Brain activation during eye gaze discrimination in stable schizophrenia

Schizophrenia Research

Volumn 99, Issue 1-3, 2008, Pages 286-293

  Kohler, Christian G ^a   Loughead, James ^a   Ruparel, Kosha ^a   Indersmitten, Tim ^a   Barrett, Frederick S ^a   Gur, Raquel E ^a   Gur, Ruben C ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Amygdala; Faces; fMRI; Frontal lobe; Gaze discrimination; Schizophrenia

Indexed keywords

ADULT; ARTICLE; BRAIN REGION; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; ELECTROENCEPHALOGRAM; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GAZE; HUMAN; NEOCORTEX; PRIORITY JOURNAL; SCHIZOPHRENIA;

ADULT; AMYGDALA; ATTENTION; BRAIN MAPPING; CEREBRAL CORTEX; DISCRIMINATION (PSYCHOLOGY); DOMINANCE, CEREBRAL; FACE; FEMALE; FIXATION, OCULAR; FRONTAL LOBE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; NERVE NET; ORIENTATION; OXYGEN; PATTERN RECOGNITION, VISUAL; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; TEMPORAL LOBE;

EID: 39149087686     PISSN: 09209964     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.schres.2007.09.038     Document Type: Article

References (48)

1. Adolphs R., Gosselin F., Buchanan T.W., Tranel D., Schyns P., and Damasio A.R. A mechanism for impaired fear recognition after amygdala damage. Nature 433 (2005) 68-72
2. Allison T., Ginter H., McCarthy G., Nobre A.C., Puce A., Luby M., and Spencer D.D. Face recognition in human extrastriate cortex. J. Neurophysiol. 71 (1994) 821-825
3. Andreasen N.C. The Scale for the Assessment of Positive Symptoms (SAPS) (1984), The University of Iowa, Iowa City
4. Andreasen N.C. The Scale for the Assessment of Negative Symptoms (SANS) (1984), The University of Iowa, Iowa City
5. Bandettini P.A., Wong E.C., Hinks R.S., Tikofsky R.S., and Hyde J.S. Time course EPI of human brain function during task activation. Magn. Reson. Med. 25 (1992) 390-397
6. Baron-Cohen S. Mindblindedness (1995), MIT Press, Cambridge MA
7. Campbell R., Heywood C.A., Cowey A., Regard M., and Landis T. Sensitivity to eye gaze in prosopagnosic patients and monkeys with superior temporal sulcus ablation. Neuropsychologia 28 (1999) 1123-1142
8. Calder A.J., Lawrence A.D., Keane J., Scott S.K., Owen A.M., Christoffels I., and Young A.W. Reading the mind from eye gaze. Neuropsychologia 40 (2002) 1129-1138
9. Chen L.L. Head movements evoked by electrical stimulation in the frontal eye field of the monkey: evidence for independent eye and head control. J. Neurophysiol. 95 (2006) 3528-3542
10. Clark V.P., Keil K., Maisog J.M., Courtney S., Ungerleider L.G., and Haxby J.V. Functional magnetic resonance imaging of human visual cortex during face matching: a comparison with positron emission tomography. NeuroImage 4 (1996) 1-15
11. Crespo-Facorro B., Roiz-Santiáñez R., Pelayo-Terán J.M., Rodríguez-Sánchez J.M., Pérez-Iglesias R., González-Blanch C., et al. Reduced thalamic volume in first-episode non-affective psychosis: correlations with clinical variables, symptomatology and cognitive functioning. Neuroimage. Neuroimage 35 (2007) 1613-1623
12. Davatzikos C., Shen D., Gur R.C., Wu X., Liu D., Fan Y., Hughett P., Turetsky B.I., and Gur R.E. Whole-brain morphometric study of schizophrenia revealing a spatially complex set of focal abnormalities. Arch. Gen. Psychiatry 62 (2005) 1218-1227
13. Franck N., Daprati E., Michel F., Saoud M., Dalery J., Marie-Cardine M., and Georgieff N. Gaze discrimination is unimpaired in schizophrenia. Psychiatry Res. 81 (1998) 67-75
14. Franck N., Montoute T., Labruyere N., Tiberghien G., Marie-Cardine M., Dalery J., et al. Gaze direction determination in schizophrenia. Schizophr. Res. 56 (2002) 225-234
15. Frith U., and Frith C.D. Development and neurophysiology of mentalizing. Philos. Trans. R. Soc. Lond., B Biol. Sci. 358 (2003) 459-473
16. Garrett A.S., Menon V., MacKenzie K., and Reiss A.L. Here's looking at you, kid: neural systems underlying face and gaze processing in fragile X syndrome. Arch. Gen. Psychiatry 61 (2004) 281-288
17. Gur R.E., Mozley P.D., Resnick S.M., Levick S., Erwin R., Saykin A.J., and Gur R.C. Relations among clinical scales in schizophrenia. Am. J. Psychiatry 148 (1991) 472-478
18. Gur R.E., and Pearlson G.D. Neuroimaging in schizophrenia research. Schizophr. Bull. 19 (1993) 337-353
19. Gur R.E., Loughead J., Kohler C.G., Elliott M.A., Lesko K., Ruparel K., Wolf D.H., Bilker W.B., and Gur R.C. Limbic activation associated with misidentification of fearful faces and flat affect in schizophrenia. Arch. Gen. Psychiatry 64 (2007) 1356-1366
20. Hirstein W., and Ramachandran V.S. Capgras syndrome: a novel probe for understanding the neural representation of the identity and familiarity of persons. Proc. Biol. Sci. 264 (1997) 437-444
