메뉴 건너뛰기




Volumn 3, Issue 1, 2008, Pages 2-9

Clinical trials with intracerebral convection-enhanced delivery of targeted toxins in malignant glioma

Author keywords

Convection enhanced delivery; Glioblastoma; Glioma; Targeted toxin

Indexed keywords

ANTICONVULSIVE AGENT; CINTREDEKIN BESUDOTOX; IMMUNOTOXIN; INTERLEUKIN 4 PSEUDOMONAS AERUGINOSA EXOTOXIN FUSION PROTEIN; LOMUSTINE; NBI 3001; NITROSOUREA DERIVATIVE; PLATINUM DERIVATIVE; PROCARBAZINE; RECOMBINANT PROTEIN; STEROID; TEMOZOLOMIDE; TP 38; TRANSFERRIN CRM 107; TRANSFORMING GROWTH FACTOR ALPHA PSEUDOMONAS AERUGINOSA EXOTOXIN FUSION PROTEIN; TRANSMID; UNCLASSIFIED DRUG; VINCRISTINE;

EID: 39449114014     PISSN: 15748871     EISSN: None     Source Type: Journal    
DOI: 10.2174/157488708783330521     Document Type: Review
Times cited : (24)

References (50)
  • 2
    • 0035843243 scopus 로고    scopus 로고
    • Brain tumors
    • DeAngelis LM. Brain tumors. N Engl J Med 2001; 344:114-23.
    • (2001) N Engl J Med , vol.344 , pp. 114-123
    • DeAngelis, L.M.1
  • 3
    • 20644454157 scopus 로고    scopus 로고
    • Surgery for malignant gliomas: Mechanistic reasoning and slippery statistics
    • Mitchell P, Ellison DW, Mendelow AD. Surgery for malignant gliomas: mechanistic reasoning and slippery statistics. Lancet Neurol 2005; 4: 413-22.
    • (2005) Lancet Neurol , vol.4 , pp. 413-422
    • Mitchell, P.1    Ellison, D.W.2    Mendelow, A.D.3
  • 4
    • 0033157174 scopus 로고    scopus 로고
    • Centralized databases available for describing primary brain tumor incidence, survival, and treatment: Central Brain Tumor Registry of the United States; Surveillance, Epidemiology, and End Results; and National Cancer Data Base
    • Davis FG, McCarthy BJ, Berger MS. Centralized databases available for describing primary brain tumor incidence, survival, and treatment: Central Brain Tumor Registry of the United States; Surveillance, Epidemiology, and End Results; and National Cancer Data Base. Neurooncology 1999; 1: 205-11.
    • (1999) Neurooncology , vol.1 , pp. 205-211
    • Davis, F.G.1    McCarthy, B.J.2    Berger, M.S.3
  • 6
    • 0028273196 scopus 로고
    • Malignant glioma: Patems of failure following individually tailored limited volume irradiation
    • Hess CF, Schaaf JC, Kortmann RD, et al. Malignant glioma: patems of failure following individually tailored limited volume irradiation. Radiotber Oncol 1994; 30: 146-9.
    • (1994) Radiotber Oncol , vol.30 , pp. 146-149
    • Hess, C.F.1    Schaaf, J.C.2    Kortmann, R.D.3
  • 7
    • 0242351013 scopus 로고    scopus 로고
    • Role of resection for newly diagnosed malignant gliomas
    • Schiff D, Shaffrey ME. Role of resection for newly diagnosed malignant gliomas. Expert Rev Anticancer Ther 2003; 3: 621-30.
    • (2003) Expert Rev Anticancer Ther , vol.3 , pp. 621-630
    • Schiff, D.1    Shaffrey, M.E.2
  • 8
    • 0036913055 scopus 로고    scopus 로고
    • Surgery for gliomas
    • Whittle IR. Surgery for gliomas. Curr Opin Neurol 2002; 5: 663-9.
