-
1
-
-
0029883235
-
The response to levodopa in Parkinson's disease: Imposing pharmacological law and order
-
Nutt JG, Holford NHG (1996) The response to levodopa in Parkinson's disease: Imposing pharmacological law and order. Ann Neurol 39:561-573
-
(1996)
Ann Neurol
, vol.39
, pp. 561-573
-
-
Nutt, J.G.1
Holford, N.H.G.2
-
2
-
-
28444454886
-
Importance of within subject variation in levodopa pharmacokinetics: A 4 year cohort study in Parkinson's disease
-
3-4
-
Chan PL, Nutt JG, Holford NH (2005) Importance of within subject variation in levodopa pharmacokinetics: a 4 year cohort study in Parkinson's disease. J Pharmacokinet Pharmacodyn 32(3-4):307-331, Aug
-
(2005)
J Pharmacokinet Pharmacodyn
, vol.32
, pp. 307-331
-
-
Chan, P.L.1
Nutt, J.G.2
Holford, N.H.3
-
3
-
-
28444499344
-
Pharmacokinetic and pharmacodynamic changes during the first four years of levodopa treatment in Parkinson's disease
-
3-4
-
Chan PL, Nutt JG, Holford NH (2005) Pharmacokinetic and pharmacodynamic changes during the first four years of levodopa treatment in Parkinson's disease. J Pharmacokinet Pharmacodyn 32(3-4):459-484, Aug
-
(2005)
J Pharmacokinet Pharmacodyn
, vol.32
, pp. 459-484
-
-
Chan, P.L.1
Nutt, J.G.2
Holford, N.H.3
-
4
-
-
33947105151
-
Levodopa slows progression of Parkinson's disease. External validation by clinical trial simulation
-
4
-
Chan PL, Nutt JG, Holford NH (2007) Levodopa slows progression of Parkinson's disease. External validation by clinical trial simulation. Pharm Res 24(4):791-802, Apr
-
(2007)
Pharm Res
, vol.24
, pp. 791-802
-
-
Chan, P.L.1
Nutt, J.G.2
Holford, N.H.3
-
5
-
-
4444289552
-
Modeling the short and long duration responses to exogenous levodopa and to endogenous levodopa production in Parkinson's disease
-
3
-
Chan PLS, Nutt JG, Holford NHG (2004) Modeling the short and long duration responses to exogenous levodopa and to endogenous levodopa production in Parkinson's disease. J Pharmacokinet Pharmacodyn 31(3):243-268
-
(2004)
J Pharmacokinet Pharmacodyna
, vol.31
, pp. 243-268
-
-
Chan, P.L.S.1
Nutt, J.G.2
Holford, N.H.G.3
-
6
-
-
33745786419
-
Disease progression and pharmacodynamics in Parkinson disease - Evidence for functional protection with levodopa and other treatments
-
3
-
Holford NHG, Chan PL, Nutt JG, Kieburtz K, Shoulson I (2006) Disease progression and pharmacodynamics in Parkinson disease - evidence for functional protection with levodopa and other treatments. J Pharmacokinet Pharmacodyn 33(3):281-311, Jun
-
(2006)
J Pharmacokinet Pharmacodyn
, vol.33
, pp. 281-311
-
-
Holford, N.H.G.1
Chan, P.L.2
Nutt, J.G.3
Kieburtz, K.4
Shoulson, I.5
-
7
-
-
0019785890
-
Understanding the dose-effect relationship: Clinical application of pharmacokinetic-pharmacodynamic models
-
6
-
Holford NHG, Sheiner LB (1981) Understanding the dose-effect relationship: clinical application of pharmacokinetic-pharmacodynamic models. Clin Pharmacokinet 6(6):429-453
-
(1981)
Clin Pharmacokinet
, vol.6
, pp. 429-453
-
-
Holford, N.H.G.1
Sheiner, L.B.2
-
8
-
-
0037135111
-
The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
-
5580
-
Hardy J, Selkoe DJ (2002) The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297(5580):353-356, Jul 19
