Challenges to pediatric HIV care and treatment in South Africa

Journal of Infectious Diseases

Volumn 196, Issue SUPPL. 3, 2007, Pages

  Meyers, Tammy ^a,b   Moultrie, Harry ^a,b   Naidoo, Kimesh ^d   Cotton, Mark ^e   Eley, Brian ^f   Sherman, Gayle ^b,c  

^a UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^b UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^c NATIONAL HEALTH LABORATORY SERVICE   (South Africa)

^d UNIVERSITY OF KWAZULU NATAL   (South Africa)

^e STELLENBOSCH UNIVERSITY   (South Africa)

^f UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; COTRIMOXAZOLE; NEVIRAPINE; STAVUDINE; ZIDOVUDINE;

CHILDHOOD MORTALITY; CLINICAL PRACTICE; COMBINATION CHEMOTHERAPY; CONFERENCE PAPER; HEALTH CARE; HEALTH PROGRAM; HEALTH SERVICE; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INCIDENCE; PATIENT COUNSELING; PATIENT EDUCATION; PNEUMOCYSTIS JIROVECI; PNEUMONIA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROPHYLAXIS; SOUTH AFRICA; VIRUS LOAD; VIRUS TRANSMISSION; WORLD HEALTH ORGANIZATION; CHILD; DISEASE TRANSMISSION; FEMALE; HUMAN IMMUNODEFICIENCY VIRUS; ISOLATION AND PURIFICATION; METHODOLOGY; PEDIATRICS; PREGNANCY; PREGNANCY COMPLICATION; REVIEW; VIROLOGY;

ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CHILD; DISEASE TRANSMISSION, VERTICAL; FEMALE; HIV; HIV INFECTIONS; HUMANS; PEDIATRICS; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; SOUTH AFRICA;

EID: 39549103048     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/521116     Document Type: Conference Paper

References (49)

