-
2
-
-
0035139885
-
Lipopolysaccharide-induced gelatinase granule mobilization primes neutrophils for activation by galectin-3 and formylmethionyl-Leu-Phe
-
Almkvist J., Faldt J., Dahlgren C., Leffler H., and Karlsson A. Lipopolysaccharide-induced gelatinase granule mobilization primes neutrophils for activation by galectin-3 and formylmethionyl-Leu-Phe. Infect. Immun. 69 (2001) 832
-
(2001)
Infect. Immun.
, vol.69
, pp. 832
-
-
Almkvist, J.1
Faldt, J.2
Dahlgren, C.3
Leffler, H.4
Karlsson, A.5
-
3
-
-
3042778592
-
Newcastle disease virus neuraminidase primes neutrophils for stimulation by galectin-3 and formyl-Met-Leu-Phe
-
Almkvist J., Dahlgren C., Leffler H., and Karlsson A. Newcastle disease virus neuraminidase primes neutrophils for stimulation by galectin-3 and formyl-Met-Leu-Phe. Exp. Cell Res. 298 (2004) 74
-
(2004)
Exp. Cell Res.
, vol.298
, pp. 74
-
-
Almkvist, J.1
Dahlgren, C.2
Leffler, H.3
Karlsson, A.4
-
4
-
-
0023258084
-
Cell surface expression of fMet-Leu-Phe receptors on human neutrophils. Correlation to changes in the cytosolic free Ca2+ level and action of phorbol myristate acetate
-
Andersson T., Dahlgren C., Lew P.D., and Stendahl O. Cell surface expression of fMet-Leu-Phe receptors on human neutrophils. Correlation to changes in the cytosolic free Ca2+ level and action of phorbol myristate acetate. J. Clin. Invest. 79 (1987) 1226
-
(1987)
J. Clin. Invest.
, vol.79
, pp. 1226
-
-
Andersson, T.1
Dahlgren, C.2
Lew, P.D.3
Stendahl, O.4
-
5
-
-
0019453314
-
Statistical aspects of cell motility determinations with a modified chemotaxis assembly for multiwell filter assays
-
Axelsson L.G., Nilsson G., and Bjorksten B. Statistical aspects of cell motility determinations with a modified chemotaxis assembly for multiwell filter assays. J. Immunol. Methods 46 (1981) 251
-
(1981)
J. Immunol. Methods
, vol.46
, pp. 251
-
-
Axelsson, L.G.1
Nilsson, G.2
Bjorksten, B.3
-
6
-
-
0025791955
-
Separation of leucocytes: improved cell purity by fine adjustments of gradient medium density and osmolality
-
Boyum A., Lovhaug D., Tresland L., and Nordlie E.M. Separation of leucocytes: improved cell purity by fine adjustments of gradient medium density and osmolality. Scand. J. Immunol. 34 (1991) 697
-
(1991)
Scand. J. Immunol.
, vol.34
, pp. 697
-
-
Boyum, A.1
Lovhaug, D.2
Tresland, L.3
Nordlie, E.M.4
-
7
-
-
0036263438
-
Lipopolysaccharide-induced granule mobilization and priming of the neutrophil response to Helicobacter pylori peptide Hp(2-20), which activates formyl peptide receptor-like 1
-
Bylund J., Karlsson A., Boulay F., and Dahlgren C. Lipopolysaccharide-induced granule mobilization and priming of the neutrophil response to Helicobacter pylori peptide Hp(2-20), which activates formyl peptide receptor-like 1. Infect. Immun. 70 (2002) 2908
-
(2002)
Infect. Immun.
, vol.70
, pp. 2908
-
-
Bylund, J.1
Karlsson, A.2
Boulay, F.3
Dahlgren, C.4
-
8
-
-
10444284915
-
Cytochalasin B triggers a novel pertussis toxin sensitive pathway in TNF-alpha primed neutrophils
-
Bylund J., Pellme S., Fu H., Mellqvist U.H., Hellstrand K., Karlsson A., and Dahlgren C. Cytochalasin B triggers a novel pertussis toxin sensitive pathway in TNF-alpha primed neutrophils. BMC Cell Biol. 5 (2004) 21
-
(2004)
BMC Cell Biol.