-
(2002)
Science
, vol.297
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
9
-
-
0015745743
-
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations
-
4
-
Bernheimer H, Birkmayer W, Hornykiewicz O, Jellinger K, Seitelberger F (1973) Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. J Neurol Sci 20(4):415-455, Dec
-
(1973)
J Neurol Sci
, vol.20
, pp. 415-455
-
-
Bernheimer, H.1
Birkmayer, W.2
Hornykiewicz, O.3
Jellinger, K.4
Seitelberger, F.5
-
10
-
-
0014208039
-
Aromatic amino acids and modification of parkinsonism
-
7
-
Cotzias GC, Van Woert MH, Schiffer LM (1967) Aromatic amino acids and modification of parkinsonism. N Engl J Med 276(7):374-379
-
(1967)
N Engl J Med
, vol.276
, pp. 374-379
-
-
Cotzias, G.C.1
Van Woert, M.H.2
Schiffer, L.M.3
-
11
-
-
0014673226
-
Modification of parkinsonism-chronic treatment with L-dopa
-
7
-
Cotzias GE, Papavasiliou PS, Gellene R (1969) Modification of parkinsonism-chronic treatment with L-dopa. N Engl J Med 280(7):337-345
-
(1969)
N Engl J Med
, vol.280
, pp. 337-345
-
-
Cotzias, G.E.1
Papavasiliou, P.S.2
Gellene, R.3
-
12
-
-
0017834407
-
Considerations in the management of parkinsonism
-
1
-
Fahn S, Calne DB (1978) Considerations in the management of parkinsonism. Neurology 28(1):5-7, Jan
-
(1978)
Neurology
, vol.28
, pp. 5-7
-
-
Fahn, S.1
Calne, D.B.2
-
13
-
-
0026484388
-
The oxidant stress hypothesis in Parkinson's disease: Evidence supporting it
-
6
-
Fahn S, Cohen G (1992) The oxidant stress hypothesis in Parkinson's disease: evidence supporting it. Ann Neurol 32(6):804-812, Dec
-
(1992)
Ann Neurol
, vol.32
, pp. 804-812
-
-
Fahn, S.1
Cohen, G.2
-
14
-
-
0345724066
-
Dopamine turnover and glutathione oxidation: Implications for Parkinson disease
-
4
-
Spina MB, Cohen G (1989) Dopamine turnover and glutathione oxidation: implications for Parkinson disease. Proc Natl Acad Sci USA 86(4):1398-1400, Feb
-
(1989)
Proc Natl Acad Sci USA
, vol.86
, pp. 1398-1400
-
-
Spina, M.B.1
Cohen, G.2
-
15
-
-
0024456653
-
Effect of deprenyl on the progression of disability in early Parkinson's disease
-
The Parkinson Study Group
-
The Parkinson Study Group (1989) Effect of deprenyl on the progression of disability in early Parkinson's disease. N Engl J Med 321:1364-1371
-
(1989)
N Engl J Med
, vol.321
, pp. 1364-1371
-
-
-
16
-
-
0024457355
-
DATATOP: A multicenter controlled clinical trial in early Parkinson's disease
-
The Parkinson Study Group
-
The Parkinson Study Group (1989) DATATOP: A multicenter controlled clinical trial in early Parkinson's disease. Arch Neurol 46:1052-1060
-
(1989)
Arch Neurol
, vol.46
, pp. 1052-1060
-
-
-
17
-
-
0026469784
-
The antiparkinson efficacy of deprenyl derives from transient improvement that is likely to be symptomatic
-
6
-
Schulzer M, Mak E, Calne DB (1992) The antiparkinson efficacy of deprenyl derives from transient improvement that is likely to be symptomatic. Ann Neurol 32(6):795-798
-
(1992)
Ann Neurol
, vol.32
, pp. 795-798
-
-
Schulzer, M.1
Mak, E.2
Calne, D.B.3
-
18
-
-
0032890731
-
Parkinson disease, the effect of levodopa, and the ELLDOPA trial. Earlier vs Later L-DOPA
-
5
-