    • (2002) Curr Opin Neurol , vol.5 , pp. 663-669
    • Whittle, I.R.1
  • 9
    • 20044366163 scopus 로고    scopus 로고
    • Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
    • Stupp R, Mason WP, van den Bent MJ, et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 2005; 352: 987-96.
    • (2005) N Engl J Med , vol.352 , pp. 987-996
    • Stupp, R.1    Mason, W.P.2    van den Bent, M.J.3
  • 11
    • 0024982338 scopus 로고
    • Malignant glioma management
    • Saleman M. Malignant glioma management. Neurosurg Clin N Am 1990; 1: 49-63.
    • (1990) Neurosurg Clin N Am , vol.1 , pp. 49-63
    • Saleman, M.1
  • 12
    • 0031059683 scopus 로고    scopus 로고
    • Cell proliferation and invasion in malignant gliomas
    • Schiffer D, Cavalla P, Dutto A, et al. Cell proliferation and invasion in malignant gliomas. Anticancer Res 1997; 17: 61-9.
    • (1997) Anticancer Res , vol.17 , pp. 61-69
    • Schiffer, D.1    Cavalla, P.2    Dutto, A.3
  • 13
    • 0037033735 scopus 로고    scopus 로고
    • Virtual brain tumours (gliomas) enhance the reality of medical imaging and highlight inadequacies of current therapy
    • Swanson KR, Alvord EC Jr, Murray JD. Virtual brain tumours (gliomas) enhance the reality of medical imaging and highlight inadequacies of current therapy. Br J Cancer 2002; 86: 14-18.
    • (2002) Br J Cancer , vol.86 , pp. 14-18
    • Swanson, K.R.1    Alvord Jr, E.C.2    Murray, J.D.3
  • 14
    • 10044264531 scopus 로고    scopus 로고
    • Advances in the biology of astrocytomas
    • Guha A, Mukherjee J. Advances in the biology of astrocytomas. Curr Opin Neurol 2004; 17: 655-62.
    • (2004) Curr Opin Neurol , vol.17 , pp. 655-662
    • Guha, A.1    Mukherjee, J.2
  • 15
    • 0032489877 scopus 로고    scopus 로고
    • Immunotoxins for targeted cancer therapy
    • Pastan I, Kreitman RJ. Immunotoxins for targeted cancer therapy. Adv Drug Deliv Rev 1998; 31: 53-88.
    • (1998) Adv Drug Deliv Rev , vol.31 , pp. 53-88
    • Pastan, I.1    Kreitman, R.J.2
  • 16
    • 0026598909 scopus 로고
    • Immunotoxins and central nervous system neoplasia
    • Hall WA, Fodstad O. Immunotoxins and central nervous system neoplasia. J Neurosurg 1992; 76: 1-12.
    • (1992) J Neurosurg , vol.76 , pp. 1-12
    • Hall, W.A.1    Fodstad, O.2
  • 17
    • 0030954720 scopus 로고    scopus 로고
    • Chronic interstitial infusion of protein to primate brain: Determination of drug distribution and clearance with single-photon emission computerized tomography imaging
    • Laske DW, Morrison PF, Lieberman DM, et al. Chronic interstitial infusion of protein to primate brain: determination of drug distribution and clearance with single-photon emission computerized tomography imaging. J Neurosurg 1997; 87: 586-94.
    • (1997) J Neurosurg , vol.87 , pp. 586-594
    • Laske, D.W.1    Morrison, P.F.2    Lieberman, D.M.3
  • 18
    • 0031451777 scopus 로고    scopus 로고
    • Tumor regression with regional distribution of the targeted toxin TF-CRM107 in patients with malignant brain tumors
    • Laske DW, Youle RJ, Oldfield EH. Tumor regression with regional distribution of the targeted toxin TF-CRM107 in patients with malignant brain tumors. Nat Med 1997; 3: 1362-8.
