Expression of the stilbene synthase (StSy) gene from grapevine in transgenic white poplar results in high accumulation of the antioxidant resveratrol glucosides

Transgenic Research

Volumn 13, Issue 3, 2004, Pages 203-214

  Giorcelli, Achille ^a   Sparvoli, Francesca ^b   Mattivi, Fulvio ^c   Tava, Aldo ^d   Balestrazzi, Alma ^e   Vrhovsek, Urska ^c   Calligari, Paolo ^a   Bollini, Roberto ^b   Confalonieri, Massimo ^a  

^a I 15033 Casale Monferrato Italy   (Italy)

^b Ist Biol Biotecnologia A   (Italy)

^c RESEARCH AND INNOVATION CENTRE   (Italy)

^d ISTITUTO NAZIONALE DELLA NUTRIZIONE   (Italy)

^e UNIVERSITY OF PAVIA   (Italy)

Author keywords

disease resistance; phytochemicals; piceid; Populus alba L.; transgenic trees

Indexed keywords

ACYLTRANSFERASE; COMPLEMENTARY DNA; GLUCOSIDE; POLYDATIN; STILBENE DERIVATIVE; STILBENE SYNTHASE;

ARTICLE; ASPEN; COMPARATIVE STUDY; ENZYMOLOGY; GENE EXPRESSION; GENETIC TRANSFORMATION; GENETICS; GRAPE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; MASS SPECTROMETRY; METABOLISM; NORTHERN BLOTTING; SOUTHERN BLOTTING; TRANSGENIC PLANT; ULTRAVIOLET SPECTROPHOTOMETRY; WESTERN BLOTTING;

ACYLTRANSFERASES; BLOTTING, NORTHERN; BLOTTING, SOUTHERN; BLOTTING, WESTERN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DNA, COMPLEMENTARY; GENE EXPRESSION; GLUCOSIDES; HYDROLYSIS; MASS SPECTROMETRY; PLANTS, GENETICALLY MODIFIED; POPULUS; SPECTROPHOTOMETRY, ULTRAVIOLET; STILBENES; TRANSFORMATION, GENETIC; VITIS;

BRASSICA OLERACEA VAR. BOTRYTIS; CAULIFLOWER MOSAIC VIRUS; EMBRYOPHYTA; EUKARYOTA; MELAMPSORA; POPULUS; POPULUS ALBA; POPULUS BEROLINENSIS; VITIS; VITIS SP.; VITIS VINIFERA;

EID: 3943106898     PISSN: 09628819     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:TRAG.0000034658.64990.7f     Document Type: Article

References (57)