Fahn S (1999) Parkinson disease, the effect of levodopa, and the ELLDOPA trial. Earlier vs Later L-DOPA. Arch Neurol 56(5):529-535
-
(1999)
Arch Neurol
, vol.56
, pp. 529-535
-
-
Fahn, S.1
-
19
-
-
0036913449
-
More efficient clinical trials through use of scientific model-based statistical tests
-
6
-
Jonsson EN, Sheiner LB (2002) More efficient clinical trials through use of scientific model-based statistical tests. Clin Pharmacol Ther 72(6):603-614, Dec
-
(2002)
Clin Pharmacol Ther
, vol.72
, pp. 603-614
-
-
Jonsson, E.N.1
Sheiner, L.B.2
-
20
-
-
0036764810
-
Quantitative description of loss of clinical benefit following withdrawal of levodopa-carbidopa and bromocriptine in early Parkinson's disease
-
5
-
Hauser RA, Holford NHG (2002) Quantitative description of loss of clinical benefit following withdrawal of levodopa-carbidopa and bromocriptine in early Parkinson's disease. Mov Disord 17(5):961-968
-
(2002)
Mov Disord
, vol.17
, pp. 961-968
-
-
Hauser, R.A.1
Holford, N.H.G.2
-
21
-
-
0024521415
-
Pharmacokinetic and pharmacodynamic modeling of L-dopa plasma concentrations and clinical effects in Parkinson's disease after Sinemet
-
2
-
Nelson MV, Berchou RC, Lewitt PA, Kareti D, Kesaree N, Schlick P et al (1989) Pharmacokinetic and pharmacodynamic modeling of L-dopa plasma concentrations and clinical effects in Parkinson's disease after Sinemet. Clin Neuropharmacol 12(2):91-97
-
(1989)
Clin Neuropharmacol
, vol.12
, pp. 91-97
-
-
Nelson, M.V.1
Berchou, R.C.2
Lewitt, P.A.3
Kareti, D.4
Kesaree, N.5
Schlick, P.6
-
22
-
-
0026480977
-
Effect of long-term therapy on the pharmacodynamics of levodopa. Relation to On-Off phenomenon
-
Nutt JG, Woodward WR, Carter JH, Gancher ST (1992) Effect of long-term therapy on the pharmacodynamics of levodopa. Relation to On-Off phenomenon. Arch Neurol 49:1123-1130
-
(1992)
Arch Neurol
, vol.49
, pp. 1123-1130
-
-
Nutt, J.G.1
Woodward, W.R.2
Carter, J.H.3
Gancher, S.T.4
-
23
-
-
0026765992
-
Kinetic-dynamic relationship of oral levodopa: Possible biphasic response after sequential doses in Parkinson's disease
-
3
-
Contin M, Riva R, Matinelli P, Baruzzi A (1992) Kinetic-dynamic relationship of oral levodopa: Possible biphasic response after sequential doses in Parkinson's disease. Mov Disord 7(3):244-248
-
(1992)
Mov Disord
, vol.7
, pp. 244-248
-
-
Contin, M.1
Riva, R.2
Matinelli, P.3
Baruzzi, A.4
-
24
-
-
0027477017
-
Pharmacodynamic modeling of oral levodopa: Clinical application in Parkinson's disease
-
Contin M, Riva R, Martinelli P, Baruzzi A (1993) Pharmacodynamic modeling of oral levodopa: Clinical application in Parkinson's disease. Neurology 43:367-371
-
(1993)
Neurology
, vol.43
, pp. 367-371
-
-
Contin, M.1
Riva, R.2
Martinelli, P.3
Baruzzi, A.4
-
25
-
-
0029764853
-
Population pharmacokinetics and pharmacodynamics of oral levodopa in parkinsonian patients
-
Triggs EJ, Charles BG, Contin M, Martinelli P, Cortelli P, Riva R et al (1996) Population pharmacokinetics and pharmacodynamics of oral levodopa in parkinsonian patients. Eur J Clin Pharmacol 51:59-67
-
(1996)
Eur J Clin Pharmacol
, vol.51
, pp. 59-67
-
-
Triggs, E.J.1
Charles, B.G.2
Contin, M.3
Martinelli, P.4
Cortelli, P.5
Riva, R.6
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