Cat odor, but not trimethylthiazoline (fox odor), activates accessory olfactory and defense-related brain regions in rats

Neuroscience

Volumn 151, Issue 4, 2008, Pages 937-947

  Staples, L G ^a   McGregor, I S ^a   Apfelbach, R ^b   Hunt, G E ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

amygdala; anxiety; AOB; c Fos; olfaction; predator

Indexed keywords

FORMALDEHYDE; PROTEIN C FOS; THIAZOLE DERIVATIVE; TRIMETHYLTHIAZOLINE; UNCLASSIFIED DRUG;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ARTICLE; BRAIN REGION; CONTROLLED STUDY; FOX; IMMUNOHISTOCHEMISTRY; MALE; NERVE CELL; NONHUMAN; OLFACTORY BULB; OLFACTORY DISCRIMINATION; ORBITAL CORTEX; PRIORITY JOURNAL; PYRIFORM CORTEX; RAT; REARING;

AGGRESSION; ANALYSIS OF VARIANCE; ANIMALS; BEHAVIOR, ANIMAL; BRAIN; CATS; ESCAPE REACTION; FOXES; MALE; ODORS; OLFACTORY BULB; OLFACTORY PATHWAYS; PROTO-ONCOGENE PROTEINS C-FOS; RATS; SMELL;

EID: 39149112483     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2007.11.039     Document Type: Article

References (40)

