Clinical management of chronic obstructive pulmonary disease and asthma in an obese patient

Expert Opinion on Pharmacotherapy

Volumn 9, Issue 1, 2008, Pages 83-93

  Lessard, Andréa ^a   Maltais, François ^a   Boulet, Louis Philippe ^a  

^a LAVAL UNIVERSITY   (Canada)

Author keywords

Asthma; BMI; COPD; Leptin; Obesity

Indexed keywords

ADIPONECTIN; AMFEBUTAMONE; ANTIASTHMATIC AGENT; ANTIDEPRESSANT AGENT; BECLOMETASONE; BRONCHODILATING AGENT; C REACTIVE PROTEIN; CORTICOSTEROID; ETANERCEPT; FAS LIGAND; FLUTICASONE; GLITAZONE DERIVATIVE; INFLIXIMAB; INTERLEUKIN 6; INTERLEUKIN 6 ANTIBODY; LEPTIN; LIPOPOLYSACCHARIDE BINDING PROTEIN; LONG ACTING DRUG; MONTELUKAST; NALTREXONE; NICOTINE DERIVATIVE; ORAL ANTIDIABETIC AGENT; PLACEBO; RIMONABANT; SALMETEROL; THEOPHYLLINE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA INHIBITOR; UNINDEXED DRUG; VARENICLINE;

ADD ON THERAPY; ASTHMA; BARIATRIC SURGERY; CHRONIC BRONCHITIS; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL FEATURE; CLINICAL TRIAL; COGNITIVE THERAPY; COMORBIDITY; DEPRESSION; DIET THERAPY; DISEASE ASSOCIATION; DISEASE CONTROL; DISEASE SEVERITY; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG MECHANISM; DRUG RESPONSE; DYSPNEA; EXERCISE; EXERCISE TOLERANCE; FORCED EXPIRATORY VOLUME; HUMAN; INCIDENCE; LUNG EMPHYSEMA; METABOLIC DISORDER; MORTALITY; NICOTINE REPLACEMENT THERAPY; NONHUMAN; OBESITY; OXIDATIVE STRESS; PATHOGENESIS; PREVALENCE; PRIMARY PREVENTION; PULMONARY REHABILITATION; QUALITY OF LIFE; RESPIRATORY TRACT INFLAMMATION; REVIEW; RISK FACTOR; SELF CARE; SEX DIFFERENCE; SIDE EFFECT; SMOKING; SMOKING CESSATION; TOBACCO DEPENDENCE; UNDERWEIGHT; WEIGHT GAIN; WEIGHT REDUCTION;

ANTI-ASTHMATIC AGENTS; ASTHMA; BODY MASS INDEX; BRONCHODILATOR AGENTS; EXPERT TESTIMONY; HEALTH BEHAVIOR; HUMANS; OBESITY; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; WEIGHT LOSS;

EID: 39049132014     PISSN: 14656566     EISSN: None     Source Type: Journal    
DOI: 10.1517/14656566.9.1.83     Document Type: Review

References (111)