, vol.5
, pp. 21
-
-
Bylund, J.1
Pellme, S.2
Fu, H.3
Mellqvist, U.H.4
Hellstrand, K.5
Karlsson, A.6
Dahlgren, C.7
-
9
-
-
0035877580
-
The synthetic peptide Trp-Lys-Tyr-Met-Val-Met-NH2 specifically activates neutrophils through FPRL1/lipoxin A4 receptors and is an agonist for the orphan monocyte-expressed chemoattractant receptor FPRL2
-
Christophe T., Karlsson A., Dugave C., Rabiet M.J., Boulay F., and Dahlgren C. The synthetic peptide Trp-Lys-Tyr-Met-Val-Met-NH2 specifically activates neutrophils through FPRL1/lipoxin A4 receptors and is an agonist for the orphan monocyte-expressed chemoattractant receptor FPRL2. J. Biol. Chem. 276 (2001) 21585
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 21585
-
-
Christophe, T.1
Karlsson, A.2
Dugave, C.3
Rabiet, M.J.4
Boulay, F.5
Dahlgren, C.6
-
11
-
-
0025762586
-
Effects of tenoxicam on superoxide anion formation, beta-glucuronidase release and fMLP binding in human neutrophils: comparison with other NSAIDs
-
Colli S., Colombo S., Tremoli E., Stragliotto E., and Nicosia S. Effects of tenoxicam on superoxide anion formation, beta-glucuronidase release and fMLP binding in human neutrophils: comparison with other NSAIDs. Pharmacol. Res. 23 (1991) 367
-
(1991)
Pharmacol. Res.
, vol.23
, pp. 367
-
-
Colli, S.1
Colombo, S.2
Tremoli, E.3
Stragliotto, E.4
Nicosia, S.5
-
12
-
-
0019978862
-
Effect of in vitro preincubation of polymorphonuclear leukocytes on formylmethionyl-leucyl-phenylalanine-induced chemiluminescence
-
Dahlgren C., and Stendahl O. Effect of in vitro preincubation of polymorphonuclear leukocytes on formylmethionyl-leucyl-phenylalanine-induced chemiluminescence. Infect. Immun. 37 (1982) 34
-
(1982)
Infect. Immun.
, vol.37
, pp. 34
-
-
Dahlgren, C.1
Stendahl, O.2
-
13
-
-
0020670097
-
Role of myeloperoxidase in luminol-dependent chemiluminescence of polymorphonuclear leukocytes
-
Dahlgren C., and Stendahl O. Role of myeloperoxidase in luminol-dependent chemiluminescence of polymorphonuclear leukocytes. Infect. Immun. 39 (1983) 736
-
(1983)
Infect. Immun.
, vol.39
, pp. 736
-
-
Dahlgren, C.1
Stendahl, O.2
-
15
-
-
0034161336
-
The synthetic chemoattractant Trp-Lys-Tyr-Met-Val-DMet activates neutrophils preferentially through the lipoxin A(4) receptor
-
Dahlgren C., Christophe T., Boulay F., Madianos P.N., Rabiet M.J., and Karlsson A. The synthetic chemoattractant Trp-Lys-Tyr-Met-Val-DMet activates neutrophils preferentially through the lipoxin A(4) receptor. Blood 95 (2000) 1810
-
(2000)
Blood
, vol.95
, pp. 1810
-
-
Dahlgren, C.1
Christophe, T.2
Boulay, F.3
Madianos, P.N.4
Rabiet, M.J.5
Karlsson, A.6
-
16
-
-
0002611354
-
Ratios involving extreme values
-
Dixon W.J. Ratios involving extreme values. Ann. Math. Stat. 22 (1951) 68
-
(1951)
Ann. Math. Stat.
, vol.22
, pp. 68
-
-
Dixon, W.J.1
-
17
-
-
27544444375
-
Integration of virtual screening with high-throughput flow cytometry to identify novel small molecule formylpeptide receptor antagonists
-
Edwards B.S., Bologa C., Young S.M., Balakin K.V., Prossnitz E.R., Savchuck N.P., Sklar L.A., and Oprea T.I. Integration of virtual screening with high-throughput flow cytometry to identify novel small molecule formylpeptide receptor antagonists. Mol. Pharmacol. 68 (2005) 1301
-
(2005)
Mol. Pharmacol.