1. Blanchard D.C., Markham C., Yang M., Hubbard D., Madarang E., and Blanchard R.J. Failure to produce conditioning with low-dose trimethylthiazoline or cat feces as unconditioned stimuli. Behav Neurosci 117 (2003) 360-368
2. Blanchard R.J., Blanchard D.C., Weiss S.M., and Meyer S. The effects of ethanol and diazepam on reactions to predatory odors. Pharmacol Biochem Behav 35 (1990) 775-780
3. Blanchard R.J., Yang M., Li C.-I., Gervacio A., and Blanchard D.C. Cue and context conditioning of defensive behaviors to cat odor stimuli. Neurosci Biobehav Rev 25 (2001) 587-595
4. Boucher Y., Simons C.T., Cuellar J.M., Jung S.-W., Carstens M.I., and Carstens E. Activation of brain stem neurons by irritant chemical stimulation of the throat assessed by c-fos immunohistochemistry. Exp Brain Res 148 (2003) 211-218
5. Brennan P., and Kendrick K. Mammalian social odours: attraction and individual recognition. Philos Trans R Soc B 361 (2006) 2061-2078
6. Brunjes P.C., Illig K.R., and Meyer E.A. A field guide to the anterior olfactory nucleus (cortex). Brain Res Rev 50 (2005) 305-335
7. Canteras N.S., Chiavegatto S., Ribeiro do Valle L.E., and Swanson L.W. Severe reduction of rat defensive behavior to a predator by discrete hypothalamic chemical lesions. Brain Res Bull 44 (1997) 297-305
8. Chang Y.-M., Kelliher K.R., and Baum M.J. Maternal odours induce Fos in the main but not the accessory olfactory bulbs of neonatal male and female ferrets. J Neuroendocrinol 13 (2001) 551-560
9. Clugnet M.-C., and Price J.L. Olfactory input to the prefrontal cortex in the rat. Ann N Y Acad Sci 510 (1987) 231-235
10. Cooper H.M., Parvopassu F., Herbin M., and Magnin M. Neuroanatomical pathways linking vision and olfaction in mammals. Psychoneuroendocrinology 19 (1994) 623-639
11. Davis M., and Whalen P.J. The amygdala: Vigilance and emotion. Mol Psychiatry 6 (2001) 13-34
12. Day H.E.W., Masini C.V., and Campeau S. The pattern of brain c-fos mRNA induced by a component of fox odor, 2,5-dihydro-2,4,5-trimethylthiazoline (TMT), in rats, suggests both systemic and processive stress characteristics. Brain Res 1025 (2004) 139-151
13. Dielenberg R.A., Arnold J.C., and Mcgregor I.S. Low-dose midazolam attenuates predatory odor avoidance in rats. Pharmacol Biochem Behav 62 (1999) 197-201
14. Dielenberg R.A., Hunt G.E., and McGregor I.S. "When a rat smells a cat": the distribution of Fos immunoreactivity in rat brain following exposure to a predatory odor. Neuroscience 104 (2001) 1085-1097
15. Fanselow M.S., and Poulos A.M. The neuroscience of mammalian associative learning. Annu Rev Psychol 56 (2005) 207-234
16. Fendt M., Endres T., and Apfelbach R. Temporary inactivation of the bed nucleus of the stria terminalis but not of the amygdala blocks freezing induced by trimethylthiazoline, a component of fox feces. J Neurosci 23 (2003) 23-28
17. Fendt M., Endres T., Lowry C.A., Apfelbach R., and McGregor I.S. TMT-induced autonomic and behavioral changes and the neural basis of its processing. Neurosci Biobehav Rev 29 (2005) 1145-1156
18. Ghatpande A.S., Sivaraaman K., and Vijayaraghavan S. Store calcium mediates cholinergic effects on mIPSCs in the rat main olfactory bulb. J Neurophysiol 95 (2006) 1345-1355
19. Hubbard D.T., Blanchard D.C., Yang M., Markham C.M., Gervacio A., Chun-I L., and Blanchard R.J. Development of defensive behavior and conditioning to cat odor in the rat. Physiol Behav 80 (2004) 525-530
20. Illig K.R., and Haberly L.W. Odor-evoked activity is spatially distributed in piriform cortex. J Comp Neurol 457 (2003) 361-373
21. Kats L.B., and Dill L.M. The scent of death: Chemosensory assessment of predation risk by prey animals. Ecoscience 5 (1998) 361-394
22. LeDoux J. The emotional brain, fear, and the amygdala. Cell Mol Neurobiol 23 (2003) 727-738
23. Linster C., and Hasselmo M.E. Neural activity in the horizontal limb of the diagonal band of Broca can be modulated by electrical stimulation of the olfactory bulb and cortex in rats. Neurosci Lett 282 (2000) 157-160
24. Maren S., and Quirk G.J. Neuronal signalling of fear memory. Nat Rev Neurosci 5 (2004) 844-852
25. McGregor I.S., Hargreaves G.A., Apfelbach R., and Hunt G.E. Neural correlates of cat odor-induced anxiety in rats: region-specific effects of the benzodiazepine midazolam. J Neurosci 24 (2004) 4134-4144
26. McGregor I.S., Schrama L., Ambermoon P., and Dielenberg R.A. Not all "predator odours" are equal: cat odour but not 2,4,5 trimethylthiazoline (TMT; fox odour) elicits specific defensive behaviours in rats. Behav Brain Res 129 (2002) 1-16
27. Myers E.A., and Rinaman L. Trimethylthiazoline supports conditioned flavor avoidance and activates viscerosensory, hypothalamic, and limbic circuits in rats. Am J Physiol Regul Integr Comp Physiol 288 (2005) R1716-R1726
28. Paxinos G., and Watson C. The rat brain in stereotaxic coordinates (1997), Academic Press, Sydney
29. Price J.L., Slotnic B.M., and Revial M.F. Olfactory projections to the hypothalamus. J Comp Neurol 306 (1991) 447-461
30. Rosen J.B. The neurobiology of conditioned and unconditioned fear: A neurobehavioral system analysis of the amygdala. Behav Cogn Neurosci Rev 3 (2004) 23-41
31. Rosen J.B., West E.A., and Donley M.P. Not all rat strains are equal: differential unconditioned fear responses to the synthetic fox odor 2,4,5-trimethylthiazoline in three outbred rat strains. Behav Neurosci 120 (2006) 290-297
32. Schoenfeld T.A., and Cleland T.A. The anatomical logic of smell. Trends Neurosci 28 (2005) 620-627
33. Staples L.G., Hunt G.E., Cornish J.L., and McGregor I.S. Neural activation during cat odor-induced conditioned fear and "trial 2" fear in rats. Neurosci Biobehav Rev 29 (2005) 1265-1277
34. Staples L.G., and McGregor I.S. Defensive responses of Wistar and Sprague-Dawley rats to cat odour and TMT. Behav Brain Res 172 (2006) 351-354
35. Takahashi L.K., Nakashima B.R., Hong H., and Watanabe K. The smell of danger: A behavioral and neural analysis of predator odor-induced fear. Neurosci Biobehav Rev 29 (2005) 1157-1167
36. Wallace K.J., and Rosen J.B. Predator odor as an unconditioned fear stimulus in rats: Elicitation of freezing by trimethylthiazoline, a component of fox feces. Behav Neurosci 114 (2000) 912-922
37. Weiler E., Deutsch S., and Apfelbach R. Combined behavioral and c-Fos studies elucidate the vital role of sodium for odor detection. Chem Senses 31 (2006) 641-647
38. Wilensky A.E., Schafe G.E., Kristensen M.P., and LeDoux J.E. Rethinking the fear circuit: The central nucleus of the amygdala is required for the acquisition, consolidation, and expression of pavlovian fear conditioning. J Neurosci 26 (2006) 12387-12396
39. Yonemori M., Nishijo H., Uwano T., Tamura R., Furuta I., Kawasaki M., Takashima Y., and Ono T. Orbital cortex neuronal responses during an odor-based conditioned associative task in rats. Neuroscience 95 (2000) 691-703
40. Zangrossi J., Helio, and File S.E. Behavioral consequences in animal tests of anxiety and exploration of exposure to cat odor. Brain Res Bull 29 (1992) 381-388