-
1
-
-
37049183697
-
Human breast cancer: Correlation of relapse and survival with amplification of the HER- 2/neu oncogene
-
Slamon DJ, Clark GM, Wong SG, et al. Human breast cancer: correlation of relapse and survival with amplification of the HER- 2/neu oncogene. Science 1987; 235: 177-82.
-
(1987)
Science
, vol.235
, pp. 177-182
-
-
Slamon, D.J.1
Clark, G.M.2
Wong, S.G.3
-
2
-
-
0024337144
-
Studies of the HER- 2/neu proto-oncogene in human breast and ovarian cancer
-
Slamon DJ, Godolphin W, Jones LA, et al. Studies of the HER- 2/neu proto-oncogene in human breast and ovarian cancer. Science 1989; 244: 707-12.
-
(1989)
Science
, vol.244
, pp. 707-712
-
-
Slamon, D.J.1
Godolphin, W.2
Jones, L.A.3
-
3
-
-
33344478381
-
Adjuvant docetaxel or vinorelbine with or without trastuzumab for breast cancer
-
Joensuu H, Kellokumpu-Lehtinen PL, Bono P, et al. Adjuvant docetaxel or vinorelbine with or without trastuzumab for breast cancer. N Engl J Med 2006; 354: 809-20.
-
(2006)
N Engl J Med
, vol.354
, pp. 809-820
-
-
Joensuu, H.1
Kellokumpu-Lehtinen, P.L.2
Bono, P.3
-
4
-
-
26844503270
-
Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer
-
Piccart-Gebhart MJ, Procter M, Leyland-Jones. B, et al. Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer. N Engl J Med 2005; 353: 1659-72.
-
(2005)
N Engl J Med
, vol.353
, pp. 1659-1672
-
-
Piccart-Gebhart, M.J.1
Procter, M.2
Leyland-Jones, B.3
-
5
-
-
33845914783
-
2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: A randomised controlled trial
-
and for the HERA study team
-
Smith I, Procter M, Gelber RD and for the HERA study team. 2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: a randomised controlled trial. Lancet 2007; 369: 29-36.
-
(2007)
Lancet
, vol.369
, pp. 29-36
-
-
Smith, I.1
Procter, M.2
Gelber, R.D.3
-
6
-
-
26844536978
-
Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer
-
Romond EH, Perez EA, Bryant J, et al. Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N Engl J Med 2005; 353: 1673-84.
-
(2005)
N Engl J Med
, vol.353
, pp. 1673-1684
-
-
Romond, E.H.1
Perez, E.A.2
Bryant, J.3
-
7
-
-
33645720799
-
Phase III randomised trial comparing doxorubicin and cyclophosphamide followed by docetaxel (AC→T) with doxorubicin and cyclophosphamide followed by docetaxel and trashizumab (AC→TH) with docetaxel, carboplatin and trastuzumab (TCH) in HER2 positive early breast cancer patients: BCIRG 006 study
-
Abstract
-
Slamon D, Eiermann, W, Robert N, et al. Phase III randomised trial comparing doxorubicin and cyclophosphamide followed by docetaxel (AC→T) with doxorubicin and cyclophosphamide followed by docetaxel and trashizumab (AC→TH) with docetaxel, carboplatin and trastuzumab (TCH) in HER2 positive early breast cancer patients: BCIRG 006 study. Breast Cancer Res Treat 2005; 94 (suppl 1): S5 (Abstract).
-
(2005)
Breast Cancer Res Treat
, vol.94
, Issue.SUPPL. 1
-
-
Slamon, D.1
Eiermann, W.2
Robert, N.3
-
8
-
-
0037434791
-
-
Cho HS, Mason K, Ramyar KR, et al. Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab. Nature 2003; 421: 756-60.
-
Cho HS, Mason K, Ramyar KR, et al. Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab. Nature 2003; 421: 756-60.
-
-
-
-
9
-
-
3042800393
-
ErbB3/HER3 does not homodimerize upon neuregulin binding at the cell surface
-
Berger MB, Mandrola JM, Lemmon MA. ErbB3/HER3 does not homodimerize upon neuregulin binding at the cell surface. FEBS Lett 2004; 569: 332-6.
-
(2004)
FEBS Lett
, vol.569
, pp. 332-336
-
-
Berger, M.B.1
Mandrola, J.M.2
Lemmon, M.A.3
-
10
-
-
3543024857
-
Inhibition of tumor growth by a monoclonal antibody reactive with an oncogene-encoded tumor antigen
-
Drebin JA, Link VC, Weinberg RA. Greene MI. Inhibition of tumor growth by a monoclonal antibody reactive with an oncogene-encoded tumor antigen. Proc Natl Acad Sci USA 1986; 83: 9129-33.
