Tissue-specific stable isotope measurements of postprandial lipid metabolism in familial combined hyperlipidaemia

Atherosclerosis

Volumn 197, Issue 1, 2008, Pages 164-170

  Evans, Kevin ^a,c   Burdge, Graham C ^b   Wootton, Stephen A ^b   Collins, Jenny M ^c   Clark, Mo L ^c   Tan, Garry D ^c   Karpe, Fredrik ^c   Frayn, Keith N ^c  

^a STAFFORDSHIRE GENERAL HOSPITAL   (United Kingdom)

^b UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Fatty acids; Hyperlipoproteinemia; Metabolism; Postprandial

Indexed keywords

3 HYDROXYBUTYRIC ACID; CHYLOMICRON; FATTY ACID; GLUCOSE; INSULIN; ISOTOPE; TRIACYLGLYCEROL;

ADIPOSE TISSUE; ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; ESTERIFICATION; FAMILIAL DISEASE; FAMILIAL HYPERLIPEMIA; FATTY ACID OXIDATION; FOREARM BLOOD FLOW; HUMAN; INSULIN BLOOD LEVEL; LIPID METABOLISM; MALE; POSTPRANDIAL STATE; PRIORITY JOURNAL; TRIACYLGLYCEROL BLOOD LEVEL;

3-HYDROXYBUTYRIC ACID; ADIPOSE TISSUE; ADULT; APOLIPOPROTEINS B; BLOOD GLUCOSE; CARBON ISOTOPES; CHOLESTEROL, VLDL; CHYLOMICRONS; ESTERIFICATION; FATTY ACIDS, NONESTERIFIED; FEMALE; HUMANS; HYPERLIPIDEMIA, FAMILIAL COMBINED; INSULIN; LIPID METABOLISM; LIVER; MALE; MIDDLE AGED; POSTPRANDIAL PERIOD; REGIONAL BLOOD FLOW;

EID: 39449094315     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2007.03.009     Document Type: Article

References (30)