    • (1997) Nat Med , vol.3 , pp. 1362-1368
    • Laske, D.W.1    Youle, R.J.2    Oldfield, E.H.3
  • 19
    • 0032949676 scopus 로고    scopus 로고
    • Variable affecting convection-enbanced delivery to the striatum: A systematic examination of rate of infusion, cannala size, infusate concentration, and tissue-cannula sealing titre
    • Chen MY, Lonser RR, Morrison PF, et al. Variable affecting convection-enbanced delivery to the striatum: a systematic examination of rate of infusion, cannala size, infusate concentration, and tissue-cannula sealing titre. J Neurosurg 1999; 90: 315-20.
    • (1999) J Neurosurg , vol.90 , pp. 315-320
    • Chen, M.Y.1    Lonser, R.R.2    Morrison, P.F.3
  • 20
    • 0028067301 scopus 로고
    • Human neurological cancer cells express interleukin-4 (IL-4) receptors which are targets for the toxic effects of IL4-Pseudomonas exotoxin chimeric protein
    • Puri RK, Leland P, Kreitman RJ, et al. Human neurological cancer cells express interleukin-4 (IL-4) receptors which are targets for the toxic effects of IL4-Pseudomonas exotoxin chimeric protein. Int J Cancer 1994; 58: 574-81.
    • (1994) Int J Cancer , vol.58 , pp. 574-581
    • Puri, R.K.1    Leland, P.2    Kreitman, R.J.3
  • 22
    • 0029751129 scopus 로고    scopus 로고
    • Preclinical development of a recombinant toxin containing circularly permitted interleukin 4 and truncated Pseudomonas exotoxin for therapy of malignant astrocytoma
    • Puri RK, Hoon DS, Leland P, et al. Preclinical development of a recombinant toxin containing circularly permitted interleukin 4 and truncated Pseudomonas exotoxin for therapy of malignant astrocytoma. Cancer Res 1996; 56: 5631-7.
    • (1996) Cancer Res , vol.56 , pp. 5631-5637
    • Puri, R.K.1    Hoon, D.S.2    Leland, P.3
  • 23
    • 0027259503 scopus 로고
    • Interleukin-4 and cancer therapy
    • Puri RK, Siegel JP. Interleukin-4 and cancer therapy. Cancer Invest 1993; 11: 473-86.
    • (1993) Cancer Invest , vol.11 , pp. 473-486
    • Puri, R.K.1    Siegel, J.P.2
  • 24
    • 0041562430 scopus 로고    scopus 로고
    • Safety, tolerability, and tumor response of IL4-Pseudomonas exotoxin (NBI-3001) in patients with recurrent malignant glioma
    • Weber F, Asher A, Bucholz R, et al. Safety, tolerability, and tumor response of IL4-Pseudomonas exotoxin (NBI-3001) in patients with recurrent malignant glioma. J Neurooncology 2003 64: 125-37.
    • (2003) J Neurooncology , vol.64 , pp. 125-137
    • Weber, F.1    Asher, A.2    Bucholz, R.3
  • 25
    • 39449125681 scopus 로고    scopus 로고
    • http://clinicaltrials.gov, study identifier NCT00014677
    • http://clinicaltrials.gov, study identifier NCT00014677
  • 26
    • 0023429079 scopus 로고
    • Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification
    • Wong AJ, Bigner SH, Bigner DD, et al. Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification. Proc Natl Acad Sci USA 1987; 84: 6899-903.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 6899-6903
    • Wong, A.J.1    Bigner, S.H.2    Bigner, D.D.3
  • 27
    • 0023948602 scopus 로고
    • Amplification and expression of the epidermal growth factor receptor gene in human glioma xenographs
    • Humphrey PA, Wong AJ, Vogelstein B, et al. Amplification and expression of the epidermal growth factor receptor gene in human glioma xenographs. Cancer Res 1988; 48: 2231-8.
