Central sleep apnea and Cheyne-Stokes respiration

Proceedings of the American Thoracic Society

Volumn 5, Issue 2, 2008, Pages 226-236

  Yumino, Dai ^a   Bradley, T Douglas ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b TORONTO GENERAL HOSPITAL   (Canada)

Author keywords

Diagnosis; Heart failure; Pathophysiology; Sleep disordered breathing

Indexed keywords

AROUSAL; BRAIN BLOOD FLOW; CARBON DIOXIDE TENSION; CARDIOVASCULAR EFFECT; CENTRAL SLEEP APNEA SYNDROME; CHEYNE STOKES BREATHING; HEART FAILURE; HUMAN; LUNG CONGESTION; MORTALITY; PATHOPHYSIOLOGY; POLYSOMNOGRAPHY; PREVALENCE; REVIEW; RISK FACTOR;

ADULT; CHEYNE-STOKES RESPIRATION; HEART FAILURE; HUMANS; POLYSOMNOGRAPHY; RISK FACTORS; SLEEP APNEA, CENTRAL;

EID: 39049173460     PISSN: 15463222     EISSN: None     Source Type: Journal    
DOI: 10.1513/pats.200708-129MG     Document Type: Review

References (93)

1. Sin DD, Logan AG, Fitzgerald FS, Liu PP, Bradley TD. Effects of continuous positive airway pressure on cardiovascular outcomes in heart failure patients with and without Cheyne-Stokes respiration. Circulation 2000;102:61-66.
2. Corra U, Pistono M, Mezzani A, Braghiroli A, Giordano A, Lanfranchi P, Bosimini E, Gnemmi M, Giannuzzi P. Sleep and exertional periodic breathing in chronic heart failure: prognostic importance and interdependence. Circulation 2006;113:44-50.
3. Javaheri S, Shukla R, Zeigler H, Wexler L. Central sleep apnea, right ventricular dysfunction, and low diastolic blood pressure are predictors of mortality in systolic heart failure. J Am Coll Cardiol 2007;49:2028-2034.
4. Lanfranchi PA, Braghiroli A, Bosimini E, Mazzuero G, Colombo R, Donner CF, Giannuzzi P. Prognostic value of nocturnal Cheyne-Stokes respiration in chronic heart failure. Circulation 1999;99:1435-1440.
5. Hanly PJ, Zuberi-Khokhar NS. Increased mortality associated with Cheyne-Stokes respiration in patients with congestive heart failure. Am J Respir Crit Care Med 1996;153:272-276.
6. Arzt M, Bradley TD. Treatment of sleep apnea in heart failure. Am J Respir Crit Care Med 2006;173:1300-1308.
7. Kushida CA, Littner MR, Morgenthaler T, Alessi CA, Bailey D, Coleman J Jr, Friedman L, Hirshkowitz M, Kapen S, Kramer M, et al. Practice parameters for the indications for polysomnography and related procedures: an update for 2005. Sleep 2005;28:499-521.
8. American Academy of Sleep Medicine Task Force. Sleep-related breathing disorders in adults: recommendations for syndrome definition and measurement techniques in clinical research. Sleep 1999;22:667-689.
9. Norman RG, Ahmed MM, Walsleben JA, Rapoport DM. Detection of respiratory events during NPSG: nasal cannula/pressure sensor versus thermistor. Sleep 1997;20:1175-1184.
10. Staats BA, Bonekat HW, Harris CD, Offord KP. Chest wall motion in sleep apnea. Am Rev Respir Dis 1984;130:59-63.
11. Clark SA, Wilson CR, Satoh M, Pegelow D, Dempsey JA. Assessment of inspiratory flow limitation invasively and noninvasively during sleep. Am J Respir Crit Care Med 1998;158:713-722.
12. Boudewyns A, Willemen M, Wagemans M, De Cock W, Van de Heyning P, De Backer W. Assessment of respiratory effort by means of strain gauges and esophageal pressure swings: a comparative study. Sleep 1997;20:168-170.
13. Bradley TD, McNicholas WT, Rutherford R, Popkin J, Zamel N, Phillipson EA. Clinical and physiologic heterogeneity of the central sleep apnea syndrome. Am Rev Respir Dis 1986;134:217-221.
14. Sin DD, Fitzgerald F, Parker JD, Newton G, Floras JS, Bradley TD. Risk factors for central and obstructive sleep apnea in 450 men and women with congestive heart failure. Am J Respir Crit Care Med 1999;160:1101-1106.
