Chemical composition and antitumor activity of different wild varieties of Moroccan thyme

Revista Brasileira de Farmacognosia

Volumn 17, Issue 4, 2007, Pages 477-491

  Jaafari, Abdeslam ^a   Mouse, Hassan Ait ^a   Rakib, El Mostapha ^a   M'Barek, Lahcen Ait ^a   Tilaoui, Mounir ^a   Benbakhta, Chouaib ^b   Boulli, Abdelali ^a   Abbad, Aziz ^c   Zyad, Abdelmajid ^a  

^a SULTAN MOULAY SLIMANE UNIVERSITY   (Morocco)

^b INSTITUT NATIONAL D HYGIÈNE   (Morocco)

^c FACULTÉ DES SCIENCES SEMLALIA   (Morocco)

Author keywords

Antitumor activity; Carvacrol; Chemical composition; GC MS; Lamiaceae; Thymol; Thymus

Indexed keywords

EID: 38949207242     PISSN: 0102695X     EISSN: None     Source Type: Journal    
DOI: 10.1590/S0102-695X2007000400002     Document Type: Article

References (33)

1. Amaral FMM, Ribeiro MNS, Barbosa-Filho JM, Reis AS, Nascimento FRF, Macedo RO 2006. Plants and chemical constituents with giardicidal activity. Rev Bras Farmacogn 16(Supl.): 696-720.
2. Bellakhdar J 1996. La Pharmacopée Marocaine Traditionnelle. Ibiss Press, p. 358.
3. Benjilali B, Hammoumi M, Richard H 1987. Polymorphisme chimique des huiles essentielles de Thym du Maroc. Sci Aliment 7: 77-91.
4. Braga PC, Dalsasso M, Cilici M, Galastril L, Marceca MT, Guffanti EE 2006. Antioxidant potential of thymol determined by chemiluminescence inhibition in human neutrophils and cell-free systems. Pharmacology 76: 61-68.
5. Brandão MGL, Cosenza GP, Moreira RA, Monte-Mor RLM 2006. Medicinal plants and other botanical products from the Brazilian Official Pharmacopoeia. Rev Bras Farmacogn 16: 408-420.
6. Carlini EA, Rodrigues E, Mendes FR, Tabach R, Gianfratti B 2006. Treatment of drug dependence with Brazilian herbal medicines. Rev Bras Farmacogn 16: 690-695.
7. Dob T, Dahmane D, Benabdelkader T, Chelghoum C, 2006. Studies on the essential oil composition and antimicrobial activity of Thymus algeriensis Boiss. et Reut. Int J Aromath 16: 95-100.
8. Dursun N, Liman N, Ozyazgan I, Gunes I, Saraymen R 1999. Role of thymus oil in burn wound healing. Lett Appl Microbiol 29:130-135.
9. Echeverrigaray S, Agostini G, Atti-Serfini L, Paroul N, Pauletti GF, dos Santos AC 2001. Correlation between the chemical and genetic relationships among commercial thyme cultivars. J Agric Food Chem 49: 4220-4223.
10. Essawi T, Srour M 2000. Screening of some Palestinian medicinal plants for antibacterial activity. J Ethnopharmacol 70: 343-349.
11. Hanci S, Sahin S, Yilmaz L 2003. Isolation of volatile oil from thyme (Thymbra spicata) by steam distillation. Nahrung 47: 252-255.
12. He L, Mo H, Hadisusilo S, Qureshi AA, Elson CE 1997. Isoprenoids suppress the growth of murine B16 melanomas in vitro and in vivo. J Nutr 127: 668-674.
13. e édition.
14. Hudaib M, Speroni E, Di Pietra AM, Cavrini V 2002. GC/MS evaluation of thyme (Thymus vulgaris L.) oil composition and variations during the vegetative cycle. J Pharm Biomed Anal 29: 691-700.
15. Ismaili H, Tortora S, Sosa S, Fkih-Tetouani S, Ilidrissi A, Della Loggia R, Tubaro A, Aquino R 2001. Topical anti-inflammatory activity of Thymus willdenowii. J Pharma Pharmacol 53: 1645-1652.
