Carbohydrate metabolism in insulin resistance: Glucose uptake and lactate production by adipose and forearm tissues in vivo before and after a mixed meal

Clinical Science

Volumn 90, Issue 5, 1996, Pages 409-415

  Coppack, Simon W ^a   Fisher, Rachel M ^a   Humphreys, Sandy M ^a   Clark, Mo L ^a   Pointon, Jennifer J ^a   Frayn, Keith N ^a  

^a RADCLIFFE INFIRMARY   (United Kingdom)

Author keywords

Insulin; Insulin resistance; Lactate metabolism; Muscle; Postprandial metabolism

Indexed keywords

CARBOHYDRATE; INSULIN; LACTIC ACID;

ADIPOSE TISSUE; ADULT; ARTICLE; CARBOHYDRATE METABOLISM; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE TRANSPORT; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; LACTATE BLOOD LEVEL; MALE; MUSCLE; OBESITY; PRIORITY JOURNAL;

EID: 0029983591     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/cs0900409     Document Type: Article

References (38)

1. Kelley D, Mitrakou A, Marsh HM, et al. Skeletal muscle glycolysis, oxidation and storage of an oral glucose load. J Clin Invest 1988; 81: 1563-71.
2. Yki-Järvinen H. Action of insulin on glucose metabolism in vivo. Baillières Clin Endocrinol Metab 1993; 7: 903-28.
3. Coppack SW, Fisher RM, Gibbons GF, et al. Postprandial substrate deposition in human forearm and adipose tissues in vivo. Clin Sci 1990; 79: 339-48.
4. Del Prato S, Enzi G, Vigili de Kreutzenberg S, et al. Insulin regulation of glucose and lipid metabolism in massive obesity. Diabetologia 1990; 33: 228-36.
5. Coppack SW, Evans RD, Fisher RM, et al. Adipose tissue metabolism in obesity: lipase action in vivo before and after a mixed meal. Metabolism 1992; 41: 264-72.
6. DeFronio RA, Ferrannini E. Insulin resistance: a multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia and atherosclerotic cardiovascular disease. Diabetes Care 1991; 14: 173-94.
7. Björntorp P, Berchtold P, Holm J, Larsson B. The glucose uptake of human adipose tissue in obesity. Eur J Clin Invest 1971; 1: 480-5.
8. Mårin P, Rebuffé-Scrive M, Smith U, Björntorp P. Glucose uptake in human adipose tissue. Metabolism 1987; 36: 1154-60.
9. Green A, Newsholme EA. Sensitivity of glucose uptake and lipolysis of white adipocytes of the rat to insulin and effects of some metabolites. Biochem J 1979; 180: 365-70.
10. Zeuzem S, Taylor R. Assessment of initial hexose uptake in adipocytes using the physiological substrate D-glucose. Particular relevance to human adipocytes. Scand J Clin Lab Invest 1985; 45: 545-51.
11. Frayn KN, Coppack SW, Humphreys SM, Whyte PL. Metabolic characteristics of human adipose tissue in vivo. Clin Sci 1989; 76: 509-16.
12. Hagström-Toft E, Arner P, Naslund B, Ungerstedt U, Bolinder J. Effects of insulin deprivation and replacement on in vivo subcutaneous adipose tissue substrate metabolism in humans. Diabetes 1991; 40: 666-72.
13. Simonsen L, Bülow J, Madsen J. Adipose tissue metabolism in humans determined by vein catheterization and microdialysis techniques. Am J Physiol 1994; 266: E357-65.
14. Hagström E, Arner P, Ungerstedt U, Bolinder J. Subcutaneous adipose tissue: a source of lactate production after glucose ingestion in humans. Am J Physiol 1990; 258: E888-93.
15. Jansson P-AE, Larsson A, Smith U, Lönnroth P. Lactate release from the subcutaneous tissue in lean and obese men. J Clin Invest 1994; 93: 240-6.
16. Durnin JVGA, Womersley J. Body fat assessed from total body density and its estimation from skinfold thicknesses: measurements on 481 men and women aged 16-72 years. Br J Nutr 1974; 32: 77-97.