, vol.68
, pp. 1301
-
-
Edwards, B.S.1
Bologa, C.2
Young, S.M.3
Balakin, K.V.4
Prossnitz, E.R.5
Savchuck, N.P.6
Sklar, L.A.7
Oprea, T.I.8
-
18
-
-
0024370014
-
Human neutrophil chemiluminescence and f-Meth-Leu-Phe receptor exposure in bacterial infections
-
Follin P., Briheim G., Sandstedt S., and Dahlgren C. Human neutrophil chemiluminescence and f-Meth-Leu-Phe receptor exposure in bacterial infections. Apmis 97 (1989) 585
-
(1989)
Apmis
, vol.97
, pp. 585
-
-
Follin, P.1
Briheim, G.2
Sandstedt, S.3
Dahlgren, C.4
-
19
-
-
0025772854
-
Human neutrophil migration into skin chambers is associated with production of NAP-1/IL8 and C5a
-
Follin P., Wymann M.P., Dewald B., Ceska M., and Dahlgren C. Human neutrophil migration into skin chambers is associated with production of NAP-1/IL8 and C5a. Eur. J. Haematol. 47 (1991) 71
-
(1991)
Eur. J. Haematol.
, vol.47
, pp. 71
-
-
Follin, P.1
Wymann, M.P.2
Dewald, B.3
Ceska, M.4
Dahlgren, C.5
-
20
-
-
24744438566
-
The two neutrophil members of the formylpeptide receptor family activate the NADPH-oxidase through signals that differ in sensitivity to a gelsolin derived phosphoinositide-binding peptide
-
Fu H., Bjorkman L., Janmey P., Karlsson A., Karlsson J., Movitz C., and Dahlgren C. The two neutrophil members of the formylpeptide receptor family activate the NADPH-oxidase through signals that differ in sensitivity to a gelsolin derived phosphoinositide-binding peptide. BMC Cell Biol. 5 (2004) 50
-
(2004)
BMC Cell Biol.
, vol.5
, pp. 50
-
-
Fu, H.1
Bjorkman, L.2
Janmey, P.3
Karlsson, A.4
Karlsson, J.5
Movitz, C.6
Dahlgren, C.7
-
21
-
-
2542553381
-
The mechanism for activation of the neutrophil NADPH-oxidase by the peptides formyl-Met-Leu-Phe and Trp-Lys-Tyr-Met-Val-Met differs from that for interleukin-8
-
Fu H., Bylund J., Karlsson A., Pellme S., and Dahlgren C. The mechanism for activation of the neutrophil NADPH-oxidase by the peptides formyl-Met-Leu-Phe and Trp-Lys-Tyr-Met-Val-Met differs from that for interleukin-8. Immunology 112 (2004) 201
-
(2004)
Immunology
, vol.112
, pp. 201
-
-
Fu, H.1
Bylund, J.2
Karlsson, A.3
Pellme, S.4
Dahlgren, C.5
-
22
-
-
33646042375
-
Ligand recognition and activation of formyl peptide receptors in neutrophils
-
Fu H., Karlsson J., Bylund J., Movitz C., Karlsson A., and Dahlgren C. Ligand recognition and activation of formyl peptide receptors in neutrophils. J. Leukoc. Biol. 79 (2006) 247
-
(2006)
J. Leukoc. Biol.
, vol.79
, pp. 247
-
-
Fu, H.1
Karlsson, J.2
Bylund, J.3
Movitz, C.4
Karlsson, A.5
Dahlgren, C.6
-
23
-
-
6344272749
-
N-terminal residues of the chemotaxis inhibitory protein of Staphylococcus aureus are essential for blocking formylated peptide receptor but not C5a receptor
-
Haas P.J., de Haas C.J., Kleibeuker W., Poppelier M.J., van Kessel K.P., Kruijtzer J.A., Liskamp R.M., and van Strijp J.A. N-terminal residues of the chemotaxis inhibitory protein of Staphylococcus aureus are essential for blocking formylated peptide receptor but not C5a receptor. J. Immunol. 173 (2004) 5704
-
(2004)
