Hemodynamic effects of substance P and its receptor antagonist RP67580 in anesthetized rats with carbon tetrachloride-induced cirrhosis

Scandinavian Journal of Gastroenterology

Volumn 43, Issue 3, 2008, Pages 328-333

  Cardenas, Andres ^a,b   Lowe, Robert ^c   Oh, Sangik ^a   Bodkin, Sheila ^c   Kenney, Tom ^c   Lamorte, Wayne W ^c   Afdhal, Nezam H ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF BARCELONA   (Spain)

^c BOSTON MEDICAL CENTER   (United States)

Author keywords

Cirrhosis; Hyperdynamic circulation; Nitric oxide; Portal hypertension; RP67580; Splanchnic vasodilation; Substance P

Indexed keywords

2 [1 IMINO 2 (2 METHOXYPHENYL)ETHYL] 7,7 DIPHENYLPERHYDROISOINDOL 4 ONE; CARBON TETRACHLORIDE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; SUBSTANCE P;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; HEMODYNAMICS; HYPOTENSION; LIVER CIRRHOSIS; MALE; MEAN ARTERIAL PRESSURE; MEASUREMENT; NONHUMAN; OUTCOME ASSESSMENT; PORTAL HYPERTENSION; PORTAL VEIN BLOOD PRESSURE; PRIORITY JOURNAL; RAT; SPLANCHNIC BLOOD FLOW; TREATMENT RESPONSE; VASODILATATION;

ANALGESICS; ANESTHESIA; ANIMALS; BIOPSY; BLOOD FLOW VELOCITY; CARBON TETRACHLORIDE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; ISOINDOLES; LIVER CIRCULATION; LIVER CIRRHOSIS, EXPERIMENTAL; NEUROTRANSMITTER AGENTS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NEUROKININ-1; SUBSTANCE P; TREATMENT OUTCOME;

EID: 39049083782     PISSN: 00365521     EISSN: 15027708     Source Type: Journal    
DOI: 10.1080/00365520701685691     Document Type: Article

References (29)