15. Bradley TD, Logan AG, Kimoff RJ, Series F, Morrison D, Ferguson K, Belenkie I, Pfeifer M, Fleetham J, Hanly P, et al. Continuous positive airway pressure for central sleep apnea and heart failure. N Engl J Med 2005;353:2025-2033.
16. Bixler EO, Vgontzas AN, Ten Have T, Tyson K, Kales A. Effects of age on sleep apnea in men: I. Prevalence and severity. Am J Respir Crit Care Med 1998;157:144-148.
17. Javaheri S. Sleep disorders in systolic heart failure: a prospective study of 100 male patients. The final report. Int J Cardiol 2006;106:21-28.
18. Nopmaneejumruslers C, Kaneko Y, Hajek V, Zivanovic V, Bradley TD. Cheyne-Stokes respiration in stroke: relationship to hypocapnia and occult cardiac dysfunction. Am J Respir Crit Care Med 2005;171:1048-1052.
19. Tkacova R, Rankin F, Fitzgerald FS, Floras JS, Bradley TD. Effects of continuous positive airway pressure on obstructive sleep apnea and left ventricular afterload in patients with heart failure. Circulation 1998;98:2269-2275.
20. Kaneko Y, Floras JS, Usui K, Plante J, Tkacova R, Kubo T, Ando S, Bradley TD. Cardiovascular effects of continuous positive airway pressure in patients with heart failure and obstructive sleep apnea. N Engl J Med 2003;348:1233-1241.
21. Buckle P, Millar T, Kryger M. The effect of short-term nasal CPAP on Cheyne-Stokes respiration in congestive heart failure. Chest 1992;102:31-35.
22. Sin DD, Fitzgerald F, Parker JD, Newton GE, Logan AG, Floras JS, Bradley TD. Relationship of systolic BP to obstructive sleep apnea in patients with heart failure. Chest 2003;123:1536-1543.
23. Andreas S, Hagenah G, Moller C, Werner GS, Kreuzer H. Cheyne-Stokes respiration and prognosis in congestive heart failure. Am J Cardiol 1996;78:1260-1264.
24. Roebuck T, Solin P, Kaye DM, Bergin P, Bailey M, Naughton MT. Increased long-term mortality in heart failure due to sleep apnoea is not yet proven. Eur Respir J 2004;23:735-740.
25. Series F, Kimoff RJ, Morrison D, Leblanc MH, Smilovitch M, Howlett J, Logan AG, Floras JS, Bradley TD. Prospective evaluation of nocturnal oximetry for detection of sleep-related breathing disturbances in patients with chronic heart failure. Chest 2005;127:1507-1514.
26. Whyte KF, Allen MB, Fitzpatrick MF, Douglas NJ. Accuracy and significance of scoring hypopneas. Sleep 1992;15:257-260.
27. Cheyne J. A case of apoplexy, in which the fleshy part of the heart was converted into fat. Dublin Hospital Reports and Communications 1818;2:216-223.
28. Hall MJ, Xie A, Rutherford R, Ando S, Floras JS, Bradley TD. Cycle length of periodic breathing in patients with and without heart failure. Am J Respir Crit Care Med 1996;154:376-381.
29. Tkacova R, Hall MJ, Liu PP, Fitzgerald FS, Bradley TD. Left ventricular volume in patients with heart failure and Cheyne-Stokes respiration during sleep. Am J Respir Crit Care Med 1997;156:1549-1555.
30. Phillipson EA. Control of breathing during sleep. Am Rev Respir Dis 1978;118:909-939.
31. Bradley TD, Phillipson EA. Central sleep apnea. Clin Chest Med 1992;13:493-505.
32. 2. Chest 1993;104:1079-1084.
33. Naughton M, Benard D, Tam A, Rutherford R, Bradley TD. Role of hyperventilation in the pathogenesis of central sleep apneas in patients with congestive heart failure. Am Rev Respir Dis 1993;148:330-338.
34. Yu J, Zhang JF, Fletcher EC. Stimulation of breathing by activation of pulmonary peripheral afferents in rabbits. J Appl Physiol 1998;85:1485-1492.
35. Solin P, Bergin P, Richardson M, Kaye DM, Walters EH, Naughton MT. Influence of pulmonary capillary wedge pressure on central apnea in heart failure. Circulation 1999;99:1574-1579.