J. Immunol.
, vol.173
, pp. 5704
-
-
Haas, P.J.1
de Haas, C.J.2
Kleibeuker, W.3
Poppelier, M.J.4
van Kessel, K.P.5
Kruijtzer, J.A.6
Liskamp, R.M.7
van Strijp, J.A.8
-
24
-
-
0037441872
-
Serum amyloid A induces IL-8 secretion through a G protein-coupled receptor, FPRL1/LXA4R
-
He R., Sang H., and Ye R.D. Serum amyloid A induces IL-8 secretion through a G protein-coupled receptor, FPRL1/LXA4R. Blood 101 (2003) 1572
-
(2003)
Blood
, vol.101
, pp. 1572
-
-
He, R.1
Sang, H.2
Ye, R.D.3
-
25
-
-
0037078334
-
An intracellular signaling hierarchy determines direction of migration in opposing chemotactic gradients
-
Heit B., Tavener S., Raharjo E., and Kubes P. An intracellular signaling hierarchy determines direction of migration in opposing chemotactic gradients. J. Cell Biol. 159 (2002) 91
-
(2002)
J. Cell Biol.
, vol.159
, pp. 91
-
-
Heit, B.1
Tavener, S.2
Raharjo, E.3
Kubes, P.4
-
26
-
-
0029900788
-
Different functions for the interleukin 8 receptors (IL-8R) of human neutrophil leukocytes: NADPH oxidase and phospholipase D are activated through IL-8R1 but not IL-8R2
-
Jones S.A., Wolf M., Qin S., Mackay C.R., and Baggiolini M. Different functions for the interleukin 8 receptors (IL-8R) of human neutrophil leukocytes: NADPH oxidase and phospholipase D are activated through IL-8R1 but not IL-8R2. Proc. Natl. Acad. Sci. U.S.A. 93 (1996) 6682
-
(1996)
Proc. Natl. Acad. Sci. U.S.A.
, vol.93
, pp. 6682
-
-
Jones, S.A.1
Wolf, M.2
Qin, S.3
Mackay, C.R.4
Baggiolini, M.5
-
27
-
-
0028792420
-
Escherichia coli-induced activation of neutrophil NADPH-oxidase: lipopolysaccharide and formylated peptides act synergistically to induce release of reactive oxygen metabolites
-
Karlsson A., Markfjall M., Stromberg N., and Dahlgren C. Escherichia coli-induced activation of neutrophil NADPH-oxidase: lipopolysaccharide and formylated peptides act synergistically to induce release of reactive oxygen metabolites. Infect. Immun. 63 (1995) 4606
-
(1995)
Infect. Immun.
, vol.63
, pp. 4606
-
-
Karlsson, A.1
Markfjall, M.2
Stromberg, N.3
Dahlgren, C.4
-
29
-
-
33749529307
-
Serum amyloid A binding to formyl peptide receptor-like 1 induces synovial hyperplasia and angiogenesis
-
Lee M.S., Yoo S.A., Cho C.S., Suh P.G., Kim W.U., and Ryu S.H. Serum amyloid A binding to formyl peptide receptor-like 1 induces synovial hyperplasia and angiogenesis. J. Immunol. 177 (2006) 5585
-
(2006)
J. Immunol.
, vol.177
, pp. 5585
-
-
Lee, M.S.1
Yoo, S.A.2
Cho, C.S.3
Suh, P.G.4
Kim, W.U.5
Ryu, S.H.6
-
30
-
-
0032032205
-
Desensitization of formyl peptide receptors is abolished in calcium ionophore-primed neutrophils: an association of the ligand-receptor complex to the cytoskeleton is not required for a rapid termination of the NADPH-oxidase response
-
Liu L., Harbecke O., Elwing H., Follin P., Karlsson A., and Dahlgren C. Desensitization of formyl peptide receptors is abolished in calcium ionophore-primed neutrophils: an association of the ligand-receptor complex to the cytoskeleton is not required for a rapid termination of the NADPH-oxidase response. J. Immunol. 160 (1998) 2463
-
(1998)
J. Immunol.
, vol.160
, pp. 2463
-
-
Liu, L.1
Harbecke, O.2
Elwing, H.3
Follin, P.4
Karlsson, A.5
Dahlgren, C.6
-
31
-
-
0029863313
-
Isoluminol-enhanced chemiluminescence: a sensitive method to study the release of superoxide anion from human neutrophils
-
Lundqvist H., and Dahlgren C. Isoluminol-enhanced chemiluminescence: a sensitive method to study the release of superoxide anion from human neutrophils. Free Radic. Biol. Med. 20 (1996) 785
-
(1996)
Free Radic. Biol. Med.
