Carboxypeptidase D: A novel TGF-β target gene dysregulated in patients with lupus erythematosus

Journal of Clinical Immunology

Volumn 27, Issue 6, 2007, Pages 568-579

  Hoff, Norman Philipp ^a,b   Degrandi, Daniel ^a   Hengge, Ulrich ^a   Pfeffer, Klaus ^a   Wurthner, Jens Ulrich ^c  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b NOT AVAILABLE   (Germany)

^c ASTRAZENECA   (United Kingdom)

Author keywords

Autoimmunity; Carboxypeptidase D; Macrophage; TGF beta

Indexed keywords

CARBOXYPEPTIDASE; CARBOXYPEPTIDASE D; CD14 ANTIGEN; TRANSFORMING GROWTH FACTOR BETA;

ADULT; ANIMAL; ARTICLE; BIOSYNTHESIS; C57BL MOUSE; CELL LINE; COMPARATIVE STUDY; DOWN REGULATION; DRUG ANTAGONISM; ENZYME INDUCTION; ENZYMOLOGY; FEEDBACK SYSTEM; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; IMMUNOLOGY; MACROPHAGE; MALE; METABOLISM; MIDDLE AGED; MOUSE; PHYSIOLOGY; SIGNAL TRANSDUCTION; SYSTEMIC LUPUS ERYTHEMATOSUS; TUMOR CELL LINE; UPREGULATION;

ADULT; ANIMALS; ANTIGENS, CD14; CARBOXYPEPTIDASES; CELL LINE; CELL LINE, TUMOR; DOWN-REGULATION; ENZYME INDUCTION; FEEDBACK, BIOCHEMICAL; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MIDDLE AGED; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA; UP-REGULATION;

EID: 39649090120     PISSN: 02719142     EISSN: 15732592     Source Type: Journal    
DOI: 10.1007/s10875-007-9118-7     Document Type: Conference Paper

References (56)

