Exercise recommendations for an increase of bone strength based on animal models and studies with athletes;Empfehlungen für ein körperliches training zur verbesserung der knochenfestigkeit: Schlussfolgerungen aus tiermodellen und untersuchungen an leistungssportlern

Deutsche Zeitschrift fur Sportmedizin

Volumn 54, Issue 11, 2003, Pages 306-316

  Kemmler, W ^a,b   Von Stengel, S ^a   Weineck, J ^b   Engelke, K ^a  

^a Inst für Medizinische Physik   (Germany)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

Bone; Exercise; Osteoporosis; Training

Indexed keywords

EID: 3943058138     PISSN: 03445925     EISSN: 03445925     Source Type: Journal    
DOI: None     Document Type: Review

References (150)

1. Alfredson H, Nordstrom P, Pietila T, Lorentzon R: Long-term loading and regional bone mass of the arm in female volleyball players. Calcif Tissue Int 62 (1998) 303-308.
2. Allen SH: Exercise considerations for postmenopausal women with osteoporosis. Arthritis Care Res 7 (1994) 205-214.
3. Andreoli A, Monteleone M, Van Loan M, Promenzio L, Tarantino U, De Lorenzo A: Effects of different sports on bone density and muscle mass in highly trained athletes. Med Sci Sports Exerc 33 (2001) 507-511.
4. Ashizawa N, Nonaka K, Michikami S, et al.: Tomographical description of tennis-loaded radius: reciprocal relation between bone size and volumetric BMD. J Appl Physiol 86 (1999) 1347-1351.
5. Baker ER: Menstrual dysfunction and hormonal status in athletic women: a review. Fertil Steril 36 (1981) 691-696.
6. Barengolts EI, Curry DJ, Bapna MS, Kukreja SC: Effects of endurance exercise on bone mass and mechanical properties in intact and ovariectomized rats. J Bone Miner Res 8 (1993) 937-942.
7. Barengolts EI, Curry DJ, Bapna MS, Kukreja SC: Effects of two non-endurance exercise protocols on established bone loss in ovariectomized adult rats. Calcif Tissue Int 52 (1993) 239-343.
8. Bassey EJ: Exercise in primary prevention of osteoporosis in women. Ann Rheum Dis 54 (1995) 861-862.
9. Bassey EJ, Rothwell MC, Littlewood JJ, Pye DW: Pre- and postmenopausal women have different bone mineral density responses to the same highimpact exercise. J Bone Miner Res 13 (1998) 1805-1813.
10. Bemben DA, Fetters NL, Bemben MG, Nabavi N, Koh ET: Musculoskeletal responses to high- and low-intensity resistance training in early postmenopausal women. Med Sci Sports Exerc 32 (2000) 1949-1957.
11. Bennell K, Page C, Khan K, et al.: Effects of resistance training on bone parameters in young and mature rats. Clin Exp Pharmacol Physiol 27 (2000) 88-94.
12. Bennell KL, Malcolm SA, Khan KM, et al.: Bone mass and bone turnover in power athletes, endurance athletes, and controls: a 12-month longitudinal study. Bone 20 (1997) 477-484.
13. Bennell KL, Malcolm SA, Wark JD, Brukner PD: Skeletal effects of menstrual disturbances in athletes. Scand J Med Sci Sports 7 (1997) 261-273.
14. Berard A, Bravo G, Gauthier P: Meta-analysis of the effectiveness of physical activity for the prevention of bone loss in postmenopausal women. Osteoporos Int 7 (1997) 331-337.
15. Blimkie CJ, Rice S, Webber CE, Martin J, Levy D, Gordon CL: Effects of resistance training on bone mineral content and density in adolescent females. Can J Physiol Pharmacol 74 (1996) 1025-1033.
16. Buhl KM, Jacobs CR, Turner RT, Evans GL, Farrell PA, Donahue HJ: Aged bone displays an increased responsiveness to low-intensity resistance exercise. J Appl Physiol 90 (2001) 1359-1364.