, vol.20
, pp. 785
-
-
Lundqvist, H.1
Dahlgren, C.2
-
32
-
-
84934438666
-
It's only innate immunity but I like it
-
Marcenaro E., Della Chiesa M., Dondero A., Ferranti B., and Moretta A. It's only innate immunity but I like it. Adv. Exp. Med. Biol. 590 (2007) 89
-
(2007)
Adv. Exp. Med. Biol.
, vol.590
, pp. 89
-
-
Marcenaro, E.1
Della Chiesa, M.2
Dondero, A.3
Ferranti, B.4
Moretta, A.5
-
33
-
-
0034162550
-
Expression and contribution of endogenous IL-13 in an experimental model of sepsis
-
Matsukawa A., Hogaboam C.M., Lukacs N.W., Lincoln P.M., Evanoff H.L., Strieter R.M., and Kunkel S.L. Expression and contribution of endogenous IL-13 in an experimental model of sepsis. J. Immunol. 164 (2000) 2738
-
(2000)
J. Immunol.
, vol.164
, pp. 2738
-
-
Matsukawa, A.1
Hogaboam, C.M.2
Lukacs, N.W.3
Lincoln, P.M.4
Evanoff, H.L.5
Strieter, R.M.6
Kunkel, S.L.7
-
34
-
-
16544390232
-
Chemotaxis receptors and signaling
-
Miller A.F., and Falke J.J. Chemotaxis receptors and signaling. Adv. Protein Chem. 68 (2004) 393
-
(2004)
Adv. Protein Chem.
, vol.68
, pp. 393
-
-
Miller, A.F.1
Falke, J.J.2
-
35
-
-
0023160761
-
Inhibition by nonsteroidal anti-inflammatory drugs of superoxide production and granule enzyme release by polymorphonuclear leukocytes stimulated with immune complexes or formyl-methionyl-leucyl-phenylalanine
-
Neal T.M., Vissers M.C., and Winterbourn C.C. Inhibition by nonsteroidal anti-inflammatory drugs of superoxide production and granule enzyme release by polymorphonuclear leukocytes stimulated with immune complexes or formyl-methionyl-leucyl-phenylalanine. Biochem. Pharmacol. 36 (1987) 2511
-
(1987)
Biochem. Pharmacol.
, vol.36
, pp. 2511
-
-
Neal, T.M.1
Vissers, M.C.2
Winterbourn, C.C.3
-
36
-
-
13644253079
-
The effect of anionic amphiphiles on the recruitment of Rac in neutrophils
-
Nigorikawa K., Okamura N., and Hazeki O. The effect of anionic amphiphiles on the recruitment of Rac in neutrophils. J. Biochem. (Tokyo) 136 (2004) 463
-
(2004)
J. Biochem. (Tokyo)
, vol.136
, pp. 463
-
-
Nigorikawa, K.1
Okamura, N.2
Hazeki, O.3
-
37
-
-
2642570282
-
Local expression of the serum amyloid A and formyl peptide receptor-like 1 genes in synovial tissue is associated with matrix metalloproteinase production in patients with inflammatory arthritis
-
O'Hara R., Murphy E.P., Whitehead A.S., FitzGerald O., and Bresnihan B. Local expression of the serum amyloid A and formyl peptide receptor-like 1 genes in synovial tissue is associated with matrix metalloproteinase production in patients with inflammatory arthritis. Arthritis Rheum. 50 (2004) 1788
-
(2004)
Arthritis Rheum.
, vol.50
, pp. 1788
-
-
O'Hara, R.1
Murphy, E.P.2
Whitehead, A.S.3
FitzGerald, O.4
Bresnihan, B.5
-
38
-
-
33751565688
-
A new staphylococcal anti-inflammatory protein that antagonizes the formyl peptide receptor-like 1
-
Prat C., Bestebroer J., de Haas C.J., van Strijp J.A., and van Kessel K.P. A new staphylococcal anti-inflammatory protein that antagonizes the formyl peptide receptor-like 1. J. Immunol. 177 (2006) 8017
-
(2006)
