Determination of N-desethylamodiaquine by hydrophilic interaction liquid chromatography with tandem mass spectrometry: Application to in vitro drug metabolism studies

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 863, Issue 1, 2008, Pages 129-134

  Dravid, Prajakta V ^a   Frye, Reginald F ^a  

^a UNIVERSITY OF FLORIDA HEALTH   (United States)

Author keywords

CYP2C8; Cytochrome P450; Desethylamodiaquine; Drug metabolism; HILIC

Indexed keywords

ENZYME ACTIVITY; HYDROPHILICITY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; REACTION KINETICS;

CYTOCHROME P450; DESETHYLAMODIAQUINE; DRUG METABOLISM;

DRUG PRODUCTS;

ACETONITRILE; AMMONIUM ACETATE; CYTOCHROME P450 2C8; DEETHYLAMODIAQUINE; FORMIC ACID; ORGANIC SOLVENT; PHOSPHATE BUFFERED SALINE; SILICON DIOXIDE;

ACCURACY; ARTICLE; DRUG DETERMINATION; DRUG METABOLISM; ELECTROSPRAY; ELUTION; ENZYME KINETICS; FLOW RATE; HUMAN; HYDROPHILICITY; IN VITRO STUDY; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; MASS SPECTROMETRY; PRECIPITATION; PRIORITY JOURNAL; QUANTUM MECHANICS; TANDEM MASS SPECTROMETRY;

AMODIAQUINE; ANTIMALARIALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DATA INTERPRETATION, STATISTICAL; HUMANS; INDICATORS AND REAGENTS; KINETICS; MICROSOMES, LIVER; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SOLVENTS; TANDEM MASS SPECTROMETRY;

EID: 39149137809     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2008.01.017     Document Type: Article

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