Cadmium reduces nitric oxide production by impairing phosphorylation of endothelial nitric oxide synthase

Biochemistry and Cell Biology

Volumn 86, Issue 1, 2008, Pages 1-10

  Majumder, Syamantak ^a   Muley, Ajit ^a   Kolluru, Gopi Krishna ^a   Saurabh, Samir ^a   Tamilarasan, K P ^a   Chandrasekhar, Sidhharth ^a   Reddy, Hima Bindu ^a   Purohit, Sharad ^b   Chatterjee, Suvro ^a  

^a ANNA UNIVERSITY   (India)

^b MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

Angiogenesis; Cadmium; Endothelial cells; Nitric oxide

Indexed keywords

ANGIOGENESIS; CELLULAR MIGRATION; ENDOTHELIAL FUNCTION;

ENDOTHELIAL CELLS; FLUORESCENCE; IMMUNOLOGY; METABOLISM; NITRIC OXIDE; PERTURBATION TECHNIQUES;

CADMIUM COMPOUNDS;

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CADMIUM; ENDOTHELIAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE; SUCCINATE DEHYDROGENASE;

ANGIOGENESIS; ARTICLE; CELL FUNCTION; CELL MIGRATION; CELL VIABILITY; CONTROLLED STUDY; EGG YOLK; ENDOTHELIUM CELL; ENERGY METABOLISM; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNODETECTION; IMMUNOFLUORESCENCE TEST; MITOCHONDRIAL MEMBRANE; PROTEIN PHOSPHORYLATION; WESTERN BLOTTING; WOUND HEALING;

ANIMALS; CADMIUM CHLORIDE; CALCIUM; CELL LINE; CELL MOVEMENT; DOSE-RESPONSE RELATIONSHIP, DRUG; EGG YOLK; ENDOTHELIAL CELLS; HUMANS; MITOCHONDRIA; NEOVASCULARIZATION, PHYSIOLOGIC; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHORYLATION; SUCCINATE DEHYDROGENASE;

EID: 39049156703     PISSN: 08298211     EISSN: None     Source Type: Journal    
DOI: 10.1139/O07-146     Document Type: Article

References (45)

