Failure to produce conditioning with low-dose trimethylthiazoline or cat feces as unconditioned stimuli

Behavioral Neuroscience

Volumn 117, Issue 2, 2003, Pages 360-368

  Blanchard, D Caroline ^a,d   Markham, Chris ^b   Yang, Mu ^b   Hubbard, David ^b   Madarang, Eric ^c   Blanchard, Robert J ^b  

^a UNIVERSITY OF HAWAII   (United States)

^b UNIVERSITY OF HAWAII   (United States)

^c UNIVERSITY OF GUAM   (Guam)

^d UNIVERSITY OF HAWAII   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

THIAZOLE DERIVATIVE; TRIMETHYLTHIAZOLINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; AVERSION; CAT; CONDITIONING; CONTROLLED STUDY; DEFENSIVE BEHAVIOR; FECES; MALE; NONHUMAN; ODOR; RAT; SKIN; URINE;

ANIMALS; ANXIETY; AVOIDANCE LEARNING; CATS; CONDITIONING (PSYCHOLOGY); CONDITIONING, CLASSICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEAR; FECES; MALE; ODORS; RATS; RATS, LONG-EVANS; THIAZOLES; TIME FACTORS;

EID: 0037380662     PISSN: 07357044     EISSN: None     Source Type: Journal    
DOI: 10.1037/0735-7044.117.2.360     Document Type: Article

References (46)

