In vivo evidence of defective postprandial and postabsorptive free fatty acid metabolism in familial combined hyperlipidemia

Journal of Lipid Research

Volumn 41, Issue 7, 2000, Pages 1096-1102

  Meijssen, S ^a   Castro Cabezas, M ^a   Twickler, T B ^a   Jansen, H ^b   Erkelens, D W ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

Acylationstimulating protein; ApoB overproduction; Atherosclerosis; Hormone sensitive lipase; Ketone bodies; Postprandial lipemia; Triglycerides; VLDL

Indexed keywords

FAT; FATTY ACID; INSULIN; VERY LOW DENSITY LIPOPROTEIN;

ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FAMILIAL HYPERLIPEMIA; FAT INTAKE; FATTY ACID METABOLISM; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; KETOGENESIS; LIPOLYSIS; MALE; METABOLIC REGULATION; POSTPRANDIAL STATE; PRIORITY JOURNAL;

ADULT; DIETARY FATS; FATTY ACIDS, NONESTERIFIED; FEMALE; HUMANS; HYDROXYBUTYRATES; HYPERLIPIDEMIA, FAMILIAL COMBINED; INSULIN; INTESTINAL ABSORPTION; KETONE BODIES; LIVER; MALE; MIDDLE AGED; POSTPRANDIAL PERIOD; TRIGLYCERIDES;