1. Obesity: preventing and managing the global epidemic. Report of a WHO consultation. World Health Organ Tech Rep Ser 2000;894(i-253)
2. Ogden CL, Carroll MD, Curtin LR, et al. Prevalence of overweight and obesity in the United States, 1999 - 2004. JAMA 2006;295(13):1549-55
3. Tjepkema M. Adult obesity. Health Rep 2006;17(3):9-25
4. Lau DC, Douketis JD, Morrison XM, et al. 2006 Canadian clinical practice guidelines on the management and prevention of obesity in adults and children. CMAJ-JAMC 2007;178(8)
5. Hodge AM, Dowse GK, Gareeboo H, et al. Incidence, increasing prevalence, and predictors of change in obesity and fat distribution over 5 years in the rapidly developing population of Mauritius. Int J Obes Relat Metab Disord 1996;20(2):137-46
6. Lazarus R, Sparrow D, Weiss ST. Effects of obesity and fat distribution on ventilatory function: the normative aging study. Chest 1997;111(4):891-8
7. Despres JP, Lemieux I, Prud'homme D. Treatment of obesity: need to focus on high risk abdominally obese patients. BMJ 2001;322(7288):716-20
8. Global initiative for chronic obstructive lung disease: global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease.
9. Agusti AG. Systemic effects of chronic obstructive pulmonary disease. Proc Am Thorac Soc 2005;2(4):367-70
10. Chen Y, Breithaupt K, Muhajarine N. Occurrence of chronic obstructive pulmonary disease among Canadians amd sex-related risk factors. J Clin Epidemiol 2000;53(7):755-61
11. Guerra S, Sherrill DL, Bobadilla A, et al. The relation of body ina index to asthma, chronic bronchitis, and emphysema. Chest 2002;122(4):1256-63
12. Pitta F, Troosters T, Spruit MA, et al. Characteristics of physical activities in daily life in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2005;171(9):972-7
13. Schols AM, Slangen J, Volovics L, Wouters EF. Weight loss is a reversible factor in the prognosis of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1998;157(6 Part 1):1791-7
14. Celli BR, Cote CG, Marin JM, et al. The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease. N Engl J Med 2004;350(10):1005-12
15. Vestbo J, Prescott E, Almdal T, et al. Body mass, fat-free body mass, and prognosis in patients with chronic obstructive pulmonary disease from a random population sample: findings from the Copenhagen city heart study. Am J Respir Crit Care Med 2006;173(1):79-83
16. Hole DJ, Watt GC, Vey-Smith G, et al. Impaired lung function and mortality risk in men and women: findings from the Renfrew and Paisley prospective population study. BMJ 1996;313(7059):711-15
17. Sin DD, Man SF. Why are patients with chronic obstructive pulmonary disease at increased risk of cardiovascular diseases? The potential role of systemic inflammation in chronic obstructive pulmonary disease. Circulation 2003;107(11):1514-19
18. Marquis K, Debigare R, Lacasse Y, et al. Midthigh muscle cross-sectional area is a better predictor of mortality than body mass index in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2002;166(6):809-13
19. Cote CG. Surrogates of mortality in chronic obstructive pulmonary disease. Am J Med 2006;119(10 Suppl 1):54-62
20. Nishimura K Izumo T, Tsukino M, Oga T. Dyspnea is a better predictor of 5-year survival than airway obstruction in patients with COPD. Chest 2002;121(5):1434-40
21. Parameswaran K, Todd DC, Soth M. Altered respiratory physiology in obesity. Can Respir J 2006;13(4):203-10
22. Sahebjami H. Dyspnca in obese healthy men. Chest 1998;114(5):1373-7
23. Ferretti A. Giampiccolo P, Cavalli A, et al. Expiratory flow limitation and orthopnea in massively obese subjects. Chest 2001;119(5):1401-8
24. Norman AC, Drinkard B, McDuffie JR, et al. Influence of excess adiposity on exercise fitness and performance in overweight children and adolescents. Pediatrics 2005;115(6):E690-6
25. Hulens M, Vansant G, Claessens Al, et al. Predictors of 6-min walk test results in lean, obese and morbidly obese women. Scand J Med Sci Sports 2003;13(2):98-105
26. Weiss ST, Shore S. Obesity and asthm: directions for research. Am J Respir Crit Care Med 2004;169(8):963-8
27. Gan WQ, Man SF, Senthilselvan A, Sin DD. Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysis. Thorax 2004;59(7):574-80
28. Pratico D, Basili S, Vieri M, et al. Chronic obstructive pulmonary disease is associated with an increase in urinary levels of isoprostane F2alpha-III, an index of oxidant stress. Am J Respir Crit Care Med 1998;158(6):1709-14