1. Roberts AB, Sporn MB. The transforming growth factors-b. In: Sporn MB, Roberts AB, editors. Handbook of experimental pharmacology. Peptide growth factors and their receptors. Berlin: Springer; 1990. p. 419-72.
2. Massague J, Blain SW, Lo RS. TGFbeta signaling in growth control, cancer, and heritable disorders. Cell 2000;2:309.
3. de Caestecker MP, Piek E, Roberts AB. Role of transforming growth factor-beta signaling in cancer. J Natl Cancer Inst 2000;17:402.
4. Blobe GC, Schiemann WP, Lodish HF. Role of transforming growth factor beta in human disease. N Engl J Med 2000;342(18):1350-8. (Pubitemid 30408720)
5. Leask A, Abraham DJ. TGF-beta signaling and the fibrotic response. FASEB J 2004;18(7):816-27.
6. Schiller M, Javelaud D, Mauviel A. TGF-beta-induced SMAD signaling and gene regulation: consequences for extracellular matrix remodeling and wound healing. J Dermatol Sci 2004;35(2):83-92. (Pubitemid 38969031)
7. Chen YG, Meng AM. Negative regulation of TGF-beta signaling in development. Cell Res 2004;14(6):441-9. (Pubitemid 43231788)
8. Shull MM, Ormsby I, Kier AB, Pawlowski S, Diebold RJ, Yin M et al. Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease. Nature 1992;359(6397):693-9.
9. Hahm KB, Im YH, Parks TW, Park SH, Markowitz S, Jung HY et al. Loss of transforming growth factor beta signalling in the intestine contributes to tissue injury in inflammatory bowel disease. Gut 2001;49(2):190-8. (Pubitemid 32675110)
10. Monteleone G, Kumberova A, Croft NM, McKenzie C, Steer HW, MacDonald TT. Blocking Smad7 restores TGF-beta1 signaling in chronic inflammatory bowel disease. J Clin Invest 2001;108(4):601-9. (Pubitemid 32777740)
11. Fiocchi C. TGF-beta/Smad signaling defects in inflammatory bowel disease: mechanisms and possible novel therapies for chronic inflammation. J Clin Invest 2001;108(4):523-6. (Pubitemid 32777731)
12. Letterio JJ, Roberts AB. Regulation of immune responses by TGF-beta. Annu Rev Immunol 1998;16:137-61, 137-61.
13. Mokhtarian F, Shi Y, Shirazian D, Morgante L, Miller A, Grob D. Defective production of anti-inflammatory cytokine, TGF-beta by T cell lines of patients with active multiple sclerosis. J Immunol 1994;152:6003-10. (Pubitemid 24174183)
14. Ohtsuka K, Gray JD, Stimmler MM, Toro B, Horwitz DA. Decreased production of TGF-beta by lymphocytes from patients with systemic lupus erythematosus. J Immunol 1998;160(5):2539-45. (Pubitemid 28119941)
15. Losy J, Michalowska-Wender G. In vivo effect of interferon-beta 1a on interleukin-12 and TGF-beta(1) cytokines in patients with relapsing-remitting multiple sclerosis. Acta Neurol Scand 2002;106(1):44-6. (Pubitemid 34666578)
16. Kim SY, Han SW, Kim GW, Lee JM, Kang YM. TGF-beta1 polymorphism determines the progression of joint damage in rheumatoid arthritis. Scand J Rheumatol 2004;33(6):389-94. (Pubitemid 40006887)
17. Flanders KC, Burmester JK. Medical applications of transforming growth factor-beta. Clin Med Res 2003;1(1):13-20.
18. Bach JF, Bendelac A, Brenner MB, Cantor H, De Libero G, Kronenberg M et al. The role of innate immunity in autoimmunity. J Exp Med 2004;200(12):1527-31. (Pubitemid 40094176)
19. Carroll M. Innate immunity in the etiopathology of autoimmunity. Nat Immunol 2001;2(12):1089-90. (Pubitemid 33130137)
20. Vollmer J, Tluk S, Schmitz C, Hamm S, Jurk M, Forsbach A et al. Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8. J Exp Med 2005;202(11):1575-85. (Pubitemid 41746603)
21. Li C, Wong WH. Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection. Proc Natl Acad Sci U S A 2001;98(1):31-6. (Pubitemid 32095858)
22. Tusher VG, Tibshirani R, Chu G. Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci U S A 2001;98(9):5116-21. (Pubitemid 32397092)
23. Eisen MB, Spellman PT, Brown PO, Botstein D. Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci U S A 1998;95(25):14863-8. (Pubitemid 29003722)
24. Too CK, Vickaryous N, Boudreau RT, Sangster SM. Identification and nuclear localization of a novel prolactin and cytokine-responsive carboxypeptidase D. Endocrinology 2001;142(3):1357-67. (Pubitemid 32202849)
25. Cox GW,Mathieson BJ, Gandino L, Blasi E, Radzioch D, Varesio L. Heterogeneity of hematopoietic cells immortalized by v-myc/v-raf recombinant retrovirus infection of bone marrow or fetal liver. J Natl Cancer Inst 1989;81(19):1492-6. (Pubitemid 19252402)
26. Hadkar V, Skidgel RA. Carboxypeptidase D is up-regulated in raw 264.7 macrophages and stimulates nitric oxide synthesis by cells in arginine-free medium. Mol Pharmacol 2001;59(5):1324-32. (Pubitemid 32381612)
27. Swaisgood CM, Schmitt D, Eaton D, Plow EF. In vivo regulation of plasminogen function by plasma carboxypeptidase B. J Clin Invest 2002;110(9):1275-82. (Pubitemid 35291121)
28. Matthews KW, Mueller-Ortiz SL, Wetsel RA. Carboxypeptidase N: a pleiotropic regulator of inflammation. Mol Immunol 2004;40(11):785-93. (Pubitemid 37542428)
29. Leurs J, Hendriks D. Carboxypeptidase U (TAFIa): a metallocarboxypeptidase with a distinct role in haemostasis and a possible risk factor for thrombotic disease. Thromb Haemost 2005;94(3):471-87. (Pubitemid 41300839)
30. Krause SW, Rehli M, Andreesen R. Carboxypeptidase M as a marker of macrophage maturation. Immunol Rev 1998;161:119-27.
31. Hook VY. Regulation of carboxypeptidase H by inhibitory and stimulatory mechanisms during neuropeptide precursor processing. Cell Mol Neurobiol 1988;8(1):49-55.
