Flow-injection spectrophotometric determination of N-acetylcysteine in pharmaceutical formulations with on-line solid-phase reactor containing Zn(II) phosphate immobilized in a polyester resin

Analytical Letters

Volumn 40, Issue 18, 2007, Pages 3417-3429

  Suarez, Willian Toito ^a   Madi, Alexandro Alves ^a   Vicentini, Fernando Campanhã ^a   Fatibello Filho, Orlando ^a  

^a FEDERAL UNIVERSITY OF SÃO CARLOS   (Brazil)

Author keywords

Flow injection; N acetylcysteine; Pharmaceutical formulation; Solid phase reactor

Indexed keywords

EID: 38949217774     PISSN: 00032719     EISSN: 1532236X     Source Type: Journal    
DOI: 10.1080/00032710701689040     Document Type: Article

References (32)

1. Alvarez-Coque, M.C.G., Hernández, M.J.M., Camañas, R.M.V., and Mongay, C. 1989. Spectrophotometric determination of N-acetylcysteine in drug formulations with o-phthalaldehyde and isoleucine. Analyst, 114 (8): 975-977.
2. Banica, F.G., Moreira, J.C., and Fogg, A.G. 1994. Application of catalytic stripping voltammetry for the determination of organic sulfur-compounds at a hanging mercury drop electrode - behavior of cysteine, cystine, and N-acetylcysteine in the presence of nickel ion. Analyst, 119 (2): 309-318.
3. Bonifacio, V.G., Marcolino-Junior, L.H., and Fatibello-Filho, O. 2004. Flow-injection spectrophotometric determination of isoproterenol with an on-line solid-phase reactor containing immobilized manganese dioxide. Anal. Lett., 37 (10): 2111-2124.
4. Borgstrom, L., Kagedal, B., and Paulsen, O. 1986. Pharmacokinetics of N-acetylcysteine in man. Eur. J. Clin. Pharmacol., 31 (2): 217-222.
5. Brazilian Pharmacopoeia 1997. Organizações; Andrei (Ed.); São Paulo, S.A.
6. Carmo, D.R., Silva, R.M., and Stradiotto, N.R. 2003. Electrocatalytic and voltammetric determination of sulfhydryl compounds through iron nitroprusside modified graphite paste electrode. J. Braz. Chem. Soc., 14 (4): 616-620.
7. Chen, C.J. and Liao, S.L. 2003. Zinc toxicity on neonatal cortical neurons: involvement of glutathione chelation. J. Neurochem., 85 (2): 443-453.
8. 2/R-SH system. Anal. Chim. Acta, 448 (1-2): 79-83.
9. Fatibello-Filho, O., Marcolino-Junior, L.H., and Pereira, A.V. 1999. Solid-phase reactor with copper(II) phosphate for flow-injection spectrophotometric determination of aspartame in tabletop sweeteners. Anal. Chim. Acta, 384 (2): 167-174.
10. Flora, S., Bennicelli, C., and Camoirano, A. 1985. In vivo effects of N-acetylcysteine on glutathione metabolism and on the biotransformation of carcinogenic and/or mutagenic compounds. Carcinogenesis, 6 (12): 1735-1745.
11. Flora, S., Cesarone, C., and Izzotti, A. 1999. N-acetylcyteine as antimutagen and anticarcinogen. Toxicol. Lett., 44: 213-221.
12. Flora, S., Rossi, G., and Flora, A. 1986. Metabolic, desmutagenic, and anticarcinogenic effects of N-acetylcysteine. Respiration, 50: 43-49.
13. Fornazari, A.L.D.T., Suarez, W.T., Vieira, H.J., and Fatibello-Filho, O. 2005. Flow-injection spectrophotometric system for N-acetyl-L- cysteine determination in pharmaceuticals. Acta Chim. Slov., 52 (2): 164-167.
14. Garcia-Molina, F., Penalver, M.J., Rodriguez-Lopez, J.N., Garcia-Canovas, F., and Tudela, J. 2005. Enzymatic method with polyphenol oxidase for the determination of cysteine and N-acetylcysteine. J. Agr. Food Chem., 53 (16): 6183-6189.
