Brief review of available evidence concerning the potential induction of genomic damage by methylphenidate

Journal of Neural Transmission

Volumn 115, Issue 2, 2008, Pages 331-334

  Stopper, H ^a   Walitza, S ^a   Warnke, A ^a   Gerlach, M ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

ADHD; Genomic damage; Methyl phenidate; Micronuclei

Indexed keywords

METHYLPHENIDATE;

ATTENTION DEFICIT DISORDER; CARCINOGENIC ACTIVITY; CARCINOGENICITY; COMPARATIVE STUDY; GENETIC DAMAGE; GENOTOXICITY; GERMANY; HUMAN; NONHUMAN; PRIORITY JOURNAL; REVIEW; RODENT; UNITED STATES;

ANIMALS; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CENTRAL NERVOUS SYSTEM STIMULANTS; DNA DAMAGE; GENOMICS; HUMANS; METHYLPHENIDATE;

EID: 39549087937     PISSN: 03009564     EISSN: 14351463     Source Type: Journal    
DOI: 10.1007/s00702-007-0829-y     Document Type: Review

References (21)

1. AC Andreazza BN Frey SS Valvassori C Zanotto KM Gomes CM Comim C Cassini L Stertz LC Ribeiro J Quevedo F Kapczinski M Berk CA Goncalves 2007 DNA damage in rats after treatment with methylphenidate Prog Neuropsychopharmacol Biol Psychiatry 31 6 1282 1288
2. J Biederman SV Faraone 2005 Attention-deficit hyperactivity disorder Lancet 366 237 248
3. S Bonassi A Znaor M Ceppi C Lando WP Chang N Holland M Kirsch-Volders E Zeiger S Ban R Barale MP Bigatti C Bolognesi A Cebulska-Wasilewska E Fabianova A Fucic L Hagmar G Joksic A Martelli L Migliore E Mirkova MR Scarfi A Zijno H Norppa M Fenech 2006 An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans Carcinogenesis 28 3 625 631
4. DP Cioca N Watanabe M Isobe 2000 Apoptosis of peripheral blood lymphocytes is induced by catecholamines Jpn Heart J 41 385 398
5. M Cosentino E Rasini C Colombo F Marino F Blandini M Ferrari A Samuele S Lecchini G Nappi G Frigo 2004 Dopaminergic modulation of oxidative stress and apoptosis in human peripheral blood lymphocytes: evidence for a D1-like receptor-dependent protective effect Free Radic Biol Med 36 1233 1240
6. DSM-IV-TR 2000 Diagnostic and statistical manual of mental disorders, 4th edn, text revision American Psychiatric Association Washington, DC
7. RA El-Zein SZ Abdel-Rahman MJ Hay MS Lopez ML Bondy DL Morris MS Legator 2005 Cytogenetic effects in children treated with methylphenidate Cancer Lett 230 2 284 291
8. RA El-Zein MJ Hay MS Lopez ML Bondy DL Morris MS Legator SZ Abdel-Rahman 2006 Response to comments on 'Cytogenetic effects in children treated with methylphenidate' by El-Zein et al Cancer Lett 231 1 146 148
9. L Hagmar U Stromberg S Bonassi IL Hansteen LE Knudsen C Lindholm H Norppa 2004 Impact of types of lymphocyte chromosomal aberrations on human cancer risk: results from Nordic and Italian cohorts Cancer Res 64 6 2258 2263
10. M Holtmann B Kaina F Poustka 2006 Methylphenidate-induced cytogenetic alterations? [in German] Z Kinder Jugendpsychiatr Psychother 34 215 220
11. M Huss 2004 Langzeiteffekte der Stimulanzientherapie M Schulte-Markwort A Warnke Methylphenidat Thieme Stuttgart 34 43
12. E Junn MM Mouradian 2001 Apoptotic signaling in dopamine-induced cell death: the role of oxidative stress, p38 mitogen-activated protein kinase, cytochrome c and caspases J Neurochem 78 2 374 383
13. MJ Le Nedelec RJ Rosengren 2002 Methylphenidate inhibits cytochrome P450 in the Swiss Webster mouse Hum Exp Toxicol 21 273 280
14. P Moldeus M Nordenskjold G Bolcsfoldi A Eiche U Haglund B Lambert 1983 Genetic toxicity of dopamine Mutat Res 124 1 9 24
15. NTP (1995) Toxicology and carcinogenesis studies of methylphenidate hydrochloride (CAS no. 298-59-9) in F344/N rats and B6C3F1 mice (feed studies). Technical report 439. National Toxicology Program, Research Triangle Park, NC
16. RJ Preston SH Kollins JM Swanson LL Greenhill T Wigal GR Elliott B Vitiello 2005 Comments on 'Cytogenetic effects in children treated with methylphenidate' by El-Zein et al Cancer Lett 230 292 294
17. JV Selby GD Friedman BH Fireman 1989 Screening prescription drugs for possible carcinogenicity: eleven to fifteen years of follow-up Cancer Res 49 5736 5747
18. W Suter HJ Martus A Elhajouji 2006 Methylphenidate is not clastogenic in cultured human lymphocytes and in the mouse bone-marrow micronucleus test Mutat Res 607 153 159
19. E Taylor M Dopfner J Sergeant P Asherson T Banaschewski J Buitelaar D Coghill M Danckaerts A Rothenberger E Sonuga-Barke HC Steinhausen A Zuddas 2004 European clinical guidelines for hyperkinetic disorder - first upgrade Eur Child Adol Psychiatry 13 Suppl 1 17 30
20. SK Teo RH San VO Wagner R Gudi DI Stirling SD Thomas VD Khetani 2003 D-Methylphenidate is non-genotoxic in in vitro and in vivo assays Mutat Res 537 67 79
21. S Walitza B Werner M Romanos A Warnke M Gerlach H Stopper 2007 Does methylphenidate cause a cytogenetic effect in children with attention deficit hyperactivity disorder? Environ Health Perspect 115 6 936 940