An HSV-1 gD mutant virus as an entry-impaired live virus vaccine

Vaccine

Volumn 26, Issue 9, 2008, Pages 1195-1203

  Awasthi, Sita ^a   Lubinski, John M ^a   Eisenberg, Roselyn J ^b   Cohen, Gary H ^c   Friedman, Harvey M ^a  

^a School of Veterinary Medicine   (United States)

^b UNIVERSITY OF PENNSYLVANIA SCHOOL OF VETERINARY MEDICINE   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Glycoprotein D; HSV; Vaccines

Indexed keywords

GLYCOPROTEIN D; LIVE VACCINE; NECTIN 1; VIRUS DNA;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; HERPES SIMPLEX VIRUS 1; IMMUNIZATION; INOCULATION; LETHAL DOSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REAL TIME POLYMERASE CHAIN REACTION; STATISTICAL ANALYSIS; VERO CELL; VIRUS ENTRY; VIRUS MUTANT; VIRUS TITRATION; VIRUS VIRULENCE; WESTERN BLOTTING;

ANIMALS; CELL ADHESION MOLECULES; CELL LINE, TUMOR; CERCOPITHECUS AETHIOPS; FEMALE; HERPES SIMPLEX; HERPES SIMPLEX VIRUS VACCINES; HERPESVIRUS 1, HUMAN; MICE; MICE, INBRED BALB C; MUTATION; RECEPTORS, TUMOR NECROSIS FACTOR, MEMBER 14; VACCINES, ATTENUATED; VERO CELLS; VIRAL ENVELOPE PROTEINS;

EID: 39149097172     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2007.12.032     Document Type: Article

References (52)