1. Sniderman A., Brown B.G., Stewart B.F., and Cianflone K. From familial combined hyperlipidaemia to hyperapoB: unravelling the overproduction of hepatic apolipoprotein B. Curr Opin Lipidol 3 (1992) 137-142
2. Teng B., Sniderman A.D., Soutar A.K., and Thompson G.R. Metabolic basis of hyperapobetalipoproteinemia. Turnover of apolipoprotein B in low density lipoprotein and its precursors and subfractions compared with normal and familial hypercholesterolemia. J Clin Invest 77 (1986) 663-672
3. Sniderman A.D., and Cianflone K. Metabolic disruptions in the adipocyte-hepatocyte fatty acid axis as the causes of HyperapoB. Int J Obes 19 suppl. 1 (1995) S27-S33
4. Gibbons G.F. Assembly and secretion of hepatic very-low-density lipoprotein. Biochem J 268 (1990) 1-13
5. Coppack S.W., Evans R.D., Fisher R.M., et al. Adipose tissue metabolism in obesity: lipase action in vivo before and after a mixed meal. Metabolism 41 (1992) 264-272
6. Babirak S.P., Brown B.G., and Brunzell J.D. Familial combined hyperlipidemia and abnormal lipoprotein lipase. Arterioscler Thromb 12 (1992) 1176-1183
7. Arner P. Is familial combined hyperlipidaemia a genetic disorder of adipose tissue?. Curr Opin Lipidol 8 (1997) 89-94
8. Kekki M. Lipoprotein-lipase action determining high density lipoprotein cholesterol level in adult normolipaemics. Atherosclerosis 37 (1980) 143-150
9. Excoffon K.J.D.A., Liu G., Miao L., et al. Correction of hypertriglyceridemia and impaired fat tolerance in lipoprotein lipase-deficient mice by adenovirus-mediated expression of human lipoprotein lipase. Arterioscler Thromb Vasc Biol 17 (1997) 2532-2539
10. Babirak S.P., Iverius P.-H., Fujimoto W.Y., and Brunzell J.D. Detection and characterisation of the heterozygote state for lipoprotein lipase deficiency. Arteriosclerosis 9 (1989) 326-334
11. Pajukanta P., Lilja H.E., Sinsheimer J.S., et al. Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1). Nat Genet 36 (2004) 371-376
12. Evans K., Burdge G., Wootton S.A., Clark M.L., and Frayn K.N. Regulation of dietary fatty acid entrapment in subcutaneous adipose tissue and skeletal muscle. Diabetes 51 (2002) 2684-2690
13. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 2001;385:2486-97.
14. Frayn K.N., Coppack S.W., and Humphreys S.M. Subcutaneous adipose tissue metabolism studied by local catheterization. Int J Obes 17 suppl. 3 (1993) S18-S21
15. Larsen O.A., Lassen N.A., and Quaade F. Blood flow through human adipose tissue determined with radioactive xenon. Acta Physiol Scand 66 (1966) 337-345
16. Greenfield A.D.M., Whitney R.J., and Mowbray J.F. Methods for the investigation of peripheral blood flow. Br Med Bull 19 (1963) 101-109
17. Karpe F., Steiner G., Olivecrona T., Carlson L.A., and Hamsten A. Metabolism of triglyceride-rich lipoproteins during alimentary lipemia. J Clin Invest 91 (1993) 748-758
18. Folch J., Lees M., and Sloane Stanley G.H. A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226 (1957) 497-509
19. Burdge G.C., Wright P., Jones A.E., and Wootton S.A. A method for separation of phosphatidylcholine, triacylglycerol, non-esterified fatty acids and cholesterol esters from plasma by solid-phase extraction. Br J Nutr 84 (2000) 781-787
20. Matthews D.R., Hosker J.P., Rudenski A.S., et al. Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28 (1985) 412-419
21. Caumo A., Bergman R.N., and Cobelli C. Insulin sensitivity from meal tolerance tests in normal subjects: a minimal model index. J Clin Endocrinol Metab 85 (2000) 4396-4402
22. Cohen J.C., Noakes T.D., and Spinnler Benade A.J. Serum triglyceride responses to fatty meals: effects of meal fat content. Am J Clin Nutr 47 (1988) 825-827
23. Brunzell J.D., Hazzard W.R., Porte Jr. D., and Bierman E.L. Evidence for a common, saturable, triglyceride removal mechanism for chylomicrons and very low density lippoproteins in man. J Clin Invest 52 (1973) 1578-1585
24. Halkes C.J.M., van Dijk H., Verseyden C., et al. Gender differences in postprandial ketone bodies in normolipidemic subjects and in untreated patients with familial combined hyperlipidaemia. Arterioscler Thromb Vasc Biol 23 (2003) 1875-1880
25. Meijssen S., Castro-Cabezas M., Twickler T.B., Jansen H., and Erkelens D.W. In vivo evidence of defective postprandial and postabsorptive free fatty acid metabolism in familial combined hyperlipidemia. J Lipid Res 41 (2000) 1096-1102
26. Coppack S.W., Fisher R.M., Humphreys S.M., et al. Carbohydrate metabolism in insulin resistance: glucose uptake and lactate production by adipose and forearm tissues in vivo before and after a mixed meal. Clin Sci 90 (1996) 409-415
27. Pihlajamäki J., Karjalainen L., Karhapää P., Vauhkonen I., and Laakso M. Impaired free fatty acid suppression during hyperlinsulinemia is a characteristic finding in familial combined hyperlipidemia, but insulin resistance is observed only in hypertriglyceridemic patients. Arterioscler Thromb Vasc Biol 20 (2000) 164-170
28. Karhapää P., Voutilainen E., Malkki M., and Laakso M. Obese men with type IIB hyperlipidaemia are insulin resistant. Arterioscler Thromb Vasc Biol 13 (1993) 1469-1475
29. van der Kallen C.J.H., Voors-Pette C., Bouwman F.G., et al. Evidence of insulin resistant lipid metabolism in familial combined hyperlipidaemia, but not type 2 diabetes mellitus. Atherosclerosis 164 (2002) 337-346
30. Castro Cabezas M., de Bruin T.W.A., de Valk H.W., et al. Impaired fatty acid metabolism in familial combined hyperlipidemia. A mechanism associating hepatic apolipoprotein B overproduction and insulin resistance. J Clin Invest 92 (1993) 160-168