EID: 0033913205     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. Goldstein, J. L., H. G. Schrott, W. R. Hazzard, E. L. Bierman, and A. G. Motulsky. 1973. Hyperlipidemia in coronary heart disease. II. Genetic analysis of lipid levels in 176 families and delineation of a new inherited disorder, combined hyperlipidemia. J. Clin. Invest. 52: 1544-1568.
2. Castro Cabezas, M., T. W. de Bruin, and D. W. Erkelens. 1992. Familial combined hyperlipidaemia: 1973-1991. Neth. J. Med. 40: 83-95.
3. Pitkanen, O. P., P. Nuutila, O. T. Raitakari, K. Porkka, H. Iida, I. Nuotio, T. Ronnemaa, J. Viikari, M. R. Taskinen, C. Ehnholm, and J. Knuuti. 1999. Coronary flow reserve in young men with familial combined hyperlipidemia. Circulation. 99: 1678-1684.
4. Nikkila, E. A., and A. Aro. 1973. Family study of serum lipids and lipoproteins in coronary heart-disease. Lancet. 1: 954-959.
5. Rose, H. G., P. Kranz, M. Weinstock, J. Juliano, and J. I. Haft. 1973. Inheritance of combined hyperlipoproteinemia: evidence for a new lipoprotein phenotype. Am. J. Med. 54: 148-160.
6. Ribalta, J., A. E. La Ville, J. C. Vallve, S. Humphries, P. R. Turner, and L. Masana. 1997. A variation in the apolipoprotein C-III gene is associated with an increased number of circulating VLDL and IDL particles in familial combined hyperlipidemia. J. Lipid Res. 38: 1061-1069.
7. Pajukanta, P., J. D. Terwilliger, M. Perola, T. Hiekkalinna, I. Nuotio, P. Ellonen, M. Parkkonen, J. Hartiala, K. Ylitalo, J. Pihlajamaki, K. Porkka, M. Laakso, J. Viikari, C. Ehnholm, M. R. Taskinen, and L. Peltonen. 1999. Genomewide scan for familial combined hyperlipidemia genes in Finnish families, suggesting multiple susceptibility loci influencing triglyceride, cholesterol, and apolipoprotein B levels. Am. J. Hum. Genet. 64: 1453-1463.
8. Aouizerat, B. E., H. Allayee, R. M. Cantor, R. C. Davis, C. D. Lanning, P. Z. Wen, G. M. Dallinga-Thie, T. W. de Bruin, J. I. Rotter, and A. J. Lusis. 1999. A genome scan for familial combined hyperlipidemia reveals evidence of linkage with a locus on chromosome 11. Am. J. Hum. Genet. 65: 397-412.
9. Cortner, J. A., P. M. Coates, N. A. Le, D. R. Cryer, M. C. Ragni, A. Faulkner, and T. Langer. 1987. Kinetics of chylomicron remnant clearance in normal and in hyperlipoproteinemic subjects. J. Lipid Res. 28: 195-206.
10. Janus, E. D., A. M. Nicoll, P. R. Turner, P. Magill, and B. Lewis. 1980. Kinetic bases of the primary hyperlipidaemias: studies of apolipoprotein B turnover in genetically defined subjects. Eur. J. Clin. Invest. 10: 161-172.
11. Chait, A., J. J. Albers, and J. D. Brunzell. 1980. Very low density lipoprotein overproduction in genetic forms of hypertriglyceridaemia. Eur. J. Clin. Invest. 10: 17-22.
12. Castro Cabezas, M., T. W. de Bruin, H. W. de Valk, C. C. Shoulders, H. Jansen, and D. W. Erkelens. 1993. Impaired fatty acid metabolism in familial combined hyperlipidemia. A mechanism associating hepatic apolipoprotein B overproduction and insulin resistance. J. Clin. Invest. 92: 160-168.
13. Genest, J., A. Sniderman, K. Cianflone, B. Teng, S. Wacholder, Y. Marcel, and P. Kwiterovich, Jr. 1986. Hyperapobetalipoproteinemia. Plasma lipoprotein responses to oral fat load. Arteriosclerosis. 6: 297-304.
14. Ascaso, J. F., A. Merchante, R. I. Lorente, J. T. Real, J. Martinez-Valls, and R. Carmena. 1998. A study of insulin resistance using the minimal model in nondiabetic familial combined hyperlipidemic patients. Metabolism. 47: 508-513.
15. Aitman, T. J., I. F. Godsland, B. Farren, D. Crook, H. J. Wong, and J. Scott. 1997. Defects of insulin action in fatty acid and carbohydrate metabolism in familial combined hyperlipidemia. Arterioscler. Thromb. Vasc. Biol. 17: 748-754.
16. Karjalainen, L., J. Pihlajamäki, P. Karhapaa, and M. Laakso. 1998. Impaired insulin-stimulated glucose oxidation and free fatty acid suppression in patients with familial combined hyperlipidemia: a precursor defect for dyslipidemia? Arterioscler. Thromb. Vasc. Biol. 18: 1548-1553.
17. Babirak, S. P., B. G. Brown, and J. D. Brunzell. 1992. Familial combined hyperlipidemia and abnormal lipoprotein lipase. Arterioscler. Thromb. 12: 1176-1183.
18. Yang, W. S., D. N. Nevin, L. Iwasaki, R. Peng, B. G. Brown, J. D. Brunzell, and S. S. Deeb. 1996. Regulatoty mutations in the human lipoprotein lipase gene in patients with familial combined hyperlipidemia and coronary artery disease. J. Lipid Res. 37: 2627-2637.
19. Sniderman, A. D., K. Cianflone, P. Arner, L. K. Summers, and K. N. Frayn. 1998. The adipocyte, fatty acid trapping, and atherogenesis. Arterioscler. Thromb. Vasc. Biol. 18: 147-151.
20. Cianflone, K. M., M. H. Maslowska, and A. D. Sniderman. 1990. Impaired response of fibroblasts from patients with hyperapobetalipoproteinemia to acylation-stimulating protein. J. Clin. Invest. 85: 722-730.
21. Reynisdottir, S., M. Eriksson, B. Angelin, and P. Arner. 1995. Impaired activation of adipocyte lipolysis in familial combined hyperlipidemia. J. Clin. Invest. 95: 2161-2169.