-
(1986)
Proc Natl Acad Sci USA
, vol.83
, pp. 9129-9133
-
-
Drebin, J.A.1
Link, V.C.2
Weinberg, R.A.3
Greene, M.I.4
-
11
-
-
31644439702
-
Herceptin: Mechanisms action and resistance
-
Nahta, R, Esteva FJ. Herceptin: mechanisms action and resistance. Cancer Lett 2006; 232: 123-138.
-
(2006)
Cancer Lett
, vol.232
, pp. 123-138
-
-
Nahta, R.1
Esteva, F.J.2
-
12
-
-
22944452422
-
Pharmacokinetics of therapeutic monoclonal antibodies used in oncology
-
Leveque D, Wisniewski S, Jehl F. Pharmacokinetics of therapeutic monoclonal antibodies used in oncology. Anticancer Res 2005; 2327-44.
-
(2005)
Anticancer Res
, pp. 2327-2344
-
-
Leveque, D.1
Wisniewski, S.2
Jehl, F.3
-
13
-
-
0026475036
-
Interstitial hypertension in human breast and colorectal tumors
-
Less JR, Posner MC, Boucher Y, et al. Interstitial hypertension in human breast and colorectal tumors. Cancer Res 1992; 52: 6371-4.
-
(1992)
Cancer Res
, vol.52
, pp. 6371-6374
-
-
Less, J.R.1
Posner, M.C.2
Boucher, Y.3
-
14
-
-
0026739369
-
Micropharmacology of monoclonal antibodies in solid tumors: Direct experimental evidence for a binding site barrier
-
Juweid M, Neumann R, Paik C, et al. Micropharmacology of monoclonal antibodies in solid tumors: direct experimental evidence for a binding site barrier. Cancer Res 1992; 52: 5144-5153.
-
(1992)
Cancer Res
, vol.52
, pp. 5144-5153
-
-
Juweid, M.1
Neumann, R.2
Paik, C.3
-
15
-
-
13044292648
-
Enhancement of fluid filtration across tumor vessels: Implication for delivery of macromolecules
-
Netti PA, Hamberg LM, Babich JW, et al. Enhancement of fluid filtration across tumor vessels: implication for delivery of macromolecules. Proc Natl Acad Sci USA 1999; 96: 3137-42.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 3137-3142
-
-
Netti, P.A.1
Hamberg, L.M.2
Babich, J.W.3
-
16
-
-
0034114282
-
-
Dellian M, Yuan F, Trubetskoy VS, Torchilin VP, Jain RK. Vascular permeability in a human tumour xenograft: molecular charge dependence. BT J Cancer 2000; 82: 1513-8.
-
Dellian M, Yuan F, Trubetskoy VS, Torchilin VP, Jain RK. Vascular permeability in a human tumour xenograft: molecular charge dependence. BT J Cancer 2000; 82: 1513-8.
-
-
-
-
17
-
-
1542320497
-
Cancer cells compress intratumoral vessels
-
Padera TP, Stoll BR, Tooredman JB, et al. Cancer cells compress intratumoral vessels. Nature 2004; 427: 695.
-
(2004)
Nature
, vol.427
, pp. 695
-
-
Padera, T.P.1
Stoll, B.R.2
Tooredman, J.B.3
-
18
-
-
9444260479
-
Biological impediments to monoclonal antibody-based cancer immunotherapy
-
Christiansen J, Rajasekaran AK. Biological impediments to monoclonal antibody-based cancer immunotherapy. Mol Cancer Ther 2004; 3: 1493-1501.
-
(2004)
Mol Cancer Ther
, vol.3
, pp. 1493-1501
-
-
Christiansen, J.1
Rajasekaran, A.K.2
-
19
-
-
17144417329
-
Resistance of tumor interstitial pressure to the penetration of intraperitoneally delivered antibodies into metastatic ovarian tumors
-
Flessner MF, Choi J, Credit K, Deverkadra R, Henderson K. Resistance of tumor interstitial pressure to the penetration of intraperitoneally delivered antibodies into metastatic ovarian tumors. Clin Cancer Res 2005; 11: 3117-25.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 3117-3125
-
-
Flessner, M.F.1
Choi, J.2
Credit, K.3
Deverkadra, R.4
Henderson, K.5
-
20
-
-
24944584755
-
The interstitial distribution of macromolecules in rat tumours is influenced by the negatively charged matrix components
-
Wiig H, Gyenge CC, Tenstad O. The interstitial distribution of macromolecules in rat tumours is influenced by the negatively charged matrix components. J Physiol 2005; 567: 557-67.