    • (1988) Cancer Res , vol.48 , pp. 2231-2238
    • Humphrey, P.A.1    Wong, A.J.2    Vogelstein, B.3
  • 28
    • 0021932240 scopus 로고
    • Amplification, enhanced expression, and possible rearrangement of EGF receptor gene in primary human brain tumors of glial origin
    • Liberman TA, Nusbaum HF, Razon N, et al. Amplification, enhanced expression, and possible rearrangement of EGF receptor gene in primary human brain tumors of glial origin. Nature 1985; 313: 144-7.
    • (1985) Nature , vol.313 , pp. 144-147
    • Liberman, T.A.1    Nusbaum, H.F.2    Razon, N.3
  • 29
    • 10744219583 scopus 로고    scopus 로고
    • Progress report of a phase I study of the intracerebral microinfusion of a recombinant chimeric protein composed of transforming growth factor (TGF)-alpha and a mutated form of the Pseudomonas exotoxin termed PE-38 (TP-38) for the treatment of malignant brain tumors
    • Sampson JH, Akabani G, Archer GE, et al. Progress report of a phase I study of the intracerebral microinfusion of a recombinant chimeric protein composed of transforming growth factor (TGF)-alpha and a mutated form of the Pseudomonas exotoxin termed PE-38 (TP-38) for the treatment of malignant brain tumors. J Neurooncology 2003; 65: 27-35.
    • (2003) J Neurooncology , vol.65 , pp. 27-35
    • Sampson, J.H.1    Akabani, G.2    Archer, G.E.3
  • 30
    • 39449137885 scopus 로고    scopus 로고
    • Preliminary results of a phase II study of TP-38 immunotoxin delivered via convection-enhanced delivery to patients with recurrent glioblastoma multiforme: Report of the TP-38 study group
    • Weber F. Preliminary results of a phase II study of TP-38 immunotoxin delivered via convection-enhanced delivery to patients with recurrent glioblastoma multiforme: report of the TP-38 study group. Annual Meeting of the German Society of Neurosurgery, http://www.egms.de/ en/meetings/dgnc2005/05dgnc0094.htm
    • Annual Meeting of the German Society of Neurosurgery
    • Weber, F.1
  • 31
    • 0344876629 scopus 로고    scopus 로고
    • Interleuikin-13 receptor-directed cytotoxin for malignant glioma therapy: From bench to bedside
    • l
    • l Husain SR, Puri RK. Interleuikin-13 receptor-directed cytotoxin for malignant glioma therapy: from bench to bedside. J Neurooncology 2003; 65: 37-48.
    • (2003) J Neurooncology , vol.65 , pp. 37-48
    • Husain, S.R.1    Puri, R.K.2
  • 32
    • 0345183090 scopus 로고    scopus 로고
    • Phase I/II study: Intratumoral infusion of IL13-PE38QQR cytotoxin for recurrent supratentorial malignant glioma
    • Weingart J, Strauss LC, Grossman SA, et al. Phase I/II study: intratumoral infusion of IL13-PE38QQR cytotoxin for recurrent supratentorial malignant glioma. Neurooncology 2002; 4: 379.
    • (2002) Neurooncology , vol.4 , pp. 379
    • Weingart, J.1    Strauss, L.C.2    Grossman, S.A.3
  • 33
    • 77952461038 scopus 로고    scopus 로고
    • Convection enhanced delivery of IL13-PE38QQR for treatment of recurrent malignant glioma: Presentation of interim findings from ongoing phase I studies
    • Kunwar S: Convection enhanced delivery of IL13-PE38QQR for treatment of recurrent malignant glioma: presentation of interim findings from ongoing phase I studies. Acta Neurochir Suppl 2003; 88: 105-11.
    • (2003) Acta Neurochir Suppl , vol.88 , pp. 105-111
    • Kunwar, S.1
  • 34
    • 3142515610 scopus 로고    scopus 로고
    • Peritumoral convection-enhanced delivery of EL13-PE38QQR in patients with recurrent malignant glioma - phase I interim results
    • Kunwar S, Prados M, Chang S, et al. Peritumoral convection-enhanced delivery of EL13-PE38QQR in patients with recurrent malignant glioma - phase I interim results. Neurooncology 2003; 5:4.