17. Burr DB, Robling AG, Turner CH: Effects of biomechanical stress on bones in animals. Bone 30 (2002) 781-786.
18. Chae AE, Platen P, Antz R, et al.: Knochendichte bei Leistungssportler/ innen aus verschiedenen Sportarten im Vergleich zu Sportstudent/innen und untrainierten Kontrollpersonen. Regulations- und Repaimechanismen 1994, Paderborn, Germany.
19. Chambers TJ, Evans M, Gardner T, Turner-Smith A, Chow JW: Induction of bone formation in rat tail vertebrae by mechanical loading. Bone Miner 20 (1993) 167-178.
20. Cheng S, Sipila S, Taaffe DR, Puolakka J, Suominen H: Change in bone mass distribution induced by hormone replacement therapy and high-impact physical exercise in post-menopausal women. Bone 31 (2002)126-135.
21. Chilibeck PD, Davison KS, Whiting SJ, Suzuki Y, Janzen CL, Peloso P: The effect of strength training combined with bisphosphonate (etidronate) therapy on bone mineral, lean tissue, and fat mass in postmenopausal women. Can J Physiol Pharmacol 80 (2002) 941-950.
22. Creighton DL, Morgan AL, Boardley D, Brolinson PG: Weight bearing exercise and markers of bone turnover in female athletes. J Appl Physiol 90(2001) 565-570.
23. Cullen DM, Smith RT, Akhter MP: Bone-loading response varies with strain magnitude and cycle number. J Appl Physiol 91 (2001) 5: 1971-6.
24. Dale E, Gerlach DH, Wilhite AL: Menstrual dysfunction in distance runners. Obstet Gynecol 54 (1979) 47-53.
25. Dalsky GP, Stocke KS, Ehsani AA, Slatopolsky E, Lee WC, Birge SJ, Jr.: Weight-bearing exercise training and lumbar bone mineral content in postmenopausal women. Ann Intern Med 108 (1988) 824-828.
26. Danz AM, Zittermann A, Schiedermaier U, Klein K, Hötzel D, Schönau E: The effect of a specific strength-development exercise on bone mineral density in perimenopausal and postmenopausal women. Journal of Women's Health 7 (1998) 701-709.
27. Drinkwater BL: Exercise in the prevention of osteoporosis. Osteoporos Int 3 (1993) Suppl 1, 169-171.
28. Duncan DS, Blimkie CJ, Cowell CT, Burke ST, Briody EN, Howman-Giles R: Bone mineral density in adolescent female athletes: relationship to exercise type and muscle strength. Med Sci Sports Exerc 34 (2002) 286-294.
29. Etherington J, Harris PA, Nandra D, et al.: The effect of weight-bearing exercise on bone mineral density: a study of female ex-elite athletes and the general population. J Bone Miner Res 11 (1996) 1333-1338.
30. Fehling PC, Alekel L, Clasey J, Rector A, Stillman RJ: A comparison of bone mineral densities among female athletes in impact loading and active loading sports. Bone 17 (1995) 205-210.
31. Fleck SJ: Periodized strength training: A critical review. J. Strength and Cond. Res. 13 (1999) 82-89.
32. Frost HM: The role of changes in mechanical usage set points in the pathogenesis of osteoporosis. J Bone Miner Res 7 (1992) 253-261.
33. Frost HM: Why do marathon runners have less bone than weight lifters? A vital-biomechanical view and explanation. Bone 20 (1997) 183-189.
34. Gardner MM, Robertson MC, Campbell AJ: Exercise in preventing falls and fall related injuries in older people: a review of randomised controlled trials. Br J Sports Med 34 (1999) 7-17.
35. Grosser M, Brüggemann P, Zintl F: Leistungssteuerung in Training und Wettkampf. München: BLV-Verlag, 1986.
36. Haapasalo H, Kannus P, Sievanen H, Heinonen A, Oja P, Vuori I: Long-term unilateral loading and bone mineral density and content in female squash players. Calcif Tissue Int 54 (1994) 249-255.
