Zn(salen)-catalyzed asymmetric alkynylation of ketones

Synlett

Volumn , Issue 9, 2004, Pages 1557-1560

  Saito, Bunnai ^a   Katsuki, Tsutomu ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

Asymmetric alkynylation; Asymmetric catalysis; Ketone; Tertiary propargylic alcohol; Zn(salen) complex

Indexed keywords

2 BUTANONE; ACETYLENE DERIVATIVE; KETONE DERIVATIVE; ZINC;

ALKYNYLATION; ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; ENANTIOSELECTIVITY; REACTION ANALYSIS;

EID: 3943102691     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2004-829057     Document Type: Article

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35. 4. After removal of the solvent under reduced pressure, the residue was chromatographed on silica gel (hexane-EtOAc = 19:1) to give the corresponding alcohol (15.2 mg, 75%). The enantiomeric excess was determined to be 91% ee by HPLC analysis (Daicel Chiralcel OD-H; hexane-i-PrOH = 49:1).
36. Enantiomeric excesses of the products were determined by HPLC analysis under the following conditions: (a) Daicel Chiralcel OD-H, hexane-i-PrOH = 24:1. (b) Daicel Chiralcel OD-H, hexane-i-PrOH = 19:1. (c) Daicel Chiralpak AD-H, hexane-i-PrOH = 19:1.
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