32. Swaisgood CM, Schmitt D, Eaton D, Plow EF. In vivo regulation of plasminogen function by plasma carboxypeptidase B. J Clin Invest 2002;110(9):1275-82. (Pubitemid 35291121)
33. Leurs J, Hendriks D. Carboxypeptidase U (TAFIa): a metallocarboxypeptidase with a distinct role in haemostasis and a possible risk factor for thrombotic disease. Thromb Haemost 2005;94(3):471-87. (Pubitemid 41300839)
34. Hook VY. Regulation of carboxypeptidase H by inhibitory and stimulatory mechanisms during neuropeptide precursor processing. Cell Mol Neurobiol 1988;8(1):49-55.
35. Reverter D, Maskos K, Tan F, Skidgel RA, BodeW. Crystal structure of human carboxypeptidase M, a membrane-bound enzyme that regulates peptide hormone activity. J Mol Biol 2004;338(2):257-69. (Pubitemid 38447084)
36. Kuroki K, Eng F, Ishikawa T, Turck C, Harada F, Ganem D. gp180, a host cell glycoprotein that binds duck hepatitis B virus particles, is encoded by a member of the carboxypeptidase gene family. J Biol Chem 1995;270(25):15022-8.
37. Song L, Fricker LD. Purification and characterization of carboxypeptidase D, a novel carboxypeptidase E-like enzyme, from bovine pituitary. J Biol Chem 1995;270(42):25007-13.
38. McGwire GB, Tan F, Michel B, Rehli M, Skidgel RA. Identification of a membrane-bound carboxypeptidase as the mammalian homolog of duck gp180, a hepatitis B virus-binding protein. Life Sci 1997;60(10):715-24. (Pubitemid 27087264)
39. Tan F, Rehli M, Krause SW, Skidgel RA. Sequence of human carboxypeptidase D reveals it to be a member of the regulatory carboxypeptidase family with three tandem active site domains. Biochem J 1997;327(Pt 1):81-7. (Pubitemid 27455464)
40. Eng FJ, Novikova EG, Kuroki K, Ganem D, Fricker LD. gp180, a protein that binds duck hepatitis B virus particles, has metallocarboxypeptidase D-like enzymatic activity. J Biol Chem 1998;273(14):8382-8. (Pubitemid 28168899)
41. Ishikawa T, Murakami K, Kido Y, Ohnishi S, Yazaki Y, Harada F et al. Cloning, functional expression, and chromosomal localization of the human and mouse gp180-carboxypeptidase D-like enzyme. Gene 1998;215(2):361-70. (Pubitemid 28382939)
42. Song L, Fricker LD. Tissue distribution and characterization of soluble and membrane-bound forms of metallocarboxypeptidase D. J Biol Chem 1996;271(46):28884-9. (Pubitemid 26382588)
43. Gagnon A, Landry A, Proulx J, Layne MD, Sorisky A. Aortic carboxypeptidase-like protein is regulated by transforming growth factor beta in 3T3-L1 preadipocytes. Exp Cell Res 2005;308(2):265-72.
44. Qiu P, Ritchie RP, Fu Z, Cao D, Cumming J, Miano JM et al. Myocardin enhances Smad3-mediated transforming growth factor-beta1 signaling in a CArG box-independent manner: Smad-binding element is an important cis element for SM22alpha transcription in vivo. Circ Res 2005;97(10):983-91. (Pubitemid 41668911)
45. Skoudy A, Rovira M, Savatier P, Martin F, Leon-Quinto T, Soria B et al. Transforming growth factor (TGF)beta, fibroblast growth factor (FGF) and retinoid signalling pathways promote pancreatic exocrine gene expression in mouse embryonic stem cells. Biochem J 2004;379(Pt 3):749-56. (Pubitemid 38703659)
46. Riley DA, Tan F, Miletich DJ, Skidgel RA. Chromosomal localization of the genes for human carboxypeptidase D (CPD) and the active 50-kilodalton subunit of human carboxypeptidase N (CPN1). Genomics 1998;50(1):105-8. (Pubitemid 28280886)
47. Timblin B, Rehli M, Skidgel RA. Structural characterization of the human carboxypeptidase D gene and its promoter. Int Immunopharmacol 2002;2(13-14):1907-17. (Pubitemid 35375262)
48. Siegel M, Lee SL. The epidemiology of systemic lupus erythematosus. Semin Arthritis Rheum 1973;3(1):1-54.
49. Lu LY, Cheng HH, Sung PK, Yeh JJ, Shiue YL, Chen A. Single-nucleotide polymorphisms of transforming growth factor-beta1 gene in Taiwanese patients with systemic lupus erythematosus. J Microbiol Immunol Infect 2004;37(3):145-52. (Pubitemid 38899944)
50. Davies KA, Peters AM, Beynon HL, Walport MJ. Immune complex processing in patients with systemic lupus erythematosus. In vivo imaging and clearance studies. J Clin Invest 1992;90(5):2075-83.
51. Yurasov S, Hammersen J, Tiller T, Tsuiji M, Wardemann H. B-cell tolerance checkpoints in healthy humans and patients with systemic lupus erythematosus. Ann N Y Acad Sci 2005;1062:165-74.
52. Chen YF, Morel L. Genetics of T cell defects in lupus. Cell Mol Immunol 2005;2(6):403-9.
53. Sanford AN, Suriano AR, Herche D, Dietzmann K, Sullivan KE. Abnormal apoptosis in chronic granulomatous disease and autoantibody production characteristic of lupus. Rheumatology (Oxford) 2006;45(2):178-81. (Pubitemid 43160079)
54. Giese A, Stuhlsatz S, Daubener W, MacKenzie CR. Inhibition of the growth of Toxoplasma gondii in immature human dendritic cells is dependent on the expression of TNF-alpha receptor 2. J Immunol 2004;173(5):3366-74. (Pubitemid 39142046)
55. Cairns AP, Crockard AD, Bell AL. The CD14+ CD16+ monocyte subset in rheumatoid arthritis and systemic lupus erythematosus. Rheumatol Int 2002 Mar;21(5):189-92. (Pubitemid 34209119)
56. Sanchez-Torres C, Garcia-Romo GS, Cornejo-Cortes MA, Rivas-Carvalho A, Sanchez-Schmitz G. CD16+ and CD16-human blood monocyte subsets differentiate in vitro to dendritic cells with different abilities to stimulate CD4+ T cells. Int Immunol 2001;13(12):1571-81. (Pubitemid 33133884)