1. Adamec, R. E., & Shallow, T. (1993). Lasting effects on rodent anxiety of a single exposure to a cat. Physiology & Behavior, 54, 101-109.
2. Adamec, R. E., Shallow, T., & Budgell, J. (1997). Blockade of CCK(B) but not CCK(A) receptors before and after the stress of predator exposure prevents lasting increases in anxiety-like behavior: Implications for anxiety associated with posttraumatic stress disorder. Behavioral Neuroscience, 111, 435-449.
3. Anisman, H., Hayley, S., Kelly, O., Borowski, T., & Merali, Z. (2001). Psychogenic, neurogenic, and systemic stressor effects on plasma corticosterone and behavior: Mouse strain-dependent outcomes. Behavioral Neuroscience, 115, 443-454.
4. Blanchard, D. C., Blanchard R. J., Rodgers R. J. (1991). Risk assessment and animal models of anxiety. In B. Olivier, J. Mos, & J. L. Slangen (Eds.), Animal models in psychopharmacology (pp. 117-134). Basel, Switzerland: Birkhauser Verlag AG.
5. Blanchard, D. C., Blanchard R. J., Tom, P., & Rodgers R. J. (1990). Diazepam alters risk assessment in an anxiety/defense test battery. Psychopharmacology (Berlin), 511-518.
6. Blanchard, D. C., Griebel, G., Rodgers, R. J., & Blanchard, R. J. (1998). Benzodiazepine and serotonergic modulation of antipredator and conspecific defense. Neuroscience and Biobehavioral Reviews, 22, 597-612.
7. Blanchard, D. C., Lee, E. M. C., Williams, G., & Blanchard, R. J. (1981). Taming of Rattus norvegicus by lesions of the mesencephalic central gray. Physiological Psychology, 9, 157-163.
8. Blanchard, D. C., Rodgers R. J., Hori, K., Hendrie, C. A., & Blanchard, R. J. (1989). Attenuation of defensive threat and attack in wild rats (Rattus rattus) by benzodiazepines. Psychopharmacology (Berlin), 97, 392-401.
9. Blanchard, R. J. (2000). [Analyses of response to cat odor stimuli]. Unpublished raw data.
10. Blanchard, R. J., & Blanchard, D. C. (1971). Defensive reactions in the albino rat. Learning and Motivation, 21, 351-362.
11. Blanchard, R. J., & Blanchard, D. C. (1972). Effects of hippocampal lesions on the rat's reaction to a cat. Journal of Comparative and Physiological Psychology, 78, 77-82.
12. Blanchard, R. J., & Blanchard, D. C. (1989). Anti-predator defensive behaviors in a visible burrow system. Journal of Comparative and Physiological Psychology, 103, 70-82.
13. Blanchard, R. J., Blanchard, D. C., & Hori, K. (1989). Ethoexperimental approaches to the study of defensive behavior. In R. J. Blanchard, P. F. Brain, D. C. Blanchard, & S. Parmigiani (Eds.), Ethoexperimental approaches to the study of behavior (pp. 114-136). Dordrecht, the Netherlands: Kluwer Academic Publishers.
14. Blanchard, R. J., Blanchard, D. C., Weiss, S. M., & Meyer, S. (1990). The effects of ethanol and diazepam on reactions to predatory odors. Pharmacology Biochemistry and Behavior, 35, 775-780.
15. Blanchard, R. J., Griebel, G., Henrie, J. A., & Blanchard, D. C. (1997). Differentiation of anxiolytic and panicolytic drugs by effects on rat and mouse defense test batteries. Neuroscience and Biobehavioral Reviews, 21, 783-789.
16. Blanchard, R. J., Yang, M., Li, C.-I., Garvacio, A., & Blanchard, D. C. (2001). Cue and context conditioning of defensive behaviors to cat odor stimuli. Neuroscience and Biobehavioral Reviews, 26, 587-595.
17. Brashares, J. S., & Arcese, P. (1999). Scent marking in a territorial African antelope: II. The economics of marking with feces. Animal Behaviour, 57, 11-17.
18. Burwash, M. D., Tobin, M. E., Woolhouse, A. D., & Sullivan, T. P. (1998a). Field testing synthetic predator odors for roof rats (Rattus rattus) in Hawaiian macadamia nut orchards. Journal of Chemical Ecology, 24, 603-630.
19. Burwash, M. D., Tobin, M. E., Woolhouse, A. D., & Sullivan, T. P. (1998b). Laboratory evaluation of predator odors for eliciting an avoidance response in roof rats (Rattus rattus). Journal of Chemical Ecology, 24, 49-66.
20. Dielenberg, R. A., Arnold, J. C., & McGregor, I. S. (1999). Low-dose midazolam attenuates predatory odor avoidance in rats. Pharmacology Biochemistry and Behavior, 62, 197-201.
21. Dielenberg, R. A., Carrive, P., & McGregor, I. S. (2001). The cardiovascular and behavioral response to cat odor in rats: Unconditioned and conditioned effects. Brain Research, 897, 228-237.
22. Dielenberg, R. A., & McGregor, I. S. (1999). Habituation of the hiding response to cat odor in rats (Rattus norvegicus). Journal of Comparative Psychology, 113, 376-387.
23. Dielenberg, R. A., & McGregor, I. S. (2001). Defensive behavior in rats towards predatory odors: A review. Neuroscience and Biobehavioral Reviews, 7-8, 597-609.
24. Enomoto, S., Asano, R., Iwahori, Y., Narui, T., Okada, Y., Singab, A. N., & Okuyama, T. (2001). Hematological studies on black cumin oil from the seeds of Nigella sativa L. Biological Pharmacology Bulletin, 24, 307-310.