21. Hoffman E.A., and Haxby J.V. Distinct representations of eye gaze and identity in the distributed human neural system for face perception. Nat. Neurosci. 3 (2000) 80-84
22. Hooker C., and Park S. You must be looking at me: the nature of gaze perception in schizophrenia. Cogn. Neuropsychiatry 10 (2005) 327-345
23. Hooker C.I., Paller K.A., Gitelman D.R., Parrish T.B., Mesulam M.M., and Reber P.J. Brain networks for analyzing eye gaze. Brain Res. Cogn. Brain Res. 17 (2003) 406-418
24. Jenkinson M., and Smith S. A global optimization method for robust affine registration of brain images. Med. Image Anal. 5 (2001) 143-156
25. Kampe K.K.W., Frith C.D., Dolan R.J., and Frith U. Reward value of attractiveness and gaze. Nature 413 (2001) 589-590
26. Kanwisher N., McDermott J., and Chun M.M. The fusiform face area. J. Neurosci. 17 (1997) 4302-4311
27. Kawashima R., Sugiura M., Kato T., Nakamura A., Hatano K., Ito K., et al. The human amygdala plays an important role in gaze monitoring-a PET study. Brain 122 (1999) 779-783
28. Kleinke C.L. Gaze and eye contact: a research review. Psychol. Bull. 100 (1986) 78-100
29. Lancaster J.L., Woldorff M.G., Parsons L.M., Liotti M., Freitas C.S., Rainey L., et al. Automated Talairach atlas labels for functional brain mapping. Hum. Brain Mapp. 10 (2000) 120-131
30. McCarley R.W., Shenton M.E., O'Donnell B.F., Faux S.F., Kikinis R., Nestor P.G., and Jolesz F.A. Auditory P300 abnormalities and left posterior superior temporal gyrus volume reduction in schizophrenia. Arch. Gen. Psychiatry 50 (1993) 190-197
31. Mobbs D., Garrett A.S., Menon V., Rose F.E., Bellugi U., and Reiss A.L. Anomalous brain activation during face and gaze processing in Williams syndrome. Neurology 62 (2004) 2070-2076
32. Onitsuka T., Niznikiewicz M.A., Spencer K.M., Frumin M., Kuroki N., Lucia L.C., et al. Functional and structural deficits in brain regions subserving face perception in schizophrenia. Am. J. Psychiatry 163 (2006) 455-462
33. Perrett D.I., Hietanen J.K., Oram M.W., and Benson P.J. Organization and functions of cells responsive to faces in the temporal cortex. Philos. Trans. R. Soc. Lond., B Biol. Sci. 335 (1992) 23-30
34. Pitman R.K., Kolb B., Orr S.P., and Singh M.M. Ethological study of facial behavior in nonparanoid and paranoid schizophrenic patients. Am. J. Psychiatry 144 (1987) 99-102
35. Premack D., and Woodruff G. Does the chimpanzee have a "theory of mind?". Behav. Brain Sci. 4 (1978) 515-526
36. Rosse R.B., Kendrick K., Wyatt R.J., Isaac A., and Deutsch S.I. Gaze discrimination in patients with schizophrenia: preliminary report. Am. J. Psychiatry 151 (1994) 919-921
37. Rossion B., Dricot L., Devolder A., Bodart J.M., Crommelinck M., De Gelder B., and Zoontjes R. Hemispheric asymmetries for whole-based and part-based face processing in the human fusiform gyrus. J. Cogn. Neurosci. 12 (2000) 793-802
38. Shtasel D.L., Gur R.E., Mozley P.D., Richards J., Taleff M.M., Heimberg C., et al. Volunteers for biomedical research. Recruitment and screening of normal controls. Arch. Gen. Psychiatry 48 (1991) 1022-1025
39. Siegal M., and Varley R. Neural systems involved in 'theory of mind'. Nat. Rev. Neurosci. 3 (2002) 463-471
40. Smith S.M. Fast robust automated brain extraction. Hum. Brain Mapp. 17 (2002) 143-155
41. Talairach J., and Tournoux P. Co-planar stereotaxic atlas of the human brain. 3-Dimensional Proportional System: An Approach to Cerebral Imaging (1988), Thieme Medical Publishers, New York
42. Walker E.F., Grimes K.E., Davis D.M., and Smith A.J. Childhood precursors of schizophrenia: facial expressions of emotion. Am. J. Psychiatry 150 (1993) 1654-1660
43. Watt N.F. Patterns of childhood social development in adult schizophrenics. Arch. Gen. Psychiatry 36 (1978) 160-165
44. Whalen P.J., Kagan J., Cook R.G., Davis F.C., Kim H., Polis S., et al. Human amygdala responsivity to masked fearful eye whites. Science 306 (2004) 2061
45. Wicker B., Michel F., Henaff M.A., and Decety J. Brain regions involved in the perception of gaze: a PET study. NeuroImage 8 (1998) 221-227
46. Woolrich M.W., Ripley B.D., Brady M., and Smith S.M. Temporal autocorrelation in univariate linear modeling of FMRI data. NeuroImage 14 (2001) 1370-1386
47. Worsley K.J., Evans A.C., Marrett S., and Neelin P. A three dimensional statistical analysis for CBF activation studies in human brain. J. Cereb. Blood Flow Metab. 12 (1992) 900-918
48. Zipursky R.B., Marsh L., Lim K.O., DeMent S., Shear P.K., Sullivan E.V., et al. Volumetric MRI assessment of temporal lobe structures in schizophrenia. Biol. Psychiatry 35 (1994) 501-516