22. Belfrage, P., G. Fredrikson, H. Olsson, and P. Stralfors. 1985. Molecular mechanisms for hormonal control of adipose tissue lipolysis. Int. J. Obes. 9: 129-135.
23. Severson, D. L., J. C. Khoo, and D. Steinberg. 1977. Role of phosphoprotein phosphatases in reversible deactivation of chicken adipose tissue hormone-sensitive lipase. J. Biol. Chem. 252: 1484-1489.
24. Snel, Y. E., R. J. Brummer, M. E. Doerga, P. M. Zelissen, and H. P. Koppeschaar. 1995. Validation of extracellular water determination by bioelectrical impedance analysis in growth hormone-deficient adults. Ann. Nutr. Metab. 39: 242-250.
25. National Institutes of Health. 1996. Bioelectrical impedance analysis in body composition measurement: National Institutes of Health Technology Assessment Conference Statement. Am. J. Clin. Nutr. 64: 524S-532S.
26. Gidez, L. I., G. J. Miller, M. Burstein, S. Slagle, and H. A. Eder. 1982. Separation and quantitation of subclasses of human plasma high density lipoproteins by a simple precipitation procedure. J. Lipids Res. 23: 1206-1223.
27. De Bruin, T. W., M. C. Vos, W. Kortlandt, B. N. Bouma, and D. W. Erkelens. 1990. Proteolysis of human apolipoprotein B: effect on quantitative immunoturbidimetry. Clin. Chim. Acta. 193: 137-145.
28. Huttunen, J. K., C. Ehnholm, P. K. Kinnunen, and E. A. Nikkila. 1975. An immunochemical method for the selective measurement of two triglyceride lipases in human postheparin plasma. Clin. Chim. Acta. 63: 335-347.
29. Dallinga-Thie, G. M., M. van Linde-Sibenius Trip, L. A. Kock, and T. W. De Bruin. 1995. Apolipoprotein E2/E3/E4 genotyping with agarose gels. Clin. Chem. 41: 73-75.
30. Matthews, D. R., J. P. Hosker, A. S. Rudenski, B. A. Naylor, D. F. Treacher, and R. C. Turner. 1985. Homeostasis model assessment: insulin resistance and beta-cell function from lasting plasma glucose and insulin concentrations in man. Diabetologia. 28: 412-419.
31. Cabezas, M. C., T. W. de Bruin, H. Jansen, L. A. Kock, W. Kortlandt, and D. W. Erkelens. 1993. Impaired chylomicron remnant clearance in familial combined hyperlipidemia. Arterioscler. Thromb. 13: 804-814.
32. Brunzell, J. D., W. R. Hazzard, D. Porte, Jr., and E. L. Bierman. 1973. Evidence for a common, saturable, triglyceride removal mechanism for chylomicrons and very low density lipoproteins in man. J. Clin. Invest. 52: 1578-1585.
33. Potts, J. L., R. M. Fisher, S. M. Humphreys, S. W. Coppack, G. F. Gibbons, and K. N. Frayn. 1991. Peripheral triacylglycerol extraction in the lasting and post-prandial states. Clin. Sci. 81: 621-626.
34. Baldo, A., A. D. Sniderman, S. St-Luce, R. K. Avramoglu, M. Maslowska, B. Hoang, J. C. Monge, A. Bell, S. Mulay, and K. Cianflone. 1993. The adipsin-acylation stimulating protein system and regulation of intracellular triglyceride synthesis. J. Clin. Invest. 92: 1543-1547.
35. Murray, I., A. D. Sniderman, and K. Cianflone. 1999. Enhanced triglyceride clearance with intraperitoneal human acylation stimulating protein in C57BL/6 mice. Am. J. Physiol. 277: E474-E480.
36. Maslowska, M., H. Vu, S. Phelis, A. D. Sniderman, B. M. Rhode, D. Blank, and K. Cianflone. 1999. Plasma acylation stimulating protein, adipsin and lipids in non-obese and obese populations. Eur. J. Clin. Invest. 29: 679-686. [See comments]
37. Cianflone, K., H. Vu, M. Walsh, A. Baldo, and A. Sniderman. 1989. Metabolic response of acylation stimulating protein to an oral fat load. J. Lipid Res. 30: 1727-1733.
38. McGarry, J. D., and D. W. Foster. 1980. Regulation of hepatic fatty acid oxidation and ketone body production. Annu. Rev. Biochem. 49: 395-420.
39. Sniderman, A. D., Z. Zhang, and K. Cianflone. 1998. Divergent responses of the liver to increased delivery of glucose or fatty acids: implications for the pathogenesis of type IV hyperlipoproteinemia. Atherosclerosis. 137: 291-301.
40. Frayn, K. N., S. Shadid, R. Hamlani, S. M. Humphreys, M. L. Clark, B. A. Fielding, O. Boland, and S. W. Coppack. 1994. Regulation of fatty acid movement in human adipose tissue in the postabsorptive-to-postprandial transition. Am. J. Physiol. 266: E308-E317.
41. Steinberg, D., and J. C. Khoo. 1977. Hormone-sensitive lipase of adipose tissue. Fed. Proc. 36: 1986-1990.
42. Langin, D., C. Holm, and M. Lafontan. 1996. Adipocyte hormone-sensitive lipase: a major regulator of lipid metabolism. Proc. Nutr. Soc. 55: 93-109.
43. Reynisdottir, S., B. Angelin, D. Langin, H. Lithell, M. Eriksson, C. Holm, and P. Arner. 1997. Adipose tissue lipoprotein lipase and hormone-sensitive lipase. Contrasting findings in familial combined hyperlipidemia and insulin resistance syndrome. Arterioscler. Thromb. Vasc. Biol. 17: 2287-2292.
44. Pihlajamäki, J., L. Karjalainen, P. Karhapaa, I. Vauhkonen, and M. Laakso. 2000. Impaired free fatty acid suppression during hyperinsulinemia is a characteristic finding in familial combined hyperlipidemia, but insulin resistance is observed only in hypertriglyceridemic patients. Arterioscler. Thromb. Vasc. Biol. 20: 164-170.