J. Immunol.
, vol.177
, pp. 8017
-
-
Prat, C.1
Bestebroer, J.2
de Haas, C.J.3
van Strijp, J.A.4
van Kessel, K.P.5
-
39
-
-
34848826063
-
C-terminal tail phosphorylation of N-formyl peptide receptor: differential recognition of two neutrophil chemoattractant receptors by monoclonal antibodies NFPR1 and NFPR2
-
Riesselman M., Miettinen H.M., Gripentrog J.M., Mumey B., Dratz E.A., Stie J., Taylor R.M., and Jesaitis A.J. C-terminal tail phosphorylation of N-formyl peptide receptor: differential recognition of two neutrophil chemoattractant receptors by monoclonal antibodies NFPR1 and NFPR2. J. Immunol. 179 (2007) 2520
-
(2007)
J. Immunol.
, vol.179
, pp. 2520
-
-
Riesselman, M.1
Miettinen, H.M.2
Gripentrog, J.M.3
Mumey, B.4
Dratz, E.A.5
Stie, J.6
Taylor, R.M.7
Jesaitis, A.J.8
-
40
-
-
0028210322
-
Subcellular localization and translocation of the receptor for N-formylmethionyl-leucyl-phenylalanine in human neutrophils
-
Sengelov H., Boulay F., Kjeldsen L., and Borregaard N. Subcellular localization and translocation of the receptor for N-formylmethionyl-leucyl-phenylalanine in human neutrophils. Biochem. J. 299 Pt 2 (1994) 473
-
(1994)
Biochem. J.
, vol.299
, Issue.PART 2
, pp. 473
-
-
Sengelov, H.1
Boulay, F.2
Kjeldsen, L.3
Borregaard, N.4
-
41
-
-
34548041876
-
The non-steroidal anti-inflammatory drug piroxicam blocks ligand binding to the formyl peptide receptor but not the formyl peptide receptor like 1
-
Stenfeldt A.L., Karlsson J., Wenneras C., Bylund J., Fu H., and Dahlgren C. The non-steroidal anti-inflammatory drug piroxicam blocks ligand binding to the formyl peptide receptor but not the formyl peptide receptor like 1. Biochem. Pharmacol. 74 (2007) 1050
-
(2007)
Biochem. Pharmacol.
, vol.74
, pp. 1050
-
-
Stenfeldt, A.L.1
Karlsson, J.2
Wenneras, C.3
Bylund, J.4
Fu, H.5
Dahlgren, C.6
-
42
-
-
0347660879
-
Promyelocytic HL60 cells express NADPH oxidase and are excellent targets in a rapid spectrophotometric microplate assay for extracellular superoxide
-
Teufelhofer O., Weiss R.M., Parzefall W., Schulte-Hermann R., Micksche M., Berger W., and Elbling L. Promyelocytic HL60 cells express NADPH oxidase and are excellent targets in a rapid spectrophotometric microplate assay for extracellular superoxide. Toxicol. Sci. 76 (2003) 376
-
(2003)
Toxicol. Sci.
, vol.76
, pp. 376
-
-
Teufelhofer, O.1
Weiss, R.M.2
Parzefall, W.3
Schulte-Hermann, R.4
Micksche, M.5
Berger, W.6
Elbling, L.7
-
43
-
-
33846964917
-
Characterisation of receptor binding by the chemotaxis inhibitory protein of Staphylococcus aureus and the effects of the host immune response
-
Wright A.J., Higginbottom A., Philippe D., Upadhyay A., Bagby S., Read R.C., Monk P.N., and Partridge L.J. Characterisation of receptor binding by the chemotaxis inhibitory protein of Staphylococcus aureus and the effects of the host immune response. Mol. Immunol. 44 (2007) 2507
-
(2007)
Mol. Immunol.
, vol.44
, pp. 2507
-
-
Wright, A.J.1
Higginbottom, A.2
Philippe, D.3
Upadhyay, A.4
Bagby, S.5
Read, R.C.6
Monk, P.N.7
Partridge, L.J.8
-
44
-
-
0030632565
-
Structure and function of leukocyte chemoattractant receptors
-
Ye R.D., and Boulay F. Structure and function of leukocyte chemoattractant receptors. Adv. Pharmacol. 39 (1997) 221
-
(1997)
Adv. Pharmacol.
, vol.39
, pp. 221
-
-
Ye, R.D.1
Boulay, F.2
|