Effects of lysine to arginine mutations in HIV-1 Vif on its expression and viral infectivity

International Journal of Molecular Medicine

Volumn 18, Issue 4, 2006, Pages 679-683

  Khamsri, Boonruang ^a,b   Fujita, Mikako ^a   Kamada, Kazuya ^a   Piroozmand, Ahmad ^a   Yamashita, Tomoki ^a   Uchiyama, Tsuneo ^a   Adachi, Akio ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b NARESUAN UNIVERSITY   (Thailand)

Author keywords

Arginine; HIV 1; Lysine; Vif

Indexed keywords

ARGININE; LYSIN; MUCOPROTEIN; VIF PROTEIN;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CELL LINE; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; GROWTH, DEVELOPMENT AND AGING; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; METABOLISM; MOLECULAR GENETICS; MUTATION; PLASMID; TUMOR CELL LINE; WESTERN BLOTTING;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARGININE; BLOTTING, WESTERN; CELL LINE; CELL LINE, TUMOR; GENE EXPRESSION REGULATION, VIRAL; GENE PRODUCTS, VIF; HIV-1; HUMANS; MOLECULAR SEQUENCE DATA; MUCOPROTEINS; MUTATION; PLASMIDS; TRANSFECTION;

EID: 39049187847     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.18.4.679     Document Type: Article

References (30)

