Effect of 26-oxygenosterols from Ganoderma lucidum and their activity as cholesterol synthesis inhibitors

Applied and Environmental Microbiology

Volumn 71, Issue 7, 2005, Pages 3653-3658

  Hajjaj, Hassan ^a,b   Macé, Catherine ^a   Roberts, Matthew ^a   Niederberger, Peter ^a   Fay, Laurent B ^a  

^a NESTLÉ RESEARCH CENTER   (Switzerland)

^b UNIV LILLE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOLS; BIOSYNTHESIS; BLOOD; CELLS; CHOLESTEROL; ENZYME INHIBITION; MEDICAL APPLICATIONS;

BIOLOGICAL EFFECTS; BLOOD CHOLESTEROL; CHINESE MEDICINES; THERAPEUTIC AGENTS;

FUNGI;

26 OXYGENOSTEROL; ACETIC ACID; ANTILIPEMIC AGENT; CARBON 14; CHOLESTEROL; GANODERAL A; GANODERIC ACID Y; GANODEROL A; GANODEROL B; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; KETOCONAZOLE; LANOSTEROL DERIVATIVE; LATHOSTEROL; MEVINOLIN; MICONAZOLE; SQUALENE; TRITIUM; UNCLASSIFIED DRUG;

ENZYME ACTIVITY; INHIBITION;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL STRUCTURE; CHINESE MEDICINE; CHOLESTEROL METABOLISM; CHOLESTEROL SYNTHESIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG ISOLATION; FUNGUS; GANODERMA LUCIDUM; GAS CHROMATOGRAPHY; HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHY; HUMAN; HUMAN CELL; LIVER CELL CULTURE; MASS SPECTROMETRY; NONHUMAN; POLYPORACEAE; PROTON NUCLEAR MAGNETIC RESONANCE; TRADITIONAL MEDICINE;

ANTICHOLESTEREMIC AGENTS; CELL LINE; CHOLESTEROL; CYTOCHROME P-450 ENZYME SYSTEM; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; LANOSTEROL; LIVER; MAGNETIC RESONANCE SPECTROSCOPY; OXIDOREDUCTASES; REISHI;

FUNGI; GANODERMA LUCIDUM; POLYPORACEAE;

EID: 22144434106     PISSN: 00992240     EISSN: None     Source Type: Journal    
DOI: 10.1128/AEM.71.7.3653-3658.2005     Document Type: Article

References (26)