29. Agusti AG, Sauleda J, Miralles C, et al. Skeletal muscle apoptosis and weight loss in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2002;166(4):485-9
30. Agusti A, Morla M, Sauleda J, et al. NF-kappaB activation and iNOS uprcguladon in skeletal muscle of patients with COPD and low body weight. Thorax 2004;59(6):483-7
31. Fabrica rc AN, Wadden TA. Psychological aspects of obesity. Clin Dermatol 2004;22(4):332-7
32. Wagena EJ, Huibers MJ, Van schayck CP. Antidepressants in the treatment of patients with COPD: possible associations between smoking cigarettes, COPD and depression. Thorax 2001;56(8):587-8
33. Raeder MB, Bjelland I, Emil VS, Steen VM. Obesity, dyslipidemia, and diabetes with selective serotonin reuptake inhibitors: the Hordaland health study. J Clin Psychiatry 2006;67(12):1974-82
34. O'donnell DE, Aaron S, Bourbeau J, et al. Canadian Thoracic society recommendations for management of chronic obstructive pulmonary disease - 2003. Can Respir J 2003;10(Suppl A)-A11-A65
35. Steuten LM, Creutzberg EC, Vrijhoef HJ, Wouters EF. COPD as a multicomponent disease: inventory of dyspnoea, underweight, obesity and fat free mass depletion in primary care. Prim Care Respir J 2006;15(2):84-91
36. O'Hara P, Connert JE, Lee WW, et al. Early and late weight gain following smoking cessation in the lung health study. Am J Epidemiol 1998;148(9):821-30
37. Jorenby DE, Leischow SJ, Nides MA, et al. A controlled trial of sustained-release bupropion, a nicotine patch, or both for smoking cessation. N Engl J Med 1999;340(9):685-91
38. Jorenby DE, Hays JT, Rigotti NA, et al. Efficacy of varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, vs placebo or sustained-release bupropion for smoking cessation: a randomized controlled trial. JAMA 2006;296(1):56-63
39. O'malley SS, Cooney JL, Krishnan-Sarin S, et al. A controlled trial of naltrexone augmentation of nicotine replacement therapy for smoking cessation. Arch Intern Med 2006;166(6):667-74
40. Toll BA. Leary V, Wu R, et al. A preliminary investigation of naltrexone augmentation of bupropion to stop smoking with less weight gain. Addict Behav. Epub 2007
41. Despres JP, Golay A. Sjostrom L. Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia. N Engl J Med 2005;353(20):2121-34
42. Cahill K, Ussher M. Cannabinoid type 1 receptor antagonists (rimonabant) for smoking cessation. Cochrane Database Syst Rev 2007;(3):CD005353
43. Filozof C, Fernandez Pinilla MC, Fernandez-Cruz A. Smoking cessation and weight gain. Obes Rev 2004;5(2):95-103
44. Oga T, Nishimura K, Tsukino M, et al. Analysis of the factors related to mortality in chronic obstructive pulmonary disease: role of exercise capacity and health status. Am J Respir Crit Care Med 2003;167(4):544-9
45. Nishimura K, Izumi T, Tsukino M, Oga T. Dyspnea is a better predictor of 5-year survival than airway obstruction in patients with COPD. Chest 2002; 121(5):1434-40
46. Global strategies for asthma management and prevention: global initiative for asthma (GINA) 2006. Available from: http://www.ginaasthma.org
47. Lemiere C, Bai T, Balter M, et al. Adult asthma consensus guidelines update 2003. Can Respir J 2004; 11 (Suppl A):A9-A18
48. Bousquet J, Jeffery PK, Busse WW. et al. Asthma. From bronchoconstriction to airways inflammation and remodeling. Am J Respir Crit Care Med 2000;161(5):1720-45
49. Shore SA. Johnston RA. Obesity and asthma. Pharmacol Ther 2006;110(1):83-102
50. Ford ES. The epidemiology of obesity and asthma. J Allergy Clin Immunol 2005;115(5):897-909
51. Nystad W, Meyer HE, Nafstad P, et al. Body mass index in relation to adult asthma among 135,000 Norwegian men and women. Am J Epidemiol 2004;160(10):969-76
52. Schachter LM, Peat JK, Salome CM. Asthma and atopy in overweight children. Thorax 2003;58(12):1031-5
53. Chen Y, Dales R, Tang M, Krewski D. Obesity may increase the incidence of asthma in women but not in men: longitudinal observations from the Canadian National population health surveys. Am J Epidemiol 2002;155(3):191-7
54. Chinn S, Jarvis D, Burney P. Relation of bronchial responsiveness to body mass index in the ECRHS. European community respiratory health survey. Thorax 2002;57(12):1028-33
55. Celedon JC, Palmer LJ, Litonjua AA, et al. Body mass index and asthma in adults in Families of subjects with asthma in Anqing, China Am J Respir Crit Care Med 2001;164(10 Part 1):1835-40
