Simultaneous determination of dexamethasone and 6β- hydroxydexamethasone in urine using solid-phase extraction and liquid chromatography: Applications to in vivo measurement of cytochrome P450 3A4 activity

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 804, Issue 2, 2004, Pages 421-429

  Zurbonsen, K ^a   Bressolle, F ^a,b   Solassol, I ^a   Aragon, P J ^b   Culine, S ^a   Pinguet, F ^a  

^a CENTRE VAL D AURELLE   (France)

^b UNIV MONTPELLIER   (France)

Author keywords

6 Hydroxydexamethasone; Cytochrome P450; Dexamethasone

Indexed keywords

ENZYMES; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHILICITY; METABOLITES; ULTRAVIOLET DETECTORS;

SOLID PHASE EXTRACTION;

BIOMEDICAL ENGINEERING;

6BETA HYDROXYDEXAMETHASONE; ACETIC ACID ETHYL ESTER; CYTOCHROME P450 3A4; DEXAMETHASONE; DEXAMETHASONE DERIVATIVE; DRUG METABOLITE; ETHER; METHYLPREDNISOLONE; NAVELBINE; SOLVENT; UNCLASSIFIED DRUG;

ACCURACY; ANALYTICAL EQUIPMENT; ARTICLE; CALIBRATION; CONTROLLED STUDY; ELUTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; SEPARATION TECHNIQUE; SOLID PHASE EXTRACTION; ULTRAVIOLET RADIATION; URINALYSIS;

CHROMATOGRAPHY, LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; DEXAMETHASONE; HUMANS; REPRODUCIBILITY OF RESULTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 1842687117     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2004.01.053     Document Type: Article

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