW, Chadrashekar V, Turyn D. Neuroendocrine and reproductive consequences of overexpression of growth hormone in transgenic mice. Proc Soc Exp Biol Med 1994; 206: 345-349.