36. Lorenzi-Filho G, Azevedo ER, Parker JD, Bradley TD. Relationship of carbon dioxide tension in arterial blood to pulmonary wedge pressure in heart failure. Eur Respir J 2002;19:37-40.
37. Paintal AS. Vagal sensory receptors and their reflex effects. Physiol Rev 1973;53:159-227.
38. Javaheri S. A mechanism of central sleep apnea in patients with heart failure. N Engl J Med 1999;341:949-954.
39. Solin P, Roebuck T, Johns DP, Walters EH, Naughton MT. Peripheral and central ventilatory responses in central sleep apnea with and without congestive heart failure. Am J Respir Crit Care Med 2000;162:2194-2200.
40. Sun SY, Wang W, Zucker IH, Schultz HD. Enhanced peripheral chemoreflex function in conscious rabbits with pacing-induced heart failure. J Appl Physiol 1999;86:1264-1272.
41. 2 in patients with congestive heart failure. Am J Respir Crit Care Med 2002;165:1245-1250.
42. Ferrier K, Campbell A, Yee B, Richards M, O'Meeghan T, Weatherall M, Neill A. Sleep-disordered breathing occurs frequently in stable outpatients with congestive heart failure. Chest 2005;128:2116-2122.
43. Lorenzi-Filho G, Rankin F, Bies I, Douglas Bradley T. Effects of inhaled carbon dioxide and oxygen on Cheyne-Stokes respiration in patients with heart failure. Am J Respir Crit Care Med 1999;159:1490-1498.
44. Xie A, Wong B, Phillipson EA, Slutsky AS, Bradley TD. Interaction of hyperventilation and arousal in the pathogenesis of idiopathic central sleep apnea. Am J Respir Crit Care Med 1994;150:489-495.
45. Khoo MC, Kronauer RE, Strohl KP, Slutsky AS. Factors inducing periodic breathing in humans: a general model. J Appl Physiol 1982;53:644-659.
46. Xi L, Smith CA, Saupe KW, Henderson KS, Dempsey JA. Effects of rapid-eye-movement sleep on the apneic threshold in dogs. J Appl Physiol 1993;75:1129-1139.
47. Phillipson EA, Yasuma F, Kozar LF, England SJ. Respiratory muscle activation by chemical stimuli in awake and sleeping dogs. Prog Clin Biol Res 1990;345:201-211. (discussion 211-203).
48. Xie A, Skatrud JB, Khayat R, Dempsey JA, Morgan B, Russell D. Cerebrovascular response to carbon dioxide in patients with congestive heart failure. Am J Respir Crit Care Med 2005;172:371-378.
49. Bradley TD. Crossing the threshold: implications for central sleep apnea. Am J Respir Crit Care Med 2002;165:1203-1204.
50. Nakayama H, Smith CA, Rodman JR, Skatrud JB, Dempsey JA. Effect of ventilatory drive on carbon dioxide sensitivity below eupnea during sleep. Am J Respir Crit Care Med 2002;165:1251-1260.
51. Javaheri S. Acetazolamide improves central sleep apnea in heart failure: a double-blind, prospective study. Am J Respir Crit Care Med 2006;173:234-237.
52. Milionis HJ, Alexandrides GE, Liberopoulos EN, Bairaktari ET, Goudevenos J, Elisaf MS. Hypomagnesemia and concurrent acid-base and electrolyte abnormalities in patients with congestive heart failure. Eur J Heart Fail 2002;4:167-173.
53. Cherniack NS, Longobardo GS. Cheyne-Stokes breathing: an instability in physiologic control. N Engl J Med 1973;288:952-957.
54. Longobardo GS, Cherniack NS, Fishman AP. Cheyne-Stokes breathing produced by a model of the human respiratory system. J Appl Physiol 1966;21:1839-1846.
55. Alex CG, Onal E, Lopata M. Upper airway occlusion during sleep in patients with Cheyne-Stokes respiration. Am Rev Respir Dis 1986;133:42-45.
56. Sullivan CE, Murphy E, Kozar LF, Phillipson EA. Waking and ventilatory responses to laryngeal stimulation in sleeping dogs. J Appl Physiol 1978;45:681-689.
57. Badr MS, Toiber F, Skatrud JB, Dempsey J. Pharyngeal narrowing/ occlusion during central sleep apnea. J Appl Physiol 1995;78:1806-1815.
58. Takasaki Y, Orr D, Popkin J, Rutherford R, Liu P, Bradley TD. Effect of nasal continuous positive airway pressure on sleep apnea in congestive heart failure. Am Rev Respir Dis 1989;140:1578-1584.
