Topical antisense-oligonucleotides targeting IFN-gamma mRNA improve incidence and severity of herpetic stromal keratitis by cytokine specific and sequence unspecific effects

Graefe's Archive for Clinical and Experimental Ophthalmology

Volumn 246, Issue 3, 2008, Pages 443-451

  Wasmuth, Susanne ^a,b   Bauer, Dirk ^a   Steuhl, Klaus Peter ^b   Heiligenhaus, Arnd ^a  

^a ST FRANZISKUS HOSPITAL   (Germany)

^b UNIVERSITY OF DUISBURG ESSEN   (Germany)

Author keywords

Antisense oligonucleotides; Experimental keratitis; Herpes simplex virus 1; IFN

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; GAMMA INTERFERON; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE SEVERITY; DRUG EFFICACY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE SEQUENCE; HERPES SIMPLEX KERATITIS; HERPES SIMPLEX VIRUS 1; HISTOPATHOLOGY; INCIDENCE; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN TARGETING;

ADMINISTRATION, TOPICAL; ANIMALS; CORNEAL STROMA; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE TARGETING; HERPESVIRUS 1, HUMAN; HYPERSENSITIVITY, DELAYED; INTERFERON TYPE II; KERATITIS, HERPETIC; MICE; MICE, INBRED BALB C; OLIGONUCLEOTIDES, ANTISENSE; RNA, MESSENGER; SPLEEN; VIRUS REPLICATION;

EID: 39149125473     PISSN: 0721832X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00417-007-0707-1     Document Type: Article

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