1. AA.VV. (2001) NTP technical report on the toxicology and carcinogenesis studies of emodin in F344/N rats and B6C3F1 mice. U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health, NIH publication No. 01-3952 (http://ehp.niehs.nih.gov/ntp/docs/tr493/tr493abs.pdf).
2. An G, Watson BD, Stachel S, Gordon MP and Nester EW (1985) New cloning vehicles for transformation of higher plants. EMBO J 4: 227-284.
3. Arichi H, Kimura Y, Okuda H, Baba K, Kozawa M and Arichi S (1980) Effects of stilbene components of the roots of Polygonum cuspidatum Sieb. Et Zucc. on lipid metabolism. Chem Pharm Bull 30(5): 1766-1770.
4. Bavaresco L and Fregoni C (2001) Physiological role and molecular aspects of grapevine stilbenic compounds. In: Roubelakis-Angelakis KA (ed), Molecular Biology and Biotechnology of the Grapevine (pp. 153-182) Kluwer Academic Publishers, Dordrecht, The Netherlands.
5. Burns J, Yokota T, Ashihara H, Lean MEJ and Crozier A (2002) Plant foods and herbal sources of resveratrol. J Agri Food Chem 50: 3337-3340.
6. Ceriotti A, Vitale A and Bollini R (1989) Lectin-like proteins accumulate as fragmentation products in bean seed protein bodies. FEBS Lett 250: 157-160.
7. Confalonieri M, Belenghi M, Balestrazzi A, Negri S, Facciotto G, Schenone G et al. (2000) Transformation of elite white poplar (Populus alba L.) cv. 'Villafranca' and evaluation of herbicide resistance. Plant Cell Rep 19: 978-982.
8. De Sa MM, Subramaniam R, Williams FE and Douglas CJ (1992) Rapid activation of phenylpropanoid metabolism in elicitor-treated hybrid poplar (Populus trichocarpa Torr. & Gray x Populus deltoides Marsh) suspension-cultured cells. Plant Physiol 98: 728-737.
9. De Wilde C, Van Houdt H, De Buck S, Angenon G, De Jaeger G and Depicker A (2000) Plants as bioreactors for protein production: avoiding the problem of transgene silencing. Plant Mol Biol 43: 347-359.
10. Douillet-Breuil AC, Jeandet P, Adrian M and Bessis R (1999) Changes in the phytoalexin content of various Vitis spp. in response to ultraviolet C elicitation. J Agri Food Chem 47: 4456-4461.
11. Falchetti R, Fuggetta MP, Lanzilli G, Tricarico M and Ravagnan G (2001) Effects of resveratrol on human immune cell function. Life Sci 70: 81-96.
12. Flores G and Hubbes M (1980) The nature and role of phytoalexin produced by aspen (Populus tremuloides Michx.). Eur J Forest Pathol 10: 95-103.
13. Frémont L (2000) Biological effects of resveratrol. Life Sci 66(8): 663-673.
14. Gorham J, Tori M and Asakawa Y (1995) The Biochemistry of the Stilbenoids. Chapman & Hall, London.
15. Hain R, Bieseler B, Kindl H, Schröder G and Stöcker R (1990) Expression of a stilbene synthase gene in Nicotiana tabacum results in synthesis of the phytoalexin resveratrol. Plant Mol Biol 15: 325-335.
16. Hain R, Reif HJ, Krause E, Langebartels R, Kindl H, Vornam B et al. (1993) Disease resistance results from foreign phytoalexin expression in a novel plant. Nature 361: 153-156.
17. Hariri EB, Sallé G and Andary C (1991) Involvement of flavonoids in the resistance of two poplar cultivars to mistletoe (Viscum album L.). Protoplasma 162: 20-26.
18. Hart JH (1981) Role of phytostilbenes in decay and disease resistance. Annu Rev Phytopathol 19: 832-834.
19. Heilman PE, Hinkley TM, Roberts DA and Ceulemans R (1996) Production physiology. In: Stettler RF, Bradshaw HD, Jr., Heilman PE and Hinkley TM (eds), Biology of Populus and its Implications for Management and Conservation (pp. 459-489) NRC Research Press, National Research Council of Canada, Ottawa.
20. Hipskind JD and Paiva NL (2000a) Transgenic plants modified to contain resveratrol glucoside and uses thereof. International patent application PCT-WO 00/44921.
21. Hipskind JD and Paiva NL (2000b) Constitutive accumulation of a resveratrol-glucoside in transgenic alfalfa increases resistance to Phoma medicaginis. Mol Plant Microbe Interact 5: 551-562.
22. Hood EE, Gelvin SB, Melchers LS and Hoekema A (1993) New Agrobacteria helper plasmids for gene transfer to plants. Transg Res 2: 208-218.
23. Jang M, Cai L, Udeani GO, Slowing KV, Thomas CF, Beecher CWW et al. (1997) Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 275: 218-220.
24. Kobayashi S, Ding CK, Nakamura Y, Nakajima I and Matsumoto R (2000) Kiwifruits (Actinidia deliciosa) transformed with a Vitis stilbene synthase gene produce piceid (resveratrol-glucoside). Plant Cell Rep 19: 904-910.
25. Kodan A, Kuroda H and Sakai F (2001) Simultaneous expression of stilbene synthase genes in Japanese red pine (Pinus densiflora) seedlings. J Wood Sci 47: 58-62.
26. Komoda Y (1989) Isolation of flavonoids from Populus nigra as delta 4-3-ketosteroid (5 alpha) reductase inhibitors. Chem Pharm Bull 37(11): 3128-3130.
27. Korhammer S, Reniero F and Mattivi F (1995) An oligostilbene from Vitis roots. Phytochemistry 38(6): 1501-1504.
28. Langcake P (1981) Disease resistance of Vitis spp. and the production of the stress metabolites resveratrol, ε-viniferin, α-viniferin and pterostilbene. Physiol Plant Pathol 18: 213-226.
