Peripheral CD4+ T cells showing a Th2 phenotype in a patient with Mikulicz's disease associated with lymphadenopathy and pleural effusion

Modern Rheumatology

Volumn 18, Issue 1, 2008, Pages 86-90

  Miyake, Katsuhisa ^a   Moriyama, Masafumi ^b   Aizawa, Kumiko ^a   Nagano, Shuji ^a   Inoue, Yasushi ^a   Sadanaga, Atsushi ^a   Nakashima, Hitoshi ^a,c   Nakamura, Seiji ^b  

^a KYUSHU UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c FUKUOKA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Mikulicz's disease; Sj gren ssyndrome; Th1 Th2 balance

Indexed keywords

ALBUMIN; C REACTIVE PROTEIN; CD4 ANTIGEN; GALLIUM 67; IMMUNOGLOBULIN A; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G4; IMMUNOGLOBULIN M; INTERLEUKIN 2 RECEPTOR; PREDNISOLONE;

AGED; ALBUMIN BLOOD LEVEL; ARTICLE; CASE REPORT; CD4+ T LYMPHOCYTE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; CYTOLOGY; DIFFERENTIAL DIAGNOSIS; DISEASE ASSOCIATION; ECHOGRAPHY; EOSINOPHIL COUNT; ERYTHROCYTE SEDIMENTATION RATE; HISTOPATHOLOGY; HUMAN; HYPERGAMMAGLOBULINEMIA; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOHISTOCHEMISTRY; LEUKOCYTE COUNT; LYMPHADENOPATHY; LYMPHOCYTIC INFILTRATION; LYMPHOMA; MALE; MEDIASTINUM LYMPH NODE; MIKULICZ DISEASE; PARAAORTIC LYMPH NODE; PHENOTYPE; PLEURA EFFUSION; PRIORITY JOURNAL; PROTEIN ELECTROPHORESIS; REMISSION; SALIVARY GLAND BIOPSY; SALIVARY GLAND DISEASE; SALIVARY GLAND SCINTISCANNING; SARCOIDOSIS; TH1 CELL; TH2 CELL; THORACOCENTESIS; TUBERCULOSIS;

AGED; ANTI-INFLAMMATORY AGENTS; HUMANS; LYMPHATIC DISEASES; LYMPHOCYTE COUNT; MALE; MIKULICZ' DISEASE; PLEURAL EFFUSION; PREDNISOLONE; TH1 CELLS; TH2 CELLS;

EID: 39149100601     PISSN: 14397595     EISSN: 14397609     Source Type: Journal    
DOI: 10.1007/s10165-007-0010-3     Document Type: Article

References (21)

1. Brookes SM, Cohen SB, Price EJ, Webb LM, Feldmann M, Maini RN, et al. T cell clones from a Sjögren's syndrome salivary gland biopsy produce high levels of IL-10. Clin Exp Immunol. 1996;103:268-72.
2. Jung T, Schauer U, Heusser C, Neumann C, Rieger C. Detection of intracellular cytokines by flow cytometry. J Immunol Meth. 1993;159:197-207.
3. Maino VC, Picker LJ. Identification of functional subsets by flow cytometry: Intracellular detection of cytokine expression. Cytometry. 1998;34:207-15.
4. Akahoshi M, Nakashima H, Tanaka Y, Kohsaka T, Nagano S, Ohgami E, et al. Th1/Th2 balance of peripheral T helper cells in systemic lupus erythematosus. Arthritis Rheum. 1999;42:1644-8.
5. Ohyama Y, Nakamura S, Matsuzaki G, Shinohara M, Hiroki A, Oka M, et al. T-cell receptor V alpha and V beta gene use by infiltrating T cells in labial glands of patients with Sjögren's syndrome. Oral Surg Oral Med Oral Path Oral Radiol Endod. 1995;79:730-7.
6. Mouri T, Nakamura S, Ohyama Y, Matsuzaki G, Shinohara M, Kishihara K, et al. T cell receptor V alpha and V beta gene usage by tumour-infiltrating lymphocytes in oral squamous cell carcinoma. Cancer Immunol Immunother. 1996;43:10-8.
7. Sasaki M, Nakamura S, Ohyama Y, Shinohara M, Ezaki I, Hara H, et al. Accumulation of common T cell clonotypes in the salivary glands of patients with human T lymphotropic virus type I-associated and idiopathic Sjögren's syndrome. J Immunol. 2000;164:2823-31.
8. Kumamaru W, Nakamura S, Kadena T, Yamada A, Kawamura E, Sasaki M, et al. T-cell receptor Vbeta gene usage by T cells reactive with the tumor-rejection antigen SART-1 in oral squamous cell carcinoma. Int J Cancer. 2004;108:686-95.
9. Kawamura E, Nakamura S, Sasaki M, Ohyama Y, Kadena T, Kumamaru W, et al. Accumulation of oligoclonal T cells in the infiltrating lymphocytes in oral lichen planus. J Oral Pathol Med. 2003;32:282-9.
10. Morgan WS, Castleman B. A clinicopathologic study of Mikulicz's disease. Am J Pathol. 1953;29:471-503.
11. Yamamoto M, Harada S, Ohara M, Suzuki C, Naishiro Y, Yamamoto H, et al. Clinical and pathological differences between Mikulicz's disease and Sjögren's syndrome. Rheumatology. 2005;44:227-34.
12. Yamamoto M, Ohara M, Suzuki C, Naishiro Y, Yamamoto H, Takahashi H, et al. Elevated IgG4 concentrations in serum of patients with Mikulicz's disease. Scand J Rheumatol. 2004;33:432-3.
13. Punnonen J, Aversa G, Cocks BG, McKenzie AN, Menon S, Zurawski G, et al. Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells. Proc Natl Acad Sci USA. 1993;90:3730-4.
14. Fox RI, Kang HI, Ando D, Abrams J, Pisa E. Cytokine mRNA expression in salivary gland biopsies of Sjögren's syndrome. J Immunol. 1994;152:5532-9.
15. Ohyama Y, Nakamura S, Matsuzaki G, Shinohara M, Hiroki A, Fujimura T, et al. Cytokine messenger RNA expression in the labial salivary glands of patients with Sjögren's syndrome. Arthritis Rheum. 1996;39:1376-84.
16. Konttinen YT, Kemppinen P, Koski H, Li TF, Jumppanen M, Hietanen J, et al. T(H)1 cytokines are produced in labial salivary glands in Sjögren's syndrome, but also in healthy individuals. Scand J Rheumatol. 1999;28:106-12.
17. Price EJ, Venables PJ. The etiopathogenesis of Sjögren's syndrome. Semin Arthritis Rheum. 1995;25:117-33.
18. Ozaki Y, Amakawa R, Ito T, Iwai H, Tajima K, Uehira K, et al. Alteration of peripheral blood dendritic cells in patients with primary Sjögren's syndrome. Arthritis Rheum. 2001;44:419-31.
19. Bonfa E, Llovet R, Elkon K. Immunoblot analysis of IgG subclasses of multiple lupus autoantibodies. J Immunol. 1988;140:2231-6.
20. Jones CC, Hamilton RG, Jordon RE. Subclass distribution of human IgG autoantibodies in pemphigus. J Clin Immunol. 1988;8:43-9.
21. Lieu TS, Reimer CB, Sontheimer RD. Immunoglobulin class and subclass profile of the Ro/SS-A autoantibody response. J Invest Dermatol. 1988;90:158-64.