1. Abu-Hayyeh, S., Sian, M., Jones, K.G., Manuel, A., and Powell, J.T. 2001. Cadmium accumulation in aortas of smokers. Arterioscler. Thromb. Vasc. Biol. 21: 863-867.
2. Baranski, B., Opacka, J., Wronska-Nofer, T., Trzcinka-Ochocka, M., and Sitarek, K. 1983. Effect of Cd on arterial blood pressure and lipid metabolism in rats. Toxicol. Lett. 18: 245-250. doi:10. 1016/0378-4274(83)90101-7.
3. Barua, R.S., Ambrose, J.A., Eales-Reynolds, L.J., DeVoe, M.C., Zervas, J.G., and Saha, D.C. 2001. Dysfunctional endothelial nitric oxide biosynthesis in healthy smokers with impaired endothelium-dependent vasodilatation. Circulation, 104: 1905-1910. doi:10.1161/hc4101.097525.
4. Bokori, J., and Fekete, S. 1995. Complex study of the physiological role of Cd. I. Cd and its physiological role. Acta Vet. Hung. 43: 3-43.
5. Caperna, T.J., and Failla, M.L. 1984. Cd metabolism by rat liver endothelial and Kupffer cells. Biochem. J. 221: 631-636.
6. Cheung, W.Y. 1984. Calmodulin: its potential role in cell proliferation and heavy metal toxicity. Fed. Proc. 43: 2995-2999.
7. Chisolm, J.C., and Handorf, C.R. 1985. Zinc, Cd, metallothionein, and progesterone: do they participate in the etiology of pregnancy induced hypertension? Med. Hypotheses, 17: 231-242. doi:10.1016/0306-9877(85) 90128-8.
8. Coonse, K.G., Coonts, A.J., Morrison, E.V., and Heggland, S.J. 2007. Cd induces apoptosis in the human osteoblast-like cell line Saos-2. J. Toxicol. Environ. Health A, 70: 575-581. doi:10.1080/15287390600882663.
9. Coutant, A., Lebeau, J., Bidon-Wagner, N., Levalois, C., Lectard, B., and Chevillard, S. 2006. Cd-induced apoptosis in lymphoblastoid cell line: involvement of caspase-dependent and -independent pathways. Biochimie, 88: 1815-1822. doi:10.1016/j.biochi.2006.09.018.
10. Demontis, M.P., Varoni, M.V., Volpe, A.R., Emanueli, C., and Madeddu, P. 1998. Role of nitric oxide synthase inhibition in the acute hypertensive response to intracerebroventricular Cd. Br. J. Pharmacol. 123: 129-135. doi:10.1038/sj.bjp.0701573.
11. Ekmekcioglu, S., Tang, C.H., and Grimm, E.A. 2005. NO news is not necessarily good news in cancer. Curr. Cancer Drug Targets, 5: 103-115. doi:10.2174/1568009053202072.
12. Fujiwara, Y., Watanabe, S., and Kaji, T. 1998. Promotion of cultured vascular smooth muscle cell proliferation by low levels of Cd. Toxicol. Lett. 94: 175-180. doi:10.1016/S0378-4274(98)00005-8.
13. Fulton, D., Gratton, J.P., and Sessa, W.C. 2001. Post-translational control of endothelial nitric oxide synthase: why isn't calcium/ calmodulin enough? J. Pharmacol. Exp. Ther. 299: 818-824.
14. Gunawardana, C.G., Martinez, R.E., Xiao, W., and Templeton, D.M. 2006. Cd inhibits both intrinsic and extrinsic apoptotic pathways in renal mesangial cells. Am. J. Physiol. Renal Physiol. 290: F1074-F1082. doi:10.1152/ajprenal.00067.2005.
15. Hinkle, P.M., Kinsella, P.A., and Osterhoudt, K.C. 1987. Cd uptake and toxicity via voltage-sensitive calcium channels. J. Biol. Chem. 262: 16333-16337.
16. Jagnandan, D., Sessa, W.C., and Fulton, D. 2005. Intracellular location regulates calcium-calmodulin-dependent activation of organelle-restricted eNOS. Am. J. Physiol. Cell Physiol. 289: C1024-C1033. doi:10.1152/ajpcell. 00162.2005.
17. Kishimoto, T., Oguri, T., Yamabe, S., and Tada, M. 2005. The role of thymidylate synthase and dihydropyrimidine dehydrogenase in resistance to 5- uorouracil in human lung cancer cells. Lung Cancer, 49: 345-351. doi:10.1016/j.lungcan.2005.05.003.
18. Kolluru, G.K., Tamilarasan, K.P., Geetha Priya, S., Durgha, N.P., and Chatterjee, S. 2006. Cd induced endothelial dysfunction: consequence of defective migratory pattern of endothelial cells in association with poor nitric oxide availability under Cd challenge. Cell Biol. Int. 30: 427-438. doi:10.1016/j.cellbi.2006.02.002.
19. Liu, Y., and Templeton, D.M. 2007. Cd activates CaMK-II and initiates CaMK-II-dependent apoptosis in mesangial cells. FEBS Lett. 581: 1481-1486. doi:10.1016/j.febslet.2007.03.003.
20. Margarita, D., Apostolova, S.C., Chakrabarti, S., and Cherian, M.G. 2001. High-glucose-induced metallothionein expression in endothelial cells: an endothelin-mediated mechanism. Am. J. Physiol. Cell Physiol. 281: C899-C907.
21. Massadeh, A.M., Alali, F.Q., and Jaradat, Q.M. 2005. Determination of Cd and lead in different cigarette brands in Jordan. Environ. Monit. Assess. 104: 163-170. doi:10.1007/s10661-005-1609-5.
22. Michaud, S.E., Menard, C., Guy, L.G., Gennaro, G., and Rivard, A. 2003. Inhibition of hypoxia-induced angiogenesis by cigarette smoke exposure: impairment of the HIF-1alpha/VEGF pathway. FASEB J. 17: 1150-1152.
