Unexpected DNA damage caused by polycyclic aromatic hydrocarbons under standard laboratory conditions

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 650, Issue 2, 2008, Pages 96-103

  Platt, Karl L ^a   Aderhold, Susanne ^a   Kulpe, Kathrin ^a   Fickler, Michael ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Comet assay; DNA damage; Photochemical activation; Polycyclic aromatic hydrocarbons

Indexed keywords

11H BENZO[B]FLUORENE; 3 METHYLCHOLANTHRENE; 7,12 DIMETHYLBENZ[A]ANTHRACENE; ANTHANTHRENE; ANTHRACENE; BENZ[A]ANTHRACENE; BENZO[A]PYRENE; BENZO[E]PYRENE; BENZO[GHI]PERYLENE; CYTOCHROME P450; DIBENZ[A,H]ANTHRACENE; FLUOROANTHENE; NAPHTHACENE DERIVATIVE; NAPHTHALENE; PHENANTHRENE; POLYCYCLIC AROMATIC HYDROCARBON; PYRENE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHEMICAL STRUCTURE; CHO CELL; COMET ASSAY; CONTROLLED STUDY; DNA ADDUCT; DNA DAMAGE; DNA STRAND BREAKAGE; FLUORESCENCE; GENOTOXICITY; ILLUMINATION; INCUBATION TIME; METABOLIC ACTIVATION; NONHUMAN; PHOTOACTIVATION; PRIORITY JOURNAL; SKIN CANCER;

ANIMALS; BIOTRANSFORMATION; CELLS, CULTURED; COMET ASSAY; CRICETINAE; CRICETULUS; CYTOCHROME P-450 CYP1A1; DNA DAMAGE; LIGHT; POLYCYCLIC HYDROCARBONS, AROMATIC;

CRICETULUS GRISEUS;

EID: 39049161960     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2007.09.011     Document Type: Article

References (33)