37. Haapasalo H, Kontulainen S, Sievanen H, Kannus P, Jarvinen M, Vuori I: Exercise-induced bone gain is due to enlargement in bone size without a change in volumetric bone density: a peripheral quantitative computed tomography study of the upper arms of male tennis players. Bone 27 (2000) 351-357.
38. Hagino H, Raab DM, Kimmel DB, Akhter MP, Recker RR: The effects of ovariectomy on bone response to in vivo external loading. J Bone Miner Res 8 (1993) 347-357.
39. Hakkinen A, Sokka T, Kotaniemi A, et al.: Dynamic strength training in patients with early rheumatoid arthritis increases muscle strength but not bone mineral density. J Rheumatol 26 (1999) 1257-1263.
40. Hakkinen K, Pakarinen A, Kraemer WJ, Newton RU, Alen M: Basal concentrations and acute responses of serum hormones and strength development during heavy resistance training in middle-aged and elderly men and women. J Gerontol A Biol Sci Med Sci 55 (2000) 2, B95-105.
41. Hart KJ, Shaw JM, Vajda E, Hegsted M, Miller SC: Swim-trained rats have greater bone mass, density, strength, and dynamics. J Appl Physiol 91 (2001) 1663-1668.
42. Heinonen A, Oja P, Kannus P, et al.: Bone mineral density in female athletes representing sports with different loading characteristics of the skeleton. Bone 17 (1995) 197-203.
43. Heinonen A, Oja P, Kannus P, Sievanen H, Manttari A, Vuori I: Bone mineral density of female athletes in different sports. Bone Miner 23 (1993) 1-14.
44. Heinrich CH, Going SB, Pamenter RW, Perry CD, Boyden TW, Lohman TG: Bone mineral content of cyclically menstruating female resistance and endurance trained athletes. Med Sci Sports Exerc 22 (1990) 558-563.
45. Hirano T, Burr DB, Turner CH, Sato M, Cain RL, Hock JM: Anabolic effects of human biosynthetic parathyroid hormone fragment (1-34), LY333334, on remodeling and mechanical properties of cortical bone in rabbits. J Bone Miner Res 14 (1999) 536-445.
46. Honda A, Sogo N, Nagasawa S, Shimizu T, Umemura Y: High-impact exercise strengthens bone in osteopenic ovariectomized rats with the same outcome as Sham rats. J Appl Physiol 95 (2003) 1032-1037.
47. Honda A, Umemura Y, Nagasawa S: Effects of high-impact and low-repetition training on bones in ovarectomized rats. J Bone Miner Res 16 (2001) 1688-1693.
48. Hoshi A, Watanabe H, Chiba M, Inaba Y: Bone Density and mechanical properties in femoral bone of swim loaded aged mice. Biomed Environ Sci 11 (1998) 243-250.
49. Hoshi A, Watanabe H, Chiba N, Inaba Y: Effects of swimming and weight loading on bone density and mechanical properties of femoral bone in mice. Environ Health Prev Med 1 (1996) 128-132.
50. Hsieh YF, Turner CH: Effects of loading frequency on mechanically induced bone formation. J Bone Miner Res 16 (2001) 918-924.
51. Huang TH, Lin SC, Chang FL, Hsieh SS, Liu SH, Yang RS: Effects of different exercise modes on mineralization, structure, and biomechanical properties of growing bone. J Appl Physiol 95 (2003) 300-307.
52. Iwamoto J, Takeda T, Ichimura S: Effect of exercise on tibial and lumbar vertebral bone mass in mature osteopenic rats: bone histomorphometry study. J Orthop Sci 3 (1998) 257-263.
53. Iwamoto J, Takeda T, Ichimura S: Effects of exercise on bone mineral density in mature osteopenic rats. J Bone Miner Res 13 (1998) 1308-1317.