56. Luder E, Ehrlich RI, lou WY, et al. Body mass index and the risk of asthma in adults. Respir Med 2004;98(1):29-37
57. Ronmark E, Andersson C, Nystrom L, et al. Obesity increases the risk of incident asthma among adults. Eur Respir J 2005;25(2):282-8
58. Boulet LP, Des CA. The link between obesity and asthma: a Canadian perspective. Can Respir J 2007;14(4):217-20
59. Sears MR. Descriptive epidemiology of asthma. Lancet 1997;350(Suppl 2)(SII1-SII4)
60. Harik-Khan RI, Wise RA, Fleg JL. The effect of gender on the relationship between body fat distribution and lung function. J Clin Epidemiol 2001;54(4):399-406
61. Boulet LP. Physiopathology of airway hyperresponsiveness. Curr Allergy Asthma Rep 2003;3(2):166-71
62. Schachter LM, Salome CM, Peat JK, Woolcock AJ. Obesity is a risk for asthma and wheeze but not airway hyperresponsiveness. Thorax 2001;56(1):4-8
63. Aaron SD, Fergusson D. Dent R, et al. Effect of weight reduction on respiratory function and airway reactivity in obese women. Chest 2004;125(6):2046-52
64. Huang SL, Shiao G, Chou P. Association between body mass index and allergy in teenage girls in Taiwan. Gin Exp Allergy 1999;29(3):323-9
65. Hancox RJ, Milne BJ, Poulton R, et al. Sex differences in the relation between body mass index and asthma and atopy in a birth cohort. Am J Respir Crit Care Med 2005;171(5):440-5
66. Castro-Rodriguez JA, Holberg CJ, Morgan WJ, et al. Increased incidence of asthmalike symptoms in girls who become overweight or obese during the school years. Am J Respir Crit Care Med 2001;163(6):1344-9
67. Kilpelainen M, Terho EO, Helenius H, Koskenvuo M. Body mass index and physical activity in relation to asthma and atopic diseases in young adults. Respir Med 2006;100(9):1518-25
68. Von ME, Schwartz J, Neas LM, et al. Relation of body mass index to asthma and atopy in children: the National health and nutrition examination study III. Thorax 2001;56(11):835-8
69. Chen Y, Dales R, Jiang Y. The association between obesity and asthma is stronger in nonallergic than allergic adults. Chest 2006;130(3):890-5
70. Appleton SL, Adam RJ, Wilson DH, et al. Central obesity is associated with nonatopic but not atopic asthma in a representative population sample. J Allergy Clin Immunol 2006;118(6):1284-91
71. Sontag SJ. Gastroesophageal reflux and asthma. Am J Med 1997;103(5A):S84-S90
72. Gislason T, Janson C, Vermeire P, et al. Respiratory symptoms and nocturnal gastroesophageal reflux: a population-based study of young adults in three European countries. Chest 2002;121(1):158-63
73. Sulit LG, Storfer-Isser A. Rosen CL, et al. Associations of obesity, sleep-disordered breathing, and wheezing in children. Am J Respir Crit Care Med 2005;171(6):659-64
74. Gunnbjornsdottir MI, Omenaas E, Gislason T, et al. Obesity and nocturnal gastro-oesophageal reflux arc related to onset of asthma and respiratory symptoms. Eur Respir J 2004;24(1):116-21
75. King GG, Brown NJ, Diba. C, et al. The effects of body weight on airway calibre. Eur Respir J 2005;25(5):896-901
76. Watson RA, Pride NB. Postural changes in lung volumes and respiratory resistance in subjects with obesity. J Appl Physiol 2005;98(2):512-17
77. Boulet LP, Turcotte H, Boulet G, et al. Deep inspiration avoidance and airway response to methacholine: influence of body mass index. Can Respir J 2005;12(7):371-6
78. Fredberg JJ. Airway smooth muscle in asthma. Perturbed equilibria of myosin binding. Am J Respir Crit Care Med 2000;161(3 Part 2):S158-60
79. Lemanske RF Jr, Busse WW, Asthma. J Allergy Clin Immunol 2003;111(2 Suppl):S502-19
80. Smith AD, Cowan JO, Filsell S, et al. Diagnosing asthma comparisons between exhaled nitric oxide measurements and conventional tests. Am J Respir Crit Care Med 2004;169(4):473-8
81. Leung TF, Li CY, lam CW, et al. The relation between obesity and asthmatic airway inflammation. Pediatr Allergy Immunol 2004;15(4):344-50
82. Buchvald F, Baraldi E, Carraro S, et al. Measurements of exhaled nitric oxide in healthy subjects age 4 to 17 years. J Allergy Clin Immunol 2005;115(6):1130-6
83. Wong GW, Liu EK, Leung TF, et al. High levels and gender difference of exhaled nitric oxide in Chinese schoolchildren. Clin Exp Allergy 2005;35(7):889-93
84. De Winter-De Groot KM, Van Der Ent CK, Prins I et al. Exhaled nitric oxide: the missing link between asthma and obesity? J Allergy Clin Immunol 2005;115(2):419-20
