Correlation between the progressive cytoplasmic expression of a novel small heat shock protein (Hsp16.2) and malignancy in brain tumors

BMC Cancer

Volumn 7, Issue , 2007, Pages

  Pozsgai, Eva ^a   Gomori, Eva ^a   Szigeti, Andras ^a   Boronkai, Arpad ^a   Gallyas Jr , Ferenc ^a   Sumegi, Balazs ^a   Bellyei, Szabolcs ^a  

^a UNIVERSITY OF PÉCS   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 16.2; POLYCLONAL ANTIBODY; UNCLASSIFIED DRUG; C1ORF41 PROTEIN, HUMAN; SMALL HEAT SHOCK PROTEIN; TUMOR MARKER;

ARTICLE; BRAIN TUMOR; CANCER GRADING; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOPLASM; DISEASE ASSOCIATION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MAJOR CLINICAL STUDY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RISK ASSESSMENT; RISK FACTOR; WESTERN BLOTTING; BIOSYNTHESIS; COMPARATIVE STUDY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY; PHYSIOLOGY;

BRAIN NEOPLASMS; CYTOPLASM; GENE EXPRESSION REGULATION, NEOPLASTIC; HEAT-SHOCK PROTEINS, SMALL; HUMANS; TUMOR MARKERS, BIOLOGICAL;

EID: 39049111571     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-7-233     Document Type: Article

References (24)