59. Issa FG, Sullivan CE. Reversal of central sleep apnea using nasal CPAP. Chest 1986;90:165-171.
60. Naughton MT, Liu PP, Bernard DC, Goldstein RS, Bradley TD. Treatment of congestive heart failure and Cheyne-Stokes respiration during sleep by continuous positive airway pressure. Am J Respir Crit Care Med 1995;151:92-97.
61. Bradley TD, Holloway RM, McLaughlin PR, Ross BL, Walters J, Liu PP. Cardiac output response to continuous positive airway pressure in congestive heart failure. Am Rev Respir Dis 1992;145:377-382.
62. Berssenbrugge A, Dempsey J, Iber C, Skatrud J, Wilson P. Mechanisms of hypoxia-induced periodic breathing during sleep in humans. J Physiol 1983;343:507-526.
63. Andreas S, Clemens C, Sandholzer H, Figulla HR, Kreuzer H. Improvement of exercise capacity with treatment of Cheyne-Stokes respiration in patients with congestive heart failure. J Am Coll Cardiol 1996;27:1486-1490.
64. Hanly PJ, Millar TW, Steljes DG, Baert R, Frais MA, Kryger MH. The effect of oxygen on respiration and sleep in patients with congestive heart failure. Ann Intern Med 1989;111:777-782.
65. Staniforth AD, Kinnear WJ, Starling R, Hetmanski DJ, Cowley AJ. Effect of oxygen on sleep quality, cognitive function and sympathetic activity in patients with chronic heart failure and Cheyne-Stokes respiration. Eur Heart J 1998;19:922-928.
66. Franklin KA, Sandstrom E, Johansson G, Balfors EM. Hemodynamics, cerebral circulation, and oxygen saturation in Cheyne-Stokes respiration. J Appl Physiol 1997;83:1184-1191.
67. Sasayama S, Izumi T, Seino Y, Ueshima K, Asanoi H. Effects of nocturnal oxygen therapy on outcome measures in patients with chronic heart failure and Cheyne-Stokes respiration. Circ J 2006;70:1-7.
68. Crowell JW, Guyton AC, Moore JW. Basic oscillating mechanism of Cheyne-Stokes breathing. Am J Physiol 1956;187:395-398.
69. Datta AK, Shea SA, Horner RL, Guz A. The influence of induced hypocapnia and sleep on the endogenous respiratory rhythm in humans. J Physiol 1991;440:17-33.
70. Dark DS, Pingleton SK, Kerby GR, Crabb JE, Gollub SB, Glatter TR, Dunn MI. Breathing pattern abnormalities and arterial oxygen desaturation during sleep in the congestive heart failure syndrome. Improvement following medical therapy. Chest 1987;91:833-836.
71. Mansfield DR, Solin P, Roebuck T, Bergin P, Kaye DM, Naughton MT. The effect of successful heart transplant treatment of heart failure on central sleep apnea. Chest 2003;124:1675-1681.
72. Walsh JT, Andrews R, Starling R, Cowley AJ, Johnston ID, Kinnear WJ. Effects of captopril and oxygen on sleep apnoea in patients with mild to moderate congestive cardiac failure. Br Heart J 1995;73:237-241.
73. Wang H, Parker JD, Newton GE, Floras JS, Mak S, Chiu KL, Ruttanaumpawan P, Tomlinson G, Bradley TD. Influence of obstructive sleep apnea on mortality in patients with heart failure. J Am Coll Cardiol 2007;49:1625-1631.
74. Lanfranchi PA, Somers VK, Braghiroli A, Corra U, Eleuteri E, Giannuzzi P. Central sleep apnea in left ventricular dysfunction: prevalence and implications for arrhythmic risk. Circulation 2003;107:727-732.
75. 2 and circulatory delay. Circulation 2001;103:238-243.
76. Tkacova R, Wang H, Bradley TD. Night-to-night alterations in sleep apnea type in patients with heart failure. J Sleep Res 2006;15:321-328.
77. Naughton MT, Benard DC, Liu PP, Rutherford R, Rankin F, Bradley TD. Effects of nasal CPAP on sympathetic activity in patients with heart failure and central sleep apnea. Am J Respir Crit Care Med 1995;152:473-479.