-
(2005)
J Physiol
, vol.567
, pp. 557-567
-
-
Wiig, H.1
Gyenge, C.C.2
Tenstad, O.3
-
21
-
-
0032850677
-
Multinational study of the efficacy and safety of humanized anti-BER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease
-
Cobleight MA, Vogel CL, Tripathy D, et al. Multinational study of the efficacy and safety of humanized anti-BER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease. J Clin Oncol 1999; 17: 2639-48.
-
(1999)
J Clin Oncol
, vol.17
, pp. 2639-2648
-
-
Cobleight, M.A.1
Vogel, C.L.2
Tripathy, D.3
-
22
-
-
17144371333
-
Phase II study of efficacy, safety, and pharmacokinetics of trastuzumab monotherapy administered on a 3-weekly schedule
-
Baselga J, Carbonell X, Castaneda-Soto NJ, et al. Phase II study of efficacy, safety, and pharmacokinetics of trastuzumab monotherapy administered on a 3-weekly schedule. J Clin Oncol 2005; 10: 2162-71.
-
(2005)
J Clin Oncol
, vol.10
, pp. 2162-2171
-
-
Baselga, J.1
Carbonell, X.2
Castaneda-Soto, N.J.3
-
23
-
-
0035869407
-
Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
-
Slamon DJ, Leyland-Jones B, Shak S, et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med 2001; 344: 783-92.
-
(2001)
N Engl J Med
, vol.344
, pp. 783-792
-
-
Slamon, D.J.1
Leyland-Jones, B.2
Shak, S.3
-
25
-
-
33845599378
-
Ratio of trastuzumab levels in serum and cerebro-spinal fluid is altered in HER2-positive breast cancer patients with brain metastases and impairment of blood-brain barrier
-
Stemmler HJ, Schmitt M, Willems A, Bernhard H, Harbeck N, Heinemann V. Ratio of trastuzumab levels in serum and cerebro-spinal fluid is altered in HER2-positive breast cancer patients with brain metastases and impairment of blood-brain barrier. Anticancer Drugs 2007; 18: 23-8.
-
(2007)
Anticancer Drugs
, vol.18
, pp. 23-28
-
-
Stemmler, H.J.1
Schmitt, M.2
Willems, A.3
Bernhard, H.4
Harbeck, N.5
Heinemann, V.6
-
26
-
-
22344441597
-
Central nervous system metastases in breast cancer patients administered trastuzumab
-
Duchnowska R, Szczylick C. Central nervous system metastases in breast cancer patients administered trastuzumab. Cancer Treat Rev 2005; 31: 312-8.
-
(2005)
Cancer Treat Rev
, vol.31
, pp. 312-318
-
-
Duchnowska, R.1
Szczylick, C.2
-
27
-
-
0035188978
-
Use of intrathecal trastuzumab in a patient with carcinomatous meningitis
-
Laufman LR, Forsthoefel KF. Use of intrathecal trastuzumab in a patient with carcinomatous meningitis. Clin Breast Cancer 2001; 2: 235.
-
(2001)
Clin Breast Cancer
, vol.2
, pp. 235
-
-
Laufman, L.R.1
Forsthoefel, K.F.2
-
28
-
-
33744939239
-
Application of intrathecal trastuzumab (herceptin®) for treatment of meningeal carcinomatosis in HER2-overexpressing metastatic breast cancer
-
Stemmler HJ, Schmitt M, Harbeck N, et al. Application of intrathecal trastuzumab (herceptin®) for treatment of meningeal carcinomatosis in HER2-overexpressing metastatic breast cancer. Oncol Rep 2006; 15: 1373-7.
-
(2006)
Oncol Rep
, vol.15
, pp. 1373-1377
-
-
Stemmler, H.J.1
Schmitt, M.2
Harbeck, N.3
-
29
-
-
33747828928
-
Meningeal carcinomatosis from breast cancer treated with intrathecal trastuzuzmab
-
Platini C, Long J, Walter S. Meningeal carcinomatosis from breast cancer treated with intrathecal trastuzuzmab. Lancet Oncol 2006; 7: 778-80.
-
(2006)
Lancet Oncol
, vol.7
, pp. 778-780
-
-
Platini, C.1
Long, J.2
Walter, S.3
-
30
-
-
11844250025
-
A passionate kiss, then run: Exocytosis and recycling of IgG by FcRn
-
Lencer WI, Blumberg RS. A passionate kiss, then run: exocytosis and recycling of IgG by FcRn. Trends Cell Biol 2005; 15: 5-9.
