Preclinical pharmacokinetics, interspecies scaling, and tissue distribution of humanized monoclonal anti-IL-13 antibodies with different IL-13 neutralization mechanisms

International Immunopharmacology

Volumn 8, Issue 3, 2008, Pages 477-483

  Vugmeyster, Yulia ^a   Szklut, Pamela ^a   Tchistiakova, Lioudmila ^a   Abraham, William ^b   Kasaian, Marion ^a   Xu, Xin ^a  

^a PFIZER INC   (United States)

^b MOUNT SINAI MEDICAL CENTER   (United States)

Author keywords

Allergy; Allometric scaling; Asthma; IL 13; Monoclonal antibody; Pharmacokinetics

Indexed keywords

IMMUNOGLOBULIN G1; INTERLEUKIN 13; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY AB 01; MONOCLONAL ANTIBODY AB 02; UNCLASSIFIED DRUG;

ALLOMETRY; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; ASCARIS; ASTHMA; CONTINUOUS INFUSION; DISTRIBUTION VOLUME; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISPOSITION; DRUG DISTRIBUTION; DRUG DOSE COMPARISON; DRUG ELIMINATION; DRUG HALF LIFE; DRUG TISSUE LEVEL; FEMALE; MALE; MONKEY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; RESPIRATORY TRACT INFLAMMATION; SHEEP; SPECIES COMPARISON; TISSUE DISTRIBUTION;

ANIMALS; ANTIBODIES, MONOCLONAL; HALF-LIFE; HUMANS; INTERLEUKIN-13; MACACA FASCICULARIS; MALE; MICE; MICE, INBRED BALB C; RATS; RATS, SPRAGUE-DAWLEY; SHEEP; SPECIES SPECIFICITY; TISSUE DISTRIBUTION;

EID: 39149100941     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2007.12.004     Document Type: Article

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