54. Jarvinen TL, Kannus P, Sievanen H, Jolma P, Heinonen A, Jarvinen M: Randomized controlled study of effects of sudden impact loading on rat femur. J Bone Miner Res 13 (1998) 1475-1482.
55. Jee WS, Li XJ: Adaption of cancellous bone to overloading in the adult rat. A single photon absorptiometry and histomorphometry study. Anat Rec 227 (1990) 418-426.
56. Judex S, Zernicke RF: Does the mechanical milieu associated with high-speed running lead to adaptive changes in diaphyseal growing bone? Bone 26 (2000) 153-159.
57. Judex S, Zernicke RF: High-impact exercise and growing bone: relation between high strain rates and enhanced bone formation. J Appl Physiol 88 (2000) 2183-2191.
58. Kannus P, Haapasalo H, Sankelo M, et al.: Effect of starting age of physical activity on bone mass in the dominant arm of tennis and squash players. Ann Intern Med 123 (1995) 27-31.
59. Karlsson MK, Magnusson H, Karlsson C, Seeman E: The duration of exercise as a regulator of bone mass. Bone 28 (2001) 128-132.
60. Kelley GA: Exercise and regional bone mineral density in postmenopausal women: a meta-analytic review of randomized trials. Am J Phys Med Rehabil 77 (1998) 76-87.
61. Kemmler W, Engelke K, Lauber D, Weineck J, Hensen J, Kalender WA: Exercise effects on fitness and BMD in early postmenopausal women: 1 year EFOPS results. Med Sci Sports Exerc 34 (2002) 2115-2123.
62. Kemmler W, Engelke K, Lauber D, Weineck J, Hensen J, Kalender WA: Impact of intense exercise on physical fitness, quality of life, and bone mineral density in early postmenopausal women. Year 2 results of the Erlangen Fitness Osteoporosis Prevention Study (EFOPS). Arch Int Med accepted for publication (2003).
63. Kemmler W, Riedel H: Körperliche Belastung und Osteoporose - Einfluß einer 10monatigen Interventionsmaßnahme auf ossäre und extraossäre Risikofaktoren einer Osteoporose. Dtsch Z Sportmed 49 (1998) 270-277.
64. Kemmler W, Weineck J, Hensen J, Lauber D, Kalender WA, Engelke K: Exercise in the early menopause prevents bone loss and reduces CHD risk factors: 3 year results of the Erlangen Fitness Osteoporosis Prevention Study (EFOPS). JAMA submitted (2003).
65. Kemmler W, Wildt L, Engelke K, et al.: Acute hormonal responses of a high impact physical exercise session in early postmenopausal women. Eur J Appl Physiol 90 (2003) 199-209.
66. Kerr D, Ackland T, Maslen B, Morton A, Prince R: Resistance training over 2 years increases bone mass in calcium-replete postmenopausal women. J Bone Miner Res 16 (2001) 175-181.
67. Kerr D, Morton A, Dick I, Prince R: Exercise effects on bone mass in postmenopausal women are site-specific and load-dependent. J Bone Miner Res 11 (1996) 218-225.
68. Kodama Y, Umemura Y, Nagasawa S, et al.: Exercise and mechanical loading increase periosteal bone formation and whole bone strength in C57BL/6J mice but not in C3H/Hej mice. Calcif Tissue Int 66 (2000) 298-306
69. Kohrt WM: Osteoprotective benefits of exercise: more pain, less gain? J Am Geriatr Soc 49 (2002) 1565-1567 .
70. Konermann W, Stubbe F, Link T, Meier N: Axiale Bruchfestigkeit von thorakolumbalen Wirbelkörpern - eine experimentelle biomechanische Studie. Z Orthopädie 137 (1999) 223-231.
71. Kontulainen S, Sievanen H, Kannus P, Pasanen M, Vuori I: Effect of long-term impact-loading on mass, size, and estimated strength of humerus and radius of female racquet-sports players: a peripheral quantitative computed tomography study between young and old starters and controls. J Bone Miner Res 17 (2002) 2281-2289.
