Congenic mapping of a blood pressure QTL region on rat chromosome 10 using the Dahl salt-sensitive rat with introgressed alleles from the Milan normotensive strain

Mammalian Genome

Volumn 19, Issue 2, 2008, Pages 85-91

  Saad, Yasser ^a   Toland, Edward J ^a   Yerga Woolwine, Shane ^a   Farms, Phyllis ^a   Joe, Bina ^a  

^a MEDICAL COLLEGE OF OHIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; ANIMAL EXPERIMENT; ARTICLE; BLOOD PRESSURE; CHROMOSOME 10; CONGENIC STRAIN; CONTROLLED STUDY; DAHL SALT SENSITIVE RAT; ESSENTIAL HYPERTENSION; MALE; NONHUMAN; QUANTITATIVE TRAIT LOCUS MAPPING; RAT;

ALLELES; ANIMALS; ANIMALS, CONGENIC; BLOOD PRESSURE; BODY WEIGHT; CHROMOSOME MAPPING; CHROMOSOMES, MAMMALIAN; HEART; INBREEDING; ORGAN SIZE; QUANTITATIVE TRAIT LOCI; RATS; RATS, INBRED DAHL; TELEMETRY;

RATTUS;

EID: 39149135849     PISSN: 09388990     EISSN: 14321777     Source Type: Journal    
DOI: 10.1007/s00335-007-9084-7     Document Type: Article

References (13)

1. Charron S, Duong C, Menard A, Roy J, Eliopoulos V, et al. (2005) Epistasis, not numbers, regulates functions of clustered Dahl rat quantitative trait loci applicable to human hypertension. Hypertension 46:1300-1308
2. Cowley AW Jr (2006) The genetic dissection of essential hypertension. Nat Rev Genet 7:829-840
3. Deng AY (2007) Positional cloning of quantitative trait loci for blood pressure: how close are we?: a critical perspective. Hypertension 49:740-747
4. Dukhanina OI, Dene H, Deng AY, Choi CR, Hoebee B, et al. (1997) Linkage map and congenic strains to localize blood pressure QTL on rat chromosome 10. Mamm Genome 8:229-235
5. Garrett MR, Rapp JP (2002) Two closely linked interactive blood pressure QTL on rat chromosome 5 defined using congenic Dahl rats. Physiol Genomics 8:81-86
6. Garrett MR, Zhang X, Dukhanina OI, Deng AY, Rapp JP (2001) Two linked blood pressure quantitative trait loci on chromosome 10 defined by Dahl rat congenic strains. Hypertension 38:779-785
7. Joe B, Garrett MR (2006) Genetic analysis of inherited hypertension in the rat. In: Dominiczak A, Connell J (eds) Genetics of Hypertension. Elsevier Science: New York, pp. 177-200
8. Kreutz R, Hubner N, James MR, Bihoreau MT, Gauguier D, et al. (1995) Dissection of a quantitative trait locus for genetic hypertension on rat chromosome 10. Proc Natl Acad Sci USA 92:8778-8782
9. Monti J, Plehm R, Schulz H, Ganten D, Kreutz R, et al. (2003) Interaction between blood pressure quantitative trait loci in rats in which trait variation at chromosome 1 is conditional upon a specific allele at chromosome 10. Hum Mol Genet 12:435-439
10. Rapp JP (2000) Genetic analysis of inherited hypertension in the rat. Physiol Rev 80:135-172
11. Saad Y, Garrett MR, Manickavasagam E, Yerga-Woolwine S, Farms P, et al. (2007a) Fine-mapping and comprehensive transcript analysis reveals nonsynonymous variants within a novel 1.17 Mb blood pressure QTL region on rat chromosome 10. Genomics 89:343-353
12. Saad Y, Yerga-Woolwine S, Saikumar J, Farms P, Manickavasagam E, et al. (2007b) Congenic interval mapping of RNO10 reveals a complex cluster of closely-linked genetic determinants of blood pressure. Hypertension 50:891-898
13. Zagato L, Modica R, Florio M, Torielli L, Bihoreau MT, et al. (2000) Genetic mapping of blood pressure quantitative trait loci in Milan hypertensive rats. Hypertension 36:734-739