-
(2005)
Trends Cell Biol
, vol.15
, pp. 5-9
-
-
Lencer, W.I.1
Blumberg, R.S.2
-
31
-
-
33645531322
-
Familial hypercatabolic hypo-proteinemia caused by deficiency of the neonatal Fc receptor, FcRn, due to a mutant-beta2-microglobulin gene
-
Wani MA, Haynes LD, Kim J, et al. Familial hypercatabolic hypo-proteinemia caused by deficiency of the neonatal Fc receptor, FcRn, due to a mutant-beta2-microglobulin gene. Proc Natl Acad Sci USA 2006; 103: 5084-9.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 5084-5089
-
-
Wani, M.A.1
Haynes, L.D.2
Kim, J.3
-
32
-
-
33846050957
-
Kinetics of FcRn-mediated recycling of IgG and albumin in human: Pathophysiology and therapeutic implications using a simplified mechanism-based model
-
Kim J, Hayton WL, Robinson JM, Anderson CL. Kinetics of FcRn-mediated recycling of IgG and albumin in human: pathophysiology and therapeutic implications using a simplified mechanism-based model. Clin Immunol 2007; 122: 146-55.
-
(2007)
Clin Immunol
, vol.122
, pp. 146-155
-
-
Kim, J.1
Hayton, W.L.2
Robinson, J.M.3
Anderson, C.L.4
-
33
-
-
0036087626
-
FcRn-mediated transcytosis of immunoglobulin G in human renal proximal tubular epithelial cells
-
Kobayashi N, Suzuki Y, Tsuge T, Okumura K, Ra C, Tomino Y. FcRn-mediated transcytosis of immunoglobulin G in human renal proximal tubular epithelial cells. Am J Physiol Renal Physiol 2002; 282: F358-F365.
-
(2002)
Am J Physiol Renal Physiol
, vol.282
-
-
Kobayashi, N.1
Suzuki, Y.2
Tsuge, T.3
Okumura, K.4
Ra, C.5
Tomino, Y.6
-
34
-
-
0029991439
-
Phase II study of weekly intravenous recombinant humanized anti-p185HER2 monoclonal antibody in patients with HER2/neu-overexpressing metastatic breast cancer
-
Baselga J, Tripathy D, Mendelsohn J, et al. Phase II study of weekly intravenous recombinant humanized anti-p185HER2 monoclonal antibody in patients with HER2/neu-overexpressing metastatic breast cancer. J Clin Onrol 1996; 14: 737-44.
-
(1996)
J Clin Onrol
, vol.14
, pp. 737-744
-
-
Baselga, J.1
Tripathy, D.2
Mendelsohn, J.3
-
35
-
-
0032713216
-
Dose escalation and pharmacokinetic study of a humanised anti-HER2 monoclonal antibody in patients with HER2/neu-overexpressing metastatic breast cancer
-
Tokuda Y, Watanabe T, Omuro Y, et al. Dose escalation and pharmacokinetic study of a humanised anti-HER2 monoclonal antibody in patients with HER2/neu-overexpressing metastatic breast cancer. Br J Cancer 1999; 81: 1419-25.
-
(1999)
Br J Cancer
, vol.81
, pp. 1419-1425
-
-
Tokuda, Y.1
Watanabe, T.2
Omuro, Y.3
-
36
-
-
23244455101
-
Population pharmacokinetics of trastuzumab in patients with HER2+ metastatic breast, cancer
-
Bruno R, Washington CB, Lu JF, Lieberman G, Banken L, Klein P. Population pharmacokinetics of trastuzumab in patients with HER2+ metastatic breast, cancer. Cancer Chemother Pharmacol 2005; 56: 361-9.
-
(2005)
Cancer Chemother Pharmacol
, vol.56
, pp. 361-369
-
-
Bruno, R.1
Washington, C.B.2
Lu, J.F.3
Lieberman, G.4
Banken, L.5
Klein, P.6
-
37
-
-
0346017700
-
Pharmacokinetics, safety, and efficacy of trastuzumab administered every three weeks in combination with paclitaxel
-
Leyland-Jones B, Gelmon K, Ayoub JP, et al. Pharmacokinetics, safety, and efficacy of trastuzumab administered every three weeks in combination with paclitaxel. J Clin Oncol 2003; 21: 3965-71.