16. Ismaili H, Sosa S, Brkic D, Fkih-Tetouani S, Ilidrissi A, Touati D, Aquino R, Tubaro A 2002. Topical anti-inflammatory activity of extracts and compounds from Thymus broussonettii. J Pharma Pharmacol 54: 1137-1140.
17. Ismaili H, Milella L, Fkih-Tetouani S, Ilidrissi A, Camporese A, Sosa S, Altinier G, Della Loggia Aquino R 2004. In vivo topical anti-inflammatory and in vitro antioxidant activities of two extracts of Thymus satureioides leaves. J Ethnopharmacol 91: 31-36.
18. Lee KG, Shibamoto T 2002. Determination of antioxidant potential of volatile extracts isolated from various herbs and spices. J Agric Food Chem 50: 4947-4952.
19. Meister A, Bernhardt G, Christoffel V, Buschauer A 1999. Antispasmodic activity of Thymus vulgaris extract on the isolated guinea-pig trachea: discrimination between drug and ethanol effects. Planta Med 65: 512-516.
20. Mosmann T, 1983. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxic assay. J Immunol Methods 65: 55-63.
21. Raal A, Paaver U, Arak E, Orav A 2004. Content and composition of the essential oil of Thymus serpyllum L. growing wild in Estonia. Medicina 40: 795-800.
22. Richard H, Benjilali B, Banquour N, Baritaux O 1985. Etude de diverses huiles essentielles de thym du Maroc. Lebensm-Wiss Technol 18: 105-110.
23. Salmenova D, Horvathora E, Sramkova M, Marsalkova L 2007. DNA protective effects of two components of essential plant oil, carvacrol and thymol on mammalian cells cultured in vitro. Neoplasma 54: 108-112
24. Schmidt A, Bischof-Deichnik C, Stahl-Biskup E 2004. Essential oil polymorphism of Thymus praecox subsp. arcticus on the British Isles. Bioch Syst Ecol 32: 409-421.
25. Seung-Joo L, Katumi U, Takayuki S, Kwang-Geun L 2005. Identification of volatile components in basil (Ocimum basilicum L.) and thyme leaves (Thymus vulgaris L.) and their antioxidant properties. J Food Chem 91: 131-137.
26. Sijelmassi A 1993. Les plantes médicinales du Maroc. Editions Le Fennec, Casablanca, 286 pp.
27. Soliman KM, Badeaa RI 2002. Effect of oil extracted from some medicinal plants on different mycotoxigenic fungi. Food Chem Toxicol 40: 1669-1675.
28. Stahl-Biskup E 1991.The chemical composition of Thymus oils: review of the literature 1960-1989. J Essent Oil Res 3: 61-82.
29. Stammati A, Bonsi P, Zucco F, Moezelaar H-L, Alakomi von Wright A 1999. Toxicity of selected plant volatils in microbial and mammalian short-term. Food Chem Toxicol 37: 813-823.
30. Tahiri B 1996. Contribution à l'étude biosystématique et chimique du genre Thymus L. (Labiatae) au Maroc. Thèse de Doctorat de 3eme cycle, Faculté des sciences Rabat.
31. Tepe B, Sokmen M, Akpulat HA, Daferera D, Polissiou M, Sokmen A 2005. Antioxidative activity of the essential oils of Thymus sipyleus subsp.sipyleus var. sipyleus and Thymus sipyleus subsp. sipyleus var. rosulans. J Food Eng 66: 447-454.
32. Vuorelaa P, Leinonenb M, Saikkuc P, Tammelaa P, Rauhad JP, Wennberge T, Vuorela H 2004. Natural products in the process of finding new drug candidates. Curr Med Chem 11: 1375-1389
33. Youdim KA, Deans SG 2000. Effect of thyme oil and thymol dietary supplementation on the antioxidant status and fatty acid composition of the ageing rat brain. Br J Nutr 83: 87-93.