1. Fairbairn D.W., Olive P.L., and O'Neill K.L. The comet assay: a comprehensive review. Mutat. Res. 339 (1995) 37-59
2. Dipple A. DNA adducts of chemical carcinogens. Carcinogenesis 16 (1995) 437-441
3. Hanelt S., Helbig R., Hartmann A., Lang M., Seidel A., and Speit G. A comparative investigation of DNA adducts, DNA strand breaks and gene mutations induced by benzo[a]pyrene and (±)-anti-benzo[a]pyrene-7,8-diol 9,10-oxide in cultured human cells. Mutat. Res. 390 (1997) 179-188
4. Frenzilli G., Bosco E., and Barale R. Validation of single cell gel assay in human leukocytes with 18 reference compounds. Mutat. Res. 468 (2000) 93-108
5. Uhl M., Helma C., and Knasmüller S. Evaluation of the single cell gel electrophoresis assay with human hepatoma (Hep G2) cells. Mutat. Res. 468 (2000) 213-225
6. ® as a tool for the comet assay. Mutat. Res. 519 (2002) 163-170
7. Wilkening S., Stahl F., and Bader A. Comparison of primary human hepatocytes and hepatoma cell line HepG2 with regard to their biotransformation properties. Drug Metab. Dispos. 31 (2003) 1035-1042
8. Annas A., Brittebo E., and Hellman B. Evaluation of benzo[a]pyrene-induced DNA damage in human endothelial cells using alkaline single cell gel electrophoresis. Mutat. Res. 471 (2000) 145-155
9. Jerina D.M., Sayer J.M., Agarwal S.K., Yagi H., Levin W., Wood A.W., Conney A.H., Pruess-Schwartz D., Baird W.M., Pigott M.A., and Dipple A. Reactivity and tumorigenicity of bay-region diol epoxides derived from polycyclic aromatic hydrocarbons. In: Kocsis J.J., Jollow D.J., Witmer C.M., Nelson J.O., and Snyder R. (Eds). Biological Reactive Intermediates III. Mechanisms of Action in Animal Models and Human Disease (1986), Plenum Press, New York and London 11-30
10. Glatt H., Gemperlein I., Setiabudi F., Platt K.L., and Oesch F. Expression of xenobiotic-metabolizing enzymes in propagatable cell cultures and induction of micronuclei by 13 compounds. Mutagenesis 5 (1990) 241-249
11. M. Lohmann. Transgene Zellsysteme zur Untersuchung des Fremdstoffmetabolismus-Etablierung katalytischer Kaskaden mittels polycistronischer Expressionsstrategien, Ph. D. Thesis, Department of Biology, University of Mainz, Mainz, 2001.
12. Platt K.L., and Oesch F. Efficient synthesis of non-K-region trans-dihydro diols of polycyclic aromatic hydrocarbons from o-quinones and catechols. J. Org. Chem. 48 (1983) 265-268
13. Yagi H., Thakker D.R., Hernandez O., Koreeda M., and Jerina D.M. Synthesis and reactions of the highly mutagenic 7,8-diol 9,10-epoxides of the carcinogen benzo[a]pyrene. J. Am. Chem. Soc. 99 (1977) 1604-1611
14. Edenharder R., Sager J.W., Glatt H., Muckel E., and Platt K.L. Protection by beverages, fruits, vegetables, herbs, and flavonoids against genotoxicity of 2-acetylaminofluorene and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in metabolically competent V79 cells. Mutat. Res. 521 (2002) 57-72
15. Schmassmann H., Sparrow A., Platt K., and Oesch F. Epoxide hydratase and benzo(a)pyrene monooxygenase activities in liver, kidney and lung after treatment of rats with epoxides of widely varying structures. Biochem. Pharmacol. 27 (1978) 2237-2245
16. Olive P.L., Banáth J.P., and Durand R.E. Heterogeneity in radiation-induced DNA damage and repair in tumor and normal cells measured using the "comet" assay. Radiat. Res. 122 (1990) 86-94
17. Martin F.L., Cole K.J., Orme M.H., Grover P.L., Phillips D.H., and Venitt S. The DNA repair inhibitors hydroxyurea and cytosine arabinoside enhance the sensitivity of the alkaline single-cell gel electrophoresis ('comet') assay in metabolically competent MCL-5 cells. Mutat. Res. 445 (1999) 21-43
18. Bradley M.O., Bhuyan B., Francis M.C., Langenbach R., Peterson A., and Huberman E. Mutagenesis by chemical agents in V79 Chinese hamster cells: A review and analysis of the literature. Mutat. Res. 87 (1981) 81-142
19. Sevanian A., and Peterson H. Induction of cytotoxicity and mutagenesis is facilitated by fatty acid hydroperoxidase activity in Chinese hamster lung fibroblasts (V79 cells). Mutat. Res. 224 (1989) 185-196
20. Lambert A.C., and Eastmond D.A. Genotoxic effects of the o-phenylphenol metabolites phenylhydroquinone and phenylbenzoquinone in V79 cells. Mutat. Res. 322 (1994) 243-256
21. Sansonetti C.J., Salit M.L., and Reader J. Wavelengths of spectral lines in mercury pencil lamps. Appl. Optics 35 (1996) 74-77
22. Silva J.E.C., Malta O.L., de Sá G.F., and Santa-Cruz P.A. Full-color simulation in a multi-doped glass and controlled quenching of luminescence using Er(III) as a suppressor for a tunable device. J. Lumin. 72-74 (1997) 270-272
23. Arfsten D.P., Schaeffer D.J., and Mulveny D.C. The effects of near ultraviolet radiation on the toxic effects of polycyclic aromatic hydrocarbons in animals and plants: A review. Ecotox. Environ. Saf. 33 (1996) 1-24
24. Yu H.T. Environmental carcinogenic polycyclic aromatic hydrocarbons: photochemistry and phototoxicity. J. Environ. Sci. Health C 20 (2002) 149-183
25. Larson R.A., and Berenbaum M.R. Environmental phototoxicity. Environ. Sci. Technol. 22 (1988) 354-360
26. Dong S., Hwang H.-M., Shi X., Holloway L., and Yu H. UVA-induced DNA single-strand cleavage by 1-hydroxypyrene and formation of covalent adducts between DNA and 1-hydroxypyrene. Chem. Res. Toxicol. 13 (2000) 585-593
27. Dong S., Hwang H.-M., Harrison C., Holloway L., Shi X., and Yu H. UVA light-induced DNA cleavage by selected polycyclic aromatic hydrocarbons. Bull. Environ. Contam. Toxicol. 64 (2000) 467-474
28. Yu H., Xia Q., Yan J., Herreno-Saenz D., Wu Y.S., Tang I.W., and Fu P.P. Photoirradiation of polycyclic aromatic hydrocarbons with UVA light-A pathway leading to the generation of reactive oxygen species, lipid peroxidation, and DNA damage. Int. J. Environ. Res. Public Health 3 (2006) 348-354
29. Toyooka T., Ibuki Y., Koike M., Ohashi N., Takahashi S., and Goto R. Coexposure to benzo[a]pyrene plus UVA induced DNA double strand breaks: visualization of Ku assembly in the nucleus having DNA lesions. Biochem. Biophys. Res. Commun. 322 (2004) 631-636
30. Ibuki Y., Warashina T., Noro T., and Goto R. Coexposure to benzo[a]pyrene plus ultraviolet A induces 8-oxo-7,8-dihydro-2'-deoxyguanosine formation in human skin fibroblasts: preventive effects of anti-oxidant agents. Environ. Toxicol. Phar. 12 (2002) 37-42
31. Jerina D.M., and Lehr E. The bay-region theory: a quantum mechanical approach to aromatic hydrocarbon-induced carcinogenicity. In: Ullrich V., Roots I., Hildebrandt A., Estabrook R.W., and Conney A.H. (Eds). Microsomes and Drug Oxidations (1977), Pergamon Press, Oxford 709-720
32. Clar E. Polycyclic hydrocarbons 1 (1964), Academic Press, London and New York
33. Clar E. Polycyclic hydrocarbons 2 (1964), Academic Press, London and New York