1. Smith J.S., and Robinson N.J. Age specific prevalence of infection with herpes simplex virus type 2 and 1: a global review. J Infect Dis 186 (2002) S3-S28
2. Xu Y., Sternberg M.R., Kottiri B.J., McQuillan G.M., Lee F.K., Nehmias A.J., et al. Trends in herpes simplex type 1 and type 2 seroprevalence in the United States. JAMA 296 (2006) 964-973
3. Whitley R.J., and Lakeman F. Herpes virus infections of central nervous system: therapeutic and diagnostic considerations. Clin Infect Dis 20 (1995) 414-420
4. Raschilas F., Delatour W.M., Chaffaut F., De Broucker C., Chevret T., Lebon S., et al. Outcome of and prognostic factors for herpes simplex encephalitis in adult patients: results of a multicenter study. Clin Infect Dis 35 (2002) 254-260
5. Liesegang T.J. Epidemology of ocular herpes simplex. Natural history in Rochester, Minn, 1950 through 1982. Arch Ophthalmol 107 (1989) 171-185
6. Genereau T., Lortholary O., Bouchaud O., Lacassin F., Vinceneux P., De Truchis P., et al. Herpes simplex esophagitis in patients with AIDS: report of 34 cases. The Cooperative Study Group on Herpetic Esophagitis in HIV infection. Clin Infect Dis 22 (1996) 926-931
7. Brown Z.A., Benedetti J., Ashley R., Burchett S., Selke S., Berry S., et al. Neonatal herpes simplex virus infection in relation to asymptomatic maternal infection at the time of labor. N Engl J Med 324 18 (1991) 1247-1252
8. Lafferty W.E., Downey L., Celum C., and Wald A. Herpes simplex virus type 1 as a cause of genital herpes: impact on surveillance and prevention. J Infect Dis 181 4 (2000) 1454-1457
9. Cheong W.K., Thirumoorthy T., Doraisingham S., and Ling A.E. Clinical and laboratory study of first episode genital herpes in Singapore. Int J STD AIDS 1 3 (1990) 195-198
10. Rodgers C.A., and O'Mahony C. High prevalence of herpes simplex virus type 1 in female anogenital herpes simplex. Int J STD AIDS 6 2 (1995) 144
11. Christie S.N., McCaughey C., McBride M., and Coyle P.V. Herpes simplex type 1 and genital herpes in Northern Ireland. Int J STD AIDS 8 1 (1997) 68-69
12. Corey L., Wald A., Celum C.L., and Quinn T.C. The effects of herpes simplex virus-2 on HIV-1 acquisition and transmission: a review of two overlapping epidemics. J Acquir Immune Defic Syndr: JAIDS 35 5 (2004) 435-445
13. Corey L., Langenberg A.G., Ashley R., Sekulovich R.E., Izu A.E., Douglas Jr. J.M., et al. Recombinant glycoprotein vaccine for the prevention of genital HSV-2 infection: two randomized controlled trials. Chiron HSV Vaccine Study Group. JAMA 282 4 (1999) 331-340
14. Stanberry L.R., Spruance S.L., Cunningham A.L., Bernstein D.I., Mindel A., Sacks S., et al. Glycoprotein-D-adjuvant vaccine to prevent genital herpes. N Engl J Med 347 21 (2002) 1652-1661
15. Da Costa X.J., Morrison L.A., and Knipe D.M. Comparison of different forms of herpes simplex replication-defective mutant viruses as vaccines in a mouse model of HSV-2 genital infection. Virology 288 2 (2001) 256-263
16. Spear P.G., Eisenberg R.J., and Cohen G.H. Three classes of cell surface receptors for alphaherpesvirus entry. Virology 275 1 (2000) 1-8
17. Shukla D., Liu J., Blaiklock P., Shworak N.W., Bai X., Esko J.D., et al. A novel role for 3-O-sulfated heparan sulfate in herpes simplex virus 1 entry. Cell 99 1 (1999) 13-22
18. Shukla D., and Spear P.G. Herpesviruses and heparan sulfate: an intimate relationship in aid of viral entry. J Clin Invest 108 4 (2001) 503-510
19. Montgomery R.I., Warner M.S., Lum B.J., and Spear P.G. Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family. Cell 87 3 (1996) 427-436
20. Whitbeck J.C., Peng C., Lou H., Xu R., Willis S.H., Ponce de Leon M., et al. Glycoprotein D of herpes simplex virus (HSV) binds directly to HVEM, a member of the tumor necrosis factor receptor superfamily and a mediator of HSV entry. J Virol 71 8 (1997) 6083-6093
21. Warner M.S., Geraghty R.J., Martinez W.M., Montgomery R.I., Whitbeck J.C., Xu R., et al. A cell surface protein with herpesvirus entry activity (HveB) confers susceptibility to infection by mutants of herpes simplex virus type 1, herpes simplex virus type 2, and pseudorabies virus. Virology 246 1 (1998) 179-189
22. Geraghty R.J., Krummenacher C., Cohen G.H., Eisenberg R.J., and Spear P.G. Entry of alphaherpesviruses mediated by poliovirus receptor-related protein 1 and poliovirus receptor. Science 280 5369 (1998) 1618-1620
23. Cocchi F., Menotti L., Mirandola P., Lopez M., and Campadelli-Fiume G. The ectodomain of a novel member of the immunoglobulin subfamily related to the poliovirus receptor has the attributes of a bona fide receptor for herpes simplex virus types 1 and 2 in human cells. J Virol 72 12 (1998) 9992-10002
24. Takai Y., and Nakanishi H. Nectin and afadin: novel organizers of intercellular junctions. J Cell Sci 116 Pt 1 (2003) 17-27
25. Takai Y., Irie K., Shimizu K., Sakisaka T., and Ikeda W. Nectins and nectin-like molecules: roles in cell adhesion, migration, and polarization. Cancer Sci 94 8 (2003) 655-667
26. Krummenacher C., Baribaud F., Ponce de Leon M., Baribaud I., Whitbeck J.C., Xu R., et al. Comparative usage of herpesvirus entry mediator A and nectin-1 by laboratory strains and clinical isolates of herpes simplex virus. Virology 322 2 (2004) 286-299
27. Turner A., Bruun B., Minson T., and Browne H. Glycoproteins gB, gD, and gHgL of herpes simplex virus type 1 are necessary and sufficient to mediate membrane fusion in a Cos cell transfection system. J Virol 72 1 (1998) 873-875
28. Spear P.G., and Longnecker R. Herpesvirus entry: an update. J Virol 77 19 (2003) 10179-10185