72. Kraemer WJ: Endocrine responses to resistance exercise. Med Sci Sports Exerc 20 (1988) 5 Suppl, S152-157.
73. Kraemer WJ: A series of studies - the physiological basis for strength training in American Football: Fact over philosophy. J. Strength and Cond. Res. 11 (1997) 131-142.
74. Kraemer WJ: Acute and long term hormonal adaptions to strength training in men and women. International Conference on weigthlifting and strength training 1998, Lahti, Finland: 23-28.
75. Lanyon LE: Functional strain as a determinant for bone remodeling. Calcif Tiss Int 36 (1984) 56-61.
76. Lanyon LE: Biomechanical factors in adaption of bone structure to function. In: Uhthoff HK, ed. Current concepts of bone fragility. Berlin: Springer,1986.
77. Lanyon LE: Using functional loading to influence bone mass and architecture: objectives, mechanisms, and relationship with estrogen of the mechanically adaptive process in bone. Bone 18 (1996) 1 Suppl, 37S-43S.
78. Lee EJ, Long KA, Risser WL, Poindexter HB, Gibbons WE, Goldzieher J: Variations in bone status of contralateral and regional sites in young athletic women. Med Sci Sports Exerc 27 (1995) 1354-1361.
79. Letzelter M: Trainingsgrundlagen. Reinbek bei Hamburg: rororo-Verlag, 1987.
80. Lohman T, Going S, Pamenter R, et al.: Effects of resistance training on regional and total bone mineral density in premenopausal women: a randomized prospective study. J Bone Miner Res 10 (1995) 1015-1024.
81. Lord SR, Ward JA, Williams P, Zivanovic E: The effect of a community exercise program on fracture risk factors in older women. Osteoporos Int 6 (1996) 361-367.
82. MacKelvie KJ, Khan KM, McKay HA: Is there a critical period for bone response to weight-bearing exercise in children and adolescents? a systematic review. Br J Sports Med 36 (2002) 250-257; discussion 257.
83. Marcus R: Relationship of age-related decreases in muscle mass and strength to skeletal status. J Gerontol 50 (1995) 86-87.
84. Matwejew LP: Periodisierung des sportlichen Trainings. Berlin: Barthels & Wernitz, 1978.
85. Mayoux-Benhamou MA, Bagheri F, Roux C, Auleley GR, Rabourdin JP, Revel M: Effects of psoas training on postmenopausal lumbar bone loss: a 3-year follow-up study. Calcified Tiss Int 60 (1997) 348-353.
86. McLeod KJ, Rubin CT: Sensitivity of the bone remodeling response to the frequency of applied strain. Trans Orthop Res Soc 17 (1992) 533.
87. Morel J, Combe B, Francisco J, Bernard J: Bone mineral density of 704 amateur sportsmen involved in different physical activities. Osteoporos Int 12 (2001) 152-157.
88. Mosekilde L, Danielsen CC, Sogaard CH, Thorling E: The effect of longterm exercise on vertebral and femoral bone mass, dimension, and strength - assessed in a rat model. Bone 15 (1994) 293-301.
89. Mosley JR, Lanyon LE: Strain rate as a controlling influence on adaptive modeling in response to dynamic loading of the ulna in growing male rats. Bone 23 (1998) 313-318.
90. Myburgh KH, Noakes TD, Roodt M, Hough FS: Effect of exercise on the development of osteoporosis in adult rats. J Appl Physiol 66 (1989) 14-19.
91. Nara-Ashizawa N, Liu LJ, Higuchi T, et al.: Paradoxical adaption of mature radius to unilateral use in tennis playing. Bone 30 (2002) 619-623.
92. Nelson DA, Bouxsein ML: Exercise maintains bone mass, but do people maintain exercise? J Bone Miner Res 16 (2001) 202-205.