25. File, S. E., & Zangrossi, H., Jr. (1993). "One-trial tolerance" to the anxiolytic actions of benzodiazepines in the elevated plus-maze, or the development of a phobic state? Psychopharmacology (Berlin), 110, 240-244.
26. Funk, D., & Amir, S. (2000). Circadian modulation of Fos responses to odor of the red fox, a rodent predator, in the rat olfactory system. Brain Research, 866, 262-267.
27. Gese, E. M., & Ruff, R. L. (1997). Scent-marking by coyotes, Canis latrans: The influence of social and ecological factors. Animal Behaviour, 54, 1155-1166.
28. Gomes-Carneiro, M. R., Felzenszwalb, I., & Paumgartten, F. J. (1998). Mutagenicity testing (+/-)-camphor, 1,8-cineole, citral, citronellal, (-)-menthol and terpineol with the salmonella/microsome assay. Mutation Research, 416, 129-136.
29. Griebel, G., Blanchard, D. C., Agnes, R., & Blanchard, R. J. (1995). Differential modulation of antipredator defensive behavior in Swiss-Webster mice following acute and chronic treatment with imipramine and fluoxetine. Psychopharmacology (Berlin), 120, 57-66.
30. Griebel, G., Blanchard, D. C., & Blanchard, R. J. (1996). Predator-elicited flight responses in Swiss-Webster mice: An experimental model of panic attacks. Progress in Psychopharmacology and Biological Psychiatry, 20, 185-205.
31. Griebel, G., Blanchard, D. C., Jung, A., & Blanchard, R. J. (1995). A model of "antipredator" defense in Swiss-Webster mice: Effects of benzodiazepine receptor ligands with different intrinsic activities. Behavioral Pharmacology, 6, 732-745.
32. Griebel, G., Blanchard, D. C., Jung, A., Masuda, C. K., & Blanchard, R. J. (1995). Further evidence that the Mouse Defense Test Battery is useful for screening anxiolytic and panicolytic drugs: Effects of acute and chronic treatment with alprazolam. Neuropharmacology, 34, 1625-1633.
33. Hotsenpiller, G., & Williams, J. L. (1997). A synthetic predator odor (TMT) enhances conditioned analgesia and fear when paired with a benzodiazepine receptor inverse agonist (FG-7142). Psychobiology, 25, 83-88.
34. Kavaliers, M., Colwell, D. D., & Perrot-Sinal, T. S. (1997). Opioid and non-opioid NMDA-mediated predator-induced analgesia in mice and the effects of parasitic infection. Brain Research, 766, 11-18.
35. McGregor, I. S., Schrama, L., Ambermoon, P., & Dielenberg, R. A. (2002). Not all "predator odors" are equal: Cat odor but not 2,4,5 trimethylthiazoline (TMT: fox odor) elicits specific defensive behaviours in rats. Behavioural Brain Research, 129, 1-16.
36. Morrow, B. A., Redmond, A. J., Roth, R. H., & Elsworth, J. D. (2000). The predator odor, TMT, displays a unique, stress-like pattern of dopaminergic and endocrinological activation in the rat. Brain Research, 864, 146-151.
37. Morrow, B. A., Roth, R. H., & Elsworth, J. D. (2000). TMT, a predator odor, elevates mesoprefrontal dopamine metabolic activity and disrupts short-term working memory in the rat. Brain Research Bulletin, 52, 519-523.
38. Pereira, S. I., Santos, P. A., Barroso, J. G., Figueiredo, A. C., Pedro, L. G., Salgueiro, L. R., et al. (2000). Chemical polymorphism of the essential oils from populations of Thymus caespilitius grown on the island S. Jorge (Azores). Phytochemistry, 55, 241-246.
39. Perrot-Sinal, T. S., Ossenkopp, K. P., & Kavaliers, M. (1999). Brief predator odour exposure activates the HPA axis independent of locomotor changes. NeuroReport, 10, 775-780.
40. Perrot-Sinal, T. S., Ossenkopp, K. P., & Kavaliers, M. (2000). Influence of a natural stressor (predator odor) on locomotor activity in the meadow vole (Microtus pennsylvanicus): Modulation by sex, reproductive condition and gonadal hormones. Psychoneuroendocrinology, 25, 259-276.
41. Vernet, M. E., Constant, B., & Chanel, J. (1992). Repellent effects of trimethylthiazoline in the wild rat Rattus norvegicus Berkenout. In R. L. Doty & D. Muller-Schwarze (Eds.), Chemical signals in vertebrates (Vol. 6., pp. 305-310). New York: Plenum Press.
42. Wallace, K. J., & Rosen, J. B. (2000). Predator odor as an unconditioned fear stimulus in rats: Elicitation of freezing by trimethylthiazoline, a component of fox feces. Behavioral Neuroscience, 114, 912-922.
43. Wallace, K. J., & Rosen, J. B. (2001). Neurotoxic lesions of the lateral nucleus of the amygdala decrease conditioned fear but not unconditioned fear of a predator odor: Comparison with electrolytic lesions. Journal of Neuroscience, 21, 3619-3627.
44. Zangrossi, H., Jr., & File, S. E. (1992a). Behavioral consequences in animal tests of anxiety and exploration of exposure to cat odor. Brain Research Bulletin, 29, 381-388.
45. Zangrossi, H., Jr., & File, S. E. (1992b). Chlordiazepoxide reduces the generalised anxiety, but not the direct responses, of rats exposed to cat odor. Pharmacology Biochemistry and Behavior, 43, 1195-1200.
46. Zibrowski, E. M., Hoh, T. E., & Vanderwolf, C. H. (1998). Fast wave activity in the rat rhinencephalon: Elicitation by the odors of phytochemicals, organic solvents, and a rodent predator. Brain Research, 800, 207-215.