29. Fuller A.O., and Lee W.C. Herpes simplex virus type 1 entry through a cascade of virus-cell interactions requires different roles of gD and gH in penetration. J Virol 66 8 (1992) 5002-5012
30. Handler C.G., Cohen G.H., and Eisenberg R.J. Cross-linking of glycoprotein oligomers during herpes simplex virus type 1 entry. J Virol 70 9 (1996) 6076-6082
31. Cocchi F., Fusco D., Menotti L., Gianni T., Eisenberg R.J., Cohen G.H., et al. The soluble ectodomain of herpes simplex virus gD contains a membrane-proximal pro-fusion domain and suffices to mediate virus entry. Proc Natl Acad Sci USA 101 19 (2004) 7445-7450
32. Carfi A., Willis S.H., Whitbeck J.C., Krummenacher C., Cohen G.H., Eisenberg R.J., et al. Herpes simplex virus glycoprotein D bound to the human receptor HveA. Mol Cell 8 1 (2001) 169-179
33. Carfi A., Gong H., Lou H., Willis S.H., Cohen G.H., Eisenberg R.J., et al. Crystallization and preliminary diffraction studies of the ectodomain of the envelope glycoprotein D from herpes simplex virus 1 alone and in complex with the ectodomain of the human receptor HveA. Acta Crystallogr Section D-Biol Crystallogr 58 Pt 5 (2002) 836-838
34. Connolly S.A., Landsburg D.J., Carfi A., Wiley D.C., Eisenberg R.J., and Cohen G.H. Structure-based analysis of the herpes simplex virus glycoprotein D binding site present on herpesvirus entry mediator HveA (HVEM). J Virol 76 21 (2002) 10894-10904
35. Connolly S.A., Landsburg D.J., Carfi A., Wiley D.C., Cohen G.H., and Eisenberg R.J. Structure-based mutagenesis of herpes simplex virus glycoprotein D defines three critical regions at the gD-HveA/HVEM binding interface. J Virol 77 14 (2003) 8127-8140
36. Whitbeck J.C., Connolly S.A., Willis S.H., Hou W., Krummenacher C., Ponce de Leon M., et al. Localization of the gD-binding region of the human herpes simplex virus receptor, HveA. J Virol 75 1 (2001) 171-180
37. Connolly S.A., Landsburg D.J., Carfi A., Whitbeck J.C., Zuo Y., Wiley D.C., et al. Potential nectin-1 binding site on herpes simplex virus glycoprotein D. J Virol 79 2 (2005) 1282-1295
38. Manoj S., Jogger C.R., Myscofski D., Yoon M., and Spear P.G. Mutations in herpes simplex virus glycoprotein D that prevent cell entry via nectins and alter cell tropism. Proc Natl Acad Sci USA 101 34 (2004) 12414-12421
39. Krummenacher C., Rux A.H., Whitbeck J.C., Ponce-de-Leon M., Lou H., Baribaud I., et al. The first immunoglobulin-like domain of HveC is sufficient to bind herpes simplex virus gD with full affinity, while the third domain is involved in oligomerization of HveC. J Virol 73 10 (1999) 8127-8137
40. Krummenacher C., Supekar V.M., Whitbeck J.C., Lazear E., Connolly S.A., Eisenberg R.J., et al. Structure of unliganded HSV gD reveals a mechanism for receptor-mediated activation of virus entry. EMBO J 24 23 (2005) 4144-4153
41. Miller C.G., Krummenacher C., Eisenberg R.J., Cohen G.H., and Fraser N.W. Development of a syngenic murine B16 cell line-derived melanoma susceptible to destruction by neuroattenuated HSV-1. Mol Ther: J Am Soc Gene Ther 3 2 (2001) 160-168
42. Dean H.J., Terhune S.S., Shieh M.T., Susmarski N., and Spear P.G. Single amino acid substitutions in gD of herpes simplex virus 1 confer resistance to gD-mediated interference and cause cell-type-dependent alterations in infectivity. Virology 199 1 (1994) 67-80
43. Ligas M.W., and Johnson D.C. A herpes simplex virus mutant in which glycoprotein D sequences are replaced by beta-galactosidase sequences binds to but is unable to penetrate into cells. J Virol 62 5 (1988) 1486-1494
44. Nagashunmugam T., Lubinski J., Wang L., Goldstein L.T., Weeks B.S., Sundaresan P., et al. In vivo immune evasion mediated by the herpes simplex virus type 1 immunoglobulin G Fc receptor. J Virol 72 7 (1998) 5351-5359
45. Friedman H.M., Wang L., Fishman N.O., Lambris J.D., Eisenberg R.J., Cohen G.H., et al. Immune evasion properties of herpes simplex virus type 1 glycoprotein gC. J Virol 70 7 (1996) 4253-4260
46. Judson K.A., Lubinski J.M., Jiang M., Chang Y., Eisenberg R.J., Cohen G.H., et al. Blocking immune evasion as a novel approach for prevention and treatment of herpes simplex virus infection. J Virol 77 23 (2003) 12639-12645
47. Lubinski J., Wang L., Mastellos D., Sahu A., Lambris J.D., and Friedman H.M. In vivo role of complement-interacting domains of herpes simplex virus type 1 glycoprotein gC.[erratum appears in J Exp Med 2000 Feb 21;191(4):following 746]. J Exp Med 190 11 (1999) 1637-1646
48. Graf Jr. L.H., Kaplan P., and Silagi S. Efficient DNA-mediated transfer of selectable genes and unselected sequences into differentiated and undifferentiated mouse melanoma clones. Somat Cell Mol Genet 10 2 (1984) 139-151
49. Milne R.S., Hanna S.L., Rux A.H., Willis S.H., Cohen G.H., and Eisenberg R.J. Function of herpes simplex virus type 1 gD mutants with different receptor-binding affinities in virus entry and fusion. J Virol 77 16 (2003) 8962-8972
50. Rixon F.J., and McGeoch D.J. Detailed analysis of the mRNAs mapping in the short unique region of herpes simplex virus type 1. Nucl Acids Res 13 3 (1985) 953-973
51. Hambleton S., and Gershon A.A. Preventing varicella-zoster disease. Clin Microbiol Rev 18 1 (2005) 70-80
52. Yoon M., Zago A., Shukla D., and Spear P.G. Mutations in the N termini of herpes simplex virus type 1 and 2 gDs alter functional interactions with the entry/fusion receptors HVEM, nectin-2, and 3-O-sulfated heparan sulfate but not with nectin-1. J Virol 77 17 (2003) 9221-9231