93. Nelson ME, Meredith CN, Dawson-Hughes B, Evans WJ: Hormone and bone mineral status in endurance-trained and sedentary women. J Clin Endocrinol Metab 66 (1988) 927-933.
94. Nilsson BE, Westlin NE: Bone density in athletes. Clin Orthop 77 (1971) 179-182.
95. Notomi T, Lee SJ, Okimoto N, et al.: Effects of resistance exercise training on mass, strength, and turnover of bone in growing rats. Eur J Appl Physiol 82 (2000) 268-274.
96. Notomi T, Okazaki Y, Okimoto N, Saitoh S, Nakamura T, Suzuki M: A comparison of resistance and aerobic training for mass, strength and turnover of bone in growing rats. Eur J Appl Physiol 83 (2000) 469-474.
97. Notomi T, Okimoto N, Okazaki Y, Nakamura T, Suzuki M: Tower climbing exercise started 3 month after ovariectomy recovers bone strength of the femur and lumbar vertebrae in aged osteopenic rats. J Bone Miner Res 18 (2003) 140-149.
98. Notomi T, Okimoto N, Okazaki Y, Tanaka Y, Nakamura T, Suzuki M: Effects of tower climbing exercise on bone mass, strength, and turnover in growing rats. J Bone Miner Res 16 (2001) 166-174.
99. Peng Z, Tuukkanen J, Vaananen HK: Exercise can provide protection against bone loss and prevent the decrease in mechanical strength of femoral neck in ovariectomized rats. J Bone Miner Res 9 (1994) 1559-1564.
100. Prince RL, Devine A, Dick I, et al.: The effect of calcium supplementation (milk powder or tablets) and exercise on bone density in postmenopausal women. J Bone Miner Res 10 (1995) 1068-1075.
101. Province MA, Hadley EC, Hornbrook MC, et al.: The effects of exercise on falls in elderly patients. A preplanned meta-analysis of the FICSIT Trials. Frailty and Injuries: Cooperative Studies of Intervention Techniques. JAMA 273 (1995) 1341-1347.
102. Puustjarvi K, Nieminen J, Rasanen T, et al.: Do more highly organized collagen fibrils increase bone mechanical strength in loss of mineral density after one-year running training? J Bone Miner Res 14 (1999) 321-329.
103. Pyka G, Wiswell RA, Marcus R: Age-dependent effect of resistance exercise on growth hormone secretion in people. J Clin Endocrinol Metab 75 (1992) 404-407.
104. Qin YX, Rubin CT, McLeod KJ: Nonlinear dependance of loading intensity and cycle number in the maintenance of bone mass and morphology. Journal of Orthopaedic Research 16 (1998) 482-489.
105. Raab DM, Smith EL, Crenshaw TD, Thomas DP: Bone mechanical properties after exercise training in young and old rats. J Appl Physiol 68(1990) 130-134.
106. Raab-Cullen DM, Akhter MP, Kimmel DB, Recker RR: Bone response to alternate-day mechanical loading of the rat tibia. J Bone Miner Res 9 (1994) 203-211.
107. Raab-Cullen DM, Akhter MP, Kimmel DB, Recker RR: Periosteal bone formation stimulated by externally induced bending strength. J Bone Miner Res 9 (1994) 1143-1152.
108. Ringe JD, Ibbeken F, Steinhagen-Thiessen E, Meier-Baumgartner HP: Osteoporoseprävention durch Gymnastik in höherem Lebensalter. Z Geriatrie 1 (1988) 86-90.
109. Robertson MC, Campbell AJ, Gardner MM, Devlin N: Preventing injuries in older people by preventing falls: A meta analysis of individual-level data. J Am Geriatr Soc 50 (2002) 905-911.
110. Robinson TL, Snow-Harter C, Taaffe DR, Gillis D, Shaw J, Marcus R: Gymnasts exhibit higher bone mass than runners despite similar prevalence of amenorrhea and oligomenorrhea. J Bone Miner Res 10 (1995)26-35.
