Stimulation of breathing by activation of pulmonary peripheral afferents in rabbits

Journal of Applied Physiology

Volumn 85, Issue 4, 1998, Pages 1485-1492

  Yu, J ^a   Zhang, J F ^a   Fletcher, E C ^a  

^a University of Louisville School of Medicine   (United States)

Author keywords

C fibers; Peripheral lung receptors; Rapidly adapting receptors; Vagal reflex

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; HYPERPNEA; NERVE FIBER C; NONHUMAN; PHRENIC NERVE; PRIORITY JOURNAL; RABBIT; RESPIRATION CONTROL; SENSORY NERVE; SENSORY RECEPTOR; TACHYPNEA; VAGUS NERVE;

EID: 0031664856     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1998.85.4.1485     Document Type: Article

References (25)

1. Anand, A., and A. S. Paintal. Reflex effects following selective stimulation of J receptors in the cat. J. Physiol. (Lond.) 299: 553-572, 1980.
2. Armstrong, D. J., J. C. Luck, and V. M. Martin. The effect of emboli upon intrapulmonary receptors in the cat. Respir. Physiol. 26: 41-54, 1976.
3. Coleridge, H. M., and J. C. G. Coleridge. Pulmonary reflexes: neural mechanisms of pulmonary defense. Annu. Rev. Physiol. 56: 69-91, 1994.
4. Coleridge, J. C. G., and H. M. Coleridge. Afferent vagal C fibre innervation of the lungs and airways and its functional significance. Rev. Physiol. Biochem. Pharmacol. 99: 1-110, 1984.
5. Coon, R. L., P. S. Clifford, F. A. Hopp, and E. J. Zuperku. Reflex ventilatory effects of KCl stimulation of lung receptors with sympathetic afferents. Respir. Physiol. 82: 349-358, 1990.
6. Davies, A., F. Sant'Ambrogio, and G. Sant'Ambrogio. Onset of inspiration in rabbits during artificial ventilation. J. Physiol. (Lond.) 318: 17-23, 1981.
7. Eldridge, F. L. Relationship between respiratory nerve and muscle activity and muscle force output. J. Appl. Physiol. 39: 567-574, 1975.
8. Green, J. F., N. D. Schmidt, H. D. Schultz, A. M. Roberts, H. M. Coleridge, and J. C. G. Coleridge. Pulmonary C fibers evoke both apnea and tachypnea of pulmonary chemoreflex. J. Appl. Physiol. 57: 562-567, 1984.
9. Guz, A., and D. W. Trenchard. The role of non-myelinated vagal afferent fibres from the lungs in the genesis of tachypnoea in the rabbit. J. Physiol. (Lond.) 213: 345-347, 1971.
10. Holmes, H. R., and J. E. Remmers. Stimulation of vagal C-fibers alters timing and distribution of respiratory motor output in cats. J. Appl. Physiol. 67: 2249-2256, 1989.
11. Karlsson, J. A., G. Sant'Ambrogio, and J. Widdicombe. Afferent neural pathways in cough and reflex bronchoconstriction. J. Appl. Physiol. 65: 1007-1023, 1988.
12. Kaufman, M. P., H. M. Coleridge, J. C. G. Coleridge, and D. G. Baker. Bradykinin stimulates afferent vagal C fibers in intrapulmonary airways of dogs. J. Appl. Physiol. 48: 511-517, 1980.
13. Kostreva, D. R., F. A. Hopp, E. J. Zuperku, F. O. Igler, R. L. Coon, and J. P. Kampine. Respiratory inhibition with sympathetic afferent stimulation in the canine and primate. J. Appl. Physiol. 44: 718-724, 1978.
14. Paintal, A. S. Vagal sensory receptors and their reflex effects. Physiol. Rev. 53: 159-227, 1973.
15. Pisarri, T. E., A. Jonzon, H. M. Coleridge, and J. C. G. Coleridge. Intravenous injection of hypertonic NaCl solution stimulates pulmonary C fibers in dogs. Am. J. Physiol. 260 (Heart Circ. Physiol. 29): H1522-H1530, 1991.
16. Pisarri, T. E., A. Jonzon, H. M. Coleridge, and J. C. G. Coleridge. Vagal afferent and reflex responses to changes in surface osmolarity in lower airways of dogs. J. Appl. Physiol. 73: 2305-2313, 1992.
17. Sant'Ambrogio, F. B., and G. Sant'Ambrogio. Circulatory accessibility of nervous receptors localized in the tracheobronchial tree. Respir. Physiol. 49: 49-73, 1982.
18. Sant'Ambrogio, G. Information arising from the tracheobronchial tree of mammals. Physiol. Rev. 62: 531-569, 1982.
19. Sant'Ambrogio, G., and F. B. Sant'Ambrogio. Reflexes from the upper airway, lungs, chest wall, and limbs. In: The Lung: Scientific Foundations, edited by R. G. Crystal, J. B. West, E. R. Weibel, and P. J. Barnes. New York: Raven, 1997, p. 1805-1819.
20. Schelegle, E. S., J. K. Mansoor, and J. F. Green. Influence of background vagal C-fiber activity on eupneic breathing pattern in anesthetized dogs. J. Appl. Physiol. 79: 600-606, 1995.
21. Schertel, E. R., L. Adams, D. A. Schneider, K. S. Smith, and J. F. Green. Rapid shallow breathing evoked by capsaicin from isolated pulmonary circulation. J. Appl. Physiol. 61: 1237-1240, 1986.
22. + receptors in the lungs of anaesthetized rabbits. Respir. Physiol. 63, 227-240, 1986.
23. Widdicombe, J. G. Receptors in the trachea and bronchi of the cat. J. Physiol. (Lond.) 123: 71-104, 1954.
24. Widdicombe, J. G. Sensory innervation of the lung and airways. In: Progress In Brain Research, edited by F. Cervero and J. F. B. Morrison. New York: Elsevier Science, 1986, vol. 67, p. 49-64.
25. Widdicombe, J. G. Neurophysiology of the cough reflex. Eur. Respir. J. 8: 1193-1202, 1995.