Investigation of the alkenyldiarylmethane non-nucleoside reverse transcriptase inhibitors as potential cAMP phosphodiesterase-4B2 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 4, 2008, Pages 1530-1533

  Cullen, Matthew D ^a   Cheung, York Fong ^b   Houslay, Miles D ^b   Hartman, Tracy L ^c   Watson, Karen M ^c   Buckheit Jr , Robert W ^c   Pannecouque, Christophe ^d   De Clercq, Erik ^d   Cushman, Mark ^a  

^a PURDUE UNIVERSITY   (United States)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c ImQuest Biosciences   (United States)

^d REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

ADAM; Alkenyldiarylmethane; HIV 1; NNRTI; Non nucleoside reverse transcriptase inhibitor; PDE4B2; Phosphodiesterase

Indexed keywords

ALKENYLDIARYLMETHANE; CYCLIC AMP; CYCLIC AMP PHOSPHODIESTERASE; CYCLIC AMP PHOSPHODIESTERASE 4B2; NEVIRAPINE; PHOSPHODIESTERASE INHIBITOR; PHOSPHODIESTERASE IV; PHOSPHODIESTERASE IV INHIBITOR; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; ROLIPRAM; UNCLASSIFIED DRUG;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; DRUG POTENCY; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HYDROLYSIS;

ALKENES; CELL LINE, TUMOR; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; HIV REVERSE TRANSCRIPTASE; HUMANS; INHIBITORY CONCENTRATION 50; METHANE; OXAZOLES; PHOSPHODIESTERASE INHIBITORS; REVERSE TRANSCRIPTASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 38949192887     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.12.015     Document Type: Article

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