111. Robling AG, Burr DB, Turner CH: Recovery periods restore mechanosensitivity to dynamically loaded bone. J Exp Biol 204 (2001) 3389-3399.
112. Robling AG, Hinant FM, Burr DB, Turner CH: Shorter, more frequent mechanical loading sessions enhance bone mass. Med Sci Sports Exerc 34 (2002) 196-202.
113. Rubin CT, Bain SD, McLeod KJ: Suppression of the osteogenic response in the aging skeleton. Calcif Tissue Int 50 (1992) 306-313.
114. Rubin CT, Donahue HJ, Rubin JE, McLeod KJ: Optimization of electric field parameters for the control of bone remodeling: Exploitation of an indigenous mechanism for the prevention of osteopenia. J Bone Miner Res 8 (1993) Suppl 2, S573-S581.
115. Rubin CT, Lanyon LE: Regulation of bone formation by applied dynamic loads. J Bone Joint Surg Am 66 (1984) 397-402.
116. Rubin CT, Lanyon LE: Regulation of bone mass by mechanical strain magnitude. Calcif Tissue Int 37 (1985) 411-417.
117. Rubin CT, McLeod KJ: Promotion of bony ingrowth by frequency specific, low-amplitude mechanical strain. Clin Orthop 298 (1994) 165-174.
118. Rubin CT, Turner AS, Müller R, et al.: Quantity and quality of trabecular bone in the femur are enhanced by a strongly anabolic, noninvasive mechanical intervention. J Bone Miner Res 17 (2002) 349-357.
119. Schoenau E, Frost HM: The muscle-bone unit in children and adolescents. Calc Tiss Int 75 (2002) 405-407.
120. Seidel EJ, Wick C, Scheibe J: Besonderheiten des sportlichen Trainings beim älteren Menschen. Phys Med 4 (1994) 158-159.
121. Senn E: Grundlagen der positiv-trophischen Wirksamkeit physikalischer Belastung auf normales, osteopenisches und osteoporotisches Knochengewebe. Phys Med 4 (1994) 133-134.
122. Sidney KH, Shephard RJ, Harrison JE: Endurance training and body composition of the elderly. Am J Clin Nutr 30 (1977) 326-333.
123. Simkin A, Leichter I, Swissa A, Samueloff S: The effect of swimming activity on bone architecture in growing rats. J Biomech 22 (1989) 845-851.
124. Sinaki M, Wahner HW, Bergstralh EJ, et al.: Three-year controlled, randomized trial of the effect of dose-specified loading and strengthening exercises on bone mineral density of spine and femur in nonathletic, physically active women. Bone 19 (1996) 233-244.
125. Singh R, Umemura Y, Honda A, Nagasawa S: Maintenance of bone mass and mechanical properties after short-term cessation of high impact exercise in rats. Int J Sports Med 23 (2002) 77-81.
126. Smidt GL, Lin SY, O'Dwyer KD, Blanpied PR: The effect of high-intensity trunk exercise on bone mineral density of postmenopausal women. Spine 17 (1992) 280-285.
127. Smith EL, Reddan W, R. C, et al.: Physical activity and calcium modalities for bone mineral increase in aged women. Med Sci Sports Exerc 13 (1981)60-64.
128. Sogaard CH, Danielsen CC, Thorling EB, Mosekilde L: Long-term exercise of young and adult female rats: effect on femoral neck biomechanical competence and bone structure. J Bone Miner Res 9 (1994) 409-416.
129. Srinivasan S, Weimer DA, Agans SC, Bain SD, Gross TS: Low-magnitude mechanical loading becomes osteogenic when rest is inserted between each load cycle. J Bone Miner Res 17 (2002) 1613-1620.
130. Swissa-Sivan A, Azoury R, Statter A, et al.: The effect of swimming on bone modeling and composition in young adult rats. Calcif Tissue Int 47(1990) 173-177.
131. Swissa-Sivan A, Simkin A, Leichter I, et al.: Effect of swimming on bone growth and development in young rats. Bone Miner 7 (1989) 91-105.