-
(2003)
J Clin Oncol
, vol.21
, pp. 3965-3971
-
-
Leyland-Jones, B.1
Gelmon, K.2
Ayoub, J.P.3
-
38
-
-
0042510536
-
Influence of tastuzumab on epirubicin pharmacokinetics in metastatic breast cancer patients
-
Lunardi G, Vannozzi MO, Bighin C, et al. Influence of tastuzumab on epirubicin pharmacokinetics in metastatic breast cancer patients. Ann Oncol 2003; 14: 1222-6.
-
(2003)
Ann Oncol
, vol.14
, pp. 1222-1226
-
-
Lunardi, G.1
Vannozzi, M.O.2
Bighin, C.3
-
39
-
-
8444219618
-
Phase II feasibility and pharmacokinetic study of concurrent administration of trastuzumab and high-dose chemotherapy in advanced HER2+ breast cancer
-
Nieto Y, Vredenburgh JJ, Shpall EJ, et al. Phase II feasibility and pharmacokinetic study of concurrent administration of trastuzumab and high-dose chemotherapy in advanced HER2+ breast cancer. Clin Cancer Res 2004; 10: 7136-43.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 7136-7143
-
-
Nieto, Y.1
Vredenburgh, J.J.2
Shpall, E.J.3
-
40
-
-
12144290704
-
Trastuzumab in combination with cisplatin and gemcitabine in patients with Her2-overexpressing, untreated, advanced non-small cell lung cancer: Report of a phase II trial and findings regarding optimal identification of patients with Her2-overexpressing disease
-
Zinner RG, Glisson BS, Fosella FV, et al. Trastuzumab in combination with cisplatin and gemcitabine in patients with Her2-overexpressing, untreated, advanced non-small cell lung cancer: report of a phase II trial and findings regarding optimal identification of patients with Her2-overexpressing disease. Lung Cancer 2004; 44: 99-110.
-
(2004)
Lung Cancer
, vol.44
, pp. 99-110
-
-
Zinner, R.G.1
Glisson, B.S.2
Fosella, F.V.3
-
41
-
-
27144531028
-
Disposition of paclitaxel and its metabolites in patients with advanced breast cancer when combined with trastuzumab
-
Furtlehner A, Schueller J, Jarish I, et al. Disposition of paclitaxel and its metabolites in patients with advanced breast cancer when combined with trastuzumab. Eur J Drug Metab Pharmacokinet 2005; 30: 145-50.
-
(2005)
Eur J Drug Metab Pharmacokinet
, vol.30
, pp. 145-150
-
-
Furtlehner, A.1
Schueller, J.2
Jarish, I.3
-
42
-
-
1842614245
-
Safety of treatment of metastatic breast cancer with trastuzumab beyond disease progression
-
Tripathy D, Slamon DJ, Cobleigh M, et al. Safety of treatment of metastatic breast cancer with trastuzumab beyond disease progression. J Clin Oncol 2004; 22: 1063-70.
-
(2004)
J Clin Oncol
, vol.22
, pp. 1063-1070
-
-
Tripathy, D.1
Slamon, D.J.2
Cobleigh, M.3
-
43
-
-
33645004564
-
Continued use of trastuzumab (Herceptin) after progression on prior trastuzumab therapy in HER-2-positive metastatic breast cancer
-
Pusztai L, Esteva FJ. Continued use of trastuzumab (Herceptin) after progression on prior trastuzumab therapy in HER-2-positive metastatic breast cancer. Cancer Invest 2006; 24: 187-91.
-
(2006)
Cancer Invest
, vol.24
, pp. 187-191
-
-
Pusztai, L.1
Esteva, F.J.2
-
44
-
-
34249077302
-
Favourable effect of continuated trastuzumab treatment in metastatic breast cancer patients: Results from the French Hermine cohort study
-
abstract
-
Extra JM, Antoine EC, Vincent-Salomon A, et al. Favourable effect of continuated trastuzumab treatment in metastatic breast cancer patients: results from the French Hermine cohort study. Breast Cancer Res Treat 2006; 100 (Suppl 1): S102 (abstract).
-
(2006)
Breast Cancer Res Treat
, vol.100
, Issue.SUPPL. 1
-
-
Extra, J.M.1
Antoine, E.C.2
Vincent-Salomon, A.3
-
45
-
-
33845886440
-
Lapatinib plus capecitabine for HER-2 positive advanced breast cancer
-
Geyer CE, Forster J, Lindquist D, et al. Lapatinib plus capecitabine for HER-2 positive advanced breast cancer. N Engl J Med 2006; 355: 2733-43.
-
(2006)
N Engl J Med
, vol.355
, pp. 2733-2743
-
-
Geyer, C.E.1
Forster, J.2
Lindquist, D.3
|