78. Trinder J, Merson R, Rosenberg JI, Fitzgerald F, Kleiman J, Bradley TD. Pathophysiological interactions of ventilation, arousals, and blood pressure oscillations during Cheyne-Stokes respiration in patients with heart failure. Am J Respir Crit Care Med 2000;162:808-813.
79. Leung RS, Diep TM, Bowman ME, Lorenzi-Filho G, Bradley TD. Provocation of ventricular ectopy by Cheyne-Stokes respiration in patients with heart failure. Sleep 2004;27:1337-1343.
80. Lorenzi-Filho G, Dajani HR, Leung RS, Floras JS, Bradley TD. Entrainment of blood pressure and heart rate oscillations by periodic breathing. Am J Respir Crit Care Med 1999;159:1147-1154.
81. Kaye DM, Lefkovits J, Jennings GL, Bergin P, Broughton A, Esler MD. Adverse consequences of high sympathetic nervous activity in the failing human heart. J Am Coll Cardiol 1995;26:1257-1263.
82. Cohn JN, Levine TB, Olivari MT, Garberg V, Lura D, Francis GS, Simon AB, Rector T. Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure. N Engl J Med 1984;311:819-823.
83. Reiken S, Gaburjakova M, Gaburjakova J, He Kl KL, Prieto A, Becker E, Yi Gh GH, Wang J, Burkhoff D, Marks AR. Beta-adrenergic receptor blockers restore cardiac calcium release channel (ryanodine receptor) structure and function in heart failure. Circulation 2001;104:2843-2848.
84. Lehnart SE, Wehrens XH, Marks AR. Calstabin deficiency, ryanodine receptors, and sudden cardiac death. Biochem Biophys Res Commun 2004;322:1267-1279.
85. Daly PA, Sole MJ. Myocardial catecholamines and the pathophysiology of heart failure. Circulation 1990;82:I35-I43.
86. Pocock SJ, Wang D, Pfeffer MA, Yusuf S, McMurray JJ, Swedberg KB, Ostergren J, Michelson EL, Pieper KS, Granger CB. Predictors of mortality and morbidity in patients with chronic heart failure. Eur Heart J 2006;27:65-75.
87. O'Meara E, Clayton T, McEntegart MB, McMurray JJ, Lang CC, Roger SD, Young JB, Solomon SD, Granger CB, Ostergren J, et al. Clinical correlates and consequences of anemia in a broad spectrum of patients with heart failure: results of the candesartan in heart failure. Assessment of reduction in mortality and morbidity (CHARM) program. Circulation 2006;113:986-994.
88. Jiang W, Kuchibhatla M, Clary GL, Cuffe MS, Christopher EJ, Alexander JD, Califf RM, Krishnan RR, O'Connor CM. Relationship between depressive symptoms and long-term mortality in patients with heart failure. Am Heart J 2007;154:102-108.
89. CIBIS-II Investigators and Committee. The cardiac insufficiency bisoprolol study II (CIBIS-II): A randomised trial. Lancet 1999;353:9-13.
90. MERIT-HF Study Group. Effect of metoprolol CR/XL in chronic heart failure: metoprolol CR/XL randomised intervention trial in congestive heart failure (MERIT-HF). Lancet 1999;353:2001-2007.
91. Pitt B, Zannad F, Remme WJ, Cody R, Castaigne A, Perez A, Palensky J, Wittes J. The effect of spironolactone on morbidity and mortality in patients with severe heart failure: randomized aldactone evaluation study investigators. N Engl J Med 1999;341:709-717.
92. Hunt SA, Abraham WT, Chin MH, Feldman AM, Francis GS, Ganiats TG, Jessup M, Konstam MA, Mancini DM, Michl K, et al. ACC/ AHA 2005 guideline update for the diagnosis and management of chronic heart failure in the adult: a report of the American College of Cardiology/American Heart Association task force on practice guidelines (writing committee to update the 2001 guidelines for the evaluation and management of heart failure) developed in collaboration with the American college of chest physicians and the international society for heart and lung transplantation: Endorsed by the heart rhythm society. Circulation 2005;112:e154-e235.
93. Leung RS, Bradley TD. Sleep apnea and cardiovascular disease. Am J Respir Crit Care Med 2001;164:2147-2165.