132. Taaffe DR, Snow-Harter C, Connolly DA, Robinson TL, Brown MD, Marcus R: Differential effects of swimming versus weight-bearing activity on bone mineral status of eumenorrheic athletes. J Bone Miner Res 10 (1995)586-593.
133. Turner CH: Homeostatic control of bone structure: an application of feedback theory. Bone 12 (1991) 203-217.
134. Turner CH, Forwood MR, Otter MW: Mechanotransduction in bone: do bone cells act as sensors of fluid flow? Faseb J 8 (1994) 875-878.
135. Turner CH, Forwood MR, Rho JY, Yoshikawa T: Mechanical loading thresholds for lamellar and woven bone formation. J Bone Miner Res 9 (1994)87-97.
136. Turner CH, Owan I, Takano Y: Mechanotransduction in bone: role of strain rate. Am J Physiol Endocrinol Metab 269 (1995) E438-E442.
137. Umemura Y, Ishiko T, Yamauchi T, Kurono M, Mashiko S: Five jumps per day increase bone mass and breaking force in rats. J Bone Miner Res 12 (1997) 1480-1485.
138. Umemura Y, Sogo N, Honda A: Effects of intervals between jumps or bouts on osteogenic response to loading. J Appl Physiol 93 (2002) 1345-1348.
139. van der Wiel HE, Lips P, Graafmans WC, et al.: Additional weight-bearing during exercise is more important than duration of exercise for anabolic stimulus of bone: a study of running exercise in female rats. Bone 16 (1995) 73-80.
140. Veenland JF, Link TM, Konermann W, Meier N, Grashuis JL, Gelsema ES: Unraveling the role of structure and density in determining vertebral bone strength. Calcif Tissue Int 61 (1997) 474-479.
141. Vuori I, Heinonen A, Sievanen H, Kannus P, Pasanen M, Oja P: Effects of unilateral strength training and detraining on bone mineral density and content in young women: a study of mechanical loading and deloading on human bones. Calcif Tissue Int 55 (1994) 59-67.
142. Vuori IM: Dose-response of physical activity and low back pain, osteoarthritis, and osteoporosis. Med Sci Sports Exerc 33 (2001) 6 Suppl, S551-S586.
143. Wallace BA, Cumming RG: Systematic review of randomized trials of the effect of exercise on bone mass in pre- and postmenopausal women. Calcif Tissue Int 67 (2000) 10-18.
144. Weineck J: Optimales Training. Erlangen: Spitta-Verlag, 2000.
145. Westerlind KC, Fluckey JD, Gordon SE, Kraemer WJ, Farrell PA, Turner RT: Effect of resistance exercise training on cortical and cancellous bone in mature male rats. J Appl Physiol 84 (1998) 459-464.
146. Whalen RT, Carter DR: Influence of physical activity on the regulation of bone density. J Biomech 21 (1988) 825-837.
147. Wolff I, van Croonenborg JJ, Kemper HC, Kostense PJ, Twisk JW: The effect of exercise training programs on bone mass: a meta-analysis of published controlled trials in pre- and postmenopausal women. Osteoporos Int 9 (1999) 1-12.
148. Woo SL, Kuei SC, Amiel D, et al.: The effect of prolonged physical training on the properties of long bone: a study of Wolff's Law. J Bone Joint Surg Am 63 (1981) 780-787.
149. Yamagata M, Hideshige M, Goto S, Takahashi K: Relationship between mechanical strength and bone mineral density of the vertebral shell and core. In: Cohn DV, Glorieux FH, Martin TJ, eds. Calcium regulation and bone metabolism: Elsevier Science Publishers, 1990, 502-508.
150. Zittermann A, Sabatschus O, Jantzen S, et al.: Exercise trained young men have higher calcium absorpztion rates and plasma calcitriol levels compared with age-matched sedentary controls. Calcif Tiss Int 67 (2000),:215-219.