29. Leckband G and Lörz H (1998) Transformation and expression of a stilbene synthase gene of Vitis vinifera L. in barley and wheat for increase fungal resistance. Theor Appl Genet 96: 1004-1012.
30. Liang H, Zheng J, Duan XY, Sheng BQ, Jia SG, Wang DW et al. (2000) A transgenic wheat with a stilbene synthase gene resistant to powdery mildew obtained by biolistic method. Chinese Sci Bull 45: 634-638.
31. Lloyd G and McCown BH (1991) Commercially feasible micropropagation of mountain laurel, Kalmia latifolia, by use of shoot-tip culture. Proc Int Plant Prop 30: 421-427.
32. Magnani G (1961) Ruggine mediterranea del pioppo bianco da Melampsora pulcherrima (Bub.) Maire. Pubbl Ente Naz Cellulosa e Carta 5: 221-236.
33. Mannila E, Talvittie A and Kolehmainen E (1993) Anti-leukaemic compounds derived from stilbenes in Picea abies bark. Phytochemistry 33: 813-816.
34. Mattivi F, Reniero F and Korhammer S (1995) Isolation, characterization, and evolution in red wine vinification of resveratrol monomers. J Agr Food Chem 43: 1820-1824.
35. Mattivi F and Reniero F (1996) Relationship between UV spectra and molecular structure of resveratrol oligomers. Polyphenols Commun 96(1): 125-126.
36. Moribondo F, Naldini Longo B, Longo N, Drovandi F and Gonnelli T (1989) Some observations on the life-cycle of Melampsora pulcherrima (Bub.) Maire. Phytopathol Meditter 28: 46-52.
37. Nicolescu C, Sandré C, Jouanin L and Chriqui D (1996) Modification de l'expression du métabolisme phénolique chez le Peuplier en relation avec la résistance aux agents pathogènes. Acta Bot Gallica 143(6): 539-546.
38. Orsini F, Pelizzoni F, Bellini B and Miglierini G (1997a) Synthesis of biologically active polyphenolic glycosides (combretastatin and resveratrol series). Carbohydrate Res 301: 95-109.
39. Orsini F, Pelizzoni F, Verotta L, Aburjai T and Rogers CB (1997b) Isolation, synthesis, and antiplatelet aggregation activity of resveratrol 3-O-β-D-glucopyranose and related compounds. J Nat Products 60: 1082-1087.
40. Pace-Asciak CR, Hahn S, Diamandis EP, Soleas G and Goldberg DM (1995) The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease. Clin Chim Acta 235: 207-219.
41. Preisig-Müller R, Schwekendiek A, Brehm I, Reif HJ and Kindl H (1999) Characterization of a pine multigene family containing elicitor-responsive stilbene synthase genes. Plant Mol Biol 39: 221-229.
42. Pyee J-H and Hyung N-I (2002) International patent application PCT-WO 02/02053.
43. Reniero F, Rudolph M, Angioni A, Bernreuther A, Cabras P and Mattivi F (1996) Identification of two stilbenoids from Vitis roots. Vitis 35(3): 125-127.
44. Schultz TP, Hubbard TF, Jin L, Fisher TH and Nicholas DD (1990) Role of stilbenes in the natural durability of wood: fungicidal structure-activity relationships. Phytochemistry 29: 1501-1507.
45. Schröder G, Brown JWS and Schröder J (1988) Molecular analysis of resveratrol synthase: cDNA clones and relationship with chalcone synthase. Eur J Biochem 172: 161-169.
46. Schwekendiek A, Pfeffer G and Kindl H (1992) Pine stilbene synthase cDNA, a tool for probing environmental stress. FEBS Lett 301: 41-44.
47. Shain L and Miller JB (1982) Pinocembrin: an antifungal compound secreted by leaf glands of eastern cottonwood. Phytopathology 27: 877-880.
48. Sotheeswaran S and Pasupathy V (1993) Distribution of resveratrol oligomers in plants. Phytochemistry 32: 1083-1092.
49. Sparvoli F and Bollini R (1998) Arcelin in wild beans (Phaseolus vulgaris L.) seeds: Sequence of variant 6 (arcelin 6) shows it is a member of the arcelin 1 and arcelin 2 subfamily. Genet Resour Crop Evol 45: 383-388.
50. Sparvoli F, Martin C, Scienza A, Gavazzi G and Tonelli C (1994) Cloning and molecular analysis of structural genes involved in flavonoid and stilbene biosynthesis in grape (Vitis vinifera L.). Plant Mol Biol 24: 743-755.
51. Stark Lorenzen P, Nelke B, Hänßler G, Mühlbach HP and Thomzik JE (1997) Transfer of a grapevine stilbene synthase gene to rice (Oryza sativa L.). Plant Cell Rep 16: 668-673.
52. Tabe LM, Wardley-Richardson T, Ceriotti A, Aryan A, McNabb W, Moore A and Higgins TJV (1995) A biotechnological approach to improve the nutritional value of alfalfa. J Anim Sci 73: 2752-2759.
53. Thomzik JE (1993) Transformation in oilseed rape Brassica napus L. In: Bajaj YPS (ed) Biotechnology in Agriculture and Forestry (pp. 171-182) Springer, Berlin/Heidelberg/New York.
54. Thomzik JE (1997) Synthesis of a grapevine phytoalexin in transgenic tomatoes (Lycopersicum esculentum Mill.) conditions resistance against Phytophtora infestans. Physiol Mol Plant Pathol 51: 265-278.
55. Tuskan GA and Walsh ME (2001) Short-rotation woody crop systems, atmospheric carbon dioxide and carbon management: A U.S. case study. Forestry Chronicle 77(2): 259-264.
56. Verwoerd TC, Dekker BMM and Hoekema A (1989) A small-scale procedure for the rapid isolation of plant RNAs. Nucleic Acids Res 17(6): 2362.
57. Wiese W, Vornam B, Krause E and Kindl H (1994) Structural organization and differential expression of three stilbene synthase genes located on a 13 kb grapevine DNA fragment. Plant Mol Biol 26: 667-677.