23. Mukhopadhyay, S., Shah, M., Patel, K., and Sehgal, P.B. 2006. Monocrotaline pyrrole-induced megalocytosis of lung and breast epithelial cells: disruption of plasma membrane and Golgi dynamics and an enhanced unfolded protein response. Toxicol. Appl. Pharmacol. 211: 209-220. doi:10.1016/j.taap.2005.06.004.
24. Nakashima, K., Yanagisawa, M., Arakawa, H., Kimura, N., Hisatsune, T., Kawabata, M., Miyazono, K., and Taga, T. 1999. Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300. Science, 284: 479-482. doi:10.1126/science.284.5413.479.
25. Navas-Acien, A., Selvin, E., Sharrett, A.R., Calderon-Aranda, E., Silbergeld, E., and Guallar, E. 2004. Lead, Cd, smoking, and increased risk of peripheral arterial disease. Circulation, 109: 3196-3201. doi:10.1161/01.CIR.0000130848.18636.B2.
26. Nelson, J.M., Duane, P.G., Rice, K.L., and Niewoehner, D.E. 1991. Cd ion-induced alterations of phospholipid metabolism in endothelial cells. Am. J. Respir. Cell Mol. Biol. 5: 328-336.
27. Nemery, B. 1990. Metal toxicity and the respiratory tract. Eur. Respir. J. 3: 202-219.
28. Nims, R.W., Cook, J.C., Krishna, M.C., Christodoulou, D., Poore, C.M., Miles, A.M., Grisham, M.B., and Wink, D.A. 1996. Colorimetric assays for nitric oxide and nitrogen oxide species formed from nitric oxide stock solutions and donor compounds. Methods Enzymol. 268: 93-105.
29. Oberdorster, G. 1986. Airborne Cd and carcinogenesis of the respiratory tract. Scand. J. Work Environ. Health, 12: 523-537.
30. Oldereid, N.B., Thomassen, Y., and Purvis, K. 1994. Seminal plasma lead, Cd and zinc in relation to tobacco consumption. Int. J. Androl. 17: 24-28.
31. Parast, C.V., Mroczkowski, B., Pinko, C., Misialek, S., Khambatta, G., and Appelt, K. 1998. Characterization and kinetic mechanism of catalytic domain of human vascular endothelial growth factor receptor-2 tyrosine kinase (VEGFR2 TK), a key enzyme in angiogenesis. Biochemistry, 37: 16788-16801. doi:10.1021/bi981291f.
32. Peereboom-Stegeman, J.H., and Jongstra-Spaapen, E.J. 1979. The effect of a single sublethal administration of Cd chloride on the microcirculation in the uterus of the rat. Toxicology, 13: 199-213.
33. Puri, V.N. 1999. Cd induced hypertension. Clin. Exp. Hypertens. 21: 79-84.
34. Reeves, P.G., Chaney, R.L., Simmons, R.W., and Cherian, M.G. 2005. Metallothionein induction is not involved in Cd accumulation in the duodenum of mice and rats fed diets containing high-Cd rice or sunflower kernels and a marginal supply of zinc, iron, and calcium. J. Nutr. 135: 99-108.
35. Sehgal, P.B., Guo, G.G., Shah, M., Kumar, V., and Patel, K. 2002. Cytokine signaling: STATS in plasma membrane rafts. J. Biol. Chem. 277: 12067-12074. doi:10.1074/jbc.M200018200.
36. Sessa, W.C. 2004. eNOS at a glance. J. Cell Sci. 117: 2427-2429. doi:10.1242/jcs.01165.
37. Shah, M., Patel, K., Fried, V.A., and Sehgal, P.B. 2002. Interactions of STAT3 with caveolin-1 and heat shock protein 90 in plasma membrane raft and cytosolic complexes: preservation of cytokine signaling during fever. J. Biol. Chem. 277: 45662-45669. doi:10.1074/jbc.M205935200.
38. Shah, M., Patel, K., and Sehgal, P.B. 2005. Monocrotaline pyrrole-induced endothelial cell megalocytosis involves a Golgi blockade mechanism. Am. J. Physiol. Cell Physiol. 288: C850-C862. doi:10.1152/ajpcell.00327.2004.
39. Skoczynska, A., and Martynowicz, H. 2005. The impact of subchronic Cd poisoning on the vascular effect of nitric oxide in rats. Hum. Exp. Toxicol. 24: 353-361. doi:10.1191/0960327105ht536oa.
40. Staton, C.A., Stribbling, S.M., Tazzyman, S., Hughes, R., Brown, N.J., and Lewis, C.E. 2004. Current methods for assaying angiogenesis in vitro and in vivo. Int. J. Exp. Pathol. 85: 233-248. doi:10.1111/j.0959-9673.2004. 00396.x.
41. Waalkes, M.P. 2003. Cd carcinogenesis. Mutat. Res. 533: 107-120.
42. Weidner, W.J., and Sillman, A.J. 1997. Low levels of Cd chloride damage the corneal endothelium. Arch. Toxicol. 71: 455-460. doi:10.1007/ s002040050411.
43. Yu, J., DeMuinck, E.D., Zhuang, Z., Drinane, M., Kauser, K., Rubanyi, G.M., et al. 2005. Endothelial nitric oxide synthase is critical for ischemic remodeling, mural cell recruitment, and blood flow reserve. Proc. Natl. Acad. Sci. U.S.A. 102: 10999-11004. doi:10.1073/pnas.0501444102.
44. Yuan, T., Gomes, A.V., Barnes, J.A., Hunter, H.N., and Vogel, H.J. 2004. Spectroscopic characterization of the calmodulin-binding and autoinhibitory domains of calcium/calmodulin-dependent protein kinase I. Arch. Biochem. Biophys. 421: 192-206. doi:10.1016/j.abb.2003.11.012.
45. Zawadzka, T., Brulinska-Ostrowska, E., Wojciechowska-Mazurek, M., Cwiek, K., and Starska, K. 1989. Cd and lead levels in domestic and imported cigarettes. Rocz. Panstw. Zakl. Hig. 40: 145-152.