1. Miller RJ, Cairns JS, Bridges S and Sarver N: Human immunodeficiency virus and AIDS: insights from animal lentiviruses. J Virol 74: 7187-7195, 2000.
2. Harada S, Koyanagi Y and Yamamoto N: Infection of HTLV-III/LAV in HTLV-I-carrying cells MT-2 and MT-4 and application in a plaque assay. Science 229: 563-566, 1985.
3. Shibata R, Kawamura M, Sakai H, Hayami M, Ishimoto A and Adachi A: Generation of a chimeric human and simian immunodeficiency virus infectious to monkey peripheral blood mononuclear cells. J Virol 65: 3514-3520, 1991.
4. + cell line H9. AIDS Res Hum Retrov 5: 253-255, 1989.
5. + T lymphocytes. J Virol 66: 6489-6495, 1992.
6. Sakai H, Shibata R, Sakuragi JI, Sakuragi S, Kawamura M and Adachi A: Cell-dependent requirement of human immunodeficiency virus type 1 Vif protein for maturation of virus particles. J Virol 67: 1663-1666, 1993.
7. von Schwedler U, Song J, Alken C and Trono D: vif is crucial for human immunodeficiency virus type 1 proviral DNA synthesis in infected cells. J Virol 67: 4945-4955, 1993.
8. Borman AM, Quillent C, Charneau P, Dauguet C and Clavel F: Human immunodeficiency virus type 1 Vif-mutant particles from restrictive cells: role of Vif in correct particle assembly and infectivity. J Virol 69: 2058-2067, 1995.
9. Simon JHM and Malim MH: The human immunodeficiency virus type 1 Vif protein modulates the postpenetration stability of viral nucleoprotein complexes. J Virol 70: 5297-5305, 1996.
10. Sheehy AM, Gaddis NC, Choi JD and Malim MH: Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein. Nature 418: 645-650, 2002.
11. Conticello SG, Harris RS and Neuberger MS: The Vif protein of HIV triggers degradation of the human antiretroviral DNA deaminase APOBEC3G. Curr Biol 13: 2009-2013, 2003.
12. Kao S, Khan MA, Miyagi E, Plishka R, Buckler-White A and Strebel K: The human immunodeficiency virus type 1 Vif protein reduces intracellular expression and inhibits packaging of APOBEC3G (CEM15), a cellular inhibitor of virus infectivity. J Virol 77: 11398-11407, 2003.
13. Mariani R, Chen D, Schrofelbauer B, Navarro F, Konig R, Bollman B, Munk C, Nymark-McMahon and Landau NR: Species-specific exclusion of APOBEC3G from HIV-1 virions by Vif. Cell 114: 21-31, 2003.
14. Marin M, Rose KM, Kozak SL and Kabat D: HIV-1 Vif protein binds the editing enzyme APOBEC3G and induces its degradation. Nat Med 9: 1398-1403, 2003.
15. Sheehy AM, Gaddis NC and Malim MH: The antiretroviral enzyme APOBEC3G is degraded by the proteasome in response to HIV-1 Vif. Nat Med 9: 1404-1407, 2003.
16. Stopak K, de Noronha C, Yonemoto W and Greene WC: HIV-1 Vif blocks the antiviral activity of APOBEC3G by impairing both its translation and intracellular stability. Mol Cell 12: 591-601, 2003.
17. Yu X, Yu Y, Liu B, Luo K, Kong W, Mao P and Yu XF: Induction of APOBEC3G ubiquitination and degradation by an HIV-1 Vif-Cul5-SCF complex. Science 302: 1056-1060, 2003.
18. Kao S, Miyagi E, Khan MA, Takeuchi H, Opi S, Goila-Gaur R and Strebel K: Production of infectious human immunodeficiency virus type 1 does not require depletion of APOBEC3G from virus-producing cells. Retrovirology 1: 27, 2004.
19. Mehle A, Strack B, Ancuta P, Zhang C, McPike M and Gabuzuda D: Vif overcomes the innate antiviral activity of APOBEC3G by promoting its degradation in the ubiquitin-proteasome pathway. J Biol Chem 279: 7792-7798, 2004.
20. Fujita M, Akari H, Sakurai A, Yoshida A, Chiba T, Tanaka K, Strebel K and Adachi A: Expression of HIV-1 accessory protein Vif is controlled uniquely to be low and optimal by proteasome degradation. Microbes Infect 6: 791-798, 2004. (Pubitemid 39055540)
21. Wang H, Sakurai A, Khamsri B, Uchiyama T, Gu H, Adachi A and Fujita M: Unique characteristics of HIV-1 Vif expression. Microbes Infect 7: 385-390, 2005.
22. Akari H, Fujita M, Kao S, Khan MA, Shehu-Xhilaga M, Adachi A and Strebel K: High level expression of human immunodeficiency virus type-1 Vif inhibits viral infectivity by modulating proteolytic processing of the Gag precursor at the p2/NC processing site. J Biol Chem 279: 12355-12362, 2004.
23. Strebel K, Daugherty D, Clouse K, Cohen D, Folks T and Martin MA: The HIV 'A' (sor) gene product is essential for virus infectivity. Nature 328: 728-730, 1987.
24. Pickart CM: Back to the future with ubiquitin. Cell 116: 181-190, 2004.
25. Lebkowski JS, Clancy S and Calos MP: Simian virus 40 replication in adenovirus-transformed human cells antagonizes gene expression. Nature 317: 169-171, 1985.
26. Adachi A, Gendelman HE, Koenig S, Folks T, Willey R, Rabson A and Martin MA: Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone. J Virol 59: 284-291, 1986.
27. Willey RL, Smith DH, Lasky LA, Theodore TS, Earl PL, Moss B, Capon DJ and Martin MA: In vitro mutagenesis identifies a region within the envelope gene of the human immunodeficiency virus that is critical for infectivity. J Virol 62: 139-147, 1998.
28. Karczewski MK and Strebel K: Cytoskeleton association and virion incorporation of the human immunodeficiency virus type 1 Vif protein. J Virol 70: 494-507, 1996.
29. Adachi A, Ono N, Sakai H, Ogawa K, Shibata R, Kiyomatsu T, Masuike H and Ueda S: Generation and characterization of the human immunodeficiency virus type 1 mutants. Arch Virol 117: 45-58, 1991.
30. Fujita M, Yoshida A, Miyaura M, Sakurai A, Akari H, Koyama AH and Adachi A: Cyclophilin A-independent replication of a human immunodeficiency virus type 1 isolate carrying a small portion of the simian immunodeficiency virus SIVMAC gag capsid region. J Virol 75: 10527-10531, 2001.