17. Elia M, Folmer P, Schlatmann A, Goren A, Austin S. Carbohydrate, fat, and protein metabolism in muscle and in the whole body after mixed meal ingestion. Metabolism 1988; 37: 542-51.
18. Møller N, Butler PC, Antsiferov MA, Alberti KGMM. Effects of growth hormone on insulin sensitivity and forearm metabolism in normal man. Diabetologia 1989; 32: 105-10.
19. Paul AA, Southgate DAT. The composition of foods. London: HMSO, 1978: 259.
20. Ministry of Agriculture Fisheries and Food. Household food consumption and expenditure. Annual report of the National Food Survey Committee. London: HMSO, 1987.
21. Mottram RF, Brown E. Influence of local cooling on the glucose and oxygen uptake of human forearm muscle. Clin Sci 1963; 25: 249-61.
22. 133Xe elimination. J Appl Physiol 1975; 39: 851-6.
23. Chen RYZ, Fan F-C, Kim S, Jan K-M, Usumi S, Chien S. Tissue-blood coefficient for xenon: temperature and hematocrit dependence. J Appl Physiol 1980; 49: 178-83.
24. Bülow J, Jelnes R, Astrup A, Madsen J, Vilmann P. Tissue/blood partition coefficients for xenon in various adipose tissue depots in man. Scand J Clin Lab Invest 1987; 47: 1-3.
25. Zierler KL. Theory of the use of arteriovenous concentration differences for measuring metabolism in steady and non-steady states. J Clin Invest 1961; 40: 2111-15.
26. Jackson RA, Blix PM, Matthews JA, Morgan LM, Rubenstein AH, Nabarro JDN. Comparison of peripheral glucose uptake after oral glucose loading and a mixed meal. Metabolism 1983; 32: 706-10.
27. Baltzan MA, Andres R, Cader G, Zierler KL. Heterogeneity of forearm metabolism with special reference to free fatty acids. J Clin Invest 1961; 41: 116-25.
28. Wahren J. Quantitative aspects of blood flow and oxygen uptake in the human forearm during rhythmic exercise. Acta Physiol Scand 1966; 67 (Suppl. 269): 5-93.
29. Hjöllund E, Beck-Nielsen H, Pedersen O, Richelsen B, Schwartz Sørensen N. Defective non-insulin-mediated and insulin mediated glucose transport and metabolism in adipocytes from obese and lean patients with untreated Type 2 diabetes mellitus. Diabetic Med 1985; 2: 468-73.
30. Baron AD. Hemodynamic actions of insulin. Am J Physiol 1994; 147: E187-202.
31. Mårin P, Högh-Kristiansen I, Jansson S, Krotkiewski M, Holm G, Björntorp P. Uptake of glucose carbon in muscle glycogen and adipose tissue triglycerides in vivo in humans. Am J Physiol 1992; 263: E473-80.
32. Newby FD, Sykes MN, DiGirolamo M. Regional differences in adipocyte lactate production from glucose. Am J Physiol 1988; 255: E716-22.
33. Frayn KN, Coppack SW, Humphreys SM. Subcutaneous adipose tissue metabolism studied by local catheterization. Int J Obesity 1993; 17 (Suppl. 3): S18-21.
34. Jackson RA, Hamling JB, Sim BM, Hawa MI, Blix PM, Nabarro JDN. Peripheral lactate and oxygen metabolism in man: the influence of oral glucose handling. Metabolism 1987; 36: 144-50.
35. Radziuk J. Tracer methods and the metabolic disposal of a carbohydrate load in man. Diabetes Metab Rev 1987; 3: 231-67.
36. Jansson P-AE, Smith U, Lönnroth P. Evidence for lactate production by human adipose tissue in vivo. Diabetologia 1990; 33: 253-6.
37. Buchalter SE, Crain MR, Kreisberg RA. Regulation of lactate metabolism in vivo. Diabetes Metab Rev 1989; 5: 379-92.
38. Lovejoy J, Newby FD, Gebhart SSP, DiGirolamo M. Insulin resistance in obesity is associated with elevated basal lactate levels and diminished lactate appearance following intravenous glucose and lactate. Metabolism 1992; 41: 22-7.