1. Groszmann RJ. Hyperdynamic circulation of liver disease 40 years later: pathophysiology and clinical consequences. Hepatology 1994;20:1359-63.
2. Moller S, Bendtsen F, Henriksen JH. Vasoactive substances in the circulatory dysfunction of cirrhosis. Scand J Clin Lab Invest 2001;61:421-9.
3. Thomas SH, Joh T, Benoit JN. Role of bile acids in splanchnic hemodynamic response to chronic portal hypertension. Dig Dis Sci 1991;36:1243-8.
4. Silva G, Navasa M, Bosch J, Chesta J, Pilar Pizcueta M, Casamitjana R, et al. Hemodynamic effects of glucagon in portal hypertension. Hepatology 1990;11:668-73.
5. Sitzmann JV, Bulkley GB, Mitchell MC, Campbell K. Role of prostacyclin in the splanchnic hyperemia contributing to portal hypertension. Ann Surg 1989;209:322-7.
6. Martin PY, Gines P, Schrier RW. Nitric oxide as a mediator of hemodynamic abnormalities and sodium and water retention in cirrhosis. N Engl J Med 1998;339:533-41.
7. Lee SS, Huang M, Ma Z, Rorstad O. Vasoactive intestinal peptide in cirrhotic rats: hemodynamic effects and mesenteric arterial receptor characteristics. Hepatology 1996;23:1174-80.
8. Hori N, Okanoue T, Sawa Y, Kashima K. Role of calcitonin gene-related peptide in the vascular system on the development of the hyperdynamic circulation in conscious cirrhotic rats. J Hepatol 1997;26:1111-9.
9. Guevara M, Gines P, Jimenez W, Sort P, Fernandez-Esparrach G, Escorsell A, et al. Increased adrenomedullin levels in cirrhosis: relationship with hemodynamic abnormalities and vasoconstrictor systems. Gastroenterology 1998;114:336-43.
10. Batkai S, Jarai Z, Wagner JA, Goparaju SK, Varga K, Liu J, et al. Endocannabinoids acting at vascular CB1 receptors mediate the vasodilated state in advanced liver cirrhosis. Nat Med 2001;7:827-32.
11. Delas Heras D, Fernandez J, Gines P, Cárdenas A, Ortega R, Navasa M, et al. Increased carbon monoxide production in patients with cirrhosis with and without spontaneous bacterial peritonitis. Hepatology 2003;38:452-9.
12. Harrison S, Geppetti P. Substance P. Int J Biochem Cell Biol 2001;33:555-76.
13. Hokfelt T, Pernow B, Wahren J. Substance P: a pioneer amongst neuropeptides. J Intern Med 2001;249:27-40.
14. Fernandez-Rodriguez CM, Prieto J, Quiroga J, Zozoya JM, Andrade A, Nunez M, et al. Plasma levels of substance P in liver cirrhosis: relationship to the activation of vasopressor systems and urinary sodium excretion. Hepatology 1995;21:35-40.
15. Lee FY, Lin HC, Tsai YT, Chang FY, Lu RH, Hou MC, et al. Plasma substance P levels in patients with liver cirrhosis: relationship to systemic and portal hemodynamics. Am J Gastroenterol 1997;92:2080-4.
16. Hortnagl H, Singer EA, Lenz K, Kleinberger G, Lochs H. Substance P is markedly increased in plasma of patients with hepatic coma. Lancet 1984;1:480-3.
17. Jimenez W, Claria J, Arroyo V, Rodes J. Carbon tetrachloride induced cirrhosis in rats: a useful tool for investigating the pathogenesis of ascites in chronic liver disease. J Gastroenterol Hepatol 1992;7:90-7.
18. Martin PY, Xu DL, Niederberger M, Weigert A, Tsai P, St John J, et al. Upregulation of endothelial constitutive NOS: a major role in the increased NO production in cirrhotic rats. Am J Physiol 1996;270:F494-9.
19. Ros J, Jimenez W, Lamas S, Claria J, Arroyo V, Rivera F, et al. Nitric oxide production in arterial vessels of cirrhotic rats. Hepatology 1995;21:554-60.
20. Sieber CC, Lopez-Talavera JC, Groszmann RJ. Role of nitric oxide in the in vitro splanchnic vascular hyporeactivity in ascitic cirrhotic rats. Gastroenterology 1993;104:1750-4.
21. Niederberger M, Gines P, Tsai P, Martin PY, Morris K, Weigert A, et al. Increased aortic cyclic guanosine monophosphate concentration in experimental cirrhosis in rats: evidence for a role of nitric oxide in the pathogenesis of arterial vasodilation in cirrhosis. Hepatology 1995;21:1625-31.
22. Arroyo V, Guevara M, Gines P. Hepatorenal syndrome in cirrhosis: pathogenesis and treatment. Gastroenterology 2002;122:1658-76.
23. Goyal RK, Irano I. The enteric nervous system. N Engl J Med 1996;334:1106-15.
24. Iwakiri Y, Groszmann R. The hyperdynamic circulation of chronic liver diseases: from the patient to the molecule. Hepatology 2006;43:S121-31.
25. Wiest R, Garcia-Tsao R. Bacterial translocation (BT) in cirrhosis. Hepatology 2005;41:422-33.
26. Petersson J, Zygmunt PM, Brandt L, Hogestatt ED. Substance P-induced relaxation and hyperpolarization in human cerebral arteries. Br J Pharmacol 1995;115:889-94.
27. Ros J, Claria J, To-Figueras J, Planaguma A, Cejudo-Martin P, Fernandez-Varo G, et al. Endogenous cannabinoids: a new system involved in the homeostasis of arterial pressure in experimental cirrhosis in the rat. Gastroenterology 2002;122:85-93.
28. Uemura M, Tsujii T, Kikuchi E, Fukui H, Tsukamoto N, Matsumura M, et al. Increased plasma levels of substance P and disturbed water excretion in patients with liver cirrhosis. Scand J Gastroenterol 1998;33:860-6.
29. Chu CJ, Lee FY, Wang SS, Chang FY, Tsai YT, Lin HC, et al. Hyperdynamic circulation of cirrhotic rats: role of substance P and its relationship to nitric oxide. Scand J Gastroenterol 1997;32:841-6.