Methylphenidate inhibits cytochrome P450 in the Swiss Webster mouse

Human and Experimental Toxicology

Volumn 21, Issue 5, 2002, Pages 273-280

  Le Nedelec, M J ^a   Rosengren, Rhonda J ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

CYP1A; CYP2E1; CYP3A; CYP450; Imipramine; Methylphenidate

Indexed keywords

ALANINE AMINOTRANSFERASE; CYTOCHROME P450; CYTOCHROME P450 1A; CYTOCHROME P450 2E1; CYTOCHROME P450 3A; CYTOCHROME P450 ISOENZYME; DESIPRAMINE; IMIPRAMINE; LIVER ENZYME; METHYLPHENIDATE; POLYPEPTIDE; SODIUM CHLORIDE; CENTRAL STIMULANT AGENT; ENZYME INHIBITOR; ISOENZYME;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ABUSE; DRUG EFFECT; DRUG MEGADOSE; DRUG STRUCTURE; ENZYME ASSAY; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME METABOLISM; LIVER INJURY; MOUSE; MOUSE STRAIN; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; SIMULATION; WESTERN BLOTTING; ANIMAL; BLOOD; DRUG ANTAGONISM; ENZYMOLOGY; INTRAPERITONEAL DRUG ADMINISTRATION; LIVER; LIVER MICROSOME; MALE; METABOLISM;

ALANINE TRANSAMINASE; ANIMAL; CENTRAL NERVOUS SYSTEM STIMULANTS; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; INJECTIONS, INTRAPERITONEAL; ISOENZYMES; LIVER; MALE; METHYLPHENIDATE; MICE; MICROSOMES, LIVER; SUPPORT, NON-U.S. GOV'T; ANIMALS;

ANIMALIA; STAPHYLOCOCCUS PHAGE 3A;

EID: 0035990360     PISSN: 09603271     EISSN: None     Source Type: Journal    
DOI: 10.1191/0960327102ht245oa     Document Type: Article

References (53)

1. The more frequent diagnosis of attention deficit-hyperactivity disorder
2. Combined pharmacotherapy: An emerging trend in pediatric psychopharmacology
3. Intravenous methylphenidate abuse. Prototype for prescription drug abuse
4. A potential clinical use for methylphenidate with tricyclic antidepressants
5. Clinical and metabolic studies with imipramine in man
6. Concomitant imipramine and methylphenidate administration: A case report
7. Sertraline with methylphenidate in an ICU patient
8. Medication-induced seizures
9. Methylphenidate interaction with both anticonvulsants and ethyl bis-coumacetate
10. Possible phenytoin-methylphenidate interaction
11. Pharmacotherapy of attention-deficit hyperactivity across the life cycle
12. Suspected adverse methylphenidate-imipramine interactions in children
13. Combined methylphenidate and imipramine complication
14. Side effects of methylphenidate and desipramine alone and in combination in children
15. Inhibition of imipramine metabolism by methylphenidate
16. Newer antidepressants and the cytochrome P450 system
17. Major pathway of imipramine metabolism is catalyzed by cytochromes P450 1A2 and P450 3A4 in human liver
18. Evidence for involvement of polymorphic CYP2C19 and 2C9 in the N-demethylation of sertraline in human liver microsomes
19. Biotransformation of xenobiotics
20. Neuronal cytochrome P450IIDI (Debrisoquine/sparteine-type): Potent inhibition of activity by (-)-cocaine and nucleotide sequence identity to human hepatic P450 gene CYP2D6
21. Methylphenidate-induced hepatotoxicity in mice and its potentiation by beta-adrenergic agonist drugs
22. Induction and genetic regulation of mouse hepatic cytochrome P450 by cannabidiol
23. Metabolism of chloroform by cytochrome P4502E1 is required for induction of toxicity in the liver, kidney and nose of male mice
24. The effect of retinol on hepatic and renal drug-metabolising enzymes
25. St. John's wort extract induces CYP3A and CYP2E1 in the Swiss Webster mouse
26. The CYP3 family
27. Enzyme assay and purification
28. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
29. The carbon monoxide-binding pigment of liver microsomes
30. Purification and characterization of hepatic microsomal cytochrome P-450
31. The utility of p-nitrophenol hydroxylation in P450IIE1 analysis
32. Retinol potentiates acetaminophen-induced hepatotoxicity in the mouse: Mechanistic studies
33. Demonstration in multiple species of inducible hepatic cytochromes P-450 and their mRNAs related to glucocorticoid-inducible cytochrome P-450 of the rat
34. Cleavage of structural proteins during the assembly of the head of macrophage T4
35. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
36. Drug interactions with psychostimulants
37. Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians
38. Degradation of cytochrome P4502E1: Selective loss after labilization of the enzyme
39. Role of cytochrome P4502E1 in retinol's attenuation of carbon tetrachloride hepatotoxicity in the mouse
40. Bioactivation of halogenated hydrocarbons by cytochrome P4502E1
41. The CYP2E Family
42. Pharmacology of the enantiomers of threo-methylphenidate
43. Methylphenidate and cocaine have a similar in vivo potency to block dopamine transporters in the human brain
44. Comparable changes in synaptic dopamine induced by methylphenidate and by cocaine in the baboon brain
45. Dopamine-transporter occupancy after intravenous doses of cocaine and methylphenidate in mice and humans
46. Conformational analysis of methylphenidate and its structural relationship to other dopamine reuptake blockers such as CFT
47. Modification of hepatic cytochrome P450 profile by cocaine-induced hepatotoxicity in DBA/2 mouse
48. Subacute cocaine treatment changes expression of mouse liver cytochrome P450 isoforms
49. Methylphenidate hydrochloride given with or before breakfast: II. Effects on plasma concentration of methylphenidate and ritalinic acid
50. Pharmacokinetics of methylphenidate in man, rat and monkey
51. Gas chromatographic/mass spectrometric analysis of methylphenidate (Ritalin) in serum
52. Psychopharmacology of attention deficit disorder: Pharmacokinetic, neuroendocrine, and behavioural measures following acute and chronic treatment with methylphenidate
53. Distribution of methylphenidate and P-hydroxymethylphenidate in rats