1. Department of Health, South Africa. National HIV and syphilis antenatal sero-prevalence survey in South Africa 2004. Available at: http://www.doh.gov. za/docs/facts-f.html. Accessed 27 April 2006.
2. Results extracted from the ASSA2003 AIDS and Demographic Model of the Actuarial Society of South Africa as downloaded 5 May 2006. Available at: http://www.assa.org.za/. Accessed 5 May 2006.
3. Solarsh G, Goga A. Child health. In: Ijumba P, Day C, Ntuli A, eds. South African health review 2003/04. Durban: Health Systems Trust, 2004.
4. Nannan N, Timaeus IM, Laubscher R, Bradshaw D. Levels and differentials in childhood mortality in South Africa, 1977-1998. J Biosoc Sci 2007; 39:613-32.
5. Rollins N, Little K, Mzolo S, Horwood C, Newell ML. Surveillance of mother-to-child transmission prevention programmes at immunization clinics: the case for universal screening. AIDS 2007; 21:1341-7.
6. Dorrington R, Bradshaw D, Johnson L, Budlender D. The demographic impact of HIV/AIDS in South Africa. National indicators for 2004. Available at: http://www.mrc.ac.za/bod/demographic.pdf. Accessed 5 May 2006.
7. Statistics South Africa. Mortality and causes of death in South Africa, 2003 and 2004: findings from death notifications. Statistical release P0309.3. Available at: http://www.statssa.gov.za. Accessed 5 June 2006.
8. Scarlatti G. Mother-to-child transmission of HIV-1: advances and controversies of the twentieth centuries. AIDS Rev 2004; 6:67-78.
9. Mofenson LM, McIntyre JA. Advances and research directions in the prevention of mother-to-child HIV-1 transmission. Lancet 2000; 355:2237-44.
10. United Nations Children's Fund (UNICEF). A world fit for children. New York: UNICEF, 2002.
11. Manzi M, Zachariah R, Teck R, et al. High acceptability of voluntary counselling and HIV-testing but unacceptable loss to follow up in a prevention of mother-to-child HIV transmission programme in rural Malawi: scaling-up requires a different way of acting. Trop Med Int Health 2005; 10:1242-50.
12. Gray RH, Li X, Kigozi G, et al. Increased risk of incident HIV during pregnancy in Rakai, Uganda: a prospective study. Lancet 2005; 366:1182-8.
13. Garcia P, Kalish LA, Pitt J. Maternal levels of plasma human immunodeficiency virus type 1 RNA and the risk of perinatal transmission. Women and Infants Transmission Study Group. N Engl J Med 1999; 341:394-402.
14. Coutsoudis A, Pillay K, Spooner E, Kuhn L, Coovadia HM. Influence of infant-feeding patterns on early mother-to-child transmission of HIV-1 in Durban, South Africa: a prospective cohort study. South African Vitamin A Study Group. Lancet 1999; 354:471-6.
15. Iliff PJ, Piwoz EG, Tavengwa NV, et al. Early exclusive breastfeeding reduces the risk of postnatal HIV-1 transmission and increases HIV-free survival. AIDS 2005; 19:699-708.
16. Chopra M, Doherty T, Jackson D, Ashworth A. Preventing HIV transmission to children: quality of counselling of mothers in South Africa. Acta Paediatrica 2005; 94:357-63.
17. Guay LA, Musoke P, Fleming T, et al. Intrapartum and neonatal single-dose nevirapine compared with zidovudine for prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: HIVNET 012 randomised trial. Lancet 1999; 354:795-802.
18. Coetzee D, Hilderbrand K, Boulle A, Draper B, Abdullah F, Goemaere E. Effectiveness of the first district-wide programme for the prevention of mother-to-child transmission of HIV in South Africa. Bull World Health Organ 2005; 83:489-94.
19. Sherman GG, Jones SA, Coovadia AH, Urban MF, Bolton KD. PMTCT from research to reality - results from a routine service. S Afr Med J 2004; 94:289-92.
20. Lallemant M, Jourdain G, Le Coeur S, et al. Single-dose perinatal nevirapine plus standard zidovudine to prevent mother-to-child transmission of HIV-1 in Thailand. N Engl J Med 2004; 351:217-28.
21. Dabis F, Bequet L, Ekouevi DK, et al. Field efficacy of zidovudine, lamivudine and single-dose nevirapine to prevent peripartum HIV transmission. AIDS 2005; 19:309-18.
22. Leroy V, Sakarovitch C, Cortina-Borja M, et al. Is there a difference in the efficacy of peripartum antiretroviral regimens in reducing mother-to-child transmission of HIV in Africa? AIDS 2005; 19:1865-75.
23. World Health Organization (WHO). Antiretroviral drugs and the prevention of mother-to-child transmission of HIV infection in resourcelimited settings: recommendations for a public health approach (2005 revision). Geneva: WHO, 2005.
24. Department of Health, South Africa. Guidelines for the management of HIV-infected children - 2005. Available at: http://www.doh.gov.za/docs/policy-f. html. Accessed 24 May 2006.
25. Stevens W, Sherman GG, Cotton M, Gerntholtz L, Webber L. Revised guidelines for diagnosis of perinatal HIV-1 infection in South Africa. S Afr J HIV Med 2006; 22:24-8.