15. Kolar, M. and Dobcnik, D. 2003. Chemically prepared silver electrode for determination of N-acetyl-L-cysteine by flow-injection potentiometry. Pharmazie, 58 (1): 25-28.
16. Marcolino-Junior, L.H., Teixeira, M.F.S., Pereira, A.V., and Fatibello-Filho, O. 2001. Flow-injection determination of levodopa in tablets using a solid-phase reactor containing lead(IV) dioxide immobilized. J. Pharm. Biomed. Anal., 25 (3-4): 393-398.
17. Martelli, P.B., Reis, B.F., Korn, M., and Rufini, I.A. 1997. The use of ion exchange resin for reagent immobilization and concentration in flow systems. Determination of nickel in steel alloys and iron speciation in waters. J. Braz. Chem. Soc., 8 (5): 479-485.
18. Martínez-Calatayud, J. and García-Mateo, J.V. 1993. Online solid-phase reactors for unsegmented continuous-flow drug analysis. Trends Anal. Chem., 12 (10): 428-436.
19. Pereira, A.V. and Fatibello-Filho, O. 1998a. Flow-injection spectrophotometric determination of L-ascorbic acid in pharmaceutical formulations with on-line solid-phase reactor containing copper (II) phosphate. Anal. Chim. Acta, 366 (1-3): 55-62.
20. Pereira, A.V. and Fatibello-Filho, O. 1998b. Spectrophotometric flow-injection determination of L-ascorbic acid with a packed reactor containing ferric hydroxide. Talanta, 47 (1): 11-18.
21. Raggi, M.A., Cavrini, V., and Pietra, A.M. 1982. Colorimetric determination of N-acetylcysteine, penicillamine, and mercaptopropionylglycine in pharmaceutical dosage forms. J. Pharm. Sci., 71 (12): 1384-1386.
22. Reis, B.F., Guiné, M.F., and Kronka, E.A.M. 1989. Análise química por injeção em fluxo contínuo. Quím. Nova, 12 (1): 82-91.
23. Rivas, G.A. and Martínez-Calatayud, J. 1995. FIA-AAS determination of salicylic acid by a solid-phase reactor of copper carbonate incorporated in polyester resin beads. Talanta, 42 (9): 1285-1289.
24. Ruzicka, J. and Hansen, E.H. 1975. Flow-Injection Analysis 1. New concept of fast continuous-flow analysis. Anal. Chim. Acta, 78 (1): 145-157.
25. Ruzicka, J. and Hansen, E.H. 1988. Flow-Injection Analysis; Wiley: New York.
26. Sanchez-Pedreño, C., Albero, M.I., Garcia, M.S., and Rodenas, V. 1992. Determination of N-acetylcysteine in pharmaceutical samples by flow injection. Analyst, 117 (5): 925-928.
27. Suarez, W.T., Marcolino-Junior, L.H., and Fatibello-Filho, O. 2006. Voltammetric determination of N-acetylcysteine using a carbon paste electrode modified with copper(II) hexacyanoferrate(III). Microchem. J., 82 (2): 163-167.
28. Suarez, W.T., Vieira, H.J., and Fatibello-Filho, O. 2005. Generation and destruction of unstable reagent in flow-injection system: determination of acetylcysteine in pharmaceutical formulations using bromine as reagent. J. Pharm. Biomed. Anal., 37 (4): 771-775.
29. Teixeira, M.F.S., Marcolino-Junior, L.H., and Fatibello-Filho, O. 2002. Flow-injection spectrophotometric determination of adrenaline in pharmaceutical formulations using a solid-phase reactor containing lead(IV) dioxide immobilized in a polyester resin. Farmaco, 57 (3): 215-219.
30. United States Pharmacopoeia 1990. U.S. Pharmacopeial Convention: Rockville.
31. Vieira, H.J. and Fatibello-Filho, O. 2005. Indirect flow-injection determination of N-acetyl-L-cysteine using cerium(IV) and ferroin. Quim. Nova, 28 (5): 797-800.
32. Vries, N. and Flora, S. 1993. N-acetyl-L-cysteine. Cell. Biochem., 17: 270-277.