    • (2003) Neurooncology , vol.5 , pp. 4
    • Kunwar, S.1    Prados, M.2    Chang, S.3
  • 35
    • 39449112794 scopus 로고    scopus 로고
    • Neuroradiographic changes following convection-enhanced delivery (CED) of the conjugated toxin IL13-PE38QQR following resection of recurrent malignant glioma
    • Chang SM. Neuroradiographic changes following convection-enhanced delivery (CED) of the conjugated toxin IL13-PE38QQR following resection of recurrent malignant glioma. Neurooncology 2003; 5:4.
    • (2003) Neurooncology , vol.5 , pp. 4
    • Chang, S.M.1
  • 36
    • 0344876629 scopus 로고    scopus 로고
    • Interleukin-13 receptor-directed cytotoxin for malignant glioma therapy: From bench to bedside
    • Husain SR, Puri RK. Interleukin-13 receptor-directed cytotoxin for malignant glioma therapy: from bench to bedside. J Neurooncol 2003; 65: 37-48.
    • (2003) J Neurooncol , vol.65 , pp. 37-48
    • Husain, S.R.1    Puri, R.K.2
  • 37
    • 4243810673 scopus 로고    scopus 로고
    • Intratumoral and intracerebral microinfusion of IL13-PE38QQR cytotoxin: Phase I/II study of pre-and post-resection infusions in recurrent resectable maliganant glioma
    • Prados MD, Lang FF, Stauss LC, et al. Intratumoral and intracerebral microinfusion of IL13-PE38QQR cytotoxin: phase I/II study of pre-and post-resection infusions in recurrent resectable maliganant glioma. Proc Am Soc Clin Oncol 2002; 21: 2087.
    • (2002) Proc Am Soc Clin Oncol , vol.21 , pp. 2087
    • Prados, M.D.1    Lang, F.F.2    Stauss, L.C.3
  • 38
    • 20244368854 scopus 로고    scopus 로고
    • Pre-operative infusion of IL13-PE38QQR cytotoxin by convection-enhanced delivery (CED) in recurrent malignant glioma: A phase I(II study
    • Ram Z, Barnett G, Vogelbaum M, et al. Pre-operative infusion of IL13-PE38QQR cytotoxin by convection-enhanced delivery (CED) in recurrent malignant glioma: A phase I(II study. Proc Am Soc Clin Oncol 2003; 22: 403.
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 403
    • Ram, Z.1    Barnett, G.2    Vogelbaum, M.3
  • 39
    • 39449136868 scopus 로고    scopus 로고
    • http://clinicaltrials.gov, study identifier NCT00076986, www.precisetrial.com
    • http://clinicaltrials.gov, study identifier NCT00076986, www.precisetrial.com
  • 40
    • 39449088562 scopus 로고    scopus 로고
    • http://www.allbusiness.com/services/business-services/39804261.htm#
    • http://www.allbusiness.com/services/business-services/39804261.htm#
  • 41
    • 0344876636 scopus 로고    scopus 로고
    • Transferrin receptor ligand-targeted toxin conjugate (Tf-CRM107) for therapy of malignant gliomas
    • Weaver M, Laske DW. Transferrin receptor ligand-targeted toxin conjugate (Tf-CRM107) for therapy of malignant gliomas. J Neurooncol 2003; 65: 3-13.
    • (2003) J Neurooncol , vol.65 , pp. 3-13
    • Weaver, M.1    Laske, D.W.2
  • 42
    • 0025298818 scopus 로고
    • Transferrin recepto in normal and neoplastic brain tissue: Implications for brain tumor im-munotherapy
    • Recht L, Torres CO, Smith TW, et al. Transferrin recepto in normal and neoplastic brain tissue: implications for brain tumor im-munotherapy. J Neurosurg 1990; 72: 941-5.
