Increased apparent oral clearance of valproic acid during intake of combined contraceptive steroids in women with epilepsy

Epilepsia

Volumn 47, Issue 9, 2006, Pages 1569-1572

  Galimberti, Carlo Andrea ^a   Mazzucchelli, Iolanda ^b   Arbasino, Carla ^a   Canevini, Maria Paola ^c   Fattore, Cinzia ^b   Perucca, Emilio ^a,b  

^a C MONDINO NATIONAL NEUROLOGICAL INSTITUTE   (Italy)

^b UNIVERSITY OF PAVIA   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

Author keywords

Contraceptive steroids; Drug interaction; Epilepsy; Pharmacokinetics; Valproic acid

Indexed keywords

CONTRACEPTIVE AGENT; DROSPIRENONE; ESTRADIOL; ETHINYLESTRADIOL; GESTODENE; VALPROIC ACID;

ADULT; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DEMOGRAPHY; DRUG BLOOD LEVEL; DRUG POTENTIATION; EPILEPSY; FEMALE; FLUORESCENCE POLARIZATION IMMUNOASSAY; HUMAN; MONOTHERAPY; PRIORITY JOURNAL; STEADY STATE;

ADMINISTRATION, ORAL; ADOLESCENT; ADULT; ANTICONVULSANTS; CONTRACEPTIVES, ORAL, COMBINED; CONTRACEPTIVES, ORAL, HORMONAL; DRUG INTERACTIONS; DRUG MONITORING; ENZYME INDUCTION; EPILEPSY; ETHINYL ESTRADIOL; FEMALE; FLUORESCENCE POLARIZATION IMMUNOASSAY; GLUCURONOSYLTRANSFERASE; HUMANS; VALPROIC ACID;

EID: 33748708898     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2006.00629.x     Document Type: Article

References (13)

1. Patsalos PN, Perucca E. Clinically important drug interactions in epilepsy: interactions between antiepileptic drugs and other drugs. Lancet Neurol 2003;2:473-81.
2. Crawford P. Interactions between antiepileptic drugs and hormonal contraception. CNS Drugs 2002;16:263-72.
3. Shenfield GM, Griffin JM. Clinical pharmacokinetics of contraceptive steroids. An update. Clin Pharmacokinet 1991;20:15-37.
4. Sabers A, Buchholt JM, Uldall P, et al. Lamotrigine plasma levels reduced by oral contraceptives. Epilepsy Res 2001;47:151-4.
5. Sabers A, Ohman I, Christensen J, et al. Oral contraceptives reduce lamotrigine plasma levels. Neurology 2003; 61:570-1.
6. Sidhu J, Job S, Singh S, et al. The pharmacokinetic and pharmacodynamic consequences of the co-administration of lamotrigine and a combined oral contraceptive in healthy female subjects. Br J Clin Pharmacol 2006;61:191-9.
7. Contin M, Albani F, Ambrosetto G, et al. Variation in lamotrigine plasma concentrations with hormonal contraceptive monthly cycles in patients with epilepsy. Epilepsia 2006 (in press).
8. Herzog AG, Farina EL, Blum AS. Serum valproate levels with oral contraceptive use. Epilepsia 2005;46:970-1.
9. Cramer JA, Mattson RH, Bennett DM, et al. Variable free and total valproic acid concentrations in sole- and multi-drug therapy. Ther Drug Monit 1986;8:411-5.
10. Yoshida H, Hirozane K, Kimoto H, et al. Valproic acid elimination rate and urinary excretion of its glucuronide conjugate in patients with epilepsy. Biol Pharm Bull 1999;22:716-20.
11. Reimers A, Helde G, Brodtkorb B. Ethinylestradiol, not progestogens, reduces lamotrigine serum concentrations. Epilepsia 2005;46:1414-7.
12. Ehmer U, Vogel A, Schutte JK, et al. Variation of hepatic glucuronidation: novel functional polymorphisms of the UDP- glucuronosyltransferase UGT1A4. Hepatology 2004;39:970-7.
13. Perucca E, Gatti G, Frigo GM, et al. Disposition of sodium valproate in epileptic patients. Br J Clin Pharmacol 1978;5:495-9.