85. Barros R, Moreira A. Fonseca J, et al. Obesity and airway inflammation in asthma. J Allergy Clin Immunol 2006;117(6):1501-2
86. Kazak A. Uriu-Adams JY, Stern JS, Albertson TE. No significant relationship between exhaled nitric oxide and body ma index in people with asthma. J Allergy Clin Immunol 2005;116(4):929-30
87. Mclachlan CR, Poulton R, Car G, et al. Adiposity, asthma, and airway inflammation. J Allergy Clin Immunol 2007;119(3):634-9
88. Dixon AE, Shade DM, Cohen RI, et al. Effect of obesity on clinical presentation and response to treatment in asthma. J Asthma 2006;43(7):553-8
89. Mai XM, Bottcher MF, Leijon I. Leptin and asthma in overweight children at 12 years of age. Pediatr Allergy Immunol 2004;15(6):523-30
90. Guler N, Kiretleri E, Ones U, et al. Leptin: does it have any role in childhood asthma? J Allergy Clin Immunol 2004; 114(2):254-59
91. Sood A, Ford ES, Camargo CA Jr. Association between leptin and asthma in adults. Thorax 2006;61(4):300-5
92. Mancuso P, Canetti C, Gottschalk A. et al. Leptin augments alveolar macrophage leukotriene synthesis by increasing phospholipase activity and enhancing group IVC iPLA2 (cPLA2gamma) protein expression. Am J Physiol Lung Cell Mol Physiol 2004;287(3):L497-L502
93. Yamauchi T, Kamon J, Waki H, et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 2001;7(8):941-6
94. Shore SA, Terry RD, Flynt L, et al. Adiponectin attenuates allergen-induced airway inflammation and hyperresponsiveness in mice. J Allergy Clin Immunol 2006;118(2):389-95
95. Akerman MJ, Calacanis CM, Madsen MK. Relationship between asthma severity and obesity. J Asthma 2004;41(5):521-6
96. Cassol VE, Rizzato TM, Techc SP, et al. Prevalence and severity of asthma among adolescents and their relationship with the body mass index. J Pediatr (Rio J) 2005;81(4):305-9
97. Varraso R. Siroux V, Maccario J, et al. Asthma severity is associated with body mass index and early menarche in women. Am J Respir Crit Care Med 2005;171(4):334-9
98. Mansell AL, Walders N, Wamboldt MZ, et al. Effect of body mass index on response to methacholine bronchial provocation in healthy and asthmatic adolescents. Pediatr Pulmonol 2006;41(5):434-40
99. Lavoie KL, Bacon SL. Labrecque M, et al. Higher BMI is associated with worse asthma control and quality of life but not asthma severity. Respir Med 2006;100(4):648-57
100. Peters-Golden M, Swern A, Bird SS, et al. Influence of body mass index on the response to asthma controller agents. Eur Respir J 2006;27(3):495-503
101. Saint-Pierre P, Bourdin A, Chanez P et al. Are overweight asthmatics more difficult to control? Allergy 2006;61(1):79-84
102. Boulet LP, Franssen E. Influence of obesity on response to fluticasone with or without salmeterol in moderate asthma Respir Med 2007
103. Simard B, Turcotte H, Marceau p, et al. Asthma and steep apnea in patients with morbid obesit: outcome after bariatric surgery. Obes Surg 2004;14(10):1381-8
104. Spivak H, Hewitt MF, Onn A, Half EE. Weight loss and improvement of obesity-related illness in 500 US patients following laparoscopic adjustable gastric banding procedure. Am J Surg 2005;189(1):27-32
105. Stenius-Aarniala B, Poussa T, Kvarnstrom J, et al. Immediate and long-term effects of weight reduction in obese people with asthma: randomised controlled study. BMJ 2000;320(7238):827-32
106. Shore SA. Obesity and asthma: implications for treatment. Curr Opin Pulm Med 2007;13(1):56-62
107. Lang JE, Williams E, Flynt L, et al. IL-6 contributes to airway responses to acute ozone exposure in lean and obese mice. Proc Am Thorac Soc 2006;3-A821 (Abstract)
108. Berry MA, Hargadon B, Shelley M, et al. Evidence of a role of TNF alpha in refractory asthma. N Engl J Med 2006;354(7):697-708
109. Erin EM, Leaker BR, Nicholson GC, et al. The effects of a monoclonal antibody directed against TNF-alpha in asthma. Am J Respir Crit Care Med 2006;174(7):753-62
110. Scherer PE. Adipose tissue: from lipid storage compartment to endocrine organ. Diabetes 2006;55(6):1537-45
111. Lee KS, Kim SR. Park SJ, et al. Peroxisome proliferator activated receptor-gamma modulates reactive oxygen species generation and activation of nuclear Factor-kappaB and hypoxia-inducible factor 1alpha in allergic airway disease of mice. J Allergy Clin Immunol 2006;118(1):120-7