    • (1990) J Neurosurg , vol.72 , pp. 941-945
    • Recht, L.1    Torres, C.O.2    Smith, T.W.3
  • 43
    • 0021130764 scopus 로고
    • Transferrin receptor on endothelium of brain capillaries
    • Jefferies WA, Brandon MR, Hunt SV, et al. Transferrin receptor on endothelium of brain capillaries. Nature 1984; 312: 162-3.
    • (1984) Nature , vol.312 , pp. 162-163
    • Jefferies, W.A.1    Brandon, M.R.2    Hunt, S.V.3
  • 44
    • 0024552545 scopus 로고
    • Improved tumor-specific immunotoxins in the treatment of CNS and leptomeningeal neoplasia
    • Johnson VG, Wrobel C, Wilson D, et al. Improved tumor-specific immunotoxins in the treatment of CNS and leptomeningeal neoplasia. J Neurosurg 1989; 70: 240-8.
    • (1989) J Neurosurg , vol.70 , pp. 240-248
    • Johnson, V.G.1    Wrobel, C.2    Wilson, D.3
  • 45
    • 39449128633 scopus 로고    scopus 로고
    • http://clinicaltrials.gov, study identifier NCT00083447, see also NCT00088 400 and NCT00087230
    • http://clinicaltrials.gov, study identifier NCT00083447, see also NCT00088 400 and NCT00087230
  • 46
    • 19444369992 scopus 로고    scopus 로고
    • Neurosurgical delivrry of chemotherapeutics, targeted toxins, genetic and viral therapies in neurooncology
    • Chiocca EA, Broaddus WC, Gillies GT, et al. Neurosurgical delivrry of chemotherapeutics, targeted toxins, genetic and viral therapies in neurooncology. Neurooncol 2004; 69: 101-17.
    • (2004) Neurooncol , vol.69 , pp. 101-117
    • Chiocca, E.A.1    Broaddus, W.C.2    Gillies, G.T.3
  • 47
    • 33747194449 scopus 로고    scopus 로고
    • Convection-enhanced delivery: Targeted toxin treatment of malignant glioma
    • Vandergrift WA; Patel SJ. Convection-enhanced delivery: targeted toxin treatment of malignant glioma. Neurosurg focus 2006; 20: E10.
    • (2006) Neurosurg focus , vol.20
    • Vandergrift, W.A.1    Patel, S.J.2
  • 48
    • 0037648606 scopus 로고    scopus 로고
    • MR imaging of epilepsy: State of the art at 1.5 T and potential of 3 T
    • Briellmann RS, Pell GS, Wellard RM, et al. MR imaging of epilepsy: state of the art at 1.5 T and potential of 3 T. Epileptic Disord 2003; 5: 3-20.
    • (2003) Epileptic Disord , vol.5 , pp. 3-20
    • Briellmann, R.S.1    Pell, G.S.2    Wellard, R.M.3
  • 49
    • 0038693428 scopus 로고    scopus 로고
    • Application of diffusion tensor imaging to magnetic-resonance-guided brain tumor resection
    • Tummala RP, Chu RM, Liu H, et al. Application of diffusion tensor imaging to magnetic-resonance-guided brain tumor resection. Ped Neurosurg 2003; 39: 39-43.
    • (2003) Ped Neurosurg , vol.39 , pp. 39-43
    • Tummala, R.P.1    Chu, R.M.2    Liu, H.3
  • 50
    • 9244240791 scopus 로고    scopus 로고
    • Diffusion tensor magnetic resonance imaging of brain tumors
    • Cruz LC Jr., Sorensen AG. Diffusion tensor magnetic resonance imaging of brain tumors. Neurosurg Clin N Am 2005; 16: 115-34.
    • (2005) Neurosurg Clin N Am , vol.16 , pp. 115-134
    • Cruz Jr., L.C.1    Sorensen, A.G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.