Rottlerin inhibits the nuclear factor κB/Cyclin-D1 cascade in MCF-7 breast cancer cells

Life Sciences

Volumn 82, Issue 11-12, 2008, Pages 638-643

  Torricelli, C ^a   Fortino, V ^a   Capurro, E ^a   Valacchi, G ^a   Pacini, A ^a   Muscettola, M ^a   Soucek, K ^b   Maioli, E ^a  

^a UNIVERSITY OF SIENA   (Italy)

^b INSTITUTE OF BIOPHYSICS   (Czech Republic)

Author keywords

CaMKII; Cyclin D1; MCF 7 cells; NF B; Rottlerin

Indexed keywords

2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; BETA ACTIN; CYCLIN D1; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE (CALCIUM,CALMODULIN) II; PROTEIN KINASE B; PROTEIN KINASE C; PROTEIN KINASE C DELTA; PROTEIN KINASE C INHIBITOR; PROTEIN P21; PROTEIN P27; ROTTLERIN; SYNAPTOTAGMIN I;

ARTICLE; AUTOPHOSPHORYLATION; BREAST CANCER; CELL NUCLEUS; CELL PROLIFERATION; CELL STRAIN MCF 7; CONTROLLED STUDY; CYTOPLASM; DOWN REGULATION; DRUG TARGETING; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; MITOCHONDRION; WESTERN BLOTTING;

ACETOPHENONES; BENZOPYRANS; BREAST NEOPLASMS; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CYCLIN D1; ENZYME INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; HUMANS; INDOLES; MALEIMIDES; NF-KAPPA B; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

EID: 39649095616     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2007.12.020     Document Type: Article

References (22)

1. Balmanno K., and Cook S.J. Sustained MAP kinase activation is required for the expression of cyclin-D1, p21Cip1 and a subset of AP-1 proteins in CCL39 cells. Oncogene 18 20 (1999) 3085-3097
2. Cho S.I., Koketsu M., Ishihara H., Matsushita M., Nairn A.C., Fukazawa H., and Uehara Y. Novel compounds, '1,3-selenazine derivatives' as specific inhibitors of eukaryotic elongation factor-2 kinase. Biochimica et Biophysica Acta 1475 3 (2000) 207-215
3. Colbran R.J., Fong Y.L., Schworer C.M., and Soderling T.R. Regulatory interactions of the calmodulin-binding, inhibitory, and autophosphorylation domains of Ca2+/calmodulin-dependent protein kinase II. Journal of Biological Chemistry 263 34 (1988) 18145-18151
4. Davies S.P., Reddy H., Caivano M., and Cohen P. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochemical Journal 351 Pt 1 (2000) 95-105
5. Gillett C., Fantl V., Smith R., Fisher C., Bartek J., Dickson C., Barnes D., and Peters G. Amplification and overexpression of cyclin-D1 in breast cancer detected by immunohistochemical staining. Cancer Research 54 7 (1994) 1812-1817
6. Gschwendt M., Muller H.J., Kielbassa K., Zang R., Kittstein W., Rincke G., and Marks F. Rottlerin, a novel protein kinase inhibitor. Biochemical and Biophysical Research Communication 199 1 (1994) 93-98
7. Gschwendt M., Kittstein W., and Marks F. Elongation factor-2 kinase: effective inhibition by the novel protein kinase inhibitor Rottlerin and relative insensitivity towards staurosporine. FEBS Letters 338 1 (1994) 85-88
8. Guttridge D.C., Albanese C., Reuther J.Y., Pestell R.G., and Baldwin Jr. A.S. NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin-D1. Molecular and Cellular Biology 19 8 (1999) 5785-5799
9. Hughes K., Edin S., Antonsson A., and Grundström T. Calmodulin-dependent kinase II mediates T cell receptor/CD3- and phorbol ester-induced activation of IkappaB kinase. Journal of Biological Chemistry 276 38 (2001) 36008-36013
10. Ishiguro K., Ando T., Goto H., and Xavier R. Bcl10 is phosphorylated on Ser138 by Ca2+/calmodulin-dependent protein kinase II. Molecular Immunology 44 8 (2007) 2095-2100
11. Jane E.P., Premkumar D.R., and Pollack I.F. Coadministration of sorafenib with rottlerin potently inhibits cell proliferation and migration in human malignant glioma cells. Journal of Pharmacology and Experimental Therapeutics 19 3 (2006) 1070-1080
12. Kashiwase K., Higuchi Y., Hirotani S., Yamaguchi O., Hikoso S., Takeda T., Watanabe T., Taniike M., Nakai A., Tsujimoto I., Matsumura Y., Ueno H., Nishida K., Hori M., and Otsu K. CaMKII activates ASK1 and NF-kappaB to induce cardiomyocyte hypertrophy. Biochemical and Biophysical Research Communication 327 1 (2005) 136-142
13. Kenny F.S., Hui R., Musgrove E.A., Gee J.M., Blamey R.W., Nicholson R.I., Sutherland R.L., and Robertson J.F. Overexpression of cyclin-D1 messenger RNA predicts for poor prognosis in estrogen receptor-positive breast cancer. Clinical Cancer Research 5 8 (1999) 2069-2076
14. Majumder P.K., Pandey P., Sun X., Cheng K., Datta R., Saxena S., Kharbanda S., and Kufe D. Mitochondrial translocation of protein kinase C delta in phorbol ester-induced cytochrome c release and apoptosis. Journal of Biological Chemistry 275 29 (2000) 21793-21796
15. Milanini-Mongiat J., Pouyssegur J., and Pages G. Identification of two Sp1 phosphorylation sites for p42/p44 mitogen-activated protein kinases: their implication in vascular endothelial growth factor gene transcription. Journal of Biological Chemistry 277 23 (2002) 20631-20639
16. Nagata D., Suzuki E., Nishimatsu H., Satonaka H., Goto A., Omata M., and Hirata Y. Transcriptional activation of the cyclin-D1 gene is mediated by multiple cis-elements, including SP1 sites and a cAMP-responsive element in vascular endothelial cells. Journal of Biological Chemistry 276 1 (2001) 662-669
17. Ouyang W., Li J., Ma Q., and Huang C. Essential roles of PI-3K/Akt/IKKbeta/NFkappaB pathway in cyclin-D1 induction by arsenite in JB6 Cl41 cells. Carcinogenesis 27 4 (2006) 864-873
18. Ozes O.N., Mayo L.D., Gustin J.A., Pfeffer S.R., Pfeffer L.M., and Donner D.B. NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature 401 (1999) 82-85
19. Pahl H.L. Activators and target genes of Rel/NF-kappaB transcription factors. Oncogene 18 49 (1999) 6853-6866
20. Schouten G.J., Vertegaal A.C., Whiteside S.T., Israel A., Toebes M., Dorsman J.C., van der Eb A.J., and Zantema A. IkappaB alpha is a target for the mitogen-activated 90 kDa ribosomal S6 kinase. EMBO Journal 16 11 (1997) 3133-3144
21. Soltoff S.P. Rottlerin is a mitochondrial uncoupler that decreases cellular ATP levels and indirectly blocks protein kinase Cδ tyrosine phosphorylation. Journal of Biological Chemistry 276 41 (2001) 37986-37992
22. Wegener E., and Krappmann D. CARD-Bcl10-Malt1 signalosomes: missing link to NF-kappaB. Science's Signal Transduction Knowledge Environment 384 (2007) pe21