26. Sherman GG, Stevens G, Jones SA, Horsfield P, Stevens WS. Dried blood spots improve access to HIV diagnosis and care for infants in low-resource settings. J Acquir Immune Defic Syndr 2005; 38:615-7.
27. Fischer A, Lejczak C, Lambert C, et al. Simple DNA extraction method for dried blood spots and comparison of two PCR assays for diagnosis of vertical human immunodeficiency virus type 1 transmission in Rwanda. J Clin Microbiol 2004; 42:16-20.
28. Cassol S, Salas T, Gill MJ, et al. Stability of dried blood spot specimens for detection of human immunodeficiency virus DNA by polymerase chain reaction. J Clin Microbiol 1992; 30:3039-42.
29. Jones SA, Sherman GG, Coovadia AH. Can clinical algorithms deliver an accurate diagnosis of HIV infection in infancy? Bull World Health Organ 2005; 83:559-60.
30. Schneider H, Kellerman R, Oyedele S. HIV Impact Surveillance System in 2005 summary report; design and data collection. Johannesburg: Wits School of Public Health, Gauteng Department of Health, 2005.
31. Krug A, Pattinson RC, Power DJ. Why children die: an under-5 health care survey in Mafikeng region. S Afr Med J 2004; 94:202-6.
32. Chintu C, Bhat GJ, Walker AS, et al. Co-trimoxazole as prophylaxis against opportunistic infections in HIV-infected Zambian children (CHAP): a double-blind randomised placebo-controlled trial. Lancet 2004; 364:1865-71.
33. Simonds RJ, Oxtoby MJ, Caldwell MB, Gwinn ML, Rogers MF. Pneu mocystis carinii pneumonia among US children with perinatally acquired HIV infection. JAMA 1993; 270:470-3.
34. Giese S, Hussey G. Rapid appraisal of primary health care services for HIV-positive children at public sector clinics in South Africa. Cape Town: Children's Institute University of Cape Town, Child Health Unit University of Cape Town, 2002.
35. Joint Civil Society Monitoring Forum. Resolutions of the 3rd meeting of the JCSMF, Durban, 18 February 2005. Available at: http://www.jcsmf.org.za/ files/3rdJCSMFmeeting.pdf. Accessed 22 August 2007.
36. Department of Health, South Africa. National comprehensive HIV and AIDS plan statistics. Available at: http://www.doh.gov.za/docs/statistics.pdf. Accessed 3 January 2007.
37. KwaZulu-Natal Department of Health. Weekly report on the ARV rollout. Pietermaritzburg: KwaZulu-Natal Department of Health, 2005.
38. McConnell MS, Byers RH, Frederick T, et al. Trends in antiretroviral therapy use and survival rates for a large cohort of HIV-infected children and adolescents in the United States, 1989-2001. J Acquir Immune Defic Syndr 2005; 38:488-94.
39. Gibb DM, Duong T, Tookey PA, et al. Decline in mortality, AIDS, and hospital admissions in perinatally HIV-1 infected children in the United Kingdom and Ireland. BMJ 2003; 327:1019.
40. Fassinou P, Elenga N, Rouet F, et al. Highly active antiretroviral therapies among HIV-1-infected children in Abidjan, Cote d'Ivoire. AIDS 2004; 18:1905-13.
41. Jooste JP, Van Zyl AJ, Baker A, Crawford W, Jassen A. Antiretroviral treatment in the Northern Cape. S Afr Med J 2005; 95:812.
42. Eley B, Nuttall J, Davies MA, et al. Initial experience of a public sector antiretroviral treatment programme for HIV-infected children and their infected parents. S Afr Med J 2004; 94:643-6.
43. Egbers C, Moultrie H, Meyers TM. Rapid growth rate in first 6 months in children initiating antiretroviral therapy (ARV) in Soweto, South Africa [abstract MoPe0221]. In: Program and abstracts of the AIDS 2006: XVI International AIDS Conference (Toronto). Geneva: International AIDS Society, 2006.
44. Egbers C, Moultrie H, Meyers T. Audit of HIV infected children on antiretroviral treatment on the government rollout program at a tertiary hospital, Soweto, South Africa [abstract MoPe11.7C14]. In: Program and abstracts of the 3rd IAS Conference on HIV Pathogenesis and Treatment (Rio de Janeiro, Brazil). Geneva: International AIDS Society, 2005.
45. Michaels D, Eley B, Ndhlovu L, Rutenberg N. Exploring current practices in pediatric ARV rollout and integration with early childhood programs in South Africa: a rapid situational analysis. Horizons final report. Washington, DC: Population Council, 2006.
46. Stewart R, Loveday M. Operational plan: implementation of the antiretroviral therapy component. In: Ijumba P, Barron P, eds. South African health review 2005. Durban: Health Systems Trust, 2005: 224-46.
47. Scott VE, Chopra M, Conrad L, Ntuli A. How equitable is the scaling up of HIV service provision in South Africa? S Afr Med J 2005; 95:109-13.
48. Chopra M, Doherty T, Jackson D, Ashworth A. Preventing HIV transmission to children: quality of counselling of mothers in South Africa. Acta Paediatr 2005; 94:357-63.
49. World Health Organization (WHO). Antiretroviral drugs for treating pregnant women and preventing HIV infection in infants: Guidelines on care, treatment and support for women living with HIV/AIDS and their children in resource-constrained settings. Geneva: WHO, 2004.