1. Arisawa, M., A. Fujita, M. Saga, H. Fukumura, T. Hayashi, M. Shimizu, and N. Morita. 1986. Three new lanostanoids from Ganoderma lucidum. J. Nat. Prod. (Lloydia) 49:621-625.
2. Chen, W. C., D. M. Hau, and S. S. Lee. 1995. Effects of Ganoderma lucidum and Krestin on cellular immuno-competence in gamma-ray irradiated mice. Am. J. Chin. Med. 23:71-80.
3. Chiu, S. W., Z. M. Wang, T. M. Leung, and D. Moore. 2000. Nutritional value of Ganoderma extract and assessment of its genotoxicity and anti-genotoxicity using comet assays of mouse lymphocytes. Food Chem. Toxicol. 38:173-178.
4. Gan, K. H., Y. F. Fann, S. H. Hsu, K. W. Kuo, and C. N. Lin. 1998. Mediation of the cytotoxicity of lanostanoids and steroids of Ganoderma tsugae through apoptosis and cell cycle. J. Nat. Prod. (Lloydia) 61:485-487.
5. Gunde-Cimerman, N., A. Plemenitas, and A. Cimerman. 1993. Pleurotus fungi produce mevinolin, an inhibitor of HGM CoA reductase. FEMS Microbiol. Lett. 133:333-338.
6. Gylling, H., H. Vanhanen, and T. A. Miettinen. 1991. Hypolipidernic effect and mechanism of ketoconazole without and with cholestyramine in familial hypercholesterolemia. Metabolism 40:35-41.
7. Jong, S. C., and R. Donovick. 1989. Antitumor and antiviral substances from fungi. Adv. Appl. Microbiol. 34:183-262.
8. Jong, S. C., and J. M. Birmingham. 1992. Medicinal benefits of the mushroom Ganoderma. Adv. Appl. Microbiol. 37:101-134.
9. Kohda, H., W. Tokumoto, K. Sakamoto, M. Fujii, Y. Hirai, K., Yamasaki, Y. Komoda, H. Nakamura, S. Ishihara, and M. Uchida. 1985. The biologically active constituents of Ganoderma lucidum (Fr.) Karst. Histamine release-inhibitory triterpenes. Chem. Pharm. Bull. (Tokyo) 33:1367-1374.
10. Komoda, Y., M. Shimizu, Y. Sonoda, and Y. Sato. 1989. Ganoderic acid and derivatives as cholesterol synthesis inhibitors. Chem. Pharm. Bull. (Tokyo) 37:531-533.
11. Kraemer, F. B., and A. Pont. 1986. Inhibition of cholesterol synthesis by Ketoconazole. Am. J. Med. 80:616-620.
12. Lin, W. H., C. H. Hung, C. I. Hsu, and J. Y. Lin. 1997. Dimerization of the N-terminal amphipathic alpha-helix domain of the fungal immunomodulatory protein from Ganoderma tsugae (Fip-gts) defined by a yeast two-hybrid system and site-directed mutagenesis. J. Biol. Chem. 272:20044-20048.
13. Miettinen, T. A. 1988. Cholesterol metabolism during Ketoconazole treatment in man. J. Lipid Res. 29:43-51.
14. Mizushina, Y., L. Hanashima, T. Yamaguchi, M. Takemura, F. Sugawara, M. Saneyoshi, A. Matsukage, S. Yoshida, and K. Sakaguchi. 1998. A mushroom fruiting body-inducing substance inhibits activities of replicative DNA polymerases. Biochem. Biophys. Res. Commun. 249:17-22.
15. Morigiwa, A., K. Kitabatake, Y. Fujimoto, and N. Ikekawa. 1986. Angiotensin converting enzyme-inhibitory triterpenes from Ganoderma lucidum. Chem. Pharm. Bull (Tokyo) 34:3025-3028.
16. Morisaki, M., Y. Sonoda, T. Makino, N. Ogihara, N. Ikekawa, and Y. Sato. 1986. Inhibitory effect of 15-oxygenated sterols on cholesterol synthesis from 24,25-dihydrolanosterol. J. Biochem. (Tokyo) 99:597-600.
17. Raucy, J. L., S. J. Carpenter, and J. M. Trzaskos. 1991. Identification of lanosterol 14 alpha-methyl demethylase in human tissues. Bio. Biophys. Res. Commun. 177:497-503.
18. Schroepfer, G. J., Jr., E. J. Parish, H. W. Chen, and A. A. Kanadutsch. 1977. Inhibition of sterol biosynthesis in L cells and mouse liver cells by 15-oxygenated sterols. J. Biol. Chem. 252:8975-8980.
19. Schroepfer, G. J., Jr., D. Monger, A. S. Tayler, J. S. Chamberlain, E. J. Parish, A. Kisic, and A. A. Kandutsch. 1977. Inhibitors of sterol synthesis. Hypocholesterolemic action of dietary 5alpha-cholest-8(14)-en-3beta-ol-15-one in rats and mice. Biochem. Biophys. Res. Commun. 78:1227-1233.
20. Sonoda, Y., N. Obi, M. Onodo, Y. Sakakibara, and Y. Sato. 1992. Effects of 32-oxygenated lanosterol derivatives on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesterol biosynthesis from 24,25-dihydrolanosterol. Chem. Pharm. Bull. (Tokyo) 40:2796-2799.
21. Toth, J. O., B. Luu, and G. Ourisson. 1983. Ganoderic acid T and Z: cytotoxic triterpenes from Ganoderma lucidum (Polyporaceae). Tetrahedron lett. 24:1081-1084.
22. Trzaskos, J. M., S. S. Ko, R. L. Magolda, M. F. Favata, R. T. Fischer, S. H. Stam, P. R. Johnson, and J. L. Gaylor. 1995. Substrate-based inhibitors of lanosterol 14 alpha-methyl demethylase. I. Assessment of inhibitor structure-activity relationship and cholesterol biosynthesis inhibition properties. Biochemistry 34:9670-9676.
23. Trzaskos, J. M., R. T. Fischer, S. S. Ko, R. L. Magolda, S. Stam, P. Johnson, and J. L. Gaylor. 1995. Substrate-based inhibitors of lanosterol 14 alpha-methyl demethylase. II. Time-dependent enzyme inactivation by selected oxylanosterol analogs. Biochemistry 34:9677-9681.
24. Van den Bossche, H. 1988. Mode of action of pyridine, pyrimidine and azole antifungals, p. 79-119. In D. Berg and M. Plempel (ed.), Sterol biosynthesis inhibitors. Ellis Horwood, Chichester, United Kingdom.
25. Wasser, S. P., and A. L. Weis. 1999. Therapeutic effects of substances occurring in higher basidiomycetes mushrooms: a modern perspective. Critical Rev. Immunol. 19:65-69.
26. Ying, J., X. Mao, Q. Ma, Y. Zonga, and H. Wen. 1989. Icons of medicinal fungi from China. Science Press, Beijing, China.