1. Sun Y MacRae TH The small heat shock proteins and their role in human disease FEBS J 2005, 272:2613-2627. 10.1111/j.1742-4658.2005.04708.x 15943797
2. Kang SH Fung MA Gandour-Edwards R Reilly D Dizon T Grahn J Isseroff RR Heat shock protein 27 is expressed in normal and malignant human melanocytes in vivo J Cutan Pathol 2004, 31:665-671. 10.1111/ j.0303-6987.2004.00248.x 15491326
3. Kappe G Franck E Verschuure P Boelens WC Leunissen JA de Jong WW The human genome encodes 10 alpha-crystallin-related small heat shock proteins: HspB1-10 Cell Stress Chaperones 2003, 8:53-61. 514853 12820654 10.1379/1466-1268(2003)8<53:THGECS>2.0.CO;2
4. Haslbeck M Buchner J Chaperone function of sHsps Prog Mol Subcell Biol 2002, 28:37-59. 11908065
5. Sreedhar AS Csermely P Heat shock proteins in the regulation of apoptosis: New strategies iA tumor therapy: a comprehensive review Pharmacol Ther 2004, 101:227-257. 10.1016/j.pharmthera.2003.11.004 15031001
6. Rogalla T Ehrnsperger M Preville X Kotlyarov A Lutsch G Ducasse C Paul C Wieske M Arrigo AP Buchner J Gaestel M Regulation of Hsp27 oligomerization, chaperone function, and protective activity against oxidative stress/tumor necrosis factor alpha by phosphorylation J Biol Chem 1999, 274:18947-18956. 10.1074/jbc.274.27.18947 10383393
7. Arrigo AP sHsp as novel regulators of programmed cell death and tumorigenicity Pathol Biol (Paris) 2000, 48:280-288. 10858960
8. Mehlen P Kretz-Remy C Preville X Arrigo AP Human hsp27, Drosophila hsp27 and human alphaB-crystallin expression-mediated increase in glutathione is essential for the protective activity of these proteins against TNFalpha-induced cell death EMBO J 1996, 15:2695-2706. 450205 8654367
9. Bellyei S Szigeti A Boronkai A Pozsgai E Gomori E Melegh B Janaky T Bognar Z Hocsak E Sumegi B Gallyas F Jr. Inhibition of cell death by a novel 16.2 kD heat shock protein predominantly via Hsp90 mediated lipid rafts stabilization and Akt activation pathway Apoptosis 2007, 12:97-112. 10.1007/s10495-006-0486-x 17136496
10. Bellyei S Szigeti A Pozsgai E Boronkai A Gomori E Hocsak E Farkas R Sumegi B Gallyas F Jr. Preventing apoptotic cell death by a novel small heat shock protein Eur J Cell Biol 2007, 86:161-171. 10.1016/ j.ejcb.2006.12.004 17275951
11. Louis DN Ohgaki H Wiestler OD Cavenee WK Burger PC Jouvet A Scheithauer BW Kleihues P The 2007 WHO classification of tumours of the central nervous system Acta Neuropathologica 2007, 114:97-109. 1929165 17618441 10.1007/s00401-007-0243-4
12. Somji S Sens MA Lamm DL Garrett SH Sens DA Metallothionein isoform 1 and 2 gene expression in the human bladder: Evidence for upregulation of MT-1X mRNA in bladder cancer Cancer Detect Prev 2001, 25:62-75. 11270423
13. Tapodi A Debreceni B Hanto K Bognar Z Wittmann I Gallyas F Jr. Varbiro G Sumegi B Pivotal role of Akt activation in mitochondrial protection and cell survival by poly(ADP-ribose)polymerase-1 inhibition in oxidative stress. J Biol Chem 2005, 280:35767-35775. 10.1074/jbc.M507075200 16115861
14. Haslbeck M Franzmann T Weinfurtner D Buchner J Some like it hot: The structure and function of small heat-shock proteins Nat Struct Mol Biol 2005, 12:842-846. 10.1038/nsmb993 16205709
15. Sun Y MacRae TH Small heat shock proteins: Molecular structure and chaperone function Cell Mol Life Sci 2005, 62:2460-2476. 10.1007/ s00018-005-5190-4 16143830
16. Haslbeck M sHsps and their role in the chaperone network Cell Mol Life Sci 2002, 59:1649-1657. 10.1007/PL00012492 12475175
17. Hitotsumatsu T Iwaki T Fukui M Tateishi J Distinctive immunohistochemical profiles of small heat shock proteins (heat shock protein 27 and alpha B-crystallin) in human brain tumors Cancer 1996, 77:352-361. 10.1002/ (SICI)1097-0142(19960115)77:2<352::AID-CNCR19>3.0.CO;2-0 8625245
18. Hermisson M Strik H Rieger J Dichgans J Meyermann R Weller M Expression and functional activity of heat shock proteins in human glioblastoma multiforme Neurology 2000, 54:1357-1365. 10746610
19. Strik HM Weller M Frank B Hermisson M Deininger MH Dichgans J Meyermann R Heat shock protein expression in human gliomas Anticancer Research 2000, 20:4457-4462. 11205288
20. Aoyama A Steiger RH Frohli E Schafer R von Deimling A Wiestler OD Klemenz R Expression of alpha B-crystallin in human brain tumors Int J Cancer 1993, 55:760-764. 10.1002/ijc.2910550511 8244572
21. Assimakopoulou M Varakis J AP-1 and heat shock protein 27 expression in human astrocytomas J Cancer Res Clin Oncol 2001, 127:727-732. 11768612
22. Khalid H Tsutsumi K Yamashita H Kishikawa M Yasunaga A Shibata S Expression of the small heat shock protein (hsp) 27 in human astrocytomas correlates with histologic grades and tumor growth fractions Cell Mol Neurobiol 1995, 15:257-268. 10.1007/BF02073332 8590455
23. Strick HM Weller M Frank B Hermisson M Deininger MH Dichgans J Meyermann R Heat shock protein expression in human gliomas Anticancer Res 2000, 20(6B):4457-4462. 11205288
24. Hauser P Hanzely Z Jakab Z Olah L Szabo E Jeney A Schuler D Fekete G Bognar L Garami M Expression and prognostic examination of heat shock proteins (HSP 27, HSP 70, and HSP 90) in medulloblastoma J Pediatr Hematol Oncol 2006, 28:461-466. 10.1097/01.mph.0000212954.35727.ad 16825994